Study of Salmonella typhimurium mutagenicity assay of (E)-piplartine by the Ames test

Detalhes bibliográficos
Autor(a) principal: Morandim-Giannetti, Andreia de A.
Data de Publicação: 2011
Outros Autores: Cotinguiba, Fernando, Regasini, Luis O., Frigieri, Mariana C. [UNESP], Varanda, Eliana Aparecida [UNESP], Coqueiro, Aline, Kato, Massuo J., Bolzani, Vanderlan da Silva [UNESP], Furlan, Maysa [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://www.ajol.info/index.php/ajb/article/view/94310
http://hdl.handle.net/11449/26248
Resumo: Phytochemical studies carried out with Piperaceae species have shown great diversity of secondary metabolites among which are several displayed considerable biological activities. The species Piper tuberculatum has been intensively investigated and a series of amides have been described. For instance, (E)-piplartine showed significant cytotoxic activity against tumor cell lines, especially human leukemia cell lines; antifungal activity against Cladosporium species; trypanocidal activity and others. Considering the popular use of P. tuberculatum and the lack of pharmacological studies regarding this plant species, the mutagenic and antimutagenic effect of (E)-piplartine was evaluated by the Ames test, using the strains TA97a, TA98, TA100 and TA102 of Salmonella typhimurium. No mutagenic activity was observed for this compound.
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spelling Study of Salmonella typhimurium mutagenicity assay of (E)-piplartine by the Ames testPiperaceaePiper tuberculatum(Z)-piplartinemutagenic activatedAmes testPhytochemical studies carried out with Piperaceae species have shown great diversity of secondary metabolites among which are several displayed considerable biological activities. The species Piper tuberculatum has been intensively investigated and a series of amides have been described. For instance, (E)-piplartine showed significant cytotoxic activity against tumor cell lines, especially human leukemia cell lines; antifungal activity against Cladosporium species; trypanocidal activity and others. Considering the popular use of P. tuberculatum and the lack of pharmacological studies regarding this plant species, the mutagenic and antimutagenic effect of (E)-piplartine was evaluated by the Ames test, using the strains TA97a, TA98, TA100 and TA102 of Salmonella typhimurium. No mutagenic activity was observed for this compound.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Estadual São Paulo, Inst Quim, Dept Quim Organ, BR-14800900 Araraquara, SP, BrazilCtr Univ FEI, Dept Engn Quim, BR-09850901 Sao Bernardo do Campo, SP, BrazilUniv Estadual Paulista, Fac Ciencias Farmaceut, Dept Ciencias Biol, BR-14801902 Araraquara, SP, BrazilUniv São Paulo, Inst Quim, Dept Quim Fundamental, BR-05508000 São Paulo, BrazilUniv Estadual Paulista, Fac Ciencias Farmaceut, Dept Ciencias Biol, BR-14801902 Araraquara, SP, BrazilAcademic JournalsUniversidade Estadual Paulista (Unesp)Ctr Univ FEIUniversidade de São Paulo (USP)Morandim-Giannetti, Andreia de A.Cotinguiba, FernandoRegasini, Luis O.Frigieri, Mariana C. [UNESP]Varanda, Eliana Aparecida [UNESP]Coqueiro, AlineKato, Massuo J.Bolzani, Vanderlan da Silva [UNESP]Furlan, Maysa [UNESP]2014-05-20T14:20:48Z2014-05-20T14:20:48Z2011-06-15info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article5398-5401application/pdfhttp://www.ajol.info/index.php/ajb/article/view/94310African Journal of Biotechnology. Victoria Island: Academic Journals, v. 10, n. 27, p. 5398-5401, 2011.1684-5315http://hdl.handle.net/11449/26248WOS:000294614400021WOS000294614400021.pdf75019302364966701308042794786872Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAfrican Journal of Biotechnologyinfo:eu-repo/semantics/openAccess2024-06-24T13:07:38Zoai:repositorio.unesp.br:11449/26248Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:09:23.049843Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Study of Salmonella typhimurium mutagenicity assay of (E)-piplartine by the Ames test
title Study of Salmonella typhimurium mutagenicity assay of (E)-piplartine by the Ames test
spellingShingle Study of Salmonella typhimurium mutagenicity assay of (E)-piplartine by the Ames test
Morandim-Giannetti, Andreia de A.
