Cinnamic acid is partially involved in propolis immunomodulatory action on human monocytes

Detalhes bibliográficos
Autor(a) principal: Conti, Bruno José [UNESP]
Data de Publicação: 2013
Outros Autores: Búfalo, Michelle Cristiane [UNESP], Golim, Marjorie de Assis [UNESP], Bankova, Vassya, Sforcin, José Maurício [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1155/2013/109864
http://hdl.handle.net/11449/75639
Resumo: Propolis is a beehive product used in traditional medicine due to its biological properties. It shows a complex chemical composition including phenolics, such as cinnamic acid (Ci). The mechanisms of action of propolis have been the subject of research recently; however, the involvement of Ci on propolis activity was not investigated on immune cells. Ci effects were evaluated on human monocytes, assessing the expression of Toll-like receptors (TLRs), HLA-DR, and CD80. Cytokine production (TNF-α and IL-10) and the fungicidal activity of monocytes were evaluated as well. Data showed that Ci downregulated TLR-2, HLA-DR, and CD80 and upregulated TLR-4 expression by human monocytes. High concentrations of Ci inhibited both TNF-α and IL-10 production, whereas the same concentrations induced a higher fungicidal activity against Candida albicans. TNF-α and IL-10 production was decreased by blocking TLR-4, while the fungicidal activity of monocytes was not affected by blocking TLRs. These results suggest that Ci modulated antigen receptors, cytokine production, and the fungicidal activity of human monocytes depending on concentration, and TLR-4 may be involved in its mechanism of action. Ci seemed to be partially involved in propolis activities. © 2013 Bruno José Conti et al.
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spelling Cinnamic acid is partially involved in propolis immunomodulatory action on human monocytesB7 antigencinnamic acidHLA DR antigeninterleukin 10propolistoll like receptor 2toll like receptor 4tumor necrosis factor alphaantiinflammatory activityCandida albicanscytokine productiondown regulationfungicidal activityhumanhuman cellimmunomodulationmonocytenonhumanpriority journalPropolis is a beehive product used in traditional medicine due to its biological properties. It shows a complex chemical composition including phenolics, such as cinnamic acid (Ci). The mechanisms of action of propolis have been the subject of research recently; however, the involvement of Ci on propolis activity was not investigated on immune cells. Ci effects were evaluated on human monocytes, assessing the expression of Toll-like receptors (TLRs), HLA-DR, and CD80. Cytokine production (TNF-α and IL-10) and the fungicidal activity of monocytes were evaluated as well. Data showed that Ci downregulated TLR-2, HLA-DR, and CD80 and upregulated TLR-4 expression by human monocytes. High concentrations of Ci inhibited both TNF-α and IL-10 production, whereas the same concentrations induced a higher fungicidal activity against Candida albicans. TNF-α and IL-10 production was decreased by blocking TLR-4, while the fungicidal activity of monocytes was not affected by blocking TLRs. These results suggest that Ci modulated antigen receptors, cytokine production, and the fungicidal activity of human monocytes depending on concentration, and TLR-4 may be involved in its mechanism of action. Ci seemed to be partially involved in propolis activities. © 2013 Bruno José Conti et al.Department of Microbiology and Immunology Biosciences Institute UNESP, 18618-970 Botucatu, SPFlow Cytometry Laboratory Medical School UNESP, 18618-970 Botucatu, SPInstitute of Organic Chemistry with Centre of Phytochemistry Bulgarian Academy of Sciences, 1113 SofiaDepartment of Microbiology and Immunology Biosciences Institute UNESP, 18618-970 Botucatu, SPFlow Cytometry Laboratory Medical School UNESP, 18618-970 Botucatu, SPUniversidade Estadual Paulista (Unesp)Bulgarian Academy of SciencesConti, Bruno José [UNESP]Búfalo, Michelle Cristiane [UNESP]Golim, Marjorie de Assis [UNESP]Bankova, VassyaSforcin, José Maurício [UNESP]2014-05-27T11:29:40Z2014-05-27T11:29:40Z2013-06-12info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1155/2013/109864Evidence-based Complementary and Alternative Medicine, v. 2013.1741-427X1741-4288http://hdl.handle.net/11449/7563910.1155/2013/109864WOS:0003195694000012-s2.0-848787371912-s2.0-84878737191.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengEvidence-based Complementary and Alternative Medicine2.0640,683info:eu-repo/semantics/openAccess2024-01-18T06:25:34Zoai:repositorio.unesp.br:11449/75639Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T23:20:37.071207Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Cinnamic acid is partially involved in propolis immunomodulatory action on human monocytes
