Interleukin 6 and 10 Serum Levels and Genetic Polymorphisms in Children with Down Syndrome
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1155/2018/6539548 http://hdl.handle.net/11449/164826 |
Resumo: | Immunological impairment is a condition that is often observed in individuals with Down syndrome (DS). The immune response is modulated by pro- and anti-inflammatory cytokines whose expressions could be influenced by genetic polymorphisms. The present study was aimed at evaluating the frequencies of -174G>C, -572G>C, and -597G>A polymorphisms in the interleukin 6 (IL-6) gene and -592C>A, -1082A>G, and -819C>T polymorphisms in the IL-10 gene and the IL-6 and IL-10 serum levels in healthy individuals with and without DS. The authors also aimed to investigate the impact of the genotypes on the interleukin concentrations. The genetic polymorphisms were investigated in 200 DS individuals and 200 controls without DS. The serum measurement of IL-6 and IL-10 was performed in a subgroup (54 cases and 54 controls) by enzyme-linked immunosorbent assay (ELISA). The frequencies of the polymorphisms and haplotypes evaluated were not different between individuals with and without DS. IL-10 concentration was higher in DS children but was not influenced by IL-10 gene polymorphisms. IL-6 genotypes had no influence on IL-6 serum levels. The IL-10 serum levels are increased in DS individuals, but IL-10 polymorphisms are not the main factors that influence the IL-10 expression in DS. |
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Interleukin 6 and 10 Serum Levels and Genetic Polymorphisms in Children with Down SyndromeImmunological impairment is a condition that is often observed in individuals with Down syndrome (DS). The immune response is modulated by pro- and anti-inflammatory cytokines whose expressions could be influenced by genetic polymorphisms. The present study was aimed at evaluating the frequencies of -174G>C, -572G>C, and -597G>A polymorphisms in the interleukin 6 (IL-6) gene and -592C>A, -1082A>G, and -819C>T polymorphisms in the IL-10 gene and the IL-6 and IL-10 serum levels in healthy individuals with and without DS. The authors also aimed to investigate the impact of the genotypes on the interleukin concentrations. The genetic polymorphisms were investigated in 200 DS individuals and 200 controls without DS. The serum measurement of IL-6 and IL-10 was performed in a subgroup (54 cases and 54 controls) by enzyme-linked immunosorbent assay (ELISA). The frequencies of the polymorphisms and haplotypes evaluated were not different between individuals with and without DS. IL-10 concentration was higher in DS children but was not influenced by IL-10 gene polymorphisms. IL-6 genotypes had no influence on IL-6 serum levels. The IL-10 serum levels are increased in DS individuals, but IL-10 polymorphisms are not the main factors that influence the IL-10 expression in DS.Faculdade de Medicina de Sao Jose do Rio Preto (FAMERP)Hospital de Base, Sao Jose do Rio Preto, SP, BrazilConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Fundacao de Apoio a Pesquisa e Extensao de Sao Jose do Rio Preto (FAPERP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fac Med Sao Jose do Rio Preto, Unidade Pesquisa Genet & Biol Mol, Sao Jose Do Rio Preto, SP, BrazilUniv Estadual Paulista, Inst Biociencias Letras & Ciencias Exatas, Sao Jose Do Rio Preto, SP, BrazilUniv Estadual Paulista, Inst Biociencias Letras & Ciencias Exatas, Sao Jose Do Rio Preto, SP, BrazilCNPq: 308551/2014-1FAPESP: 2014/26218-5Fundacao de Apoio a Pesquisa e Extensao de Sao Jose do Rio Preto (FAPERP): 21/2015Hindawi LtdUniversidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Mattos, Marlon FragaBiselli-Chicote, Patricia MatosBiselli, Joice Matos [UNESP]Silva Assembleia, Thiago Luis daGoloni-Bertollo, Eny MariaPavarino, Erika Cristina2018-11-26T22:40:49Z2018-11-26T22:40:49Z2018-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article9application/pdfhttp://dx.doi.org/10.1155/2018/6539548Mediators Of Inflammation. London: Hindawi Ltd, 9 p., 2018.0962-9351http://hdl.handle.net/11449/16482610.1155/2018/6539548WOS:000442883500001WOS000442883500001.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMediators Of Inflammation1,370info:eu-repo/semantics/openAccess2023-10-17T06:04:10Zoai:repositorio.unesp.br:11449/164826Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:09:17.711570Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Interleukin 6 and 10 Serum Levels and Genetic Polymorphisms in Children with Down Syndrome |
