Biochemical and structural investigations of bothropstoxin-II, a myotoxic Asp49 phospholipase A2 from Bothrops jararacussu venom

Detalhes bibliográficos
Autor(a) principal: Murakami, Mário T. [UNESP]
Data de Publicação: 2008
Outros Autores: Lourenzoni, Marco R., Arruda, Emerson Z., Tomaz, Marcelo A., Viçoti, Magno M. [UNESP], Abrego, José R. B. [UNESP], Melo, Paulo A., Arni, Raghuvir K. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.2174/092986608785849245
http://hdl.handle.net/11449/225292
Resumo: Bothropstoxin-II a calcium-dependent enzyme from Bothrops jararacussu venom causes tissue damage and several haemostatic disorders including platelet aggregation. In order to elucidate the structural determinants of its multiple pharmacological activities, we have studied the effects of suramin on Bothropstoxin-II and present details concerning the mode of binding. © 2008 Bentham Science Publishers Ltd.
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spelling Biochemical and structural investigations of bothropstoxin-II, a myotoxic Asp49 phospholipase A2 from Bothrops jararacussu venomPharmacological activitiesPhospholipases A2Structural studiesSuraminBothropstoxin-II a calcium-dependent enzyme from Bothrops jararacussu venom causes tissue damage and several haemostatic disorders including platelet aggregation. In order to elucidate the structural determinants of its multiple pharmacological activities, we have studied the effects of suramin on Bothropstoxin-II and present details concerning the mode of binding. © 2008 Bentham Science Publishers Ltd.Center for Structural Molecular Biology Brazilian Synchrotron Light Laboratory LNLS, Campinas, SPCenter for Structural and Molecular Biology Department of Physics IBILCE/UNESP, São José do Rio Preto, SPAssociated Researcher, São Carlos, SPDepartment of Basic and Clinical Pharmacology ICB UFRJ, RJCenter for Applied Toxinology Butantan Institute, São Paulo, SPDepartment of Physics IBILCE/UNESP, Cristovão Colombo 2265, São José do Rio Preto, SP, 15054-000Center for Structural and Molecular Biology Department of Physics IBILCE/UNESP, São José do Rio Preto, SPDepartment of Physics IBILCE/UNESP, Cristovão Colombo 2265, São José do Rio Preto, SP, 15054-000LNLSUniversidade Estadual Paulista (UNESP)Associated ResearcherUniversidade Federal do Rio de Janeiro (UFRJ)Butantan InstituteMurakami, Mário T. [UNESP]Lourenzoni, Marco R.Arruda, Emerson Z.Tomaz, Marcelo A.Viçoti, Magno M. [UNESP]Abrego, José R. B. [UNESP]Melo, Paulo A.Arni, Raghuvir K. [UNESP]2022-04-28T20:44:02Z2022-04-28T20:44:02Z2008-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1002-1008http://dx.doi.org/10.2174/092986608785849245Protein and Peptide Letters, v. 15, n. 9, p. 1002-1008, 2008.0929-8665http://hdl.handle.net/11449/22529210.2174/0929866087858492452-s2.0-52749091852Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengProtein and Peptide Lettersinfo:eu-repo/semantics/openAccess2022-04-28T20:44:02Zoai:repositorio.unesp.br:11449/225292Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:23:17.328650Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Biochemical and structural investigations of bothropstoxin-II, a myotoxic Asp49 phospholipase A2 from Bothrops jararacussu venom
title Biochemical and structural investigations of bothropstoxin-II, a myotoxic Asp49 phospholipase A2 from Bothrops jararacussu venom
spellingShingle Biochemical and structural investigations of bothropstoxin-II, a myotoxic Asp49 phospholipase A2 from Bothrops jararacussu venom
Murakami, Mário T. [UNESP]
Pharmacological activities
Phospholipases A2
Structural studies
Suramin
title_short Biochemical and structural investigations of bothropstoxin-II, a myotoxic Asp49 phospholipase A2 from Bothrops jararacussu venom
title_full Biochemical and structural investigations of bothropstoxin-II, a myotoxic Asp49 phospholipase A2 from Bothrops jararacussu venom
title_fullStr Biochemical and structural investigations of bothropstoxin-II, a myotoxic Asp49 phospholipase A2 from Bothrops jararacussu venom
title_full_unstemmed Biochemical and structural investigations of bothropstoxin-II, a myotoxic Asp49 phospholipase A2 from Bothrops jararacussu venom
title_sort Biochemical and structural investigations of bothropstoxin-II, a myotoxic Asp49 phospholipase A2 from Bothrops jararacussu venom
author Murakami, Mário T. [UNESP]
author_facet Murakami, Mário T. [UNESP]
Lourenzoni, Marco R.
Arruda, Emerson Z.
Tomaz, Marcelo A.
Viçoti, Magno M. [UNESP]
Abrego, José R. B. [UNESP]
Melo, Paulo A.
Arni, Raghuvir K. [UNESP]
author_role author
author2 Lourenzoni, Marco R.
Arruda, Emerson Z.
Tomaz, Marcelo A.
Viçoti, Magno M. [UNESP]
Abrego, José R. B. [UNESP]
Melo, Paulo A.
Arni, Raghuvir K. [UNESP]
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv LNLS
Universidade Estadual Paulista (UNESP)
Associated Researcher
Universidade Federal do Rio de Janeiro (UFRJ)
Butantan Institute
dc.contributor.author.fl_str_mv Murakami, Mário T. [UNESP]
Lourenzoni, Marco R.
Arruda, Emerson Z.
Tomaz, Marcelo A.
Viçoti, Magno M. [UNESP]
Abrego, José R. B. [UNESP]
Melo, Paulo A.
Arni, Raghuvir K. [UNESP]
dc.subject.por.fl_str_mv Pharmacological activities
Phospholipases A2
Structural studies
Suramin
topic Pharmacological activities
Phospholipases A2
Structural studies
Suramin
description Bothropstoxin-II a calcium-dependent enzyme from Bothrops jararacussu venom causes tissue damage and several haemostatic disorders including platelet aggregation. In order to elucidate the structural determinants of its multiple pharmacological activities, we have studied the effects of suramin on Bothropstoxin-II and present details concerning the mode of binding. © 2008 Bentham Science Publishers Ltd.
publishDate 2008
dc.date.none.fl_str_mv 2008-09-01
2022-04-28T20:44:02Z
2022-04-28T20:44:02Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.2174/092986608785849245
Protein and Peptide Letters, v. 15, n. 9, p. 1002-1008, 2008.
0929-8665
http://hdl.handle.net/11449/225292
10.2174/092986608785849245
2-s2.0-52749091852
url http://dx.doi.org/10.2174/092986608785849245
http://hdl.handle.net/11449/225292
identifier_str_mv Protein and Peptide Letters, v. 15, n. 9, p. 1002-1008, 2008.
0929-8665
10.2174/092986608785849245
2-s2.0-52749091852
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Protein and Peptide Letters
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1002-1008
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128507349303296

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