Frequency of Porphyromonas gingivalis fimA in smokers and nonsmokers after periodontal therapy
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/1678-7757-2018-0205 http://hdl.handle.net/11449/189047 |
Resumo: | Porphyromonas gingivalis is one of the most important Gram-negative anaerobe bacteria involved in the pathogenesis of periodontitis. P. gingivalis has an arsenal of specialized virulence factors that contribute to its pathogenicity. Among them, fimbriae play a role in the initial attachment and organization of biofilms. Different genotypes of fimA have been related to length of fimbriae and pathogenicity of the bacterium. Objectives: The aim of this study was to identify 5 types of fimA genotype strains in smokers and nonsmokers with periodontitis, before and after periodontal therapy. Material and Methods: Thirty-one patients with periodontitis harboring P. gingivalis were selected: 16 nonsmokers (NS) and 15 smokers (SM). Clinical and microbiological parameters were evaluated at baseline and 3 months after periodontal treatment, namely: plaque index, bleeding on probe, probing depth, gingival recession and clinical attachment level. The frequency of P. gingivalis and fimA genotype strains were determined by polymerase chain reaction. Results: Type I fimA was detected in the majority of SM and NS at baseline, and the frequency did not diminish after 3 months of treatment. The frequency of type II genotype was higher in SM than NS at baseline. After 3 months, statistical reduction was observed only for types II and V fimA genotypes in SM. The highest association was found between types I and II at baseline for NS (37.5%) and SM (53.3%). Conclusion: The most prevalent P. gingivalis fimA genotypes detected in periodontal and smoker patients were genotypes I and II. However, the presence of fimA genotype II was higher in SM. Periodontal treatment was effective in controlling periodontal disease and reducing type II and V P. gingivalis fimA. |
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Frequency of Porphyromonas gingivalis fimA in smokers and nonsmokers after periodontal therapyPeriodontal diseasePorphyromonasSmokingPorphyromonas gingivalis is one of the most important Gram-negative anaerobe bacteria involved in the pathogenesis of periodontitis. P. gingivalis has an arsenal of specialized virulence factors that contribute to its pathogenicity. Among them, fimbriae play a role in the initial attachment and organization of biofilms. Different genotypes of fimA have been related to length of fimbriae and pathogenicity of the bacterium. Objectives: The aim of this study was to identify 5 types of fimA genotype strains in smokers and nonsmokers with periodontitis, before and after periodontal therapy. Material and Methods: Thirty-one patients with periodontitis harboring P. gingivalis were selected: 16 nonsmokers (NS) and 15 smokers (SM). Clinical and microbiological parameters were evaluated at baseline and 3 months after periodontal treatment, namely: plaque index, bleeding on probe, probing depth, gingival recession and clinical attachment level. The frequency of P. gingivalis and fimA genotype strains were determined by polymerase chain reaction. Results: Type I fimA was detected in the majority of SM and NS at baseline, and the frequency did not diminish after 3 months of treatment. The frequency of type II genotype was higher in SM than NS at baseline. After 3 months, statistical reduction was observed only for types II and V fimA genotypes in SM. The highest association was found between types I and II at baseline for NS (37.5%) and SM (53.3%). Conclusion: The most prevalent P. gingivalis fimA genotypes detected in periodontal and smoker patients were genotypes I and II. However, the presence of fimA genotype II was higher in SM. Periodontal treatment was effective in controlling periodontal disease and reducing type II and V P. gingivalis fimA.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Universidade Federal Fluminense Departamento de Odontologia Área de PeriodontiaUniversidade de São Paulo Instituto de Ciências Biomédicas Departamento de MicrobiologiaUniversidade Federal Fluminense Departamento de Ciências BásicasUniversidade Estadual Paulista (UNESP) Faculdade de Odontologia de Araçatuba Departamento de Endodontia AraçatubaUniversidade Estadual Paulista (UNESP) Faculdade de Odontologia de Araçatuba Departamento de Odontopediatria e Saúde PúblicaUniversidade Estadual Paulista (UNESP) Faculdade de Odontologia de Araçatuba Departamento de Endodontia AraçatubaUniversidade Estadual Paulista (UNESP) Faculdade de Odontologia de Araçatuba Departamento de Odontopediatria e Saúde PúblicaUniversidade Federal Fluminense (UFF)Universidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Abreu, Mariana Gouvêa LatiniKawamoto, DioneMayer, Marcia Pinto AlvesPascoal, Vinicius D’Avila BitencourtCaiaffa, Karina Sampaio [UNESP]Zuza, Elizangela P.Duque, Cristiane [UNESP]Camargo, Gabriela Alessandra da Cruz Galhardo2019-10-06T16:28:05Z2019-10-06T16:28:05Z2019-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1590/1678-7757-2018-0205Journal of Applied Oral Science, v. 27.1678-77651678-7757http://hdl.handle.net/11449/18904710.1590/1678-7757-2018-0205S1678-775720190001004412-s2.0-85064975217S1678-77572019000100441.pdf56518745094936170000-0002-2575-279XScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Applied Oral Scienceinfo:eu-repo/semantics/openAccess2024-09-19T18:31:51Zoai:repositorio.unesp.br:11449/189047Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-19T18:31:51Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Frequency of Porphyromonas gingivalis fimA in smokers and nonsmokers after periodontal therapy |
