Antiadipogenic Activity of γ-Oryzanol and Its Stability in Pigmented Rice
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1089/jmf.2015.3647 http://hdl.handle.net/11449/178166 |
Resumo: | γ-Oryzanol, a prevalent compound in pigmented rice varieties, has been reported to ameliorate obesity-associated metabolic disorders. Antiadipogenic activities of γ-oryzanol were determined in human adipose-derived mesenchymal stem cells and mouse-derived 3T3-L1 cells. γ-Oryzanol significantly decreased lipid accumulation and reduced glycerol-3-phosphate dehydrogenase activities in both adipocytes. In addition, γ-oryzanol in four pigmented rice varieties (black with giant embryo, brown, sugary brown, and red) was stable when stored at 4°C and also at room temperature for 22 weeks, whereas other bioactives such as lutein and β-carotene were stable only at -80°C. Furthermore, the yield of γ-oryzanol from these rice varieties was significantly increased through steaming and roasting processes. Therefore, γ-oryzanol exerts antiadipogenic activity by suppressing adipocyte differentiations and is stable in pigmented rice for an extended period of time during storage and after cooking. Thus, the intake of pigmented rice may be a useful strategy for preventing obesity. |
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Antiadipogenic Activity of γ-Oryzanol and Its Stability in Pigmented Riceadipogenesisbioactive compoundc-oryzanolmesenchymal stem cellsobesityγ-Oryzanol, a prevalent compound in pigmented rice varieties, has been reported to ameliorate obesity-associated metabolic disorders. Antiadipogenic activities of γ-oryzanol were determined in human adipose-derived mesenchymal stem cells and mouse-derived 3T3-L1 cells. γ-Oryzanol significantly decreased lipid accumulation and reduced glycerol-3-phosphate dehydrogenase activities in both adipocytes. In addition, γ-oryzanol in four pigmented rice varieties (black with giant embryo, brown, sugary brown, and red) was stable when stored at 4°C and also at room temperature for 22 weeks, whereas other bioactives such as lutein and β-carotene were stable only at -80°C. Furthermore, the yield of γ-oryzanol from these rice varieties was significantly increased through steaming and roasting processes. Therefore, γ-oryzanol exerts antiadipogenic activity by suppressing adipocyte differentiations and is stable in pigmented rice for an extended period of time during storage and after cooking. Thus, the intake of pigmented rice may be a useful strategy for preventing obesity.Rural Development AdministrationJean Mayer USDA-Human Nutrition Research Center on Aging Tufts UniversityBotucatu Medical School UNESP-Universidade Estadual PaulistaDivision of Food Bioscience College of Biomedical and Health Sciences Konkuk UniversityInterdisciplinary Research Center for Health Konkuk UniversityNational Institute of Crop Science Rural Development AdministrationBotucatu Medical School UNESP-Universidade Estadual PaulistaRural Development Administration: PJ010059Tufts UniversityUniversidade Estadual Paulista (Unesp)Konkuk UniversityRural Development AdministrationMinatel, Igor Otavio [UNESP]Lee, Yoon-MiYoon, HaelimYoon, YoungHan, Sang-IkCorrea, Camila Renata [UNESP]Fecchio, Denise [UNESP]Yeum, Kyung-Jin2018-12-11T17:29:07Z2018-12-11T17:29:07Z2016-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article710-715http://dx.doi.org/10.1089/jmf.2015.3647Journal of Medicinal Food, v. 19, n. 7, p. 710-715, 2016.1557-76001096-620Xhttp://hdl.handle.net/11449/17816610.1089/jmf.2015.36472-s2.0-84979031682Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Medicinal Foodinfo:eu-repo/semantics/openAccess2021-10-23T14:40:36Zoai:repositorio.unesp.br:11449/178166Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T14:40:36Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Antiadipogenic Activity of γ-Oryzanol and Its Stability in Pigmented Rice |
