Biology of bone tissue: structure, function, and factors that influence bone cells
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1155/2015/421746 http://hdl.handle.net/11449/131203 |
Resumo: | Bone tissue is continuously remodeled through the concerted actions of bone cells, which include bone resorption by osteoclasts and bone formation by osteoblasts, whereas osteocytes act as mechanosensors and orchestrators of the bone remodeling process. This process is under the control of local (e.g., growth factors and cytokines) and systemic (e.g., calcitonin and estrogens) factors that all together contribute for bone homeostasis. An imbalance between bone resorption and formation can result in bone diseases including osteoporosis. Recently, it has been recognized that, during bone remodeling, there are an intricate communication among bone cells. For instance, the coupling from bone resorption to bone formation is achieved by interaction between osteoclasts and osteoblasts. Moreover, osteocytes produce factors that influence osteoblast and osteoclast activities, whereas osteocyte apoptosis is followed by osteoclastic bone resorption. The increasing knowledge about the structure and functions of bone cells contributed to a better understanding of bone biology. It has been suggested that there is a complex communication between bone cells and other organs, indicating the dynamic nature of bone tissue. In this review, we discuss the current data about the structure and functions of bone cells and the factors that influence bone remodeling. |
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Biology of bone tissue: structure, function, and factors that influence bone cellsBone tissue is continuously remodeled through the concerted actions of bone cells, which include bone resorption by osteoclasts and bone formation by osteoblasts, whereas osteocytes act as mechanosensors and orchestrators of the bone remodeling process. This process is under the control of local (e.g., growth factors and cytokines) and systemic (e.g., calcitonin and estrogens) factors that all together contribute for bone homeostasis. An imbalance between bone resorption and formation can result in bone diseases including osteoporosis. Recently, it has been recognized that, during bone remodeling, there are an intricate communication among bone cells. For instance, the coupling from bone resorption to bone formation is achieved by interaction between osteoclasts and osteoblasts. Moreover, osteocytes produce factors that influence osteoblast and osteoclast activities, whereas osteocyte apoptosis is followed by osteoclastic bone resorption. The increasing knowledge about the structure and functions of bone cells contributed to a better understanding of bone biology. It has been suggested that there is a complex communication between bone cells and other organs, indicating the dynamic nature of bone tissue. In this review, we discuss the current data about the structure and functions of bone cells and the factors that influence bone remodeling.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Departamento de Morfologia e Genética, Laboratório de Histologia e Biologia Estrutural, Universidade Federal de São Paulo, 04023-900 São Paulo, SP, BrasilDepartamento de Morfologia, Laboratório de Histologia e Embriologia, Faculdade de Odontologia, Universidade Estadual Paulista (UNESP), 14801-903 Araraquara, SP, BrasilUniversidade Estadual Paulista, Departamento de Morfologia, Faculdade de Odontologia de AraraquaraFAPESP: 2010/10391-9FAPESP: 2012/19428-8FAPESP: 2012/22666-8Hindawi Publishing CorporationUniversidade Federal de São Paulo (UNIFESP)Universidade Estadual Paulista (Unesp)Florencio-Silva, RinaldoSasso, Gisela Rodrigues da SilvaSasso-Cerri, Estela [UNESP]Simões, Manuel JesusCerri, Paulo Sérgio [UNESP]2015-12-07T15:32:34Z2015-12-07T15:32:34Z2015info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1-18application/pdfhttp://dx.doi.org/10.1155/2015/421746BioMed Research International, v. 2015, p. 1-18, 2015.2314-6141http://hdl.handle.net/11449/13120310.1155/2015/421746PMC4515490.pdf44556300768413023278495911207882327849591120788226247020PMC45154900000-0001-5756-5828PubMedreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBioMed Research International0,935info:eu-repo/semantics/openAccess2023-12-04T06:18:16Zoai:repositorio.unesp.br:11449/131203Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-12-04T06:18:16Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Biology of bone tissue: structure, function, and factors that influence bone cells |
title |
Biology of bone tissue: structure, function, and factors that influence bone cells |
spellingShingle |
Biology of bone tissue: structure, function, and factors that influence bone cells Florencio-Silva, Rinaldo |
title_short |
Biology of bone tissue: structure, function, and factors that influence bone cells |
title_full |
Biology of bone tissue: structure, function, and factors that influence bone cells |
title_fullStr |
Biology of bone tissue: structure, function, and factors that influence bone cells |
title_full_unstemmed |
Biology of bone tissue: structure, function, and factors that influence bone cells |
title_sort |
Biology of bone tissue: structure, function, and factors that influence bone cells |
author |
Florencio-Silva, Rinaldo |
author_facet |
Florencio-Silva, Rinaldo Sasso, Gisela Rodrigues da Silva Sasso-Cerri, Estela [UNESP] Simões, Manuel Jesus Cerri, Paulo Sérgio [UNESP] |
author_role |
author |
author2 |
Sasso, Gisela Rodrigues da Silva Sasso-Cerri, Estela [UNESP] Simões, Manuel Jesus Cerri, Paulo Sérgio [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Florencio-Silva, Rinaldo Sasso, Gisela Rodrigues da Silva Sasso-Cerri, Estela [UNESP] Simões, Manuel Jesus Cerri, Paulo Sérgio [UNESP] |
description |
Bone tissue is continuously remodeled through the concerted actions of bone cells, which include bone resorption by osteoclasts and bone formation by osteoblasts, whereas osteocytes act as mechanosensors and orchestrators of the bone remodeling process. This process is under the control of local (e.g., growth factors and cytokines) and systemic (e.g., calcitonin and estrogens) factors that all together contribute for bone homeostasis. An imbalance between bone resorption and formation can result in bone diseases including osteoporosis. Recently, it has been recognized that, during bone remodeling, there are an intricate communication among bone cells. For instance, the coupling from bone resorption to bone formation is achieved by interaction between osteoclasts and osteoblasts. Moreover, osteocytes produce factors that influence osteoblast and osteoclast activities, whereas osteocyte apoptosis is followed by osteoclastic bone resorption. The increasing knowledge about the structure and functions of bone cells contributed to a better understanding of bone biology. It has been suggested that there is a complex communication between bone cells and other organs, indicating the dynamic nature of bone tissue. In this review, we discuss the current data about the structure and functions of bone cells and the factors that influence bone remodeling. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-12-07T15:32:34Z 2015-12-07T15:32:34Z 2015 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1155/2015/421746 BioMed Research International, v. 2015, p. 1-18, 2015. 2314-6141 http://hdl.handle.net/11449/131203 10.1155/2015/421746 PMC4515490.pdf 4455630076841302 3278495911207882 3278495911207882 26247020 PMC4515490 0000-0001-5756-5828 |
url |
http://dx.doi.org/10.1155/2015/421746 http://hdl.handle.net/11449/131203 |
identifier_str_mv |
BioMed Research International, v. 2015, p. 1-18, 2015. 2314-6141 10.1155/2015/421746 PMC4515490.pdf 4455630076841302 3278495911207882 26247020 PMC4515490 0000-0001-5756-5828 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
BioMed Research International 0,935 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1-18 application/pdf |
dc.publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
dc.source.none.fl_str_mv |
PubMed reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1803046799619915776 |