Probiotics in intestinal modulation as an adjuvant in the treatment of signs and symptoms of depression
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/16634 |
Resumo: | Objective: This study aimed to investigate whether probiotics improved symptoms of depression and anxiety as assessed by different psychometric scales. Methodology: The present study is an integrative bibliographic review, carried out through a literature survey bibliographic research in PubMed combining the terms "Probiotics", "Intestinal Modulation" and "Depression" to identify clinical trial studies in humans who investigated the relationship between depressive, anxious aspects and the microbiota. Results: Data were extracted from 12 studies of clinical trials (922 humans), randomized, controlled, doubleblind. In the assessed context, probiotics reduced scores on different psychometric scales, reducing anxiety-like and depressive behavior. Analyzes of analyzes at the level of probiotic species, identified subspecies of the genus Lactobacillus and Bifidobacterium the capacity for anxiolytic activity. ⩾60% improvements in evaluation scales were demonstrated with supplementation of probiotics and even improvements in quality of life in individuals with inflammatory bowel diseases. Conclusion: The microbiota was raised to a potential target for the treatment of psychiatric and antidepressant disorders. Depression is a challenge for global health, as it requires multidisciplinary interventions since this disease is characterized as a cerebral metabolic disorder and probiotics would play an essential role on the individual's health and disease status. |
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Probiotics in intestinal modulation as an adjuvant in the treatment of signs and symptoms of depression Probióticos en modulación intestinal como adyuvante en el tratamiento de signos y síntomas depresiónProbióticos na modulação intestinal como adjuvante no tratamento de sinais e sintomas de depressãoDepressionProbioticsMicrobiota.DepresiónProbióticosMicrobiota.DepressãoProbióticosMicrobiota.Objective: This study aimed to investigate whether probiotics improved symptoms of depression and anxiety as assessed by different psychometric scales. Methodology: The present study is an integrative bibliographic review, carried out through a literature survey bibliographic research in PubMed combining the terms "Probiotics", "Intestinal Modulation" and "Depression" to identify clinical trial studies in humans who investigated the relationship between depressive, anxious aspects and the microbiota. Results: Data were extracted from 12 studies of clinical trials (922 humans), randomized, controlled, doubleblind. In the assessed context, probiotics reduced scores on different psychometric scales, reducing anxiety-like and depressive behavior. Analyzes of analyzes at the level of probiotic species, identified subspecies of the genus Lactobacillus and Bifidobacterium the capacity for anxiolytic activity. ⩾60% improvements in evaluation scales were demonstrated with supplementation of probiotics and even improvements in quality of life in individuals with inflammatory bowel diseases. Conclusion: The microbiota was raised to a potential target for the treatment of psychiatric and antidepressant disorders. Depression is a challenge for global health, as it requires multidisciplinary interventions since this disease is characterized as a cerebral metabolic disorder and probiotics would play an essential role on the individual's health and disease status.Objetivo: Este estudio tuvo como objetivo investigar si los probióticos mejoraron los síntomas de depresión y ansiedad evaluados por diferentes escalas psicométricas. Metodología: El presente estudio es una revisión bibliográfica integrativa, realizada mediante una encuesta bibliográfica de investigación bibliográfica en PubMed combinando los términos "Probióticos", "Modulación intestinal" y "Depresión" para identificar estudios de ensayos clínicos en humanos que investigaron la relación entre aspectos depresivos, ansiosos y la microbiota. Resultados: Se extrajeron datos de 12 estudios de ensayos clínicos (922 humanos), aleatorizados, controlados, doble ciego. En el contexto evaluado, los probióticos redujeron las puntuaciones en diferentes escalas psicométricas, reduciendo el comportamiento depresivo y de ansiedad. Análisis de análisis a nivel de especies probióticas, identificaron