Effects of active smoking on airway and systemic inflammation profiles in patients with chronic obstructive pulmonary disease
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo de conferência |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1097/MAJ.0b013e31825f32a7 http://hdl.handle.net/11449/75538 |
Resumo: | Background: The markers that characterize local and systemic inflammation in chronic obstructive pulmonary disease (COPD) remain unclear, as do their correlations with smoking status and presence of disease. The aim of this study was to assess markers of inflammation in the peripheral blood and airways of current smokers without COPD, of current smokers with COPD and of ex-smokers with COPD. METHODS: In this study, 17 current smokers with COPD (mean age: 58.2 ± 9.6 years; mean forced expiratory volume in 1 second [FEV1]: 56.1 ± 15.9%), 35 ex-smokers with COPD (mean age: 66.3 ± 7.3 years; mean FEV1: 47.9 ± 17.2%) and 20 current smokers without COPD (mean age: 49.1 ± 6.2 years; mean FEV1: 106.5 ± 15.8%) were evaluated. Spirometry findings, body composition and serum/induced sputum concentrations of tumor necrosis factor α (TNF-α), interleukin (IL)-6, IL-8 and IL-10, together with serum C-reactive protein (CRP) levels, were assessed. RESULTS: Serum TNF-α concentration was higher in all current smokers than in ex-smokers with COPD. In current smokers without COPD, serum CRP level was lower than in ex-smokers with COPD and significantly lower than in current smokers with COPD. Sputum TNF-α concentration was higher in current and ex-smokers with COPD than in current smokers without COPD. Multiple regression analyses showed that serum TNF-α was associated with active smoking, and serum CRP and sputum TNF-α were associated with COPD diagnosis. CONCLUSIONS: Smoking is associated with higher systemic inflammation in patients with COPD. Current findings also support the hypothesis that smoking and COPD have different effects on the regulation of airway and systemic inflammatory processes. © 2013 Lippincott Williams and Wilkins. |
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Effects of active smoking on airway and systemic inflammation profiles in patients with chronic obstructive pulmonary diseaseBiomarkersCOPDInduced sputumSmokingSystemic inflammationC reactive proteincorticosteroidinterleukin 10interleukin 6interleukin 8tumor necrosis factor alphaadultbody compositionchronic obstructive lung diseaseconference papercontrolled studycorticosteroid therapyfemaleforced expiratory volumehumanlung flow volume curvemajor clinical studymaleprotein blood levelrespiratory tract inflammationsmokingspirometrysputum levelAdultAgedBiological MarkersC-Reactive ProteinCytokinesFemaleHumansMaleMiddle AgedPneumoniaPulmonary Disease, Chronic ObstructiveRegression AnalysisRespiratory Function TestsRespiratory SystemSputumBackground: The markers that characterize local and systemic inflammation in chronic obstructive pulmonary disease (COPD) remain unclear, as do their correlations with smoking status and presence of disease. The aim of this study was to assess markers of inflammation in the peripheral blood and airways of current smokers without COPD, of current smokers with COPD and of ex-smokers with COPD. METHODS: In this study, 17 current smokers with COPD (mean age: 58.2 ± 9.6 years; mean forced expiratory volume in 1 second [FEV1]: 56.1 ± 15.9%), 35 ex-smokers with COPD (mean age: 66.3 ± 7.3 years; mean FEV1: 47.9 ± 17.2%) and 20 current smokers without COPD (mean age: 49.1 ± 6.2 years; mean FEV1: 106.5 ± 15.8%) were evaluated. Spirometry findings, body composition and serum/induced sputum concentrations of tumor necrosis factor α (TNF-α), interleukin (IL)-6, IL-8 and IL-10, together with serum C-reactive protein (CRP) levels, were assessed. RESULTS: Serum TNF-α concentration was higher in all current smokers than in ex-smokers with COPD. In current smokers without COPD, serum CRP level was lower than in ex-smokers with COPD and significantly lower than in current smokers with COPD. Sputum TNF-α concentration was higher in current and ex-smokers with COPD than