Study of Salmonella typhimurium mutagenicity assay of (Z)-piplartine by the Ames test
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNESP |
| Texto Completo: | http://hdl.handle.net/11449/122438 |
Resumo: | Phytochemical studies carried out with Piperaceae species have shown great diversity of secondary metabolites among which are several displayed considerable biological activities. The species Piper tuberculatum has been intensively investigated and a series of amides have been described. For instance, (E)-piplartine showed significant cytotoxic activity against tumor cell lines, especially human leukemia cell lines; antifungal activity against Cladosporium species; trypanocidal activity and others. Considering the popular use of P. tuberculatum and the lack of pharmacological studies regarding this plant species, the mutagenic and antimutagenic effect of (E)-piplartine was evaluated by the Ames test, using the strains TA97a, TA98, TA100 and TA102 of Salmonella typhimurium. No mutagenic activity was observed for this compound. |
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Study of Salmonella typhimurium mutagenicity assay of (Z)-piplartine by the Ames testPiperaceaePiper tuberculatum(Z)-piplartinemutagenic activatedAmes test.Phytochemical studies carried out with Piperaceae species have shown great diversity of secondary metabolites among which are several displayed considerable biological activities. The species Piper tuberculatum has been intensively investigated and a series of amides have been described. For instance, (E)-piplartine showed significant cytotoxic activity against tumor cell lines, especially human leukemia cell lines; antifungal activity against Cladosporium species; trypanocidal activity and others. Considering the popular use of P. tuberculatum and the lack of pharmacological studies regarding this plant species, the mutagenic and antimutagenic effect of (E)-piplartine was evaluated by the Ames test, using the strains TA97a, TA98, TA100 and TA102 of Salmonella typhimurium. No mutagenic activity was observed for this compound.Universidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Química e Ciências Ambientais, Instituto de Biociências Letras e Ciências Exatas de São José do Rio Preto, São José do Rio Preto, Rua Cristóvão Colombo, 2265, Jardim Nazareth, CEP 15054000, SP, BrasilUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Química e Ciências Ambientais, Instituto de Biociências Letras e Ciências Exatas de São José do Rio Preto, São José do Rio Preto, Rua Cristóvão Colombo, 2265, Jardim Nazareth, CEP 15054000, SP, Brasil1Departamento de Química Orgânica, Instituto de Química, Universidade Estadual de São Paulo, Rua Francisco Degni, s/n, 14800-900 Araraquara-SP, Brazil.Departamento de Ciências Biológicas, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista, Rodovia Araraquara/Jaú Km 1, 14801-902 Araraquara-SP, Brazil.FAPESPCNPqUniversidade Estadual Paulista (Unesp)Departamento de Engenharia Química, Centro Universitário da FEI4Departamento de Química Fundamental, Instituto de Química, Universidade de São Paulo (USP)Morandim, Andréia de AraújoCotinguiba, Fernando [UNESP]Regasini, Luis Octavio [UNESP]Frigieri, Mariana Carina [UNESP]Varanda, Eliana Aparecida [UNESP]Coqueiro, Aline [UNESP]Kato, Massuo JorgeBolzani, Vanderlan da Silva [UNESP]Furlan, Maysa [UNESP]2015-04-27T11:55:45Z2015-04-27T11:55:45Z2011info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article5398-5401application/pdfAfrican Journal of Biotechnology, v. 10, n. 27, p. 5398-5401, 2011.1684-5315http://hdl.handle.net/11449/12243810.5897/AJB10.2576ISSN1684-5315-2011-10-27-5398-5401.pdf79483885847172874484083685251673099273645276455013080427947868727501930236496670Currículo Lattesreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAfrican Journal of Biotechnologyinfo:eu-repo/semantics/openAccess2023-11-16T06:10:25Zoai:repositorio.unesp.br:11449/122438Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-11-16T06:10:25Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
| dc.title.none.fl_str_mv |
Study of Salmonella typhimurium mutagenicity assay of (Z)-piplartine by the Ames test |
| title |
Study of Salmonella typhimurium mutagenicity assay of (Z)-piplartine by the Ames test |
| spellingShingle |
