Interleukin 6 and 10 Serum Levels and Genetic Polymorphisms in Children with Down Syndrome

Detalhes bibliográficos
Autor(a) principal: Mattos, Marlon Fraga
Data de Publicação: 2018
Outros Autores: Biselli-Chicote, Patricia Matos, Biselli, Joice Matos [UNESP], Silva Assembleia, Thiago Luis da, Goloni-Bertollo, Eny Maria, Pavarino, Erika Cristina
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1155/2018/6539548
http://hdl.handle.net/11449/164826
Resumo: Immunological impairment is a condition that is often observed in individuals with Down syndrome (DS). The immune response is modulated by pro- and anti-inflammatory cytokines whose expressions could be influenced by genetic polymorphisms. The present study was aimed at evaluating the frequencies of -174G>C, -572G>C, and -597G>A polymorphisms in the interleukin 6 (IL-6) gene and -592C>A, -1082A>G, and -819C>T polymorphisms in the IL-10 gene and the IL-6 and IL-10 serum levels in healthy individuals with and without DS. The authors also aimed to investigate the impact of the genotypes on the interleukin concentrations. The genetic polymorphisms were investigated in 200 DS individuals and 200 controls without DS. The serum measurement of IL-6 and IL-10 was performed in a subgroup (54 cases and 54 controls) by enzyme-linked immunosorbent assay (ELISA). The frequencies of the polymorphisms and haplotypes evaluated were not different between individuals with and without DS. IL-10 concentration was higher in DS children but was not influenced by IL-10 gene polymorphisms. IL-6 genotypes had no influence on IL-6 serum levels. The IL-10 serum levels are increased in DS individuals, but IL-10 polymorphisms are not the main factors that influence the IL-10 expression in DS.
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spelling Interleukin 6 and 10 Serum Levels and Genetic Polymorphisms in Children with Down SyndromeImmunological impairment is a condition that is often observed in individuals with Down syndrome (DS). The immune response is modulated by pro- and anti-inflammatory cytokines whose expressions could be influenced by genetic polymorphisms. The present study was aimed at evaluating the frequencies of -174G>C, -572G>C, and -597G>A polymorphisms in the interleukin 6 (IL-6) gene and -592C>A, -1082A>G, and -819C>T polymorphisms in the IL-10 gene and the IL-6 and IL-10 serum levels in healthy individuals with and without DS. The authors also aimed to investigate the impact of the genotypes on the interleukin concentrations. The genetic polymorphisms were investigated in 200 DS individuals and 200 controls without DS. The serum measurement of IL-6 and IL-10 was performed in a subgroup (54 cases and 54 controls) by enzyme-linked immunosorbent assay (ELISA). The frequencies of the polymorphisms and haplotypes evaluated were not different between individuals with and without DS. IL-10 concentration was higher in DS children but was not influenced by IL-10 gene polymorphisms. IL-6 genotypes had no influence on IL-6 serum levels. The IL-10 serum levels are increased in DS individuals, but IL-10 polymorphisms are not the main factors that influence the IL-10 expression in DS.Faculdade de Medicina de Sao Jose do Rio Preto (FAMERP)Hospital de Base, Sao Jose do Rio Preto, SP, BrazilConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Fundacao de Apoio a Pesquisa e Extensao de Sao Jose do Rio Preto (FAPERP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fac Med Sao Jose do Rio Preto, Unidade Pesquisa Genet & Biol Mol, Sao Jose Do Rio Preto, SP, BrazilUniv Estadual Paulista, Inst Biociencias Letras & Ciencias Exatas, Sao Jose Do Rio Preto, SP, BrazilUniv Estadual Paulista, Inst Biociencias Letras & Ciencias Exatas, Sao Jose Do Rio Preto, SP, BrazilCNPq: 308551/2014-1FAPESP: 2014/26218-5Fundacao de Apoio a Pesquisa e Extensao de Sao Jose do Rio Preto (FAPERP): 21/2015Hindawi LtdUniversidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Mattos, Marlon FragaBiselli-Chicote, Patricia MatosBiselli, Joice Matos [UNESP]Silva Assembleia, Thiago Luis daGoloni-Bertollo, Eny MariaPavarino, Erika Cristina2018-11-26T22:40:49Z2018-11-26T22:40:49Z2018-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article9application/pdfhttp://dx.doi.org/10.1155/2018/6539548Mediators Of Inflammation. London: Hindawi Ltd, 9 p., 2018.0962-9351http://hdl.handle.net/11449/16482610.1155/2018/6539548WOS:000442883500001WOS000442883500001.