title |
Antiadipogenic Activity of γ-Oryzanol and Its Stability in Pigmented Rice |
spellingShingle |
Antiadipogenic Activity of γ-Oryzanol and Its Stability in Pigmented Rice Minatel, Igor Otavio [UNESP] adipogenesis bioactive compound c-oryzanol mesenchymal stem cells obesity |
title_short |
Antiadipogenic Activity of γ-Oryzanol and Its Stability in Pigmented Rice |
title_full |
Antiadipogenic Activity of γ-Oryzanol and Its Stability in Pigmented Rice |
title_fullStr |
Antiadipogenic Activity of γ-Oryzanol and Its Stability in Pigmented Rice |
title_full_unstemmed |
Antiadipogenic Activity of γ-Oryzanol and Its Stability in Pigmented Rice |
title_sort |
Antiadipogenic Activity of γ-Oryzanol and Its Stability in Pigmented Rice |
author |
Minatel, Igor Otavio [UNESP] |
author_facet |
Minatel, Igor Otavio [UNESP] Lee, Yoon-Mi Yoon, Haelim Yoon, Young Han, Sang-Ik Correa, Camila Renata [UNESP] Fecchio, Denise [UNESP] Yeum, Kyung-Jin |
author_role |
author |
author2 |
Lee, Yoon-Mi Yoon, Haelim Yoon, Young Han, Sang-Ik Correa, Camila Renata [UNESP] Fecchio, Denise [UNESP] Yeum, Kyung-Jin |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Tufts University Universidade Estadual Paulista (Unesp) Konkuk University Rural Development Administration |
dc.contributor.author.fl_str_mv |
Minatel, Igor Otavio [UNESP] Lee, Yoon-Mi Yoon, Haelim Yoon, Young Han, Sang-Ik Correa, Camila Renata [UNESP] Fecchio, Denise [UNESP] Yeum, Kyung-Jin |
dc.subject.por.fl_str_mv |
adipogenesis bioactive compound c-oryzanol mesenchymal stem cells obesity |
topic |
adipogenesis bioactive compound c-oryzanol mesenchymal stem cells obesity |
description |
γ-Oryzanol, a prevalent compound in pigmented rice varieties, has been reported to ameliorate obesity-associated metabolic disorders. Antiadipogenic activities of γ-oryzanol were determined in human adipose-derived mesenchymal stem cells and mouse-derived 3T3-L1 cells. γ-Oryzanol significantly decreased lipid accumulation and reduced glycerol-3-phosphate dehydrogenase activities in both adipocytes. In addition, γ-oryzanol in four pigmented rice varieties (black with giant embryo, brown, sugary brown, and red) was stable when stored at 4°C and also at room temperature for 22 weeks, whereas other bioactives such as lutein and β-carotene were stable only at -80°C. Furthermore, the yield of γ-oryzanol from these rice varieties was significantly increased through steaming and roasting processes. Therefore, γ-oryzanol exerts antiadipogenic activity by suppressing adipocyte differentiations and is stable in pigmented rice for an extended period of time during storage and after cooking. Thus, the intake of pigmented rice may be a useful strategy for preventing obesity. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-07-01 2018-12-11T17:29:07Z 2018-12-11T17:29:07Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1089/jmf.2015.3647 Journal of Medicinal Food, v. 19, n. 7, p. 710-715, 2016. 1557-7600 1096-620X http://hdl.handle.net/11449/178166 10.1089/jmf.2015.3647 2-s2.0-84979031682 |
url |
http://dx.doi.org/10.1089/jmf.2015.3647 http://hdl.handle.net/11449/178166 |
identifier_str_mv |
Journal of Medicinal Food, v. 19, n. 7, p. 710-715, 2016. 1557-7600 1096-620X 10.1089/jmf.2015.3647 2-s2.0-84979031682 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Medicinal Food |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
710-715 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1803047012966334464 |