DOES LIDOCAINE HAVE ANTIMICROBIAL EFFECTS AGAINST MAJOR PATHOGENS THAT INFECT WOUNDS? AN “IN VITRO” STUDY

Detalhes bibliográficos
Autor(a) principal: Carvalho Henriques, Bruno
Data de Publicação: 2020
Outros Autores: Delfino Caldeira , Isadora, Schadeck Portelinha, Maria Júlia, Lopes Medina , Denis Aloísio, Talavera Martelli, Cesar Alberto, Silva Cayres de Oliveira, Mayla, de Carvalho Almeida, Mércia, Alencar Marques, Mariângela Esther, Nai, Gisele Alborghetti
Tipo de documento: Artigo
Idioma: por
Título da fonte: Colloquium Vitae
Texto Completo: http://revistas.unoeste.br/index.php/cv/article/view/3396
Resumo: Local anesthetics are commonly used in medicine and dentistry and have a low cost, but their action as a microbicidal agent is still controversial. This study aimed to evaluate the antimicrobial effects of lidocaine against bacteria that most commonly infect surgical wounds. We evaluated Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Proteus mirabilis and Enterococcus faecalis. The solutions tested were saline, chlorhexidine, lidocaine (solution and pure) and an antibiotic solution. The agar diffusion test was performed using Petri dishes. The plates tested with lidocaine (pure or solution) presented no inhibition halo. The antibiotic solution presented the largest inhibition halos for all the bacteria (p < 0.05). Chlorhexidine formed an inhibition halo similar to that of the antibiotic solution for Escherichia coli (p > 0.05). Lidocaine did not present an antimicrobial effect for any of the tested bacteria. However, the antibiotic solution and the chlorhexidine inhibited the growth of all bacteria.
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spelling DOES LIDOCAINE HAVE ANTIMICROBIAL EFFECTS AGAINST MAJOR PATHOGENS THAT INFECT WOUNDS? AN “IN VITRO” STUDYLocal anesthetics are commonly used in medicine and dentistry and have a low cost, but their action as a microbicidal agent is still controversial. This study aimed to evaluate the antimicrobial effects of lidocaine against bacteria that most commonly infect surgical wounds. We evaluated Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Proteus mirabilis and Enterococcus faecalis. The solutions tested were saline, chlorhexidine, lidocaine (solution and pure) and an antibiotic solution. The agar diffusion test was performed using Petri dishes. The plates tested with lidocaine (pure or solution) presented no inhibition halo. The antibiotic solution presented the largest inhibition halos for all the bacteria (p < 0.05). Chlorhexidine formed an inhibition halo similar to that of the antibiotic solution for Escherichia coli (p > 0.05). Lidocaine did not present an antimicrobial effect for any of the tested bacteria. However, the antibiotic solution and the chlorhexidine inhibited the growth of all bacteria.Os anestésicos locais são utilizados comumente como agente para analgesia pós-operatória e tem um baixo custo, porém sua ação como agente microbicida ainda é controversa. O objetivo deste estudo foi avaliar se a lidocaína tem efeito antimicrobiano frente à infecção pelas bactérias que mais comumente infectam feridas cirúrgicas. Para este estudo, foram avaliados os seguintes microorganismos: Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Proteus mirabilis e Enterococcus faecalis. As soluções testadas foram soro fisiológico, clorexidina, solução de lidocaína, lidocaína pura e solução de antibióticos. As placas testadas com solução de lidocaína e a lidocaína pura não apresentaram halo de inibição. A solução de antibióticos apresentou os maiores halos de inibição em todas as bactérias testadas (p < 0.05). A clorexidina formou halo semelhante ao da solução de antibióticos para Escherichia coli (p > 0.05). A lidocaína não apresentou efeito antimicrobiano em relação a nenhuma das bactérias testadas. Porém, a solução de antibióticos e o digliconato de clorexidina inibiram o crescimento de todas as bactérias.Universidade do Oeste Paulista - UNOESTE2020-06-17info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAvaliado por paresapplication/pdfhttp://revistas.unoeste.br/index.php/cv/article/view/3396Colloquium Vitae. ISSN: 1984-6436; v. 12 n. 2 (2020): Colloquium Vitae, Vol. 12, n. 2; 19-231984-6436reponame:Colloquium Vitaeinstname:Universidade do Oeste Paulista (UNOESTE)instacron:UNIOESTEporhttp://revistas.unoeste.br/index.php/cv/article/view/3396/3014Copyright (c) 2020 Colloquium Vitae. ISSN: 1984-6436info:eu-repo/semantics/openAccessCarvalho Henriques, Bruno Delfino Caldeira , Isadora Schadeck Portelinha, Maria Júlia Lopes Medina , Denis AloísioTalavera Martelli, Cesar Alberto Silva Cayres de Oliveira, Mayla de Carvalho Almeida, Mércia Alencar Marques, Mariângela Esther Nai, Gisele AlborghettiNai, Gisele Alborghetti2020-11-13T14:20:44Zoai:ojs.pkp.sfu.ca:article/3396Revistahttps://revistas.unoeste.br/index.php/cv/indexONGhttp://revistas.unoeste.br/revistas/ojs/index.php/cv/oaijgjunior@unoeste.br||jgjunior@unoeste.br1984-64361984-6436opendoar:2020-11-13T14:20:44Colloquium Vitae - Universidade do Oeste Paulista (UNOESTE)false
