Immunomodulatory activities associated with β-glucan derived from Saccharomyces cerevisiae
Autor(a) principal: | |
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Data de Publicação: | 2005 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://www.biomed.cas.cz/physiolres/2005/issue5/pelizon.htm http://hdl.handle.net/11449/68495 |
Resumo: | In this study we investigated the effect of β-glucan derived from Saccharomyces cerevisiae on fungicidal activity, cytokine production and natural killer activity. Spleen and peritoneal cells from female C57BL/6 mice, previously injected (24 or 48 h) with 20 or 100 μg of glucan by i.p. route, were assayed. In vivo β-glucan administration primed spleen cells for a higher production of IL-12 and TNF-α when S. aureus was used as a stimulus. In addition, β-glucan increased NK spleen cells activity against YAC target cells. Some immunomodulatory activities not yet described for β-glucan were observed in this work. © 2005 Institute of Physiology, Academy of Sciences of the Czech Republic. |
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Immunomodulatory activities associated with β-glucan derived from Saccharomyces cerevisiaeβ-glucanFungicidal activityIL-12NK activityTNF-αbeta glucaninterleukin 12tumor necrosis factor alphaanimal cellanimal experimentcell activitycontrolled studycytokine productiondrug effectfemalefungicidal activityimmunomodulationmousenatural killer cellnonhumanperitoneum cellSaccharomyces cerevisiaespleen celltarget cellAnimalsAntifungal Agentsbeta-GlucansCytokinesDose-Response Relationship, DrugFemaleImmunologic FactorsKiller Cells, NaturalMiceMice, Inbred C57BLParacoccidioidesIn this study we investigated the effect of β-glucan derived from Saccharomyces cerevisiae on fungicidal activity, cytokine production and natural killer activity. Spleen and peritoneal cells from female C57BL/6 mice, previously injected (24 or 48 h) with 20 or 100 μg of glucan by i.p. route, were assayed. In vivo β-glucan administration primed spleen cells for a higher production of IL-12 and TNF-α when S. aureus was used as a stimulus. In addition, β-glucan increased NK spleen cells activity against YAC target cells. Some immunomodulatory activities not yet described for β-glucan were observed in this work. © 2005 Institute of Physiology, Academy of Sciences of the Czech Republic.Department of Microbiology and Immunology Institute de Biosciences State University of Sao Paulo, Sao PauloDepartment of Tropical Diseases and Diagnosis by Image Faculty of Medicine State University of Sao Paulo, Sao PauloDepartment of Microbiology and Immunology Instituto de Biociências Universidade Estadual Paulista (UNESP)Department of Microbiology and Immunology Instituto de Biociências Universidade Estadual Paulista (UNESP)Universidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Pelizon, A. C. [UNESP]Kaneno, Ramon [UNESP]Soares, A. M V CMeira, D. A.Sartori, A.2014-05-27T11:21:40Z2014-05-27T11:21:40Z2005-11-16info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article557-564application/pdfhttp://www.biomed.cas.cz/physiolres/2005/issue5/pelizon.htmPhysiological Research, v. 54, n. 5, p. 557-564, 2005.0862-8408http://hdl.handle.net/11449/684952-s2.0-276445255842-s2.0-27644525584.pdf884583555063780949775724161295270000-0002-4292-3298Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPhysiological Research1.3240,568info:eu-repo/semantics/openAccess2023-11-12T06:11:25Zoai:repositorio.unesp.br:11449/68495Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:27:23.240108Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Immunomodulatory activities associated with β-glucan derived from Saccharomyces cerevisiae |
title |
Immunomodulatory activities associated with β-glucan derived from Saccharomyces cerevisiae |
spellingShingle |
