Issues surrounding the anti-Inflammatory actions of the citrus polymethoxylated flavones
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | |
Tipo de documento: | Artigo de conferência |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1021/bk-2013-1129.ch010 http://hdl.handle.net/11449/227842 |
Resumo: | The polymethoxylated flavones in citrus have been evaluated for their in vivo anti-Inflammatory actions in several animal assays. Strong anti-Inflammatory effects were observed following administration of 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF) dissolved in vegetable oil by intraperitoneal (i.p.) injection, but neglibible action was detected following doses of HMF suspended as fine particulates in vegetable oil. This contradiction is shown to be a reflection of differences in the bioavailabilities of HMF following different routes of administration. Evidence of contrasting bioavailabilities among different PMFs is shown through comparisons of the pharmacokinetics of nobiletin and tangeretin administered in rats. ©2013 American Chemical Society. |
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Issues surrounding the anti-Inflammatory actions of the citrus polymethoxylated flavonesThe polymethoxylated flavones in citrus have been evaluated for their in vivo anti-Inflammatory actions in several animal assays. Strong anti-Inflammatory effects were observed following administration of 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF) dissolved in vegetable oil by intraperitoneal (i.p.) injection, but neglibible action was detected following doses of HMF suspended as fine particulates in vegetable oil. This contradiction is shown to be a reflection of differences in the bioavailabilities of HMF following different routes of administration. Evidence of contrasting bioavailabilities among different PMFs is shown through comparisons of the pharmacokinetics of nobiletin and tangeretin administered in rats. ©2013 American Chemical Society.U.S. Horticultural Research Laboratory, USDA-ARS, Ft. Pierce, FL 34945Department of Food and Nutrition, Faculty of Pharmaceutical Sciences-UNESP, Araraquara, SPDepartment of Food and Nutrition, Faculty of Pharmaceutical Sciences-UNESP, Araraquara, SPU.S. Horticultural Research Laboratory, USDA-ARSUniversidade Estadual Paulista (UNESP)Manthey, John A.César, Thaïs B. [UNESP]2022-04-29T07:20:25Z2022-04-29T07:20:25Z2013-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObject159-169http://dx.doi.org/10.1021/bk-2013-1129.ch010ACS Symposium Series, v. 1129, p. 159-169.1947-59180097-6156http://hdl.handle.net/11449/22784210.1021/bk-2013-1129.ch0102-s2.0-84905394353Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengACS Symposium Seriesinfo:eu-repo/semantics/openAccess2024-06-21T12:47:34Zoai:repositorio.unesp.br:11449/227842Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:06:40.365742Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Issues surrounding the anti-Inflammatory actions of the citrus polymethoxylated flavones |
title |
Issues surrounding the anti-Inflammatory actions of the citrus polymethoxylated flavones |
spellingShingle |
Issues surrounding the anti-Inflammatory actions of the citrus polymethoxylated flavones Manthey, John A. |
title_short |
Issues surrounding the anti-Inflammatory actions of the citrus polymethoxylated flavones |
title_full |
Issues surrounding the anti-Inflammatory actions of the citrus polymethoxylated flavones |
title_fullStr |
Issues surrounding the anti-Inflammatory actions of the citrus polymethoxylated flavones |
title_full_unstemmed |
Issues surrounding the anti-Inflammatory actions of the citrus polymethoxylated flavones |
title_sort |
Issues surrounding the anti-Inflammatory actions of the citrus polymethoxylated flavones |
author |
Manthey, John A. |
author_facet |
Manthey, John A. César, Thaïs B. [UNESP] |
author_role |
author |
author2 |
César, Thaïs B. [UNESP] |
author2_role |
author |
dc.contributor.none.fl_str_mv |
U.S. Horticultural Research Laboratory, USDA-ARS Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Manthey, John A. César, Thaïs B. [UNESP] |
description |
The polymethoxylated flavones in citrus have been evaluated for their in vivo anti-Inflammatory actions in several animal assays. Strong anti-Inflammatory effects were observed following administration of 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF) dissolved in vegetable oil by intraperitoneal (i.p.) injection, but neglibible action was detected following doses of HMF suspended as fine particulates in vegetable oil. This contradiction is shown to be a reflection of differences in the bioavailabilities of HMF following different routes of administration. Evidence of contrasting bioavailabilities among different PMFs is shown through comparisons of the pharmacokinetics of nobiletin and tangeretin administered in rats. ©2013 American Chemical Society. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-01-01 2022-04-29T07:20:25Z 2022-04-29T07:20:25Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/conferenceObject |
format |
conferenceObject |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1021/bk-2013-1129.ch010 ACS Symposium Series, v. 1129, p. 159-169. 1947-5918 0097-6156 http://hdl.handle.net/11449/227842 10.1021/bk-2013-1129.ch010 2-s2.0-84905394353 |
url |
http://dx.doi.org/10.1021/bk-2013-1129.ch010 http://hdl.handle.net/11449/227842 |
identifier_str_mv |
ACS Symposium Series, v. 1129, p. 159-169. 1947-5918 0097-6156 10.1021/bk-2013-1129.ch010 2-s2.0-84905394353 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
ACS Symposium Series |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
159-169 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808129021644374016 |