subespecies del género Lactobacillus y Bifidobacterium la capacidad de actividad ansiolítica. Se han demostrado mejoras de aproximadamente un 60% en las escalas de evaluación con la suplementación de probióticos e incluso mejoras en la calidad de vida en personas con enfermedades inflamatorias del intestino. Conclusión: La microbiota se convirtió en un objetivo potencial para el tratamiento de trastornos psiquiátricos y antidepresivos. La depresión es un desafío para la salud global, ya que requiere intervenciones multidisciplinarias ya que esta enfermedad se caracteriza como un trastorno metabólico del cerebro y los probióticos jugarían un papel fundamental en la salud y enfermedad del individuo.Objetivo: Este estudo teve como objetivo investigar se os probióticos melhoraram sintomas de depressão e ansiedade em avaliadas por diferentes escalas psicométricas. Metodologia: O presente estudo trata-se de uma revisão bibliográfica do tipo integrativa, realizada por meio de um levantamento de literatura pesquisa bibliográfica no PubMed combinando os termos "Probióticos", "Modulação Intestinal" e "Depressão" para identificar os estudos de ensaios clínicos em humanos que investigaram as relações entre aspectos depressivos, ansiosos e a microbiota. Resultados: Os dados foram extraídos de 12 estudos de ensaios clínicos (922 humanos), randomizado, controlados, duplo-cego. No contexto avaliado, probióticos reduziram pontuação nas diferentes escalas psicométricas reduzindo o comportamento semelhante a ansiedade e depressivo. Análises de análises em nível de espécie probiótica, identificaram subespécies do gênero Lactobacillus e Bifidobacterium a capacidade de atividade ansiolítica. Melhoras ⩾60% em escalas avaliativas foram demonstradas com suplementação de probióticos e até mesmo melhoras na qualidade de vida em indivíduos com doenças inflamatórias intestinais. Conclusão: A microbiota foi alçada a um alvo potencial para o tratamento de transtornos psiquiátricos e antidepressivos. A depressão é um desafio para a saúde global, pois demanda intervenções multidisciplinar já que está doença se caracteriza como uma desordem metabólica cerebral e os probióticos desempenhariam uma ação essencial sobre o estado de saúde e doença do indivíduo.Research, Society and Development2021-07-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1663410.33448/rsd-v10i8.16634Research, Society and Development; Vol. 10 No. 8; e55910816634Research, Society and Development; Vol. 10 Núm. 8; e55910816634Research, Society and Development; v. 10 n. 8; e559108166342525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/16634/15340Copyright (c) 2021 Erick Michell Bezerra Oliveira; Manoel Augusto de Moura; Luanna da Silva de Assunção; Aline Cristina Ribeiro da Luz; Adyelle Karoline Atan; Rubenilson Luna Matos; Julianne de Area Leão Pereira da Silva; Thiago Henrique Gonçalves Moreira; Jonas Alves Cardoso; Flávio Bruno Rodrigues de Assunção; Domingas Marlyene Silva Conceição; Francisco de Assis Viana dos Santos; Géofrey Henrick Silva Galvão; Hernandys Ribeiro Bezerra; Nathália Cássia Martins Sampaiohttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessOliveira, Erick Michell Bezerra Moura, Manoel Augusto de Assunção, Luanna da Silva deLuz, Aline Cristina Ribeiro daAtan, Adyelle Karoline Matos, Rubenilson Luna Silva, Julianne de Area Leão Pereira da Moreira, Thiago Henrique Gonçalves Cardoso, Jonas Alves Assunção, Flávio Bruno Rodrigues de Conceição, Domingas Marlyene SilvaSantos, Francisco de Assis Viana dos Galvão, Géofrey Henrick Silva Bezerra, Hernandys Ribeiro Sampaio, Nathália Cássia Martins 2021-08-21T18:46:59Zoai:ojs.pkp.sfu.ca:article/16634Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:37:07.977Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Probiotics in intestinal modulation as an adjuvant in the treatment of signs and symptoms of depression Probióticos en modulación intestinal como adyuvante en el tratamiento de signos y síntomas depresión Probióticos na modulação intestinal como adjuvante no tratamento de sinais e sintomas de depressão |
title |
Probiotics in intestinal modulation as an adjuvant in the treatment of signs and symptoms of depression |
spellingShingle |
Probiotics in intestinal modulation as an adjuvant in the treatment of signs and symptoms of depression Oliveira, Erick Michell Bezerra Depression Probiotics Microbiota. Depresión Probióticos Microbiota. Depressão Probióticos Microbiota. |