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMediators Of Inflammation1,370info:eu-repo/semantics/openAccess2023-10-17T06:04:10Zoai:repositorio.unesp.br:11449/164826Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:09:17.711570Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Interleukin 6 and 10 Serum Levels and Genetic Polymorphisms in Children with Down Syndrome
title Interleukin 6 and 10 Serum Levels and Genetic Polymorphisms in Children with Down Syndrome
spellingShingle Interleukin 6 and 10 Serum Levels and Genetic Polymorphisms in Children with Down Syndrome
Mattos, Marlon Fraga
title_short Interleukin 6 and 10 Serum Levels and Genetic Polymorphisms in Children with Down Syndrome
title_full Interleukin 6 and 10 Serum Levels and Genetic Polymorphisms in Children with Down Syndrome
title_fullStr Interleukin 6 and 10 Serum Levels and Genetic Polymorphisms in Children with Down Syndrome
title_full_unstemmed Interleukin 6 and 10 Serum Levels and Genetic Polymorphisms in Children with Down Syndrome
title_sort Interleukin 6 and 10 Serum Levels and Genetic Polymorphisms in Children with Down Syndrome
author Mattos, Marlon Fraga
author_facet Mattos, Marlon Fraga
Biselli-Chicote, Patricia Matos
Biselli, Joice Matos [UNESP]
Silva Assembleia, Thiago Luis da
Goloni-Bertollo, Eny Maria
Pavarino, Erika Cristina
author_role author
author2 Biselli-Chicote, Patricia Matos
Biselli, Joice Matos [UNESP]
Silva Assembleia, Thiago Luis da
Goloni-Bertollo, Eny Maria
Pavarino, Erika Cristina
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Mattos, Marlon Fraga
Biselli-Chicote, Patricia Matos
Biselli, Joice Matos [UNESP]
Silva Assembleia, Thiago Luis da
Goloni-Bertollo, Eny Maria
Pavarino, Erika Cristina
description Immunological impairment is a condition that is often observed in individuals with Down syndrome (DS). The immune response is modulated by pro- and anti-inflammatory cytokines whose expressions could be influenced by genetic polymorphisms. The present study was aimed at evaluating the frequencies of -174G>C, -572G>C, and -597G>A polymorphisms in the interleukin 6 (IL-6) gene and -592C>A, -1082A>G, and -819C>T polymorphisms in the IL-10 gene and the IL-6 and IL-10 serum levels in healthy individuals with and without DS. The authors also aimed to investigate the impact of the genotypes on the interleukin concentrations. The genetic polymorphisms were investigated in 200 DS individuals and 200 controls without DS. The serum measurement of IL-6 and IL-10 was performed in a subgroup (54 cases and 54 controls) by enzyme-linked immunosorbent assay (ELISA). The frequencies of the polymorphisms and haplotypes evaluated were not different between individuals with and without DS. IL-10 concentration was higher in DS children but was not influenced by IL-10 gene polymorphisms. IL-6 genotypes had no influence on IL-6 serum levels. The IL-10 serum levels are increased in DS individuals, but IL-10 polymorphisms are not the main factors that influence the IL-10 expression in DS.
publishDate 2018
dc.date.none.fl_str_mv 2018-11-26T22:40:49Z
2018-11-26T22:40:49Z
2018-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1155/2018/6539548
Mediators Of Inflammation. London: Hindawi Ltd, 9 p., 2018.
0962-9351
http://hdl.handle.net/11449/164826
10.1155/2018/6539548
WOS:000442883500001
WOS000442883500001.pdf
url http://dx.doi.org/10.1155/2018/6539548
http://hdl.handle.net/11449/164826
identifier_str_mv Mediators Of Inflammation. London: Hindawi Ltd, 9 p., 2018.
0962-9351
10.1155/2018/6539548
WOS:000442883500001
WOS000442883500001.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Mediators Of Inflammation
1,370
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 9
application/pdf
dc.publisher.none.fl_str_mv Hindawi Ltd
publisher.none.fl_str_mv Hindawi Ltd
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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