title |
Frequency of Porphyromonas gingivalis fimA in smokers and nonsmokers after periodontal therapy |
spellingShingle |
Frequency of Porphyromonas gingivalis fimA in smokers and nonsmokers after periodontal therapy Abreu, Mariana Gouvêa Latini Periodontal disease Porphyromonas Smoking |
title_short |
Frequency of Porphyromonas gingivalis fimA in smokers and nonsmokers after periodontal therapy |
title_full |
Frequency of Porphyromonas gingivalis fimA in smokers and nonsmokers after periodontal therapy |
title_fullStr |
Frequency of Porphyromonas gingivalis fimA in smokers and nonsmokers after periodontal therapy |
title_full_unstemmed |
Frequency of Porphyromonas gingivalis fimA in smokers and nonsmokers after periodontal therapy |
title_sort |
Frequency of Porphyromonas gingivalis fimA in smokers and nonsmokers after periodontal therapy |
author |
Abreu, Mariana Gouvêa Latini |
author_facet |
Abreu, Mariana Gouvêa Latini Kawamoto, Dione Mayer, Marcia Pinto Alves Pascoal, Vinicius D’Avila Bitencourt Caiaffa, Karina Sampaio [UNESP] Zuza, Elizangela P. Duque, Cristiane [UNESP] Camargo, Gabriela Alessandra da Cruz Galhardo |
author_role |
author |
author2 |
Kawamoto, Dione Mayer, Marcia Pinto Alves Pascoal, Vinicius D’Avila Bitencourt Caiaffa, Karina Sampaio [UNESP] Zuza, Elizangela P. Duque, Cristiane [UNESP] Camargo, Gabriela Alessandra da Cruz Galhardo |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal Fluminense (UFF) Universidade de São Paulo (USP) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Abreu, Mariana Gouvêa Latini Kawamoto, Dione Mayer, Marcia Pinto Alves Pascoal, Vinicius D’Avila Bitencourt Caiaffa, Karina Sampaio [UNESP] Zuza, Elizangela P. Duque, Cristiane [UNESP] Camargo, Gabriela Alessandra da Cruz Galhardo |
dc.subject.por.fl_str_mv |
Periodontal disease Porphyromonas Smoking |
topic |
Periodontal disease Porphyromonas Smoking |
description |
Porphyromonas gingivalis is one of the most important Gram-negative anaerobe bacteria involved in the pathogenesis of periodontitis. P. gingivalis has an arsenal of specialized virulence factors that contribute to its pathogenicity. Among them, fimbriae play a role in the initial attachment and organization of biofilms. Different genotypes of fimA have been related to length of fimbriae and pathogenicity of the bacterium. Objectives: The aim of this study was to identify 5 types of fimA genotype strains in smokers and nonsmokers with periodontitis, before and after periodontal therapy. Material and Methods: Thirty-one patients with periodontitis harboring P. gingivalis were selected: 16 nonsmokers (NS) and 15 smokers (SM). Clinical and microbiological parameters were evaluated at baseline and 3 months after periodontal treatment, namely: plaque index, bleeding on probe, probing depth, gingival recession and clinical attachment level. The frequency of P. gingivalis and fimA genotype strains were determined by polymerase chain reaction. Results: Type I fimA was detected in the majority of SM and NS at baseline, and the frequency did not diminish after 3 months of treatment. The frequency of type II genotype was higher in SM than NS at baseline. After 3 months, statistical reduction was observed only for types II and V fimA genotypes in SM. The highest association was found between types I and II at baseline for NS (37.5%) and SM (53.3%). Conclusion: The most prevalent P. gingivalis fimA genotypes detected in periodontal and smoker patients were genotypes I and II. However, the presence of fimA genotype II was higher in SM. Periodontal treatment was effective in controlling periodontal disease and reducing type II and V P. gingivalis fimA. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-06T16:28:05Z 2019-10-06T16:28:05Z 2019-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/1678-7757-2018-0205 Journal of Applied Oral Science, v. 27. 1678-7765 1678-7757 http://hdl.handle.net/11449/189047 10.1590/1678-7757-2018-0205 S1678-77572019000100441 2-s2.0-85064975217 S1678-77572019000100441.pdf 5651874509493617 0000-0002-2575-279X |
url |
http://dx.doi.org/10.1590/1678-7757-2018-0205 http://hdl.handle.net/11449/189047 |
identifier_str_mv |
Journal of Applied Oral Science, v. 27. 1678-7765 1678-7757 10.1590/1678-7757-2018-0205 S1678-77572019000100441 2-s2.0-85064975217 S1678-77572019000100441.pdf 5651874509493617 0000-0002-2575-279X |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Applied Oral Science |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
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1813546492160376832 |