Clinical, radiological, and transbronchial biopsy findings in patients with long COVID-19: a case series

• Autor(a) principal: Baldi, Bruno Guedes
• Data de Publicação: 2022
• Outros Autores: Fabro, Alexandre Todorovic, Franco, Andreia Craveiro [UNESP], Machado, Marília Helena C. [UNESP], Prudente, Robson Aparecido [UNESP], Franco, Estefânia Thomé [UNESP], Marrone, Sergio Ribeiro [UNESP], Vale, Simone Alves do [UNESP], Cezare, Talita Jacon [UNESP], Moraes, Marcelo Padovani de Toledo, Ferreira, Eloara Vieira Machado, Albuquerque, André Luis Pereira, Sawamura, Marcio Valente Yamada, Tanni, Suzana Erico [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.36416/1806-3756/e20210438; http://hdl.handle.net/11449/240933
• topic: Biopsy; COVID-19; COVID-19/pathology; Pulmonary fibrosis; Respiratory function tests

This brief communication demonstrates the correlation of persistent respiratory symptoms with functional, tomographic, and transbronchial pulmonary biopsy findings in patients with COVID-19 who had a long follow-up period. We report a series of six COVID-19 patients with pulmonary involvement who presented with persistent dyspnea within 4-15 months of discharge. We performed transbronchial biopsies, and the histopathological pattern consistently demonstrated peribronchial remodeling with interstitial pulmonary fibrosis. Therefore, lung biopsy may be useful in the approach of patients with long COVID-19, although the type of procedure, its precise indication, and the moment to perform it are yet to be clarified. (Brazilian Registry of Clinical Trials–ReBEC; identifier: RBR-8j9kqy [http://www. ensaiosclinicos.gov.br]).