Study of Salmonella typhimurium mutagenicity assay of (Z)-piplartine by the Ames test Morandim, Andréia de Araújo Piperaceae Piper tuberculatum (Z)-piplartine mutagenic activated Ames test. |
| title_short |
Study of Salmonella typhimurium mutagenicity assay of (Z)-piplartine by the Ames test |
| title_full |
Study of Salmonella typhimurium mutagenicity assay of (Z)-piplartine by the Ames test |
| title_fullStr |
Study of Salmonella typhimurium mutagenicity assay of (Z)-piplartine by the Ames test |
| title_full_unstemmed |
Study of Salmonella typhimurium mutagenicity assay of (Z)-piplartine by the Ames test |
| title_sort |
Study of Salmonella typhimurium mutagenicity assay of (Z)-piplartine by the Ames test |
| author |
Morandim, Andréia de Araújo |
| author_facet |
Morandim, Andréia de Araújo Cotinguiba, Fernando [UNESP] Regasini, Luis Octavio [UNESP] Frigieri, Mariana Carina [UNESP] Varanda, Eliana Aparecida [UNESP] Coqueiro, Aline [UNESP] Kato, Massuo Jorge Bolzani, Vanderlan da Silva [UNESP] Furlan, Maysa [UNESP] |
| author_role |
author |
| author2 |
Cotinguiba, Fernando [UNESP] Regasini, Luis Octavio [UNESP] Frigieri, Mariana Carina [UNESP] Varanda, Eliana Aparecida [UNESP] Coqueiro, Aline [UNESP] Kato, Massuo Jorge Bolzani, Vanderlan da Silva [UNESP] Furlan, Maysa [UNESP] |
| author2_role |
author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Departamento de Engenharia Química, Centro Universitário da FEI 4Departamento de Química Fundamental, Instituto de Química, Universidade de São Paulo (USP) |
| dc.contributor.author.fl_str_mv |
Morandim, Andréia de Araújo Cotinguiba, Fernando [UNESP] Regasini, Luis Octavio [UNESP] Frigieri, Mariana Carina [UNESP] Varanda, Eliana Aparecida [UNESP] Coqueiro, Aline [UNESP] Kato, Massuo Jorge Bolzani, Vanderlan da Silva [UNESP] Furlan, Maysa [UNESP] |
| dc.subject.por.fl_str_mv |
Piperaceae Piper tuberculatum (Z)-piplartine mutagenic activated Ames test. |
| topic |
Piperaceae Piper tuberculatum (Z)-piplartine mutagenic activated Ames test. |
| description |
Phytochemical studies carried out with Piperaceae species have shown great diversity of secondary metabolites among which are several displayed considerable biological activities. The species Piper tuberculatum has been intensively investigated and a series of amides have been described. For instance, (E)-piplartine showed significant cytotoxic activity against tumor cell lines, especially human leukemia cell lines; antifungal activity against Cladosporium species; trypanocidal activity and others. Considering the popular use of P. tuberculatum and the lack of pharmacological studies regarding this plant species, the mutagenic and antimutagenic effect of (E)-piplartine was evaluated by the Ames test, using the strains TA97a, TA98, TA100 and TA102 of Salmonella typhimurium. No mutagenic activity was observed for this compound. |
| publishDate |
2011 |
| dc.date.none.fl_str_mv |
2011 2015-04-27T11:55:45Z 2015-04-27T11:55:45Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
African Journal of Biotechnology, v. 10, n. 27, p. 5398-5401, 2011. 1684-5315 http://hdl.handle.net/11449/122438 10.5897/AJB10.2576 ISSN1684-5315-2011-10-27-5398-5401.pdf 7948388584717287 4484083685251673 0992736452764550 1308042794786872 7501930236496670 |
| identifier_str_mv |
African Journal of Biotechnology, v. 10, n. 27, p. 5398-5401, 2011. 1684-5315 10.5897/AJB10.2576 ISSN1684-5315-2011-10-27-5398-5401.pdf 7948388584717287 4484083685251673 0992736452764550 1308042794786872 7501930236496670 |
| url |
http://hdl.handle.net/11449/122438 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
African Journal of Biotechnology |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
5398-5401 application/pdf |
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Currículo Lattes reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
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Universidade Estadual Paulista (UNESP) |
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UNESP |
| institution |
UNESP |
| reponame_str |
Repositório Institucional da UNESP |
| collection |
Repositório Institucional da UNESP |
| repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
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1803649727170871296 |