Development and characterization of a novel liquid crystalline system containing sodium alginate for incorporation of trans-resveratrol intended for treatment of buccal candidiasis

Detalhes bibliográficos
Autor(a) principal: Miyashiro, C. A. [UNESP]
Data de Publicação: 2020
Outros Autores: Bernegossi, J. [UNESP], Bonifácio, B. V. [UNESP], de Toledo, L. G. [UNESP], Ramos, M. A.S. [UNESP], Bauab, T. M. [UNESP], Chorilli, M. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1691/ph.2020.9165
http://hdl.handle.net/11449/201745
Resumo: Trans-resveratrol has antimicrobial effects; however, its hydrophobic properties hamper its incorporation into pharmaceutical formulations. The aim of this study was to develop liquid crystals and a liquid crystal precursor (microemulsion), a common nanotechnology-based drug delivery system using a surfactant, an oil phase, and a polymer dispersion, for topical administration against buccal candidiasis. A ternary diagram was constructed and a potential formulation was selected, in order to run characterization tests. We chose the formulation that presented microemulsion and crystal liquid characteristics through polarized light microscopy and small-angle X-ray scattering experiments. The stability and structural features of the formulations were observed by performing rheological assay, measuring mucoadhesion, and analyzing texture profiles. It was verified that the chosen system was capable of transiting from microemulsion to liquid crystals when added in aqueous phase; further, the presence of sodium alginate as the polymer increased its mucoadhesion strength. Microbiological assay of trans-resveratrol, using amphotericin B and fluconazole as controls against strains of Candida albicans, showed positive anti-microbiological effect; however, a high concentration of the compound was needed.
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spelling Development and characterization of a novel liquid crystalline system containing sodium alginate for incorporation of trans-resveratrol intended for treatment of buccal candidiasisTrans-resveratrol has antimicrobial effects; however, its hydrophobic properties hamper its incorporation into pharmaceutical formulations. The aim of this study was to develop liquid crystals and a liquid crystal precursor (microemulsion), a common nanotechnology-based drug delivery system using a surfactant, an oil phase, and a polymer dispersion, for topical administration against buccal candidiasis. A ternary diagram was constructed and a potential formulation was selected, in order to run characterization tests. We chose the formulation that presented microemulsion and crystal liquid characteristics through polarized light microscopy and small-angle X-ray scattering experiments. The stability and structural features of the formulations were observed by performing rheological assay, measuring mucoadhesion, and analyzing texture profiles. It was verified that the chosen system was capable of transiting from microemulsion to liquid crystals when added in aqueous phase; further, the presence of sodium alginate as the polymer increased its mucoadhesion strength. Microbiological assay of trans-resveratrol, using amphotericin B and fluconazole as controls against strains of Candida albicans, showed positive anti-microbiological effect; however, a high concentration of the compound was needed.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Laboratório Nacional de Luz SíncrotronUniversidade de São PauloSchool of Pharmaceutical Sciences São Paulo State University (Unesp)School of Pharmaceutical Sciences São Paulo State University (Unesp)Universidade de São Paulo: 22045-9Universidade Estadual Paulista (Unesp)Miyashiro, C. A. [UNESP]Bernegossi, J. [UNESP]Bonifácio, B. V. [UNESP]de Toledo, L. G. [UNESP]Ramos, M. A.S. [UNESP]Bauab, T. M. [UNESP]Chorilli, M. [UNESP]2020-12-12T02:40:43Z2020-12-12T02:40:43Z2020-05-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article179-185http://dx.doi.org/10.1691/ph.2020.9165Pharmazie, v. 75, n. 5, p. 179-185, 2020.0031-7144http://hdl.handle.net/11449/20174510.1691/ph.2020.91652-s2.0-85084554252Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPharmazieinfo:eu-repo/semantics/openAccess2024-06-24T13:45:18Zoai:repositorio.unesp.br:11449/201745Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:01:46.107216Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Development and characterization of a novel liquid crystalline system containing sodium alginate for incorporation of trans-resveratrol intended for treatment of buccal candidiasis