title Cinnamic acid is partially involved in propolis immunomodulatory action on human monocytes
spellingShingle Cinnamic acid is partially involved in propolis immunomodulatory action on human monocytes
Conti, Bruno José [UNESP]
B7 antigen
cinnamic acid
HLA DR antigen
interleukin 10
propolis
toll like receptor 2
toll like receptor 4
tumor necrosis factor alpha
antiinflammatory activity
Candida albicans
cytokine production
down regulation
fungicidal activity
human
human cell
immunomodulation
monocyte
nonhuman
priority journal
title_short Cinnamic acid is partially involved in propolis immunomodulatory action on human monocytes
title_full Cinnamic acid is partially involved in propolis immunomodulatory action on human monocytes
title_fullStr Cinnamic acid is partially involved in propolis immunomodulatory action on human monocytes
title_full_unstemmed Cinnamic acid is partially involved in propolis immunomodulatory action on human monocytes
title_sort Cinnamic acid is partially involved in propolis immunomodulatory action on human monocytes
author Conti, Bruno José [UNESP]
author_facet Conti, Bruno José [UNESP]
Búfalo, Michelle Cristiane [UNESP]
Golim, Marjorie de Assis [UNESP]
Bankova, Vassya
Sforcin, José Maurício [UNESP]
author_role author
author2 Búfalo, Michelle Cristiane [UNESP]
Golim, Marjorie de Assis [UNESP]
Bankova, Vassya
Sforcin, José Maurício [UNESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Bulgarian Academy of Sciences
dc.contributor.author.fl_str_mv Conti, Bruno José [UNESP]
Búfalo, Michelle Cristiane [UNESP]
Golim, Marjorie de Assis [UNESP]
Bankova, Vassya
Sforcin, José Maurício [UNESP]
dc.subject.por.fl_str_mv B7 antigen
cinnamic acid
HLA DR antigen
interleukin 10
propolis
toll like receptor 2
toll like receptor 4
tumor necrosis factor alpha
antiinflammatory activity
Candida albicans
cytokine production
down regulation
fungicidal activity
human
human cell
immunomodulation
monocyte
nonhuman
priority journal
topic B7 antigen
cinnamic acid
HLA DR antigen
interleukin 10
propolis
toll like receptor 2
toll like receptor 4
tumor necrosis factor alpha
antiinflammatory activity
Candida albicans
cytokine production
down regulation
fungicidal activity
human
human cell
immunomodulation
monocyte
nonhuman
priority journal
description Propolis is a beehive product used in traditional medicine due to its biological properties. It shows a complex chemical composition including phenolics, such as cinnamic acid (Ci). The mechanisms of action of propolis have been the subject of research recently; however, the involvement of Ci on propolis activity was not investigated on immune cells. Ci effects were evaluated on human monocytes, assessing the expression of Toll-like receptors (TLRs), HLA-DR, and CD80. Cytokine production (TNF-α and IL-10) and the fungicidal activity of monocytes were evaluated as well. Data showed that Ci downregulated TLR-2, HLA-DR, and CD80 and upregulated TLR-4 expression by human monocytes. High concentrations of Ci inhibited both TNF-α and IL-10 production, whereas the same concentrations induced a higher fungicidal activity against Candida albicans. TNF-α and IL-10 production was decreased by blocking TLR-4, while the fungicidal activity of monocytes was not affected by blocking TLRs. These results suggest that Ci modulated antigen receptors, cytokine production, and the fungicidal activity of human monocytes depending on concentration, and TLR-4 may be involved in its mechanism of action. Ci seemed to be partially involved in propolis activities. © 2013 Bruno José Conti et al.
publishDate 2013
dc.date.none.fl_str_mv 2013-06-12
2014-05-27T11:29:40Z
2014-05-27T11:29:40Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1155/2013/109864
Evidence-based Complementary and Alternative Medicine, v. 2013.
1741-427X
1741-4288
http://hdl.handle.net/11449/75639
10.1155/2013/109864
WOS:000319569400001
2-s2.0-84878737191
2-s2.0-84878737191.pdf
url http://dx.doi.org/10.1155/2013/109864
http://hdl.handle.net/11449/75639
identifier_str_mv Evidence-based Complementary and Alternative Medicine, v. 2013.
1741-427X
1741-4288
10.1155/2013/109864
WOS:000319569400001
2-s2.0-84878737191
2-s2.0-84878737191.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Evidence-based Complementary and Alternative Medicine
2.064
0,683
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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