Bioinspired engineered nickel nanoparticles with multifunctional attributes for reproductive toxicity
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.chemosphere.2022.136927 http://hdl.handle.net/11449/246161 |
Resumo: | Nickel nanoparticles (Ni-NPs) have potential applications in high-tech sectors such as battery manufacturing, catalysis, nanotube printing and textile. Apart from their increasing utilisation in daily life, there are concerns about their hazardous nature as they are highly penetrable in biological systems. The carcinogenic and mutagenic ability of Ni-NPs is evident but the research gaps are still there concerning the safety evaluation of Ni-NPs regarding male reproductive ability. This controlled randomized research was planned to assess the male reproductive toxicity of Ni-NPs in Sprague Dawley rats. Ni-NPs of spherical shape and mean particle size of 56 nm were used in the study, characterized by SEM, EDS and XRD. The twenty-five healthy rats (200–220 g) were used for toxicity investigation of Ni-NPs and divided into five groups; negative control (0 Ni-NPs), placebo group (0.9% saline) and three Ni-NPs treated groups (@ 15, 30 and 45 mg/kg BW). The results of 14 days of intraperitoneal exposure to Ni-NPs revealed that a higher dose (45 mg/kg BW) of Ni-NPs caused a significant reduction in body weight, serum testosterone, daily sperm production while the testis index and Ni accumulation and histological changes (necrosis in basement membrane and seminiferous tubules, vacuole formation) in testicular tissues increased with increasing dose of Ni-NPs. It can be concluded from the study that Ni-NPs have potential reproductive toxicity. This study provided the baseline data of Ni-NPs toxicity for the male reproductive system and can be applied for risk assessment in Ni-NPs based products. |
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Bioinspired engineered nickel nanoparticles with multifunctional attributes for reproductive toxicityHistological alterations and lipid peroxidationNanoparticlesOxidative stressReproductive toxicitySerum testosteroneSperm productionNickel nanoparticles (Ni-NPs) have potential applications in high-tech sectors such as battery manufacturing, catalysis, nanotube printing and textile. Apart from their increasing utilisation in daily life, there are concerns about their hazardous nature as they are highly penetrable in biological systems. The carcinogenic and mutagenic ability of Ni-NPs is evident but the research gaps are still there concerning the safety evaluation of Ni-NPs regarding male reproductive ability. This controlled randomized research was planned to assess the male reproductive toxicity of Ni-NPs in Sprague Dawley rats. Ni-NPs of spherical shape and mean particle size of 56 nm were used in the study, characterized by SEM, EDS and XRD. The twenty-five healthy rats (200–220 g) were used for toxicity investigation of Ni-NPs and divided into five groups; negative control (0 Ni-NPs), placebo group (0.9% saline) and three Ni-NPs treated groups (@ 15, 30 and 45 mg/kg BW). The results of 14 days of intraperitoneal exposure to Ni-NPs revealed that a higher dose (45 mg/kg BW) of Ni-NPs caused a significant reduction in body weight, serum testosterone, daily sperm production while the testis index and Ni accumulation and histological changes (necrosis in basement membrane and seminiferous tubules, vacuole formation) in testicular tissues increased with increasing dose of Ni-NPs. It can be concluded from the study that Ni-NPs have potential reproductive toxicity. This study provided the baseline data of Ni-NPs toxicity for the male reproductive system and can be applied for risk assessment in Ni-NPs based products.Engineering and Physical Sciences Research CouncilVirtual University of PakistanPrincess Nourah Bint Abdulrahman UniversityDepartment of Zoology Government College UniversityDepartment of Biology Virtual University of PakistanDepartment of Zoology Government College for Women UniversityDepartment of Biochemistry Cellular and Molecular Biology University of TennesseeDepartment of Biosciences School of Science and Technology Nottingham Trent UniversityDepartment of Chemistry College of Science Princess Nourah bint Abdulrahman University, P.O. Box 84428Department of Forest Science Soils and Environment School of Agronomic Sciences São Paulo State University (UNESP) Ave. Universitária, 3780, SPGraduate Program in Environmental Sciences Brazil University, Street Carolina Fonseca, 584, SPDepartment of Engineering School of Science and Technology Nottingham Trent University, Nottingham NG11 8NSDepartment of Forest Science Soils and Environment School of Agronomic Sciences São Paulo State University (UNESP) Ave. Universitária, 3780, SPPrincess Nourah Bint Abdulrahman University: PNURSP2022R26Government College UniversityVirtual University of PakistanGovernment College for Women UniversityUniversity of TennesseeNottingham Trent UniversityPrincess Nourah bint Abdulrahman UniversityUniversidade Estadual Paulista (UNESP)Brazil UniversityIftikhar, MehwishNoureen, AasmaJabeen, FarhatUzair, MuhammadRehman, NaginaSher, Emina KarahmetKatubi, Khadijah MohammedsalehAmérico-Pinheiro, Juliana Heloisa Pinê [UNESP]Sher, Farooq2023-07-29T12:33:21Z2023-07-29T12:33:21Z2023-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.chemosphere.2022.136927Chemosphere, v. 311.1879-12980045-6535http://hdl.handle.net/11449/24616110.1016/j.chemosphere.2022.1369272-s2.0-85140633752Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengChemosphereinfo:eu-repo/semantics/openAccess2023-07-29T12:33:22Zoai:repositorio.unesp.br:11449/246161Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:11:35.803472Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Bioinspired engineered nickel nanoparticles with multifunctional attributes for reproductive toxicity |
