Tissue Tropism in Host Transcriptional Response to Members of the Bovine Respiratory Disease Complex
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1038/s41598-017-18205-0 http://hdl.handle.net/11449/175681 |
Resumo: | Bovine respiratory disease (BRD) is the most common infectious disease of beef and dairy cattle and is characterized by a complex infectious etiology that includes a variety of viral and bacterial pathogens. We examined the global changes in mRNA abundance in healthy lung and lung lesions and in the lymphoid tissues bronchial lymph node, retropharyngeal lymph node, nasopharyngeal lymph node and pharyngeal tonsil collected at the peak of clinical disease from beef cattle experimentally challenged with either bovine respiratory syncytial virus, infectious bovine rhinotracheitis, bovine viral diarrhea virus, Mannheimia haemolytica or Mycoplasma bovis. We identified signatures of tissue-specific transcriptional responses indicative of tropism in the coordination of host's immune tissue responses to infection by viral or bacterial infections. Furthermore, our study shows that this tissue tropism in host transcriptional response to BRD pathogens results in the activation of different networks of response genes. The differential crosstalk among genes expressed in lymphoid tissues was predicted to be orchestrated by specific immune genes that act as 'key players' within expression networks. The results of this study serve as a basis for the development of innovative therapeutic strategies and for the selection of cattle with enhanced resistance to BRD. |
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Tissue Tropism in Host Transcriptional Response to Members of the Bovine Respiratory Disease ComplexBovine respiratory disease (BRD) is the most common infectious disease of beef and dairy cattle and is characterized by a complex infectious etiology that includes a variety of viral and bacterial pathogens. We examined the global changes in mRNA abundance in healthy lung and lung lesions and in the lymphoid tissues bronchial lymph node, retropharyngeal lymph node, nasopharyngeal lymph node and pharyngeal tonsil collected at the peak of clinical disease from beef cattle experimentally challenged with either bovine respiratory syncytial virus, infectious bovine rhinotracheitis, bovine viral diarrhea virus, Mannheimia haemolytica or Mycoplasma bovis. We identified signatures of tissue-specific transcriptional responses indicative of tropism in the coordination of host's immune tissue responses to infection by viral or bacterial infections. Furthermore, our study shows that this tissue tropism in host transcriptional response to BRD pathogens results in the activation of different networks of response genes. The differential crosstalk among genes expressed in lymphoid tissues was predicted to be orchestrated by specific immune genes that act as 'key players' within expression networks. The results of this study serve as a basis for the development of innovative therapeutic strategies and for the selection of cattle with enhanced resistance to BRD.Division of Animal Sciences University of MissouriEmbrapa Southeast LivestockDepartamento de Ciencias Exatas UNESP Univ Estadual Paulista Faculdade de Ciencias Agrarias e VeterinariasDepartment of Veterinary Pathobiology College of Veterinary Medicine Texas AandM UniversityInformatics Institute University of MissouriDepartment of Pathology Microbiology and Immunology School of Veterinary Medicine University of CaliforniaDepartment of Animal Science College of Agriculture University of CaliforniaDepartment of Animal Sciences College of Agriculture Natural Resource Sciences Washington State UniversityDepartamento de Ciencias Exatas UNESP Univ Estadual Paulista Faculdade de Ciencias Agrarias e VeterinariasUniversity of MissouriEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)Universidade Estadual Paulista (Unesp)Texas AandM UniversityUniversity of CaliforniaWashington State UniversityBehura, Susanta K.Tizioto, Polyana C.Kim, JaewooGrupioni, Natalia V. [UNESP]Seabury, Christopher M.Schnabel, Robert D.Gershwin, Laurel J.Van Eenennaam, Alison L.Toaff-Rosenstein, RachelNeibergs, Holly L.Regitano, Luciana C. A.Taylor, Jeremy F.2018-12-11T17:17:03Z2018-12-11T17:17:03Z2017-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1038/s41598-017-18205-0Scientific Reports, v. 7, n. 1, 2017.2045-2322http://hdl.handle.net/11449/17568110.1038/s41598-017-18205-02-s2.0-850388791122-s2.0-85038879112.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengScientific Reports1,533info:eu-repo/semantics/openAccess2024-06-06T13:43:31Zoai:repositorio.unesp.br:11449/175681Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-06-06T13:43:31Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Tissue Tropism in Host Transcriptional Response to Members of the Bovine Respiratory Disease Complex |