dc.title.none.fl_str_mv DOES LIDOCAINE HAVE ANTIMICROBIAL EFFECTS AGAINST MAJOR PATHOGENS THAT INFECT WOUNDS? AN “IN VITRO” STUDY
title DOES LIDOCAINE HAVE ANTIMICROBIAL EFFECTS AGAINST MAJOR PATHOGENS THAT INFECT WOUNDS? AN “IN VITRO” STUDY
spellingShingle DOES LIDOCAINE HAVE ANTIMICROBIAL EFFECTS AGAINST MAJOR PATHOGENS THAT INFECT WOUNDS? AN “IN VITRO” STUDY
Carvalho Henriques, Bruno
title_short DOES LIDOCAINE HAVE ANTIMICROBIAL EFFECTS AGAINST MAJOR PATHOGENS THAT INFECT WOUNDS? AN “IN VITRO” STUDY
title_full DOES LIDOCAINE HAVE ANTIMICROBIAL EFFECTS AGAINST MAJOR PATHOGENS THAT INFECT WOUNDS? AN “IN VITRO” STUDY
title_fullStr DOES LIDOCAINE HAVE ANTIMICROBIAL EFFECTS AGAINST MAJOR PATHOGENS THAT INFECT WOUNDS? AN “IN VITRO” STUDY
title_full_unstemmed DOES LIDOCAINE HAVE ANTIMICROBIAL EFFECTS AGAINST MAJOR PATHOGENS THAT INFECT WOUNDS? AN “IN VITRO” STUDY
title_sort DOES LIDOCAINE HAVE ANTIMICROBIAL EFFECTS AGAINST MAJOR PATHOGENS THAT INFECT WOUNDS? AN “IN VITRO” STUDY
author Carvalho Henriques, Bruno
author_facet Carvalho Henriques, Bruno
Delfino Caldeira , Isadora
Schadeck Portelinha, Maria Júlia
Lopes Medina , Denis Aloísio
Talavera Martelli, Cesar Alberto
Silva Cayres de Oliveira, Mayla
de Carvalho Almeida, Mércia
Alencar Marques, Mariângela Esther
Nai, Gisele Alborghetti
author_role author
author2 Delfino Caldeira , Isadora
Schadeck Portelinha, Maria Júlia
Lopes Medina , Denis Aloísio
Talavera Martelli, Cesar Alberto
Silva Cayres de Oliveira, Mayla
de Carvalho Almeida, Mércia
Alencar Marques, Mariângela Esther
Nai, Gisele Alborghetti
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Carvalho Henriques, Bruno
Delfino Caldeira , Isadora
Schadeck Portelinha, Maria Júlia
Lopes Medina , Denis Aloísio
Talavera Martelli, Cesar Alberto
Silva Cayres de Oliveira, Mayla
de Carvalho Almeida, Mércia
Alencar Marques, Mariângela Esther
Nai, Gisele Alborghetti
Nai, Gisele Alborghetti
description Local anesthetics are commonly used in medicine and dentistry and have a low cost, but their action as a microbicidal agent is still controversial. This study aimed to evaluate the antimicrobial effects of lidocaine against bacteria that most commonly infect surgical wounds. We evaluated Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Proteus mirabilis and Enterococcus faecalis. The solutions tested were saline, chlorhexidine, lidocaine (solution and pure) and an antibiotic solution. The agar diffusion test was performed using Petri dishes. The plates tested with lidocaine (pure or solution) presented no inhibition halo. The antibiotic solution presented the largest inhibition halos for all the bacteria (p < 0.05). Chlorhexidine formed an inhibition halo similar to that of the antibiotic solution for Escherichia coli (p > 0.05). Lidocaine did not present an antimicrobial effect for any of the tested bacteria. However, the antibiotic solution and the chlorhexidine inhibited the growth of all bacteria.
publishDate 2020
dc.date.none.fl_str_mv 2020-06-17
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Avaliado por pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://revistas.unoeste.br/index.php/cv/article/view/3396
url http://revistas.unoeste.br/index.php/cv/article/view/3396
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv http://revistas.unoeste.br/index.php/cv/article/view/3396/3014
dc.rights.driver.fl_str_mv Copyright (c) 2020 Colloquium Vitae. ISSN: 1984-6436
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2020 Colloquium Vitae. ISSN: 1984-6436
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade do Oeste Paulista - UNOESTE
publisher.none.fl_str_mv Universidade do Oeste Paulista - UNOESTE
dc.source.none.fl_str_mv Colloquium Vitae. ISSN: 1984-6436; v. 12 n. 2 (2020): Colloquium Vitae, Vol. 12, n. 2; 19-23
1984-6436
reponame:Colloquium Vitae
instname:Universidade do Oeste Paulista (UNOESTE)
instacron:UNIOESTE
instname_str Universidade do Oeste Paulista (UNOESTE)
instacron_str UNIOESTE
institution UNIOESTE
reponame_str Colloquium Vitae
collection Colloquium Vitae
repository.name.fl_str_mv Colloquium Vitae - Universidade do Oeste Paulista (UNOESTE)
repository.mail.fl_str_mv jgjunior@unoeste.br||jgjunior@unoeste.br
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