in current smokers without COPD. Multiple regression analyses showed that serum TNF-α was associated with active smoking, and serum CRP and sputum TNF-α were associated with COPD diagnosis. CONCLUSIONS: Smoking is associated with higher systemic inflammation in patients with COPD. Current findings also support the hypothesis that smoking and COPD have different effects on the regulation of airway and systemic inflammatory processes. © 2013 Lippincott Williams and Wilkins.Department of Pulmonology Botucatu School of Medicine São Paulo State University, BotucatuDepartment of Internal Medicine Botucatu School of Medicine São Paulo State University, BotucatuDepartment of Pulmonology Botucatu School of Medicine São Paulo State University, BotucatuDepartment of Internal Medicine Botucatu School of Medicine São Paulo State University, BotucatuUniversidade Estadual Paulista (Unesp)Pelegrino, Nilva R.G. [UNESP]Tanni, Suzana E. [UNESP]Amaral, Renata A.F. [UNESP]Angeleli, Aparecida Y.O. [UNESP]Correa, Camila [UNESP]Godoy, Irma de [UNESP]2014-05-27T11:29:35Z2014-05-27T11:29:35Z2013-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObject440-445http://dx.doi.org/10.1097/MAJ.0b013e31825f32a7American Journal of the Medical Sciences, v. 345, n. 6, p. 440-445, 2013.0002-96291538-2990http://hdl.handle.net/11449/7553810.1097/MAJ.0b013e31825f32a7WOS:0003194377000062-s2.0-848784626305079454858778041Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAmerican Journal of the Medical Sciences1.7730,767info:eu-repo/semantics/openAccess2021-10-22T14:02:42Zoai:repositorio.unesp.br:11449/75538Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-22T14:02:42Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Effects of active smoking on airway and systemic inflammation profiles in patients with chronic obstructive pulmonary disease |
title |
Effects of active smoking on airway and systemic inflammation profiles in patients with chronic obstructive pulmonary disease |
spellingShingle |
Effects of active smoking on airway and systemic inflammation profiles in patients with chronic obstructive pulmonary disease Pelegrino, Nilva R.G. [UNESP] Biomarkers COPD Induced sputum Smoking Systemic inflammation C reactive protein corticosteroid interleukin 10 interleukin 6 interleukin 8 tumor necrosis factor alpha adult body composition chronic obstructive lung disease conference paper controlled study corticosteroid therapy female forced expiratory volume human lung flow volume curve major clinical study male protein blood level respiratory tract inflammation smoking spirometry sputum level Adult Aged Biological Markers C-Reactive Protein Cytokines Female Humans Male Middle Aged Pneumonia Pulmonary Disease, Chronic Obstructive Regression Analysis Respiratory Function Tests Respiratory System Sputum |
title_short |
Effects of active smoking on airway and systemic inflammation profiles in patients with chronic obstructive pulmonary disease |
title_full |
Effects of active smoking on airway and systemic inflammation profiles in patients with chronic obstructive pulmonary disease |
title_fullStr |
Effects of active smoking on airway and systemic inflammation profiles in patients with chronic obstructive pulmonary disease |
title_full_unstemmed |
Effects of active smoking on airway and systemic inflammation profiles in patients with chronic obstructive pulmonary disease |
title_sort |
Effects of active smoking on airway and systemic inflammation profiles in patients with chronic obstructive pulmonary disease |
author |
Pelegrino, Nilva R.G. [UNESP] |
author_facet |
Pelegrino, Nilva R.G. [UNESP] Tanni, Suzana E. [UNESP] Amaral, Renata A.F. [UNESP] Angeleli, Aparecida Y.O. [UNESP] Correa, Camila [UNESP] Godoy, Irma de [UNESP] |
author_role |
author |
author2 |
Tanni, Suzana E. [UNESP] Amaral, Renata A.F. [UNESP] Angeleli, Aparecida Y.O. [UNESP] Correa, Camila [UNESP] Godoy, Irma de [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Pelegrino, Nilva R.G. [UNESP] Tanni, Suzana E. [UNESP] Amaral, Renata A.F. [UNESP] Angeleli, Aparecida Y.O. [UNESP] Correa, Camila [UNESP] Godoy, Irma de [UNESP] |