Immunomodulatory activities associated with β-glucan derived from Saccharomyces cerevisiae Pelizon, A. C. [UNESP] β-glucan Fungicidal activity IL-12 NK activity TNF-α beta glucan interleukin 12 tumor necrosis factor alpha animal cell animal experiment cell activity controlled study cytokine production drug effect female fungicidal activity immunomodulation mouse natural killer cell nonhuman peritoneum cell Saccharomyces cerevisiae spleen cell target cell Animals Antifungal Agents beta-Glucans Cytokines Dose-Response Relationship, Drug Female Immunologic Factors Killer Cells, Natural Mice Mice, Inbred C57BL Paracoccidioides |
title_short |
Immunomodulatory activities associated with β-glucan derived from Saccharomyces cerevisiae |
title_full |
Immunomodulatory activities associated with β-glucan derived from Saccharomyces cerevisiae |
title_fullStr |
Immunomodulatory activities associated with β-glucan derived from Saccharomyces cerevisiae |
title_full_unstemmed |
Immunomodulatory activities associated with β-glucan derived from Saccharomyces cerevisiae |
title_sort |
Immunomodulatory activities associated with β-glucan derived from Saccharomyces cerevisiae |
author |
Pelizon, A. C. [UNESP] |
author_facet |
Pelizon, A. C. [UNESP] Kaneno, Ramon [UNESP] Soares, A. M V C Meira, D. A. Sartori, A. |
author_role |
author |
author2 |
Kaneno, Ramon [UNESP] Soares, A. M V C Meira, D. A. Sartori, A. |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Pelizon, A. C. [UNESP] Kaneno, Ramon [UNESP] Soares, A. M V C Meira, D. A. Sartori, A. |
dc.subject.por.fl_str_mv |
β-glucan Fungicidal activity IL-12 NK activity TNF-α beta glucan interleukin 12 tumor necrosis factor alpha animal cell animal experiment cell activity controlled study cytokine production drug effect female fungicidal activity immunomodulation mouse natural killer cell nonhuman peritoneum cell Saccharomyces cerevisiae spleen cell target cell Animals Antifungal Agents beta-Glucans Cytokines Dose-Response Relationship, Drug Female Immunologic Factors Killer Cells, Natural Mice Mice, Inbred C57BL Paracoccidioides |
topic |
β-glucan Fungicidal activity IL-12 NK activity TNF-α beta glucan interleukin 12 tumor necrosis factor alpha animal cell animal experiment cell activity controlled study cytokine production drug effect female fungicidal activity immunomodulation mouse natural killer cell nonhuman peritoneum cell Saccharomyces cerevisiae spleen cell target cell Animals Antifungal Agents beta-Glucans Cytokines Dose-Response Relationship, Drug Female Immunologic Factors Killer Cells, Natural Mice Mice, Inbred C57BL Paracoccidioides |
description |
In this study we investigated the effect of β-glucan derived from Saccharomyces cerevisiae on fungicidal activity, cytokine production and natural killer activity. Spleen and peritoneal cells from female C57BL/6 mice, previously injected (24 or 48 h) with 20 or 100 μg of glucan by i.p. route, were assayed. In vivo β-glucan administration primed spleen cells for a higher production of IL-12 and TNF-α when S. aureus was used as a stimulus. In addition, β-glucan increased NK spleen cells activity against YAC target cells. Some immunomodulatory activities not yet described for β-glucan were observed in this work. © 2005 Institute of Physiology, Academy of Sciences of the Czech Republic. |
publishDate |
2005 |
dc.date.none.fl_str_mv |
2005-11-16 2014-05-27T11:21:40Z 2014-05-27T11:21:40Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.biomed.cas.cz/physiolres/2005/issue5/pelizon.htm Physiological Research, v. 54, n. 5, p. 557-564, 2005. 0862-8408 http://hdl.handle.net/11449/68495 2-s2.0-27644525584 2-s2.0-27644525584.pdf 8845835550637809 4977572416129527 0000-0002-4292-3298 |
url |
http://www.biomed.cas.cz/physiolres/2005/issue5/pelizon.htm http://hdl.handle.net/11449/68495 |
identifier_str_mv |
Physiological Research, v. 54, n. 5, p. 557-564, 2005. 0862-8408 2-s2.0-27644525584 2-s2.0-27644525584.pdf 8845835550637809 4977572416129527 0000-0002-4292-3298 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Physiological Research 1.324 0,568 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
557-564 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128815125233664 |