Estudo in vivo do potencial anti-inflamatório do Ibuprofeno empregado em dentes de ratos submetidos à clareação dentária

• Autor(a) principal: Proença, Ariane Santana de [UNESP]
• Data de Publicação: 2014
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://hdl.handle.net/11449/149541; http://www.athena.biblioteca.unesp.br/exlibris/bd/capelo/2017-01-27/000866284.pdf
• topic: Clareamento dental; Ibuprofeno; Pulpite; Agentes anti-inflamatórios; Teeth bleaching

Ibuprofen is a non-steroidal anti-inflammatory and also has an analgesic and antipyrect action. It is indicated to acute and chronic pain releave associated with inflammatory reaction, head-ache pain, dental pain, mescle pain, fever and surgery pain. Although usually used by doctors and dentists, it's anti-inflammatory properties were not studied as an agent for pos- dental bleaching. The main of this study was verify the local anti-inflammatory potencial of Ibuprofen in rat's teeth submitted to dental bleaching. Twenty rats were divided into four groups of 10 hemi-maxillae each. The animals were anesthetized and the dental bleaching was performed in the three upper right molars following the protocol: G1- bleaching agent without Ibuprofen administration; G2- bleaching agent followed by Ibuprofen administration. The three upper left molars were used as control group and received the vehicle of bleaching agent also divided in groups C-G1: vehicle of bleaching agent without Ibuprofen administration, C-G2: vehicle of bleaching agent followed by Ibuprofen administration. After bleaching procedures the Ibuprofen was administrated by gavage in intervals of 12/12 hours for two days in half of G2 and C-G2 animals, and for six days to the other half. At two and 30 days pos-bleaching, all animals were killed and the maxillae removed and processed for analisys on light microscopy. The tissue sections were stained with hematoxylin and eosin (H&E) and evaluated by scores according to the microscopic events (p<0.05). The groups treated with dental bleaching agent presented a severa inflammatory infiltrate on occlusal third of coronal pulp, and the Ibuprofen was not able to reduce the damages caused by dental bleaching