Effects of chronic stress and high-fat diet on metabolic and nutritional parameters in Wistar rats
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0004-27302013000800010&lng=en&nrm=iso&tlng=en http://hdl.handle.net/11449/137204 |
Resumo: | Objective: The aim of this study was assess the role of chronic stress on the metabolic and nutritional profile of rats exposed to a high-fat diet. Materials and methods: Thirty-day-old male Wistar rats (70-100 g) were distributed into four groups: normal-diet (NC), chronic stress (St), high-fat diet (HD), and chronic stress/high-fat diet (HD/St). Stress consisted at immobilization during 15 weeks, 5 times per week, 1h per day; and exposure to the high-fat diet lasted 15 weeks. Nutritional and metabolic parameters were assessed. The level of significance was 5%. Results: The HD group had final body weight, total fat, as well as insulin and leptin increased, and they were insulin resistant. The St and HD/St had arterial hypertension and increased levels of corticosterone. Stress blocked the effects of the high-fat diet. Conclusion: Chronic stress prevented the appearance of obesity. Our results help to clarify the mechanisms involved in metabolic and nutritional dysfunction, and contribute to clinical cases linked to stress and high-fat diet. |
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Effects of chronic stress and high-fat diet on metabolic and nutritional parameters in Wistar ratsEfeitos do estresse crônico e da dieta rica em gordura sobre os parâmetros metabólicos e nutricionais em ratos WistarChronic stressHigh-fat dietCalorie intake and food intakeEstresse crônicoDieta rica em gorduraConsumo calórico e metabolismoObjective: The aim of this study was assess the role of chronic stress on the metabolic and nutritional profile of rats exposed to a high-fat diet. Materials and methods: Thirty-day-old male Wistar rats (70-100 g) were distributed into four groups: normal-diet (NC), chronic stress (St), high-fat diet (HD), and chronic stress/high-fat diet (HD/St). Stress consisted at immobilization during 15 weeks, 5 times per week, 1h per day; and exposure to the high-fat diet lasted 15 weeks. Nutritional and metabolic parameters were assessed. The level of significance was 5%. Results: The HD group had final body weight, total fat, as well as insulin and leptin increased, and they were insulin resistant. The St and HD/St had arterial hypertension and increased levels of corticosterone. Stress blocked the effects of the high-fat diet. Conclusion: Chronic stress prevented the appearance of obesity. Our results help to clarify the mechanisms involved in metabolic and nutritional dysfunction, and contribute to clinical cases linked to stress and high-fat diet.Objetivo: Avaliar o papel do estresse crônico sobre parâmetros metabólicos e nutricionais de ratos expostos à dieta rica em gordura. Materiais e métodos: Ratos Wistar machos (30 dias de idade/70-100 g) foram distribuídos em quatro grupos: dieta-normal (NC), estresse crônico (St), dieta rica em gordura (HD) e estresse crônico/dieta rica em gordura (HD/St). O estresse consistiu em imobiliza- ção durante 15 semanas, 5 vezes por semana 1h por dia e a dieta rica em gordura foi oferecida por 15 semanas. Parâmetros nutricionais e metabólicos foram avaliados. O nível de significância foi de 5%. Resultados: HD tiveram peso corpóreo, gordura total e níveis de insulina e leptina aumentados e foram resistentes à insulina. Os grupos St e HD/St manifestaram hipertensão e níveis séricos de corticosterona elevados. O estresse bloqueou os efeitos da dieta. Conclusão: O estresse impediu o surgimento dela. Nossos resultados ajudam compreender os mecanismos envolvidos na disfunção metabólica e nutricional e contribuem para casos clínicos de estresse e dietas ricas em gorduras.Department of Pharmacology, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (FMRP-USP), Ribeirão Preto, SP, BrazilDepartment of Pharmacology, Institute of Biosciences, Universidade Estadual Paulista (Unesp), Botucatu, SP, BrazilDepartment of Medicine Clinical, Faculdade de Medicina de Botucatu, Unesp, Botucatu, SP, BrazilDepartment of Morphology, Institute of Biosciences, Unesp, Botucatu, SP, BrazilUniversidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Bruder-Nascimento, Thiago [UNESP]Campos, Dijon Henrique Salomé [UNESP]Alves, Carlos [UNESP]Thomaz, Samuel [UNESP]Cicogna, Antonio Carlos [UNESP]Cordellini, Sandra [UNESP]2016-04-01T18:44:40Z2016-04-01T18:44:40Z2013info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article642-649application/pdfhttp://www.scielo.br/scielo.php?script=sci_abstract&pid=S0004-27302013000800010&lng=en&nrm=iso&tlng=enArquivos Brasileiros