title |
Bioinspired engineered nickel nanoparticles with multifunctional attributes for reproductive toxicity |
spellingShingle |
Bioinspired engineered nickel nanoparticles with multifunctional attributes for reproductive toxicity Iftikhar, Mehwish Histological alterations and lipid peroxidation Nanoparticles Oxidative stress Reproductive toxicity Serum testosterone Sperm production |
title_short |
Bioinspired engineered nickel nanoparticles with multifunctional attributes for reproductive toxicity |
title_full |
Bioinspired engineered nickel nanoparticles with multifunctional attributes for reproductive toxicity |
title_fullStr |
Bioinspired engineered nickel nanoparticles with multifunctional attributes for reproductive toxicity |
title_full_unstemmed |
Bioinspired engineered nickel nanoparticles with multifunctional attributes for reproductive toxicity |
title_sort |
Bioinspired engineered nickel nanoparticles with multifunctional attributes for reproductive toxicity |
author |
Iftikhar, Mehwish |
author_facet |
Iftikhar, Mehwish Noureen, Aasma Jabeen, Farhat Uzair, Muhammad Rehman, Nagina Sher, Emina Karahmet Katubi, Khadijah Mohammedsaleh Américo-Pinheiro, Juliana Heloisa Pinê [UNESP] Sher, Farooq |
author_role |
author |
author2 |
Noureen, Aasma Jabeen, Farhat Uzair, Muhammad Rehman, Nagina Sher, Emina Karahmet Katubi, Khadijah Mohammedsaleh Américo-Pinheiro, Juliana Heloisa Pinê [UNESP] Sher, Farooq |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Government College University Virtual University of Pakistan Government College for Women University University of Tennessee Nottingham Trent University Princess Nourah bint Abdulrahman University Universidade Estadual Paulista (UNESP) Brazil University |
dc.contributor.author.fl_str_mv |
Iftikhar, Mehwish Noureen, Aasma Jabeen, Farhat Uzair, Muhammad Rehman, Nagina Sher, Emina Karahmet Katubi, Khadijah Mohammedsaleh Américo-Pinheiro, Juliana Heloisa Pinê [UNESP] Sher, Farooq |
dc.subject.por.fl_str_mv |
Histological alterations and lipid peroxidation Nanoparticles Oxidative stress Reproductive toxicity Serum testosterone Sperm production |
topic |
Histological alterations and lipid peroxidation Nanoparticles Oxidative stress Reproductive toxicity Serum testosterone Sperm production |
description |
Nickel nanoparticles (Ni-NPs) have potential applications in high-tech sectors such as battery manufacturing, catalysis, nanotube printing and textile. Apart from their increasing utilisation in daily life, there are concerns about their hazardous nature as they are highly penetrable in biological systems. The carcinogenic and mutagenic ability of Ni-NPs is evident but the research gaps are still there concerning the safety evaluation of Ni-NPs regarding male reproductive ability. This controlled randomized research was planned to assess the male reproductive toxicity of Ni-NPs in Sprague Dawley rats. Ni-NPs of spherical shape and mean particle size of 56 nm were used in the study, characterized by SEM, EDS and XRD. The twenty-five healthy rats (200–220 g) were used for toxicity investigation of Ni-NPs and divided into five groups; negative control (0 Ni-NPs), placebo group (0.9% saline) and three Ni-NPs treated groups (@ 15, 30 and 45 mg/kg BW). The results of 14 days of intraperitoneal exposure to Ni-NPs revealed that a higher dose (45 mg/kg BW) of Ni-NPs caused a significant reduction in body weight, serum testosterone, daily sperm production while the testis index and Ni accumulation and histological changes (necrosis in basement membrane and seminiferous tubules, vacuole formation) in testicular tissues increased with increasing dose of Ni-NPs. It can be concluded from the study that Ni-NPs have potential reproductive toxicity. This study provided the baseline data of Ni-NPs toxicity for the male reproductive system and can be applied for risk assessment in Ni-NPs based products. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-07-29T12:33:21Z 2023-07-29T12:33:21Z 2023-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.chemosphere.2022.136927 Chemosphere, v. 311. 1879-1298 0045-6535 http://hdl.handle.net/11449/246161 10.1016/j.chemosphere.2022.136927 2-s2.0-85140633752 |
url |
http://dx.doi.org/10.1016/j.chemosphere.2022.136927 http://hdl.handle.net/11449/246161 |
identifier_str_mv |
Chemosphere, v. 311. 1879-1298 0045-6535 10.1016/j.chemosphere.2022.136927 2-s2.0-85140633752 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Chemosphere |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808129402219790336 |