Biodistribution Profile of Magnetic Nanoparticles in Cirrhosis-Associated Hepatocarcinogenesis in Rats by AC Biosusceptometry
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3390/pharmaceutics14091907 http://hdl.handle.net/11449/247657 |
Resumo: | Since magnetic nanoparticles (MNPs) have been used as multifunctional probes to diagnose and treat liver diseases in recent years, this study aimed to assess how the condition of cirrhosis-associated hepatocarcinogenesis alters the biodistribution of hepatic MNPs. Using a real-time image acquisition approach, the distribution profile of MNPs after intravenous administration was monitored using an AC biosusceptometry (ACB) assay. We assessed the biodistribution profile based on the ACB images obtained through selected regions of interest (ROIs) in the heart and liver position according to the anatomical references previously selected. The signals obtained allowed for the quantification of pharmacokinetic parameters, indicating that the uptake of hepatic MNPs is compromised during liver cirrhosis, since scar tissue reduces blood flow through the liver and slows its processing function. Since liver monocytes/macrophages remained constant during the cirrhotic stage, the increased intrahepatic vascular resistance associated with impaired hepatic sinusoidal circulation was considered the potential reason for the change in the distribution of MNPs. |
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Biodistribution Profile of Magnetic Nanoparticles in Cirrhosis-Associated Hepatocarcinogenesis in Rats by AC BiosusceptometryAC biosuceptometrycirrhosis-associated rat hepatocarcinogenesismagnetic nanoparticlesnanotechnologySince magnetic nanoparticles (MNPs) have been used as multifunctional probes to diagnose and treat liver diseases in recent years, this study aimed to assess how the condition of cirrhosis-associated hepatocarcinogenesis alters the biodistribution of hepatic MNPs. Using a real-time image acquisition approach, the distribution profile of MNPs after intravenous administration was monitored using an AC biosusceptometry (ACB) assay. We assessed the biodistribution profile based on the ACB images obtained through selected regions of interest (ROIs) in the heart and liver position according to the anatomical references previously selected. The signals obtained allowed for the quantification of pharmacokinetic parameters, indicating that the uptake of hepatic MNPs is compromised during liver cirrhosis, since scar tissue reduces blood flow through the liver and slows its processing function. Since liver monocytes/macrophages remained constant during the cirrhotic stage, the increased intrahepatic vascular resistance associated with impaired hepatic sinusoidal circulation was considered the potential reason for the change in the distribution of MNPs.Department of Biophysics and Pharmacology Institute of Biosciences São Paulo State University—UNESP, SPDepartment of Pathology Botucatu Medical School São Paulo State University (UNESP), SPDepartment of Strucutral and Functional Biology Institute of Biosciences São Paulo State University—UNESP, SPInstitute of Physics Federal University of Goiás, GOFaculty of Philosophy Sciences and Letters at Ribeirão Preto University of São Paulo, SPDepartment of Biophysics and Pharmacology Institute of Biosciences São Paulo State University—UNESP, SPDepartment of Pathology Botucatu Medical School São Paulo State University (UNESP), SPDepartment of Strucutral and Functional Biology Institute of Biosciences São Paulo State University—UNESP, SPUniversidade Estadual Paulista (UNESP)Universidade Federal de Goiás (UFG)Universidade de São Paulo (USP)Soares, Guilherme A. [UNESP]Pereira, Gabriele M. [UNESP]Romualdo, Guilherme R. [UNESP]Biasotti, Gabriel G. A. [UNESP]Stoppa, Erick G. [UNESP]Bakuzis, Andris F.Baffa, OswaldoBarbisan, Luis F. [UNESP]Miranda, Jose R. A. [UNESP]2023-07-29T13:22:12Z2023-07-29T13:22:12Z2022-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/pharmaceutics14091907Pharmaceutics, v. 14, n. 9, 2022.1999-4923http://hdl.handle.net/11449/24765710.3390/pharmaceutics140919072-s2.0-85138599478Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPharmaceuticsinfo:eu-repo/semantics/openAccess2024-09-03T13:15:28Zoai:repositorio.unesp.br:11449/247657Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:15:28Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Biodistribution Profile of Magnetic Nanoparticles in Cirrhosis-Associated Hepatocarcinogenesis in Rats by AC Biosusceptometry |
