Effects of chronic stress and high-fat diet on metabolic and nutritional parameters in Wistar rats

• Autor(a) principal: Bruder-nascimento, Thiago [UNESP]
• Data de Publicação: 2013
• Outros Autores: Campos, Dijon Henrique Salomé [UNESP], Alves, Carlos [UNESP], Thomaz, Samuel [UNESP], Cicogna, Antonio Carlos [UNESP], Cordellini, Sandra [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1590/S0004-27302013000800010; http://hdl.handle.net/11449/109816
• topic: Estresse crônico; dieta rica em gordura; consumo calórico e metabolismo; Chronic stress; high-fat diet; calorie intake and food intake

OBJECTIVE: The aim of this study was assess the role of chronic stress on the metabolic and nutritional profile of rats exposed to a high-fat diet. MATERIALS AND METHODS: Thirty-day-old male Wistar rats (70-100 g) were distributed into four groups: normal-diet (NC), chronic stress (St), high-fat diet (HD), and chronic stress/high-fat diet (HD/St). Stress consisted at immobilization during 15 weeks, 5 times per week, 1h per day; and exposure to the high-fat diet lasted 15 weeks. Nutritional and metabolic parameters were assessed. The level of significance was 5%. RESULTS: The HD group had final body weight, total fat, as well as insulin and leptin increased, and they were insulin resistant. The St and HD/St had arterial hypertension and increased levels of corticosterone. Stress blocked the effects of the high-fat diet. CONCLUSION: Chronic stress prevented the appearance of obesity. Our results help to clarify the mechanisms involved in metabolic and nutritional dysfunction, and contribute to clinical cases linked to stress and high-fat diet.