title |
Interleukin 6 and 10 Serum Levels and Genetic Polymorphisms in Children with Down Syndrome |
spellingShingle |
Interleukin 6 and 10 Serum Levels and Genetic Polymorphisms in Children with Down Syndrome Mattos, Marlon Fraga |
title_short |
Interleukin 6 and 10 Serum Levels and Genetic Polymorphisms in Children with Down Syndrome |
title_full |
Interleukin 6 and 10 Serum Levels and Genetic Polymorphisms in Children with Down Syndrome |
title_fullStr |
Interleukin 6 and 10 Serum Levels and Genetic Polymorphisms in Children with Down Syndrome |
title_full_unstemmed |
Interleukin 6 and 10 Serum Levels and Genetic Polymorphisms in Children with Down Syndrome |
title_sort |
Interleukin 6 and 10 Serum Levels and Genetic Polymorphisms in Children with Down Syndrome |
author |
Mattos, Marlon Fraga |
author_facet |
Mattos, Marlon Fraga Biselli-Chicote, Patricia Matos Biselli, Joice Matos [UNESP] Silva Assembleia, Thiago Luis da Goloni-Bertollo, Eny Maria Pavarino, Erika Cristina |
author_role |
author |
author2 |
Biselli-Chicote, Patricia Matos Biselli, Joice Matos [UNESP] Silva Assembleia, Thiago Luis da Goloni-Bertollo, Eny Maria Pavarino, Erika Cristina |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Mattos, Marlon Fraga Biselli-Chicote, Patricia Matos Biselli, Joice Matos [UNESP] Silva Assembleia, Thiago Luis da Goloni-Bertollo, Eny Maria Pavarino, Erika Cristina |
description |
Immunological impairment is a condition that is often observed in individuals with Down syndrome (DS). The immune response is modulated by pro- and anti-inflammatory cytokines whose expressions could be influenced by genetic polymorphisms. The present study was aimed at evaluating the frequencies of -174G>C, -572G>C, and -597G>A polymorphisms in the interleukin 6 (IL-6) gene and -592C>A, -1082A>G, and -819C>T polymorphisms in the IL-10 gene and the IL-6 and IL-10 serum levels in healthy individuals with and without DS. The authors also aimed to investigate the impact of the genotypes on the interleukin concentrations. The genetic polymorphisms were investigated in 200 DS individuals and 200 controls without DS. The serum measurement of IL-6 and IL-10 was performed in a subgroup (54 cases and 54 controls) by enzyme-linked immunosorbent assay (ELISA). The frequencies of the polymorphisms and haplotypes evaluated were not different between individuals with and without DS. IL-10 concentration was higher in DS children but was not influenced by IL-10 gene polymorphisms. IL-6 genotypes had no influence on IL-6 serum levels. The IL-10 serum levels are increased in DS individuals, but IL-10 polymorphisms are not the main factors that influence the IL-10 expression in DS. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-11-26T22:40:49Z 2018-11-26T22:40:49Z 2018-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1155/2018/6539548 Mediators Of Inflammation. London: Hindawi Ltd, 9 p., 2018. 0962-9351 http://hdl.handle.net/11449/164826 10.1155/2018/6539548 WOS:000442883500001 WOS000442883500001.pdf |
url |
http://dx.doi.org/10.1155/2018/6539548 http://hdl.handle.net/11449/164826 |
identifier_str_mv |
Mediators Of Inflammation. London: Hindawi Ltd, 9 p., 2018. 0962-9351 10.1155/2018/6539548 WOS:000442883500001 WOS000442883500001.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Mediators Of Inflammation 1,370 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
9 application/pdf |
dc.publisher.none.fl_str_mv |
Hindawi Ltd |
publisher.none.fl_str_mv |
Hindawi Ltd |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128469375123456 |