title Development and characterization of a novel liquid crystalline system containing sodium alginate for incorporation of trans-resveratrol intended for treatment of buccal candidiasis
spellingShingle Development and characterization of a novel liquid crystalline system containing sodium alginate for incorporation of trans-resveratrol intended for treatment of buccal candidiasis
Miyashiro, C. A. [UNESP]
title_short Development and characterization of a novel liquid crystalline system containing sodium alginate for incorporation of trans-resveratrol intended for treatment of buccal candidiasis
title_full Development and characterization of a novel liquid crystalline system containing sodium alginate for incorporation of trans-resveratrol intended for treatment of buccal candidiasis
title_fullStr Development and characterization of a novel liquid crystalline system containing sodium alginate for incorporation of trans-resveratrol intended for treatment of buccal candidiasis
title_full_unstemmed Development and characterization of a novel liquid crystalline system containing sodium alginate for incorporation of trans-resveratrol intended for treatment of buccal candidiasis
title_sort Development and characterization of a novel liquid crystalline system containing sodium alginate for incorporation of trans-resveratrol intended for treatment of buccal candidiasis
author Miyashiro, C. A. [UNESP]
author_facet Miyashiro, C. A. [UNESP]
Bernegossi, J. [UNESP]
Bonifácio, B. V. [UNESP]
de Toledo, L. G. [UNESP]
Ramos, M. A.S. [UNESP]
Bauab, T. M. [UNESP]
Chorilli, M. [UNESP]
author_role author
author2 Bernegossi, J. [UNESP]
Bonifácio, B. V. [UNESP]
de Toledo, L. G. [UNESP]
Ramos, M. A.S. [UNESP]
Bauab, T. M. [UNESP]
Chorilli, M. [UNESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Miyashiro, C. A. [UNESP]
Bernegossi, J. [UNESP]
Bonifácio, B. V. [UNESP]
de Toledo, L. G. [UNESP]
Ramos, M. A.S. [UNESP]
Bauab, T. M. [UNESP]
Chorilli, M. [UNESP]
description Trans-resveratrol has antimicrobial effects; however, its hydrophobic properties hamper its incorporation into pharmaceutical formulations. The aim of this study was to develop liquid crystals and a liquid crystal precursor (microemulsion), a common nanotechnology-based drug delivery system using a surfactant, an oil phase, and a polymer dispersion, for topical administration against buccal candidiasis. A ternary diagram was constructed and a potential formulation was selected, in order to run characterization tests. We chose the formulation that presented microemulsion and crystal liquid characteristics through polarized light microscopy and small-angle X-ray scattering experiments. The stability and structural features of the formulations were observed by performing rheological assay, measuring mucoadhesion, and analyzing texture profiles. It was verified that the chosen system was capable of transiting from microemulsion to liquid crystals when added in aqueous phase; further, the presence of sodium alginate as the polymer increased its mucoadhesion strength. Microbiological assay of trans-resveratrol, using amphotericin B and fluconazole as controls against strains of Candida albicans, showed positive anti-microbiological effect; however, a high concentration of the compound was needed.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-12T02:40:43Z
2020-12-12T02:40:43Z
2020-05-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1691/ph.2020.9165
Pharmazie, v. 75, n. 5, p. 179-185, 2020.
0031-7144
http://hdl.handle.net/11449/201745
10.1691/ph.2020.9165
2-s2.0-85084554252
url http://dx.doi.org/10.1691/ph.2020.9165
http://hdl.handle.net/11449/201745
identifier_str_mv Pharmazie, v. 75, n. 5, p. 179-185, 2020.
0031-7144
10.1691/ph.2020.9165
2-s2.0-85084554252
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Pharmazie
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 179-185
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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