Polyethyleneimine and Chitosan Polymer-Based Mucoadhesive Liquid Crystalline Systems Intended for Buccal Drug Delivery
Autor(a) principal: | |
---|---|
Data de Publicação: | 2018 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1208/s12249-017-0890-2 http://hdl.handle.net/11449/175319 |
Resumo: | The buccal mucosa is accessible, shows rapid repair, has an excellent blood supply, and shows the absence of the first-pass effect, which makes it a very attractive drug delivery route. However, this route has limitations, mainly due to the continuous secretion of saliva (0.5 to 2 L/day), which may lead to dilution, possible ingestion, and unintentional removal of the active drug. Nanotechnology-based drug delivery systems, such as liquid crystalline systems (LCSs), can increase drug permeation through the mucosa and thereby improve drug delivery. This study aimed at developing and characterizing the mechanical, rheological, and mucoadhesive properties of four liquid crystalline precursor systems (LCPSs) composed of four different aqueous phases (i) water (FW), (ii) chitosan (FC), (iii) polyethyleneimine (FP), or (iv) both polymers (FPC); oleic acid was used as the oil phase, and ethoxylated and propoxylated cetyl alcohol was used as the surfactant. Polarized light microscopy and small-angle X-ray scattering indicated that all LCPSs formed liquid crystalline states after incorporation of saliva. Rheological, texture, and mucoadhesive assays showed that FPC had the most suitable characteristics for buccal application. In vitro release study showed that FPC could act as a controlled drug delivery system. Finally, based on in vitro cytotoxicity data, FPC is a safe buccal drug delivery system for the treatment of several buccal diseases. |
id |
UNSP_a4e24c1fa4b1730797f7a311e7a03f77 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/175319 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Polyethyleneimine and Chitosan Polymer-Based Mucoadhesive Liquid Crystalline Systems Intended for Buccal Drug Deliverybuccal routechitosandrug delivery systemliquid crystalline systempolyethyleneimineThe buccal mucosa is accessible, shows rapid repair, has an excellent blood supply, and shows the absence of the first-pass effect, which makes it a very attractive drug delivery route. However, this route has limitations, mainly due to the continuous secretion of saliva (0.5 to 2 L/day), which may lead to dilution, possible ingestion, and unintentional removal of the active drug. Nanotechnology-based drug delivery systems, such as liquid crystalline systems (LCSs), can increase drug permeation through the mucosa and thereby improve drug delivery. This study aimed at developing and characterizing the mechanical, rheological, and mucoadhesive properties of four liquid crystalline precursor systems (LCPSs) composed of four different aqueous phases (i) water (FW), (ii) chitosan (FC), (iii) polyethyleneimine (FP), or (iv) both polymers (FPC); oleic acid was used as the oil phase, and ethoxylated and propoxylated cetyl alcohol was used as the surfactant. Polarized light microscopy and small-angle X-ray scattering indicated that all LCPSs formed liquid crystalline states after incorporation of saliva. Rheological, texture, and mucoadhesive assays showed that FPC had the most suitable characteristics for buccal application. In vitro release study showed that FPC could act as a controlled drug delivery system. Finally, based on in vitro cytotoxicity data, FPC is a safe buccal drug delivery system for the treatment of several buccal diseases.Faculdade de Ciências Farmacêuticas Departamento de Fármacos e Medicamentos UNESP—Universidade Estadual Paulista Campus AraraquaraAraraquara Dental School UNESP- Univ Estadual PaulistaFaculdade de Ciências Farmacêuticas Departamento de Fármacos e Medicamentos UNESP—Universidade Estadual Paulista Campus AraraquaraAraraquara Dental School UNESP- Univ Estadual PaulistaUniversidade Estadual Paulista (Unesp)Calixto, Giovana Maria Fioramonti [UNESP]Victorelli, Francesca Damiani [UNESP]Dovigo, Lívia Nordi [UNESP]Chorilli, Marlus [UNESP]2018-12-11T17:15:16Z2018-12-11T17:15:16Z2018-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article820-836application/pdfhttp://dx.doi.org/10.1208/s12249-017-0890-2AAPS PharmSciTech, v. 19, n. 2, p. 820-836, 2018.1530-9932http://hdl.handle.net/11449/17531910.1208/s12249-017-0890-22-s2.0-850308475152-s2.0-85030847515.pdf01275704806813421427125996716282Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAAPS PharmSciTech0,752info:eu-repo/semantics/openAccess2024-06-24T13:46:23Zoai:repositorio.unesp.br:11449/175319Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:04:07.896181Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Polyethyleneimine and Chitosan Polymer-Based Mucoadhesive Liquid Crystalline Systems Intended for Buccal Drug Delivery |
