Age as a prognostic factor in early breast cancer

• Autor(a) principal: Garicochea, Bernardo
• Data de Publicação: 2009
• Outros Autores: Morelle, Alessandra, Andrighetti, Ana Elisa, Cancella, Anna, Bós, Ângelo, Werutsky, Gustavo
• Tipo de documento: Artigo
• Idioma: por; eng
• Título da fonte: Revista de Saúde Pública
• Texto Completo: https://www.revistas.usp.br/rsp/article/view/32600
• topic: Mulheres; Neoplasias da Mama; Idade de Início; Efeito Idade; Diagnóstico Precoce; Prognóstico; Estudos Retrospectivos; Mujeres; Neoplasias de la Mama; Edad de Inicio; Efecto Edad; Diagnóstico Precoz; Pronóstico; Estudios Retrospectivos; Women; Breast Neoplasms; Age of Onset; Age Effect; Early Diagnosis; Prognosis; Retrospective Studies

OBJECTIVE: To analyze age as a prognostic factor in early breast cancer. METHODS: Retrospective study analyzing the clinical profile and disease-free survival in a group of 280 subjects aged 25 to 81 years with stage I and II breast cancer followed-up in Porto Alegre, southern Brazil, from 1995 to 2000. Clinical, pathological, treatment and outcome data were obtained from medical records. Subjects were divided into two groups according to age at diagnosis (;40 years). The two groups were compared for clinical stage, histology, hormone receptor expression, therapy and radiotherapy using the chi-square and/or Fisher's exact test and for analysis of survival the Kaplan-Meier method with a long-rank test. RESULTS: Of 280 women studied, 54 (19.3%) were younger than 40 years. Both groups were similar regarding clinical stage, histology, and hormone receptor expression. The proportion of subjects with disease-free survival in the 56-month follow-up was significantly higher in those over 40 years (84% versus 70%). Proportionally, younger subjects received more adjuvant therapy (88.8% vs. 77.8%). Those women over 40 years were significantly more likely to remain disease-free (84%), and this difference was more remarkable when they were compared to those over 40 years at stage I breast cancer. CONCLUSIONS: The study findings confirm that women younger than 40 years with early breast cancer have a poorer prognosis. However, this prognosis does not seem to be related to increased number of hormone receptor-negative cases. Younger patients who remained disease-free received more adjuvant therapy, suggesting a positive effect of chemotherapy and endocrine therapy.