CURCUMIN NANOFORMULATIONS AND THEIR THERAPEUTIC APPLICABILITY TO DEPRESSIVE DISORDER
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Interfaces Científicas. Saúde e Ambiente (Online) |
Texto Completo: | https://periodicos.set.edu.br/saude/article/view/11165 |
Resumo: | Depressive disorder is one of the most prevalent multifactorial psychiatric syndromes, recognized as a global public health problem. Recent research with the nanostructured systems of curcumin has aroused the interest of the scientific community, for emerging neuroprotective effects with potential applicability in biological systems. Curcumin is a natural substance, considered for therapy in various diseases, including neuropsychiatric such as depressive disorder. This is a systematic review, with articles published in PubMed, Scielo and Science Direct, filtered from 2014-2021. The inclusion criteria started from a guiding question, combined with the DeSs indexes for the search: depression, curcumin, nanoparticles, antidepressant agent, linked to Boolean operators to combine the terms of your search and the StArt system to exclude duplicates. Twenty-two articles were included, and approximately 60-70% of them showed some therapeutic potential of reduced curcumin in nanoformulation applicable to the biological system. It was possible to verify that nanostructured curcumin exhibits differentiated properties that increase antioxidant and antidepressant action and low cytotoxicity. Its therapeutic potential is able to interfere in neuro-inflammatory processes. The perspective is the development of drugs with controlled delivery of bioactive such as curcumin, with multiple organic functions. The increased bioavailability of curcumin may promote neurogenesis in the cortico-hippocampal region and function as adjuvants in antidepressant treatment. |
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CURCUMIN NANOFORMULATIONS AND THEIR THERAPEUTIC APPLICABILITY TO DEPRESSIVE DISORDERCURCUMIN NANOFORMULATIONS AND THEIR THERAPEUTIC APPLICABILITY TO DEPRESSIVE DISORDERDepressive disorder is one of the most prevalent multifactorial psychiatric syndromes, recognized as a global public health problem. Recent research with the nanostructured systems of curcumin has aroused the interest of the scientific community, for emerging neuroprotective effects with potential applicability in biological systems. Curcumin is a natural substance, considered for therapy in various diseases, including neuropsychiatric such as depressive disorder. This is a systematic review, with articles published in PubMed, Scielo and Science Direct, filtered from 2014-2021. The inclusion criteria started from a guiding question, combined with the DeSs indexes for the search: depression, curcumin, nanoparticles, antidepressant agent, linked to Boolean operators to combine the terms of your search and the StArt system to exclude duplicates. Twenty-two articles were included, and approximately 60-70% of them showed some therapeutic potential of reduced curcumin in nanoformulation applicable to the biological system. It was possible to verify that nanostructured curcumin exhibits differentiated properties that increase antioxidant and antidepressant action and low cytotoxicity. Its therapeutic potential is able to interfere in neuro-inflammatory processes. The perspective is the development of drugs with controlled delivery of bioactive such as curcumin, with multiple organic functions. The increased bioavailability of curcumin may promote neurogenesis in the cortico-hippocampal region and function as adjuvants in antidepressant treatment.El trastorno depresivo es uno de los síndromes psiquiátricas multifactoriales más prevalentes, reconocido como un problema de salud pública mundial. Investigaciones recientes con los sistemas nanoestructurados de la curcumina han despertado el interés de la comunidad científica, por los emergentes efectos neuroprotectores con potencial aplicabilidad en sistemas biológicos. La curcumina es una sustancia natural, considerada para la terapia en diversas enfermedades, incluidas las neuropsiquiátricas, como el trastorno depresivo. Esta es una revisión sistemática, con artículos publicados en PubMed, Scielo y Science