title |
Tissue Tropism in Host Transcriptional Response to Members of the Bovine Respiratory Disease Complex |
spellingShingle |
Tissue Tropism in Host Transcriptional Response to Members of the Bovine Respiratory Disease Complex Behura, Susanta K. |
title_short |
Tissue Tropism in Host Transcriptional Response to Members of the Bovine Respiratory Disease Complex |
title_full |
Tissue Tropism in Host Transcriptional Response to Members of the Bovine Respiratory Disease Complex |
title_fullStr |
Tissue Tropism in Host Transcriptional Response to Members of the Bovine Respiratory Disease Complex |
title_full_unstemmed |
Tissue Tropism in Host Transcriptional Response to Members of the Bovine Respiratory Disease Complex |
title_sort |
Tissue Tropism in Host Transcriptional Response to Members of the Bovine Respiratory Disease Complex |
author |
Behura, Susanta K. |
author_facet |
Behura, Susanta K. Tizioto, Polyana C. Kim, Jaewoo Grupioni, Natalia V. [UNESP] Seabury, Christopher M. Schnabel, Robert D. Gershwin, Laurel J. Van Eenennaam, Alison L. Toaff-Rosenstein, Rachel Neibergs, Holly L. Regitano, Luciana C. A. Taylor, Jeremy F. |
author_role |
author |
author2 |
Tizioto, Polyana C. Kim, Jaewoo Grupioni, Natalia V. [UNESP] Seabury, Christopher M. Schnabel, Robert D. Gershwin, Laurel J. Van Eenennaam, Alison L. Toaff-Rosenstein, Rachel Neibergs, Holly L. Regitano, Luciana C. A. Taylor, Jeremy F. |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
University of Missouri Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA) Universidade Estadual Paulista (Unesp) Texas AandM University University of California Washington State University |
dc.contributor.author.fl_str_mv |
Behura, Susanta K. Tizioto, Polyana C. Kim, Jaewoo Grupioni, Natalia V. [UNESP] Seabury, Christopher M. Schnabel, Robert D. Gershwin, Laurel J. Van Eenennaam, Alison L. Toaff-Rosenstein, Rachel Neibergs, Holly L. Regitano, Luciana C. A. Taylor, Jeremy F. |
description |
Bovine respiratory disease (BRD) is the most common infectious disease of beef and dairy cattle and is characterized by a complex infectious etiology that includes a variety of viral and bacterial pathogens. We examined the global changes in mRNA abundance in healthy lung and lung lesions and in the lymphoid tissues bronchial lymph node, retropharyngeal lymph node, nasopharyngeal lymph node and pharyngeal tonsil collected at the peak of clinical disease from beef cattle experimentally challenged with either bovine respiratory syncytial virus, infectious bovine rhinotracheitis, bovine viral diarrhea virus, Mannheimia haemolytica or Mycoplasma bovis. We identified signatures of tissue-specific transcriptional responses indicative of tropism in the coordination of host's immune tissue responses to infection by viral or bacterial infections. Furthermore, our study shows that this tissue tropism in host transcriptional response to BRD pathogens results in the activation of different networks of response genes. The differential crosstalk among genes expressed in lymphoid tissues was predicted to be orchestrated by specific immune genes that act as 'key players' within expression networks. The results of this study serve as a basis for the development of innovative therapeutic strategies and for the selection of cattle with enhanced resistance to BRD. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-12-01 2018-12-11T17:17:03Z 2018-12-11T17:17:03Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1038/s41598-017-18205-0 Scientific Reports, v. 7, n. 1, 2017. 2045-2322 http://hdl.handle.net/11449/175681 10.1038/s41598-017-18205-0 2-s2.0-85038879112 2-s2.0-85038879112.pdf |
url |
http://dx.doi.org/10.1038/s41598-017-18205-0 http://hdl.handle.net/11449/175681 |
identifier_str_mv |
Scientific Reports, v. 7, n. 1, 2017. 2045-2322 10.1038/s41598-017-18205-0 2-s2.0-85038879112 2-s2.0-85038879112.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Scientific Reports 1,533 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1803045469190881280 |