C-reactive protein concentrations are higher in dogs with stage IV chronic kidney disease treated with intermittent hemodialysis

• Autor(a) principal: de Azevedo, Maria Gabriela Picelli [UNESP]
• Data de Publicação: 2022
• Outros Autores: Geraldes, Silvano Salgueiro [UNESP], Sant'Anna, Paula Bilbau, Batista, Beatriz Poloni, Maia, Suellen Rodrigues [UNESP], de Moraes, Reiner Silveira [UNESP], dos Santos Schmidt, Elizabeth Moreira [UNESP], de Souza, Fabiana Ferreira [UNESP], Melchert, Alessandra [UNESP], Ferreira, João Carlos Pinheiro [UNESP], Dadalto, Carmel Rezende [UNESP], García, Henry David Mogollón [UNESP], Guimarães-Okamoto, Priscylla Tatiana Chalfun [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1371/journal.pone.0274510; http://hdl.handle.net/11449/247679

In chronic kidney disease dogs, the inflammatory process increases C-reactive protein concentrations. This study aimed to determine C-reactive protein serum concentrations in stage IV chronic kidney disease dogs treated with intermittent hemodialysis. A prospective cohort study was conducted with 23 dogs allocated into three groups: control group (CG, n = 7), intermittent hemodialysis group (IHG, n = 8) and clinical treatment group (CTG, n = 8), both comprised of stage IV chronic kidney disease dogs. One blood sample from CG (initial evaluation) and two samples from IHG and CTG (first- and last-moment) were obtained to determine C-reactive protein concentration, total leukocytes, platelets, erythrocytes, total plasma protein, serum albumin, urea, creatinine, and phosphorus. C-reactive protein was higher in IHG compared to CG in the first- and last-moments (p <0.001) and compared to CTG in the first-moment (p = 0.0406). C-reactive protein presented moderate positive correlation with leukocytes (r = 0.5479; p = 0.01), and moderate negative correlation with albumin (r = - 0.5974; p = 0.006) and red blood cells (r = - 0.5878, p = 0.01). A high correlation coefficient was observed in the tests' evaluation (CI = 0.59-0.78; r = 0.70; P<0.0001). In conclusion, both assays used in this study to measure C-reactive protein have provided safe and reliable quantification of the results. Additionally, despite IHG dogs presented an active inflammatory profile, intermittent hemodialysis has proven to be beneficial, leading to a clinical improvement in life quality of patients, and thus being recommended for stage IV CKD dogs when performed by trained professionals.