Direct, filtrados desde 2014-2021. Los criterios de inclusión partieron de una pregunta orientadora, combinada con los índices DeSs para la búsqueda: depresión, curcumina, nanopartículas, agente antidepresivo, vinculados a operadores booleanos para combine los términos de su búsqueda y el sistema StArt para excluir duplicados. Se incluyeron veintidós artículos, y aproximadamente el 60-70% de ellos mostraron algún potencial terapéutico de curcumina reducida en nanoformulaciones aplicables al sistema biológico. Se pudo verificar que la curcumina nanoestructurada exhibe propiedades diferenciadas que aumentan la acción antioxidante y antidepresiva y baja citotoxicidad. Su potencial terapéutico es capaz de interferir en procesos neuroinflamatorios. La perspectiva es el desarrollo de fármacos con liberación controlada de bioactivos como la curcumina, con múltiples funciones orgánicas. La mayor biodisponibilidad de la curcumina puede promover la neurogénesis en la región corticohipocampal y funcionar como adyuvantes en el tratamiento antidepresivo.O transtorno depressivo é uma das síndromes psiquiátricas multifatorial das mais prevalentes, reconhecida como problema de saúde pública mundial. Recentes pesquisas com os sistemas nanoestruturados de curcumina, tem despertado interesse da comunidade científica, por despontar efeitos neuroprotetores com potencial de aplicabilidades em sistemas biológicos. A curcumina é uma substância natural, cogitada para terapia em várias doenças, que inclui as neuropsiquiátricas como o transtorno depressivo. Trata-se de uma revisão sistematizada, com artigos publicados na PubMed, Scielo e Science Direct, filtrados de 2014-2021. Os critérios inclusão partiu de uma pergunta norteadora, aliada aos indexadores DeSs para busca, na língua inglesa: depression, curcumin, nanoparticles, antidepressant agent, vinculados aos operadores booleanos para combinar os termos de sua pesquisa e o sistema StArt para excluir duplicidades. Foram inclusos 22 artigos, sendo que aproximadamente 60-70% deles evidenciaram algum potencial terapêutico da curcumina reduzida em nanoformulações aplicáveis ao sistema biológico. Foi possível verificar que curcumina nanoestruturada exibe propriedades diferenciadas que aumentam a ação antioxidante, antidepressiva e baixa citotoxicidade. Desponta seu potencial terapêutico capaz de interferir em processos neuro-inflamatórios. A perspectiva é o desenvolvimento de medicamentos de entrega controlada de bioativos como a curcumina, com múltiplas funções orgânicas. O aumento da biodisponibilidade da curcumina pode promover neurogênese na região córtico-hipocampal e funcionar como adjuvantes no tratamento antidepressivo.Editora Universitária Tiradentes2023-02-28info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.set.edu.br/saude/article/view/1116510.17564/2316-3798.2023v9n2p56-72Interfaces Científicas - Saúde e Ambiente; v. 9 n. 2 (2023): Fluxo Contínuo; 56-722316-37982316-331310.17564/2316-3798.2023v9n2reponame:Interfaces Científicas. Saúde e Ambiente (Online)instname:Universidade Tiradentes (UNIT)instacron:UNITporhttps://periodicos.set.edu.br/saude/article/view/11165/5312Copyright (c) 2023 Interfaces Científicas - Saúde e Ambientehttps://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessCordeiro Matias, Amanda GilvaniSousa Costa, Anderson Pitanga Evangelista dos Santos, Luiz Henrique Santos Brito, Karen de Andrade Fonseca, Marília 2023-05-18T18:04:52Zoai:ojs.emnuvens.com.br:article/11165Revistahttps://periodicos.set.edu.br/saudePRIhttps://periodicos.set.edu.br/index.php/saude/oai||crismporto@gmail.com||interfaces_saude_editor@yahoo.com.br2316-37982316-3313opendoar:2023-05-18T18:04:52Interfaces Científicas. Saúde e Ambiente (Online) - Universidade Tiradentes (UNIT)false |
dc.title.none.fl_str_mv |
CURCUMIN NANOFORMULATIONS AND THEIR THERAPEUTIC APPLICABILITY TO DEPRESSIVE DISORDER CURCUMIN NANOFORMULATIONS AND THEIR THERAPEUTIC APPLICABILITY TO DEPRESSIVE DISORDER |
title |
CURCUMIN NANOFORMULATIONS AND THEIR THERAPEUTIC APPLICABILITY TO DEPRESSIVE DISORDER |
spellingShingle |
CURCUMIN NANOFORMULATIONS AND THEIR THERAPEUTIC APPLICABILITY TO DEPRESSIVE DISORDER Cordeiro Matias, Amanda Gilvani |
title_short |
