Intrauterine growth restricted rats exercised before and during pregnancy: maternal and perinatal repercussions
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1155/2015/294850 http://hdl.handle.net/11449/131103 |
Resumo: | This study aimed at evaluating the effect of swimming before and during pregnancy on rats born with intrauterine growth restriction (IUGR) and their offspring. For this, nondiabetic and streptozotocin-induced severely diabetic (SD) pregnant rats were mated and generated offspring with appropriate (control, C) and small (IUGR) for pregnancy age, respectively. Following that, C and IUGR groups were further distributed into nonexercised control (C), exercised control (Cex), nonexercised IUGR (IUGR), and exercised IUGR (IUGRex). IUGR rats presented lower mating rate than control rats. Regardless of physical exercise IUGR rats presented decreased body weight from birth to lactation. At 90 days of life, IUGR rats presented glucose intolerance. Maternal organ weights were increased and relative adiposity of IUGRex rats was lower than Cex. IUGR and IUGRex offspring presented reduced body weight than C and Cex, respectively. IUGRex dams presented an increased rate of appropriate for pregnancy age newborns. IUGEex male and female offspring relative brain weight was increased compared with Cex. Therefore, swimming before and during pregnancy prevented glucose intolerance, reduced general adiposity, and increased maternal and offspring organ weight in rats, showing the benefit of physical exercise for IUGR rats. |
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Intrauterine growth restricted rats exercised before and during pregnancy: maternal and perinatal repercussionsThis study aimed at evaluating the effect of swimming before and during pregnancy on rats born with intrauterine growth restriction (IUGR) and their offspring. For this, nondiabetic and streptozotocin-induced severely diabetic (SD) pregnant rats were mated and generated offspring with appropriate (control, C) and small (IUGR) for pregnancy age, respectively. Following that, C and IUGR groups were further distributed into nonexercised control (C), exercised control (Cex), nonexercised IUGR (IUGR), and exercised IUGR (IUGRex). IUGR rats presented lower mating rate than control rats. Regardless of physical exercise IUGR rats presented decreased body weight from birth to lactation. At 90 days of life, IUGR rats presented glucose intolerance. Maternal organ weights were increased and relative adiposity of IUGRex rats was lower than Cex. IUGR and IUGRex offspring presented reduced body weight than C and Cex, respectively. IUGRex dams presented an increased rate of appropriate for pregnancy age newborns. IUGEex male and female offspring relative brain weight was increased compared with Cex. Therefore, swimming before and during pregnancy prevented glucose intolerance, reduced general adiposity, and increased maternal and offspring organ weight in rats, showing the benefit of physical exercise for IUGR rats.Laboratory of Experimental Research on Gynecology and Obstetrics, Gynecology, Obstetrics and Mastology Graduate Course, Botucatu Medical School, São Paulo State University (Unesp), 18618-970 Botucatu, SP, Brazil.Laboratory of Experimental Research on Gynecology and Obstetrics, Gynecology, Obstetrics and Mastology Graduate Course, Botucatu Medical School, São Paulo State University (Unesp), 18618-970 Botucatu, SP, Brazil ; Institute of Biological and Health Sciences, University Center of Araguaia, 78600-000 Barra do Garças, MT, Mato Grosso Federal University (UFMT), Brazil.Laboratory of Experimental Research on Gynecology and Obstetrics, Gynecology, Obstetrics and Mastology Graduate Course, Botucatu Medical School, São Paulo State University (Unesp), 18618-970 Botucatu, SP, Brazil.Laboratory of Experimental Research on Gynecology and Obstetrics, Gynecology, Obstetrics and Mastology Graduate Course, Botucatu Medical School, São Paulo State University (Unesp), 18618-970 Botucatu, SP, Brazil ; Institute of Biological and Health Sciences, University Center of Araguaia, 78600-000 Barra do Garças, MT, Mato Grosso Federal University (UFMT), Brazil.Universidade Estadual Paulista (Unesp)Corvino, S. B. [UNESP]Volpato, G. T. [UNESP]Rudge, Marilza Vieira Cunha [UNESP]Damasceno, D. C. [UNESP]2015-12-07T15:31:37Z2015-12-07T15:31:37Z2015info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1155/2015/294850Evidence-based Complementary And Alternative Medicine : Ecam, v. 2015, 2015.1741-427Xhttp://hdl.handle.net/11449/13110310.1155/2015/294850PMC4540985.pdf675868038883507826345406PMC45409850000-0002-9227-832XPubMedreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengEvidence-based Complementary And Alternative Medicine : Ecam2.064info:eu-repo/semantics/openAccess2024-08-16T14:06:53Zoai:repositorio.unesp.br:11449/131103Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-16T14:06:53Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Intrauterine growth restricted rats exercised before and during pregnancy: maternal and perinatal repercussions |
title |
Intrauterine growth restricted rats exercised before and during pregnancy: maternal and perinatal repercussions |
spellingShingle |
Intrauterine growth restricted rats exercised before and during pregnancy: maternal and perinatal repercussions Corvino, S. B. [UNESP] |
title_short |
Intrauterine growth restricted rats exercised before and during pregnancy: maternal and perinatal repercussions |
title_full |
Intrauterine growth restricted rats exercised before and during pregnancy: maternal and perinatal repercussions |
title_fullStr |
Intrauterine growth restricted rats exercised before and during pregnancy: maternal and perinatal repercussions |
title_full_unstemmed |
Intrauterine growth restricted rats exercised before and during pregnancy: maternal and perinatal repercussions |
title_sort |
Intrauterine growth restricted rats exercised before and during pregnancy: maternal and perinatal repercussions |
author |
Corvino, S. B. [UNESP] |
author_facet |
Corvino, S. B. [UNESP] Volpato, G. T. [UNESP] Rudge, Marilza Vieira Cunha [UNESP] Damasceno, D. C. [UNESP] |
author_role |
author |
author2 |
Volpato, G. T. [UNESP] Rudge, Marilza Vieira Cunha [UNESP] Damasceno, D. C. [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Corvino, S. B. [UNESP] Volpato, G. T. [UNESP] Rudge, Marilza Vieira Cunha [UNESP] Damasceno, D. C. [UNESP] |
description |
This study aimed at evaluating the effect of swimming before and during pregnancy on rats born with intrauterine growth restriction (IUGR) and their offspring. For this, nondiabetic and streptozotocin-induced severely diabetic (SD) pregnant rats were mated and generated offspring with appropriate (control, C) and small (IUGR) for pregnancy age, respectively. Following that, C and IUGR groups were further distributed into nonexercised control (C), exercised control (Cex), nonexercised IUGR (IUGR), and exercised IUGR (IUGRex). IUGR rats presented lower mating rate than control rats. Regardless of physical exercise IUGR rats presented decreased body weight from birth to lactation. At 90 days of life, IUGR rats presented glucose intolerance. Maternal organ weights were increased and relative adiposity of IUGRex rats was lower than Cex. IUGR and IUGRex offspring presented reduced body weight than C and Cex, respectively. IUGRex dams presented an increased rate of appropriate for pregnancy age newborns. IUGEex male and female offspring relative brain weight was increased compared with Cex. Therefore, swimming before and during pregnancy prevented glucose intolerance, reduced general adiposity, and increased maternal and offspring organ weight in rats, showing the benefit of physical exercise for IUGR rats. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-12-07T15:31:37Z 2015-12-07T15:31:37Z 2015 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1155/2015/294850 Evidence-based Complementary And Alternative Medicine : Ecam, v. 2015, 2015. 1741-427X http://hdl.handle.net/11449/131103 10.1155/2015/294850 PMC4540985.pdf 6758680388835078 26345406 PMC4540985 0000-0002-9227-832X |
url |
http://dx.doi.org/10.1155/2015/294850 http://hdl.handle.net/11449/131103 |
identifier_str_mv |
Evidence-based Complementary And Alternative Medicine : Ecam, v. 2015, 2015. 1741-427X 10.1155/2015/294850 PMC4540985.pdf 6758680388835078 26345406 PMC4540985 0000-0002-9227-832X |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Evidence-based Complementary And Alternative Medicine : Ecam 2.064 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
PubMed reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128130957705216 |