title |
Polyethyleneimine and Chitosan Polymer-Based Mucoadhesive Liquid Crystalline Systems Intended for Buccal Drug Delivery |
spellingShingle |
Polyethyleneimine and Chitosan Polymer-Based Mucoadhesive Liquid Crystalline Systems Intended for Buccal Drug Delivery Calixto, Giovana Maria Fioramonti [UNESP] buccal route chitosan drug delivery system liquid crystalline system polyethyleneimine |
title_short |
Polyethyleneimine and Chitosan Polymer-Based Mucoadhesive Liquid Crystalline Systems Intended for Buccal Drug Delivery |
title_full |
Polyethyleneimine and Chitosan Polymer-Based Mucoadhesive Liquid Crystalline Systems Intended for Buccal Drug Delivery |
title_fullStr |
Polyethyleneimine and Chitosan Polymer-Based Mucoadhesive Liquid Crystalline Systems Intended for Buccal Drug Delivery |
title_full_unstemmed |
Polyethyleneimine and Chitosan Polymer-Based Mucoadhesive Liquid Crystalline Systems Intended for Buccal Drug Delivery |
title_sort |
Polyethyleneimine and Chitosan Polymer-Based Mucoadhesive Liquid Crystalline Systems Intended for Buccal Drug Delivery |
author |
Calixto, Giovana Maria Fioramonti [UNESP] |
author_facet |
Calixto, Giovana Maria Fioramonti [UNESP] Victorelli, Francesca Damiani [UNESP] Dovigo, Lívia Nordi [UNESP] Chorilli, Marlus [UNESP] |
author_role |
author |
author2 |
Victorelli, Francesca Damiani [UNESP] Dovigo, Lívia Nordi [UNESP] Chorilli, Marlus [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Calixto, Giovana Maria Fioramonti [UNESP] Victorelli, Francesca Damiani [UNESP] Dovigo, Lívia Nordi [UNESP] Chorilli, Marlus [UNESP] |
dc.subject.por.fl_str_mv |
buccal route chitosan drug delivery system liquid crystalline system polyethyleneimine |
topic |
buccal route chitosan drug delivery system liquid crystalline system polyethyleneimine |
description |
The buccal mucosa is accessible, shows rapid repair, has an excellent blood supply, and shows the absence of the first-pass effect, which makes it a very attractive drug delivery route. However, this route has limitations, mainly due to the continuous secretion of saliva (0.5 to 2 L/day), which may lead to dilution, possible ingestion, and unintentional removal of the active drug. Nanotechnology-based drug delivery systems, such as liquid crystalline systems (LCSs), can increase drug permeation through the mucosa and thereby improve drug delivery. This study aimed at developing and characterizing the mechanical, rheological, and mucoadhesive properties of four liquid crystalline precursor systems (LCPSs) composed of four different aqueous phases (i) water (FW), (ii) chitosan (FC), (iii) polyethyleneimine (FP), or (iv) both polymers (FPC); oleic acid was used as the oil phase, and ethoxylated and propoxylated cetyl alcohol was used as the surfactant. Polarized light microscopy and small-angle X-ray scattering indicated that all LCPSs formed liquid crystalline states after incorporation of saliva. Rheological, texture, and mucoadhesive assays showed that FPC had the most suitable characteristics for buccal application. In vitro release study showed that FPC could act as a controlled drug delivery system. Finally, based on in vitro cytotoxicity data, FPC is a safe buccal drug delivery system for the treatment of several buccal diseases. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-11T17:15:16Z 2018-12-11T17:15:16Z 2018-02-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1208/s12249-017-0890-2 AAPS PharmSciTech, v. 19, n. 2, p. 820-836, 2018. 1530-9932 http://hdl.handle.net/11449/175319 10.1208/s12249-017-0890-2 2-s2.0-85030847515 2-s2.0-85030847515.pdf 0127570480681342 1427125996716282 |
url |
http://dx.doi.org/10.1208/s12249-017-0890-2 http://hdl.handle.net/11449/175319 |
identifier_str_mv |
AAPS PharmSciTech, v. 19, n. 2, p. 820-836, 2018. 1530-9932 10.1208/s12249-017-0890-2 2-s2.0-85030847515 2-s2.0-85030847515.pdf 0127570480681342 1427125996716282 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
AAPS PharmSciTech 0,752 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
820-836 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129388684771328 |