Segmentation of Cell Nuclei Regions in Epithelium of Prostate Glands

• Autor(a) principal: Oliveira, Domingos Lucas Latore de
• Data de Publicação: 2012
• Outros Autores: Nascimento, Marcelo Zanchetta do, Neves, Leandro Alves [UNESP], Godoy, Moacir F., Arruda, Pedro Francisco Ferraz de, Santi Neto, Dalisio de
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://connection.ebscohost.com/c/articles/90307465/segmentation-cell-nuclei-regions-epithelium-prostate-glands; http://hdl.handle.net/11449/122835
• topic: Cell Nuclei Regions Segmentation; Histological Segmentation; Prostate Glands; Digital Pathology; Contrast Stretching; Global Thresholding

This paper proposes a method for segmentation of cell nuclei regions in epithelium of prostate glands. This structure provides information to diagnosis and prognosis of prostate cancer. In the initial step, the contrast stretching technique was applied in image in order to improve the contrast between regions of interest and other regions. After, the global thresholding technique was applied and the value of threshold was defined empirically. Finally, the false positive regions were removed using the connected components technique. The performance of the proposed method was compared with the Otsu technique and statistical measures of accuracy were calculated based on reference images (gold standard). The result of the mean value of accuracy of proposed method was 93% ± 0.07.