title_short |
Probiotics in intestinal modulation as an adjuvant in the treatment of signs and symptoms of depression |
title_full |
Probiotics in intestinal modulation as an adjuvant in the treatment of signs and symptoms of depression |
title_fullStr |
Probiotics in intestinal modulation as an adjuvant in the treatment of signs and symptoms of depression |
title_full_unstemmed |
Probiotics in intestinal modulation as an adjuvant in the treatment of signs and symptoms of depression |
title_sort |
Probiotics in intestinal modulation as an adjuvant in the treatment of signs and symptoms of depression |
author |
Oliveira, Erick Michell Bezerra |
author_facet |
Oliveira, Erick Michell Bezerra Moura, Manoel Augusto de Assunção, Luanna da Silva de Luz, Aline Cristina Ribeiro da Atan, Adyelle Karoline Matos, Rubenilson Luna Silva, Julianne de Area Leão Pereira da Moreira, Thiago Henrique Gonçalves Cardoso, Jonas Alves Assunção, Flávio Bruno Rodrigues de Conceição, Domingas Marlyene Silva Santos, Francisco de Assis Viana dos Galvão, Géofrey Henrick Silva Bezerra, Hernandys Ribeiro Sampaio, Nathália Cássia Martins |
author_role |
author |
author2 |
Moura, Manoel Augusto de Assunção, Luanna da Silva de Luz, Aline Cristina Ribeiro da Atan, Adyelle Karoline Matos, Rubenilson Luna Silva, Julianne de Area Leão Pereira da Moreira, Thiago Henrique Gonçalves Cardoso, Jonas Alves Assunção, Flávio Bruno Rodrigues de Conceição, Domingas Marlyene Silva Santos, Francisco de Assis Viana dos Galvão, Géofrey Henrick Silva Bezerra, Hernandys Ribeiro Sampaio, Nathália Cássia Martins |
author2_role |
author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Oliveira, Erick Michell Bezerra Moura, Manoel Augusto de Assunção, Luanna da Silva de Luz, Aline Cristina Ribeiro da Atan, Adyelle Karoline Matos, Rubenilson Luna Silva, Julianne de Area Leão Pereira da Moreira, Thiago Henrique Gonçalves Cardoso, Jonas Alves Assunção, Flávio Bruno Rodrigues de Conceição, Domingas Marlyene Silva Santos, Francisco de Assis Viana dos Galvão, Géofrey Henrick Silva Bezerra, Hernandys Ribeiro Sampaio, Nathália Cássia Martins |
dc.subject.por.fl_str_mv |
Depression Probiotics Microbiota. Depresión Probióticos Microbiota. Depressão Probióticos Microbiota. |
topic |
Depression Probiotics Microbiota. Depresión Probióticos Microbiota. Depressão Probióticos Microbiota. |
description |
Objective: This study aimed to investigate whether probiotics improved symptoms of depression and anxiety as assessed by different psychometric scales. Methodology: The present study is an integrative bibliographic review, carried out through a literature survey bibliographic research in PubMed combining the terms "Probiotics", "Intestinal Modulation" and "Depression" to identify clinical trial studies in humans who investigated the relationship between depressive, anxious aspects and the microbiota. Results: Data were extracted from 12 studies of clinical trials (922 humans), randomized, controlled, doubleblind. In the assessed context, probiotics reduced scores on different psychometric scales, reducing anxiety-like and depressive behavior. Analyzes of analyzes at the level of probiotic species, identified subspecies of the genus Lactobacillus and Bifidobacterium the capacity for anxiolytic activity. ⩾60% improvements in evaluation scales were demonstrated with supplementation of probiotics and even improvements in quality of life in individuals with inflammatory bowel diseases. Conclusion: The microbiota was raised to a potential target for the treatment of psychiatric and antidepressant disorders. Depression is a challenge for global health, as it requires multidisciplinary interventions since this disease is characterized as a cerebral metabolic disorder and probiotics would play an essential role on the individual's health and disease status. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-07-09 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/16634 10.33448/rsd-v10i8.16634 |
url |
https://rsdjournal.org/index.php/rsd/article/view/16634 |
identifier_str_mv |
10.33448/rsd-v10i8.16634 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/16634/15340 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 10 No. 8; e55910816634 Research, Society and Development; Vol. 10 Núm. 8; e55910816634 Research, Society and Development; v. 10 n. 8; e55910816634 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052807371554816 |