Issues surrounding the anti-Inflammatory actions of the citrus polymethoxylated flavones

Detalhes bibliográficos
Autor(a) principal: Manthey, John A.
Data de Publicação: 2013
Outros Autores: César, Thaïs B. [UNESP]
Tipo de documento: Artigo de conferência
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1021/bk-2013-1129.ch010
http://hdl.handle.net/11449/227842
Resumo: The polymethoxylated flavones in citrus have been evaluated for their in vivo anti-Inflammatory actions in several animal assays. Strong anti-Inflammatory effects were observed following administration of 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF) dissolved in vegetable oil by intraperitoneal (i.p.) injection, but neglibible action was detected following doses of HMF suspended as fine particulates in vegetable oil. This contradiction is shown to be a reflection of differences in the bioavailabilities of HMF following different routes of administration. Evidence of contrasting bioavailabilities among different PMFs is shown through comparisons of the pharmacokinetics of nobiletin and tangeretin administered in rats. ©2013 American Chemical Society.
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spelling Issues surrounding the anti-Inflammatory actions of the citrus polymethoxylated flavonesThe polymethoxylated flavones in citrus have been evaluated for their in vivo anti-Inflammatory actions in several animal assays. Strong anti-Inflammatory effects were observed following administration of 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF) dissolved in vegetable oil by intraperitoneal (i.p.) injection, but neglibible action was detected following doses of HMF suspended as fine particulates in vegetable oil. This contradiction is shown to be a reflection of differences in the bioavailabilities of HMF following different routes of administration. Evidence of contrasting bioavailabilities among different PMFs is shown through comparisons of the pharmacokinetics of nobiletin and tangeretin administered in rats. ©2013 American Chemical Society.U.S. Horticultural Research Laboratory, USDA-ARS, Ft. Pierce, FL 34945Department of Food and Nutrition, Faculty of Pharmaceutical Sciences-UNESP, Araraquara, SPDepartment of Food and Nutrition, Faculty of Pharmaceutical Sciences-UNESP, Araraquara, SPU.S. Horticultural Research Laboratory, USDA-ARSUniversidade Estadual Paulista (UNESP)Manthey, John A.César, Thaïs B. [UNESP]2022-04-29T07:20:25Z2022-04-29T07:20:25Z2013-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObject159-169http://dx.doi.org/10.1021/bk-2013-1129.ch010ACS Symposium Series, v. 1129, p. 159-169.1947-59180097-6156http://hdl.handle.net/11449/22784210.1021/bk-2013-1129.ch0102-s2.0-84905394353Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengACS Symposium Seriesinfo:eu-repo/semantics/openAccess2024-06-21T12:47:34Zoai:repositorio.unesp.br:11449/227842Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:06:40.365742Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Issues surrounding the anti-Inflammatory actions of the citrus polymethoxylated flavones
title Issues surrounding the anti-Inflammatory actions of the citrus polymethoxylated flavones
spellingShingle Issues surrounding the anti-Inflammatory actions of the citrus polymethoxylated flavones
Manthey, John A.
title_short Issues surrounding the anti-Inflammatory actions of the citrus polymethoxylated flavones
title_full Issues surrounding the anti-Inflammatory actions of the citrus polymethoxylated flavones
title_fullStr Issues surrounding the anti-Inflammatory actions of the citrus polymethoxylated flavones
title_full_unstemmed Issues surrounding the anti-Inflammatory actions of the citrus polymethoxylated flavones
title_sort Issues surrounding the anti-Inflammatory actions of the citrus polymethoxylated flavones
author Manthey, John A.
author_facet Manthey, John A.
César, Thaïs B. [UNESP]
author_role author
author2 César, Thaïs B. [UNESP]
author2_role author
dc.contributor.none.fl_str_mv U.S. Horticultural Research Laboratory, USDA-ARS
Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv Manthey, John A.
César, Thaïs B. [UNESP]
description The polymethoxylated flavones in citrus have been evaluated for their in vivo anti-Inflammatory actions in several animal assays. Strong anti-Inflammatory effects were observed following administration of 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF) dissolved in vegetable oil by intraperitoneal (i.p.) injection, but neglibible action was detected following doses of HMF suspended as fine particulates in vegetable oil. This contradiction is shown to be a reflection of differences in the bioavailabilities of HMF following different routes of administration. Evidence of contrasting bioavailabilities among different PMFs is shown through comparisons of the pharmacokinetics of nobiletin and tangeretin administered in rats. ©2013 American Chemical Society.
publishDate 2013
dc.date.none.fl_str_mv 2013-01-01
2022-04-29T07:20:25Z
2022-04-29T07:20:25Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/conferenceObject
format conferenceObject
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1021/bk-2013-1129.ch010
ACS Symposium Series, v. 1129, p. 159-169.
1947-5918
0097-6156
http://hdl.handle.net/11449/227842
10.1021/bk-2013-1129.ch010
2-s2.0-84905394353
url http://dx.doi.org/10.1021/bk-2013-1129.ch010
http://hdl.handle.net/11449/227842
identifier_str_mv ACS Symposium Series, v. 1129, p. 159-169.
1947-5918
0097-6156
10.1021/bk-2013-1129.ch010
2-s2.0-84905394353
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv ACS Symposium Series
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 159-169
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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