de Endocrinologia e Metabologia, v. 57, n. 8, p. 642-649, 2013.0004-2730http://hdl.handle.net/11449/137204ISSN0004-2730-2013-57-08-642-649.pdf5616488317690037Currículo Lattesreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengArquivos Brasileiros de Endocrinologia e Metabologia1.515info:eu-repo/semantics/openAccess2023-12-06T06:16:13Zoai:repositorio.unesp.br:11449/137204Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:36:10.180105Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Effects of chronic stress and high-fat diet on metabolic and nutritional parameters in Wistar rats Efeitos do estresse crônico e da dieta rica em gordura sobre os parâmetros metabólicos e nutricionais em ratos Wistar |
title |
Effects of chronic stress and high-fat diet on metabolic and nutritional parameters in Wistar rats |
spellingShingle |
Effects of chronic stress and high-fat diet on metabolic and nutritional parameters in Wistar rats Bruder-Nascimento, Thiago [UNESP] Chronic stress High-fat diet Calorie intake and food intake Estresse crônico Dieta rica em gordura Consumo calórico e metabolismo |
title_short |
Effects of chronic stress and high-fat diet on metabolic and nutritional parameters in Wistar rats |
title_full |
Effects of chronic stress and high-fat diet on metabolic and nutritional parameters in Wistar rats |
title_fullStr |
Effects of chronic stress and high-fat diet on metabolic and nutritional parameters in Wistar rats |
title_full_unstemmed |
Effects of chronic stress and high-fat diet on metabolic and nutritional parameters in Wistar rats |
title_sort |
Effects of chronic stress and high-fat diet on metabolic and nutritional parameters in Wistar rats |
author |
Bruder-Nascimento, Thiago [UNESP] |
author_facet |
Bruder-Nascimento, Thiago [UNESP] Campos, Dijon Henrique Salomé [UNESP] Alves, Carlos [UNESP] Thomaz, Samuel [UNESP] Cicogna, Antonio Carlos [UNESP] Cordellini, Sandra [UNESP] |
author_role |
author |
author2 |
Campos, Dijon Henrique Salomé [UNESP] Alves, Carlos [UNESP] Thomaz, Samuel [UNESP] Cicogna, Antonio Carlos [UNESP] Cordellini, Sandra [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Bruder-Nascimento, Thiago [UNESP] Campos, Dijon Henrique Salomé [UNESP] Alves, Carlos [UNESP] Thomaz, Samuel [UNESP] Cicogna, Antonio Carlos [UNESP] Cordellini, Sandra [UNESP] |
dc.subject.por.fl_str_mv |
Chronic stress High-fat diet Calorie intake and food intake Estresse crônico Dieta rica em gordura Consumo calórico e metabolismo |
topic |
Chronic stress High-fat diet Calorie intake and food intake Estresse crônico Dieta rica em gordura Consumo calórico e metabolismo |
description |
Objective: The aim of this study was assess the role of chronic stress on the metabolic and nutritional profile of rats exposed to a high-fat diet. Materials and methods: Thirty-day-old male Wistar rats (70-100 g) were distributed into four groups: normal-diet (NC), chronic stress (St), high-fat diet (HD), and chronic stress/high-fat diet (HD/St). Stress consisted at immobilization during 15 weeks, 5 times per week, 1h per day; and exposure to the high-fat diet lasted 15 weeks. Nutritional and metabolic parameters were assessed. The level of significance was 5%. Results: The HD group had final body weight, total fat, as well as insulin and leptin increased, and they were insulin resistant. The St and HD/St had arterial hypertension and increased levels of corticosterone. Stress blocked the effects of the high-fat diet. Conclusion: Chronic stress prevented the appearance of obesity. Our results help to clarify the mechanisms involved in metabolic and nutritional dysfunction, and contribute to clinical cases linked to stress and high-fat diet. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013 2016-04-01T18:44:40Z 2016-04-01T18:44:40Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0004-27302013000800010&lng=en&nrm=iso&tlng=en Arquivos Brasileiros de Endocrinologia e Metabologia, v. 57, n. 8, p. 642-649, 2013. 0004-2730 http://hdl.handle.net/11449/137204 ISSN0004-2730-2013-57-08-642-649.pdf 5616488317690037 |
url |
http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0004-27302013000800010&lng=en&nrm=iso&tlng=en http://hdl.handle.net/11449/137204 |
identifier_str_mv |
Arquivos Brasileiros de Endocrinologia e Metabologia, v. 57, n. 8, p. 642-649, 2013. 0004-2730 ISSN0004-2730-2013-57-08-642-649.pdf 5616488317690037 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Arquivos Brasileiros de Endocrinologia e Metabologia 1.515 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
642-649 application/pdf |
dc.source.none.fl_str_mv |
Currículo Lattes reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808129094566543360 |