title |
Biodistribution Profile of Magnetic Nanoparticles in Cirrhosis-Associated Hepatocarcinogenesis in Rats by AC Biosusceptometry |
spellingShingle |
Biodistribution Profile of Magnetic Nanoparticles in Cirrhosis-Associated Hepatocarcinogenesis in Rats by AC Biosusceptometry Soares, Guilherme A. [UNESP] AC biosuceptometry cirrhosis-associated rat hepatocarcinogenesis magnetic nanoparticles nanotechnology |
title_short |
Biodistribution Profile of Magnetic Nanoparticles in Cirrhosis-Associated Hepatocarcinogenesis in Rats by AC Biosusceptometry |
title_full |
Biodistribution Profile of Magnetic Nanoparticles in Cirrhosis-Associated Hepatocarcinogenesis in Rats by AC Biosusceptometry |
title_fullStr |
Biodistribution Profile of Magnetic Nanoparticles in Cirrhosis-Associated Hepatocarcinogenesis in Rats by AC Biosusceptometry |
title_full_unstemmed |
Biodistribution Profile of Magnetic Nanoparticles in Cirrhosis-Associated Hepatocarcinogenesis in Rats by AC Biosusceptometry |
title_sort |
Biodistribution Profile of Magnetic Nanoparticles in Cirrhosis-Associated Hepatocarcinogenesis in Rats by AC Biosusceptometry |
author |
Soares, Guilherme A. [UNESP] |
author_facet |
Soares, Guilherme A. [UNESP] Pereira, Gabriele M. [UNESP] Romualdo, Guilherme R. [UNESP] Biasotti, Gabriel G. A. [UNESP] Stoppa, Erick G. [UNESP] Bakuzis, Andris F. Baffa, Oswaldo Barbisan, Luis F. [UNESP] Miranda, Jose R. A. [UNESP] |
author_role |
author |
author2 |
Pereira, Gabriele M. [UNESP] Romualdo, Guilherme R. [UNESP] Biasotti, Gabriel G. A. [UNESP] Stoppa, Erick G. [UNESP] Bakuzis, Andris F. Baffa, Oswaldo Barbisan, Luis F. [UNESP] Miranda, Jose R. A. [UNESP] |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Universidade Federal de Goiás (UFG) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Soares, Guilherme A. [UNESP] Pereira, Gabriele M. [UNESP] Romualdo, Guilherme R. [UNESP] Biasotti, Gabriel G. A. [UNESP] Stoppa, Erick G. [UNESP] Bakuzis, Andris F. Baffa, Oswaldo Barbisan, Luis F. [UNESP] Miranda, Jose R. A. [UNESP] |
dc.subject.por.fl_str_mv |
AC biosuceptometry cirrhosis-associated rat hepatocarcinogenesis magnetic nanoparticles nanotechnology |
topic |
AC biosuceptometry cirrhosis-associated rat hepatocarcinogenesis magnetic nanoparticles nanotechnology |
description |
Since magnetic nanoparticles (MNPs) have been used as multifunctional probes to diagnose and treat liver diseases in recent years, this study aimed to assess how the condition of cirrhosis-associated hepatocarcinogenesis alters the biodistribution of hepatic MNPs. Using a real-time image acquisition approach, the distribution profile of MNPs after intravenous administration was monitored using an AC biosusceptometry (ACB) assay. We assessed the biodistribution profile based on the ACB images obtained through selected regions of interest (ROIs) in the heart and liver position according to the anatomical references previously selected. The signals obtained allowed for the quantification of pharmacokinetic parameters, indicating that the uptake of hepatic MNPs is compromised during liver cirrhosis, since scar tissue reduces blood flow through the liver and slows its processing function. Since liver monocytes/macrophages remained constant during the cirrhotic stage, the increased intrahepatic vascular resistance associated with impaired hepatic sinusoidal circulation was considered the potential reason for the change in the distribution of MNPs. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-09-01 2023-07-29T13:22:12Z 2023-07-29T13:22:12Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3390/pharmaceutics14091907 Pharmaceutics, v. 14, n. 9, 2022. 1999-4923 http://hdl.handle.net/11449/247657 10.3390/pharmaceutics14091907 2-s2.0-85138599478 |
url |
http://dx.doi.org/10.3390/pharmaceutics14091907 http://hdl.handle.net/11449/247657 |
identifier_str_mv |
Pharmaceutics, v. 14, n. 9, 2022. 1999-4923 10.3390/pharmaceutics14091907 2-s2.0-85138599478 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Pharmaceutics |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1810021394378915840 |