Piperaceae
Piper tuberculatum
(Z)-piplartine
mutagenic activated
Ames test
title_short Study of Salmonella typhimurium mutagenicity assay of (E)-piplartine by the Ames test
title_full Study of Salmonella typhimurium mutagenicity assay of (E)-piplartine by the Ames test
title_fullStr Study of Salmonella typhimurium mutagenicity assay of (E)-piplartine by the Ames test
title_full_unstemmed Study of Salmonella typhimurium mutagenicity assay of (E)-piplartine by the Ames test
title_sort Study of Salmonella typhimurium mutagenicity assay of (E)-piplartine by the Ames test
author Morandim-Giannetti, Andreia de A.
author_facet Morandim-Giannetti, Andreia de A.
Cotinguiba, Fernando
Regasini, Luis O.
Frigieri, Mariana C. [UNESP]
Varanda, Eliana Aparecida [UNESP]
Coqueiro, Aline
Kato, Massuo J.
Bolzani, Vanderlan da Silva [UNESP]
Furlan, Maysa [UNESP]
author_role author
author2 Cotinguiba, Fernando
Regasini, Luis O.
Frigieri, Mariana C. [UNESP]
Varanda, Eliana Aparecida [UNESP]
Coqueiro, Aline
Kato, Massuo J.
Bolzani, Vanderlan da Silva [UNESP]
Furlan, Maysa [UNESP]
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Ctr Univ FEI
Universidade de São Paulo (USP)
dc.contributor.author.fl_str_mv Morandim-Giannetti, Andreia de A.
Cotinguiba, Fernando
Regasini, Luis O.
Frigieri, Mariana C. [UNESP]
Varanda, Eliana Aparecida [UNESP]
Coqueiro, Aline
Kato, Massuo J.
Bolzani, Vanderlan da Silva [UNESP]
Furlan, Maysa [UNESP]
dc.subject.por.fl_str_mv Piperaceae
Piper tuberculatum
(Z)-piplartine
mutagenic activated
Ames test
topic Piperaceae
Piper tuberculatum
(Z)-piplartine
mutagenic activated
Ames test
description Phytochemical studies carried out with Piperaceae species have shown great diversity of secondary metabolites among which are several displayed considerable biological activities. The species Piper tuberculatum has been intensively investigated and a series of amides have been described. For instance, (E)-piplartine showed significant cytotoxic activity against tumor cell lines, especially human leukemia cell lines; antifungal activity against Cladosporium species; trypanocidal activity and others. Considering the popular use of P. tuberculatum and the lack of pharmacological studies regarding this plant species, the mutagenic and antimutagenic effect of (E)-piplartine was evaluated by the Ames test, using the strains TA97a, TA98, TA100 and TA102 of Salmonella typhimurium. No mutagenic activity was observed for this compound.
publishDate 2011
dc.date.none.fl_str_mv 2011-06-15
2014-05-20T14:20:48Z
2014-05-20T14:20:48Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.ajol.info/index.php/ajb/article/view/94310
African Journal of Biotechnology. Victoria Island: Academic Journals, v. 10, n. 27, p. 5398-5401, 2011.
1684-5315
http://hdl.handle.net/11449/26248
WOS:000294614400021
WOS000294614400021.pdf
7501930236496670
1308042794786872
url http://www.ajol.info/index.php/ajb/article/view/94310
http://hdl.handle.net/11449/26248
identifier_str_mv African Journal of Biotechnology. Victoria Island: Academic Journals, v. 10, n. 27, p. 5398-5401, 2011.
1684-5315
WOS:000294614400021
WOS000294614400021.pdf
7501930236496670
1308042794786872
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv African Journal of Biotechnology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 5398-5401
application/pdf
dc.publisher.none.fl_str_mv Academic Journals
publisher.none.fl_str_mv Academic Journals
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128902620512256

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