dc.subject.por.fl_str_mv |
Biomarkers COPD Induced sputum Smoking Systemic inflammation C reactive protein corticosteroid interleukin 10 interleukin 6 interleukin 8 tumor necrosis factor alpha adult body composition chronic obstructive lung disease conference paper controlled study corticosteroid therapy female forced expiratory volume human lung flow volume curve major clinical study male protein blood level respiratory tract inflammation smoking spirometry sputum level Adult Aged Biological Markers C-Reactive Protein Cytokines Female Humans Male Middle Aged Pneumonia Pulmonary Disease, Chronic Obstructive Regression Analysis Respiratory Function Tests Respiratory System Sputum |
topic |
Biomarkers COPD Induced sputum Smoking Systemic inflammation C reactive protein corticosteroid interleukin 10 interleukin 6 interleukin 8 tumor necrosis factor alpha adult body composition chronic obstructive lung disease conference paper controlled study corticosteroid therapy female forced expiratory volume human lung flow volume curve major clinical study male protein blood level respiratory tract inflammation smoking spirometry sputum level Adult Aged Biological Markers C-Reactive Protein Cytokines Female Humans Male Middle Aged Pneumonia Pulmonary Disease, Chronic Obstructive Regression Analysis Respiratory Function Tests Respiratory System Sputum |
description |
Background: The markers that characterize local and systemic inflammation in chronic obstructive pulmonary disease (COPD) remain unclear, as do their correlations with smoking status and presence of disease. The aim of this study was to assess markers of inflammation in the peripheral blood and airways of current smokers without COPD, of current smokers with COPD and of ex-smokers with COPD. METHODS: In this study, 17 current smokers with COPD (mean age: 58.2 ± 9.6 years; mean forced expiratory volume in 1 second [FEV1]: 56.1 ± 15.9%), 35 ex-smokers with COPD (mean age: 66.3 ± 7.3 years; mean FEV1: 47.9 ± 17.2%) and 20 current smokers without COPD (mean age: 49.1 ± 6.2 years; mean FEV1: 106.5 ± 15.8%) were evaluated. Spirometry findings, body composition and serum/induced sputum concentrations of tumor necrosis factor α (TNF-α), interleukin (IL)-6, IL-8 and IL-10, together with serum C-reactive protein (CRP) levels, were assessed. RESULTS: Serum TNF-α concentration was higher in all current smokers than in ex-smokers with COPD. In current smokers without COPD, serum CRP level was lower than in ex-smokers with COPD and significantly lower than in current smokers with COPD. Sputum TNF-α concentration was higher in current and ex-smokers with COPD than in current smokers without COPD. Multiple regression analyses showed that serum TNF-α was associated with active smoking, and serum CRP and sputum TNF-α were associated with COPD diagnosis. CONCLUSIONS: Smoking is associated with higher systemic inflammation in patients with COPD. Current findings also support the hypothesis that smoking and COPD have different effects on the regulation of airway and systemic inflammatory processes. © 2013 Lippincott Williams and Wilkins. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-06-01 2014-05-27T11:29:35Z 2014-05-27T11:29:35Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/conferenceObject |
format |
conferenceObject |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1097/MAJ.0b013e31825f32a7 American Journal of the Medical Sciences, v. 345, n. 6, p. 440-445, 2013. 0002-9629 1538-2990 http://hdl.handle.net/11449/75538 10.1097/MAJ.0b013e31825f32a7 WOS:000319437700006 2-s2.0-84878462630 5079454858778041 |
url |
http://dx.doi.org/10.1097/MAJ.0b013e31825f32a7 http://hdl.handle.net/11449/75538 |
identifier_str_mv |
American Journal of the Medical Sciences, v. 345, n. 6, p. 440-445, 2013. 0002-9629 1538-2990 10.1097/MAJ.0b013e31825f32a7 WOS:000319437700006 2-s2.0-84878462630 5079454858778041 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
American Journal of the Medical Sciences 1.773 0,767 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
440-445 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1799964381220438016 |