CURCUMIN NANOFORMULATIONS AND THEIR THERAPEUTIC APPLICABILITY TO DEPRESSIVE DISORDER |
title_full |
CURCUMIN NANOFORMULATIONS AND THEIR THERAPEUTIC APPLICABILITY TO DEPRESSIVE DISORDER |
title_fullStr |
CURCUMIN NANOFORMULATIONS AND THEIR THERAPEUTIC APPLICABILITY TO DEPRESSIVE DISORDER |
title_full_unstemmed |
CURCUMIN NANOFORMULATIONS AND THEIR THERAPEUTIC APPLICABILITY TO DEPRESSIVE DISORDER |
title_sort |
CURCUMIN NANOFORMULATIONS AND THEIR THERAPEUTIC APPLICABILITY TO DEPRESSIVE DISORDER |
author |
Cordeiro Matias, Amanda Gilvani |
author_facet |
Cordeiro Matias, Amanda Gilvani Sousa Costa, Anderson Pitanga Evangelista dos Santos, Luiz Henrique Santos Brito, Karen de Andrade Fonseca, Marília |
author_role |
author |
author2 |
Sousa Costa, Anderson Pitanga Evangelista dos Santos, Luiz Henrique Santos Brito, Karen de Andrade Fonseca, Marília |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Cordeiro Matias, Amanda Gilvani Sousa Costa, Anderson Pitanga Evangelista dos Santos, Luiz Henrique Santos Brito, Karen de Andrade Fonseca, Marília |
description |
Depressive disorder is one of the most prevalent multifactorial psychiatric syndromes, recognized as a global public health problem. Recent research with the nanostructured systems of curcumin has aroused the interest of the scientific community, for emerging neuroprotective effects with potential applicability in biological systems. Curcumin is a natural substance, considered for therapy in various diseases, including neuropsychiatric such as depressive disorder. This is a systematic review, with articles published in PubMed, Scielo and Science Direct, filtered from 2014-2021. The inclusion criteria started from a guiding question, combined with the DeSs indexes for the search: depression, curcumin, nanoparticles, antidepressant agent, linked to Boolean operators to combine the terms of your search and the StArt system to exclude duplicates. Twenty-two articles were included, and approximately 60-70% of them showed some therapeutic potential of reduced curcumin in nanoformulation applicable to the biological system. It was possible to verify that nanostructured curcumin exhibits differentiated properties that increase antioxidant and antidepressant action and low cytotoxicity. Its therapeutic potential is able to interfere in neuro-inflammatory processes. The perspective is the development of drugs with controlled delivery of bioactive such as curcumin, with multiple organic functions. The increased bioavailability of curcumin may promote neurogenesis in the cortico-hippocampal region and function as adjuvants in antidepressant treatment. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-02-28 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://periodicos.set.edu.br/saude/article/view/11165 10.17564/2316-3798.2023v9n2p56-72 |
url |
https://periodicos.set.edu.br/saude/article/view/11165 |
identifier_str_mv |
10.17564/2316-3798.2023v9n2p56-72 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://periodicos.set.edu.br/saude/article/view/11165/5312 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2023 Interfaces Científicas - Saúde e Ambiente https://creativecommons.org/licenses/by-nc/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2023 Interfaces Científicas - Saúde e Ambiente https://creativecommons.org/licenses/by-nc/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Editora Universitária Tiradentes |
publisher.none.fl_str_mv |
Editora Universitária Tiradentes |
dc.source.none.fl_str_mv |
Interfaces Científicas - Saúde e Ambiente; v. 9 n. 2 (2023): Fluxo Contínuo; 56-72 2316-3798 2316-3313 10.17564/2316-3798.2023v9n2 reponame:Interfaces Científicas. Saúde e Ambiente (Online) instname:Universidade Tiradentes (UNIT) instacron:UNIT |
instname_str |
Universidade Tiradentes (UNIT) |
instacron_str |
UNIT |
institution |
UNIT |
reponame_str |
Interfaces Científicas. Saúde e Ambiente (Online) |
collection |
Interfaces Científicas. Saúde e Ambiente (Online) |
repository.name.fl_str_mv |
Interfaces Científicas. Saúde e Ambiente (Online) - Universidade Tiradentes (UNIT) |
repository.mail.fl_str_mv |
||crismporto@gmail.com||interfaces_saude_editor@yahoo.com.br |
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1800220510064214016 |