Immunomodulatory activities associated with β-glucan derived from Saccharomyces cerevisiae

• Autor(a) principal: Pelizon, A. C. [UNESP]
• Data de Publicação: 2005
• Outros Autores: Kaneno, Ramon [UNESP], Soares, A. M V C, Meira, D. A., Sartori, A.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://www.biomed.cas.cz/physiolres/2005/issue5/pelizon.htm; http://hdl.handle.net/11449/68495
• topic: β-glucan; Fungicidal activity; IL-12; NK activity; TNF-α; beta glucan; interleukin 12; tumor necrosis factor alpha; animal cell; animal experiment; cell activity; controlled study; cytokine production; drug effect; female; fungicidal activity; immunomodulation; mouse; natural killer cell; nonhuman; peritoneum cell; Saccharomyces cerevisiae; spleen cell; target cell; Animals; Antifungal Agents; beta-Glucans; Cytokines; Dose-Response Relationship, Drug; Female; Immunologic Factors; Killer Cells, Natural; Mice; Mice, Inbred C57BL; Paracoccidioides

In this study we investigated the effect of β-glucan derived from Saccharomyces cerevisiae on fungicidal activity, cytokine production and natural killer activity. Spleen and peritoneal cells from female C57BL/6 mice, previously injected (24 or 48 h) with 20 or 100 μg of glucan by i.p. route, were assayed. In vivo β-glucan administration primed spleen cells for a higher production of IL-12 and TNF-α when S. aureus was used as a stimulus. In addition, β-glucan increased NK spleen cells activity against YAC target cells. Some immunomodulatory activities not yet described for β-glucan were observed in this work. © 2005 Institute of Physiology, Academy of Sciences of the Czech Republic.