Probiotics in intestinal modulation as an adjuvant in the treatment of signs and symptoms of depression

• Autor(a) principal: Oliveira, Erick Michell Bezerra
• Data de Publicação: 2021
• Outros Autores: Moura, Manoel Augusto de, Assunção, Luanna da Silva de, Luz, Aline Cristina Ribeiro da, Atan, Adyelle Karoline, Matos, Rubenilson Luna, Silva, Julianne de Area Leão Pereira da, Moreira, Thiago Henrique Gonçalves, Cardoso, Jonas Alves, Assunção, Flávio Bruno Rodrigues de, Conceição, Domingas Marlyene Silva, Santos, Francisco de Assis Viana dos, Galvão, Géofrey Henrick Silva, Bezerra, Hernandys Ribeiro, Sampaio, Nathália Cássia Martins
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Research, Society and Development
• Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/16634
• topic: Depression; Probiotics; Microbiota.; Depresión; Probióticos; Microbiota.; Depressão; Probióticos; Microbiota.

Objective: This study aimed to investigate whether probiotics improved symptoms of depression and anxiety as assessed by different psychometric scales. Methodology: The present study is an integrative bibliographic review, carried out through a literature survey bibliographic research in PubMed combining the terms "Probiotics", "Intestinal Modulation" and "Depression" to identify clinical trial studies in humans who investigated the relationship between depressive, anxious aspects and the microbiota. Results: Data were extracted from 12 studies of clinical trials (922 humans), randomized, controlled, doubleblind.  In the assessed context, probiotics reduced scores on different psychometric scales, reducing anxiety-like and depressive behavior.  Analyzes of analyzes at the level of probiotic species, identified subspecies of the genus Lactobacillus and Bifidobacterium the capacity for anxiolytic activity.  ⩾60% improvements in evaluation scales were demonstrated with supplementation of probiotics and even improvements in quality of life in individuals with inflammatory bowel diseases. Conclusion: The microbiota was raised to a potential target for the treatment of psychiatric and antidepressant disorders.  Depression is a challenge for global health, as it requires multidisciplinary interventions since this disease is characterized as a cerebral metabolic disorder and probiotics would play an essential role on the individual's health and disease status.