Molecular subtypes as a prognostic breast cancer factor in women users of the São Paulo public health system, Brazil
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/1980-549720230028 http://hdl.handle.net/11449/249093 |
Resumo: | OBJECTIVE: This study aimed to analyze the prognosis of women with breast cancer by molecular subtypes, sociodemographic variables, and clinical and treatment characteristics. METHODS: This hospital-based retrospective cohort study analyzed 1,654 women over 18 years of age diagnosed with invasive breast cancer from 2000 to 2018. Data were extracted from Brazil's Oncocenter Foundation of São Paulo. The variables analyzed were age, histology, molecular subtypes, clinical staging, treatment type, and diagnosis-to-treatment time. Cox regression analysis was applied to estimate death risk. RESULTS: Women with HER-2-positive (nonluminal) and triple-negative molecular subtypes were more than twice more likely to be at risk of death, with adjusted hazard ratio - HRadj=2.30 (95% confidence interval - 95%CI 1.34-3.94) and HRadj=2.51 (95%CI 1.61-3.92), respectively. A delayed treatment associated with an advanced clinical stage at diagnosis increased fourfold the risk of death (HRadj=4.20 (95%CI 2.36-7.49). CONCLUSION: In summary, besides that interaction between advanced clinical stage and longer time between diagnosis and treatment, HER-2-positive (nonluminal) and triple-negative phenotypes were associated with a worse prognosis. Therefore, actions to reduce barriers in diagnosis and treatment can provide better outcome, even in aggressive phenotypes. |
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Repositório Institucional da UNESP |
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spelling |
Molecular subtypes as a prognostic breast cancer factor in women users of the São Paulo public health system, BrazilOBJECTIVE: This study aimed to analyze the prognosis of women with breast cancer by molecular subtypes, sociodemographic variables, and clinical and treatment characteristics. METHODS: This hospital-based retrospective cohort study analyzed 1,654 women over 18 years of age diagnosed with invasive breast cancer from 2000 to 2018. Data were extracted from Brazil's Oncocenter Foundation of São Paulo. The variables analyzed were age, histology, molecular subtypes, clinical staging, treatment type, and diagnosis-to-treatment time. Cox regression analysis was applied to estimate death risk. RESULTS: Women with HER-2-positive (nonluminal) and triple-negative molecular subtypes were more than twice more likely to be at risk of death, with adjusted hazard ratio - HRadj=2.30 (95% confidence interval - 95%CI 1.34-3.94) and HRadj=2.51 (95%CI 1.61-3.92), respectively. A delayed treatment associated with an advanced clinical stage at diagnosis increased fourfold the risk of death (HRadj=4.20 (95%CI 2.36-7.49). CONCLUSION: In summary, besides that interaction between advanced clinical stage and longer time between diagnosis and treatment, HER-2-positive (nonluminal) and triple-negative phenotypes were associated with a worse prognosis. Therefore, actions to reduce barriers in diagnosis and treatment can provide better outcome, even in aggressive phenotypes.Fundação Oncocentro de São Paulo Department of Information and Epidemiology - São Paulo (SP)A.C. Camargo Cancer Center Centro International de Pesquisa Cancer Epidemiology and Statistics Group - São Paulo (SP)Fundação Oncocentro de São Paulo Department of Pathology - São Paulo (SP)Universidade de São Paulo Clinical Hospital - São Paulo (SP)Grupo Oncoclínicas de São Paulo Department of Mastology - São Paulo (SP)Universidade de São Paulo Faculty of Medicine of Botucatu Graduate Program in Obstetrics and Gynecology - Botucatu (SP)Hospital do Câncer de Barretos Graduate Program in Oncology - Barretos (SP)Fundação Oncocentro de São PauloCancer Epidemiology and Statistics Group - São Paulo (SP)Universidade de São Paulo (USP)Grupo Oncoclínicas de São PauloGraduate Program in Oncology - Barretos (SP)Peres, Stela VerzinhasseArantes, Paola EngelmannFagundes, Marcela de AraújoAb'Saber, Alexandre MuxfeldtGimenes, Daniel LuizCurado, Maria PaulaVieira, René Aloisio da Costa2023-07-29T14:02:11Z2023-07-29T14:02:11Z2023-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlee230028http://dx.doi.org/10.1590/1980-549720230028Revista brasileira de epidemiologia = Brazilian journal of epidemiology, v. 26, p. e230028-.1980-5497http://hdl.handle.net/11449/24909310.1590/1980-5497202300282-s2.0-85160590877Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRevista brasileira de epidemiologia = Brazilian journal of epidemiologyinfo:eu-repo/semantics/openAccess2024-08-16T14:06:54Zoai:repositorio.unesp.br:11449/249093Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-16T14:06:54Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Molecular subtypes as a prognostic breast cancer factor in women users of the São Paulo public health system, Brazil |
