Influence of interleukin 17 A and 17 F polymorphisms in keratoconus

• Autor(a) principal: Gomes, Isabela Bronchtein
• Data de Publicação: 2021
• Outros Autores: Ayo, Christiane Maria, Lopes, Alessandro Garcia [UNESP], Kumano, Laurie Sayuri, de Faria Junior, Geraldo Magela, de Almeida, Gildásio Castello, Castiglioni, Lilian [UNESP], de Mattos, Luiz Carlos, Brandão, Cinara Cássia
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1007/s11033-021-06708-z; http://hdl.handle.net/11449/231514
• topic: Cytokines; Ectasia; Genetic polymorphisms; IL17 genotypes; Interleukins; Keratoconus

Background: Until a few years ago, keratoconus was defined as a noninflammatory degenerative disease. However, recent studies have shown that the altered balance between inflammatory cytokines, proteases, and protease inhibitors, as well as free radicals and oxidants, have a crucial role in the pathogenesis of this disease. The aim of this study is to investigate whether interleukin 17 A G197A (rs2275913) and interleukin 17 F T7488C (rs763780) polymorphisms are associated with keratoconus in patients from a population of the northwestern region of the State of São Paulo, Brazil. Methods and Results: 35 patients and 61 controls were enrolled. Genotyping of interleukin 17 A G197A and interleukin 17 F T7488C polymorphisms was carried out using the polymerase chain reaction-restriction fragment length polymorphism technique. Statistical analyses were conducted using the chi-square test, and an odds ratio with a 95% confidence interval was also calculated to evaluate the association between polymorphisms and disease. Evaluating interleukin 17 F T7488C, we found that the TT genotype is associated as a risk factor for keratoconus (P = 0.04; OR = 3.01; CI 1.11–8.14). As for evaluating interleukin 17 A G197A, the allele and genotype frequencies between patients and controls were compared and no statistically significant differences were found. Conclusions: Our data showed that the interleukin 17 F T7488C polymorphisms may exert an influence in keratoconus.