title |
Molecular subtypes as a prognostic breast cancer factor in women users of the São Paulo public health system, Brazil |
spellingShingle |
Molecular subtypes as a prognostic breast cancer factor in women users of the São Paulo public health system, Brazil Peres, Stela Verzinhasse |
title_short |
Molecular subtypes as a prognostic breast cancer factor in women users of the São Paulo public health system, Brazil |
title_full |
Molecular subtypes as a prognostic breast cancer factor in women users of the São Paulo public health system, Brazil |
title_fullStr |
Molecular subtypes as a prognostic breast cancer factor in women users of the São Paulo public health system, Brazil |
title_full_unstemmed |
Molecular subtypes as a prognostic breast cancer factor in women users of the São Paulo public health system, Brazil |
title_sort |
Molecular subtypes as a prognostic breast cancer factor in women users of the São Paulo public health system, Brazil |
author |
Peres, Stela Verzinhasse |
author_facet |
Peres, Stela Verzinhasse Arantes, Paola Engelmann Fagundes, Marcela de Araújo Ab'Saber, Alexandre Muxfeldt Gimenes, Daniel Luiz Curado, Maria Paula Vieira, René Aloisio da Costa |
author_role |
author |
author2 |
Arantes, Paola Engelmann Fagundes, Marcela de Araújo Ab'Saber, Alexandre Muxfeldt Gimenes, Daniel Luiz Curado, Maria Paula Vieira, René Aloisio da Costa |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Fundação Oncocentro de São Paulo Cancer Epidemiology and Statistics Group - São Paulo (SP) Universidade de São Paulo (USP) Grupo Oncoclínicas de São Paulo Graduate Program in Oncology - Barretos (SP) |
dc.contributor.author.fl_str_mv |
Peres, Stela Verzinhasse Arantes, Paola Engelmann Fagundes, Marcela de Araújo Ab'Saber, Alexandre Muxfeldt Gimenes, Daniel Luiz Curado, Maria Paula Vieira, René Aloisio da Costa |
description |
OBJECTIVE: This study aimed to analyze the prognosis of women with breast cancer by molecular subtypes, sociodemographic variables, and clinical and treatment characteristics. METHODS: This hospital-based retrospective cohort study analyzed 1,654 women over 18 years of age diagnosed with invasive breast cancer from 2000 to 2018. Data were extracted from Brazil's Oncocenter Foundation of São Paulo. The variables analyzed were age, histology, molecular subtypes, clinical staging, treatment type, and diagnosis-to-treatment time. Cox regression analysis was applied to estimate death risk. RESULTS: Women with HER-2-positive (nonluminal) and triple-negative molecular subtypes were more than twice more likely to be at risk of death, with adjusted hazard ratio - HRadj=2.30 (95% confidence interval - 95%CI 1.34-3.94) and HRadj=2.51 (95%CI 1.61-3.92), respectively. A delayed treatment associated with an advanced clinical stage at diagnosis increased fourfold the risk of death (HRadj=4.20 (95%CI 2.36-7.49). CONCLUSION: In summary, besides that interaction between advanced clinical stage and longer time between diagnosis and treatment, HER-2-positive (nonluminal) and triple-negative phenotypes were associated with a worse prognosis. Therefore, actions to reduce barriers in diagnosis and treatment can provide better outcome, even in aggressive phenotypes. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-07-29T14:02:11Z 2023-07-29T14:02:11Z 2023-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/1980-549720230028 Revista brasileira de epidemiologia = Brazilian journal of epidemiology, v. 26, p. e230028-. 1980-5497 http://hdl.handle.net/11449/249093 10.1590/1980-549720230028 2-s2.0-85160590877 |
url |
http://dx.doi.org/10.1590/1980-549720230028 http://hdl.handle.net/11449/249093 |
identifier_str_mv |
Revista brasileira de epidemiologia = Brazilian journal of epidemiology, v. 26, p. e230028-. 1980-5497 10.1590/1980-549720230028 2-s2.0-85160590877 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Revista brasileira de epidemiologia = Brazilian journal of epidemiology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
e230028 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808128136465874944 |