Abo blood groups and helicobacter pylori cagA infection: Evidence of an association

Detalhes bibliográficos
Autor(a) principal: Mattos, D. E. [UNESP]
Data de Publicação: 2010
Outros Autores: Cintra, J. R., Brandão de Mattos, C. C., Nakashima, F. [UNESP], Silva, R. C.M.A., Moreira, H. W. [UNESP], de Mattos, L. C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S1678-91992010005000004
http://hdl.handle.net/11449/225825
Resumo: Diseases resulting from Helicobacter pylori infection appear to be dependent on a host of genetic traits and virulence factors possessed by this microorganism. This paper aimed to investigate the association between the ABO histo-blood groups and H. pylori cagA infections. Genomic DNA samples (n = 110) of gastric biopsies obtained from patients with endoscopic diagnosis of peptic ulcers (n = 25) and chronic active gastritis (n = 85) were analyzed by PCR using specific primers for the cagA gene. Of the samples, 66.4% (n = 73) tested positive and 33.6% (n = 37) negative for the gene. The cagA strain was predominant in peptic ulcers (n = 21; 84.0%) compared with chronic active gastritis (n = 52; 61.2%) (p = 0.05; OR 3.332; 95% CI: 1.050-10.576). Additionally, the cagA strain was prevalent in the type O blood (48/63; 76.2%) compared with other ABO phenotypes (25/47; 53.2%) (p = 0.01; OR 2.816; 95% CI: 1.246-6.364). These results suggest that H. pylori cagA infection is associated with the O blood group in Brazilian patients suffering from chronic active gastritis and peptic ulcers.
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spelling Abo blood groups and helicobacter pylori cagA infection: Evidence of an associationABO blood groupsCagA strainChronic active gastritisH. pylori infectionPeptic ulcersDiseases resulting from Helicobacter pylori infection appear to be dependent on a host of genetic traits and virulence factors possessed by this microorganism. This paper aimed to investigate the association between the ABO histo-blood groups and H. pylori cagA infections. Genomic DNA samples (n = 110) of gastric biopsies obtained from patients with endoscopic diagnosis of peptic ulcers (n = 25) and chronic active gastritis (n = 85) were analyzed by PCR using specific primers for the cagA gene. Of the samples, 66.4% (n = 73) tested positive and 33.6% (n = 37) negative for the gene. The cagA strain was predominant in peptic ulcers (n = 21; 84.0%) compared with chronic active gastritis (n = 52; 61.2%) (p = 0.05; OR 3.332; 95% CI: 1.050-10.576). Additionally, the cagA strain was prevalent in the type O blood (48/63; 76.2%) compared with other ABO phenotypes (25/47; 53.2%) (p = 0.01; OR 2.816; 95% CI: 1.246-6.364). These results suggest that H. pylori cagA infection is associated with the O blood group in Brazilian patients suffering from chronic active gastritis and peptic ulcers.Clinical Analysis Department School of Pharmaceutical Sciences São Paulo State University UNESP, Araraquara, São Paulo StateRegional Blood Center of São José do Rio Preto Regional Medical School Foundation FUNFARME, São José do Rio Preto, São Paulo StateImmunogenetics Laboratory Molecular Biology Department São José do Rio Preto Medical School FAMERP, São José do Rio Preto, São Paulo StateBiology Department Institute of Biosciences Letters and Exact Sciences São Paulo State University UNESP, São José do Rio Preto, São Paulo StateSpecialized Gastroenterology Laboratory Base Hospital FUNFARME, São José do Rio Preto, São Paulo StateClinical Analysis Department School of Pharmaceutical Sciences São Paulo State University UNESP, Araraquara, São Paulo StateBiology Department Institute of Biosciences Letters and Exact Sciences São Paulo State University UNESP, São José do Rio Preto, São Paulo StateUniversidade Estadual Paulista (UNESP)FUNFARMEFAMERPMattos, D. E. [UNESP]Cintra, J. R.Brandão de Mattos, C. C.Nakashima, F. [UNESP]Silva, R. C.M.A.Moreira, H. W. [UNESP]de Mattos, L. C.2022-04-28T21:00:54Z2022-04-28T21:00:54Z2010-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article87-95http://dx.doi.org/10.1590/S1678-91992010005000004Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 16, n. 1, p. 87-95, 2010.1678-9199http://hdl.handle.net/11449/22582510.1590/S1678-919920100050000042-s2.0-77950801470Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Venomous Animals and Toxins Including Tropical Diseasesinfo:eu-repo/semantics/openAccess2022-04-28T21:00:54Zoai:repositorio.unesp.br:11449/225825Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-28T21:00:54Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Abo blood groups and helicobacter pylori cagA infection: Evidence of an association
title Abo blood groups and helicobacter pylori cagA infection: Evidence of an association
spellingShingle Abo blood groups and helicobacter pylori cagA infection: Evidence of an association
Mattos, D. E. [UNESP]
ABO blood groups
CagA strain
Chronic active gastritis
H. pylori infection
Peptic ulcers
title_short Abo blood groups and helicobacter pylori cagA infection: Evidence of an association
title_full Abo blood groups and helicobacter pylori cagA infection: Evidence of an association
title_fullStr Abo blood groups and helicobacter pylori cagA infection: Evidence of an association
title_full_unstemmed Abo blood groups and helicobacter pylori cagA infection: Evidence of an association
title_sort Abo blood groups and helicobacter pylori cagA infection: Evidence of an association
author Mattos, D. E. [UNESP]
author_facet Mattos, D. E. [UNESP]
Cintra, J. R.
Brandão de Mattos, C. C.
Nakashima, F. [UNESP]
Silva, R. C.M.A.
Moreira, H. W. [UNESP]
de Mattos, L. C.
author_role author
author2 Cintra, J. R.
Brandão de Mattos, C. C.
Nakashima, F. [UNESP]
Silva, R. C.M.A.
Moreira, H. W. [UNESP]
de Mattos, L. C.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
FUNFARME
FAMERP
dc.contributor.author.fl_str_mv Mattos, D. E. [UNESP]
Cintra, J. R.
Brandão de Mattos, C. C.
Nakashima, F. [UNESP]
Silva, R. C.M.A.
Moreira, H. W. [UNESP]
de Mattos, L. C.
dc.subject.por.fl_str_mv ABO blood groups
CagA strain
Chronic active gastritis
H. pylori infection
Peptic ulcers
topic ABO blood groups
CagA strain
Chronic active gastritis
H. pylori infection
Peptic ulcers
description Diseases resulting from Helicobacter pylori infection appear to be dependent on a host of genetic traits and virulence factors possessed by this microorganism. This paper aimed to investigate the association between the ABO histo-blood groups and H. pylori cagA infections. Genomic DNA samples (n = 110) of gastric biopsies obtained from patients with endoscopic diagnosis of peptic ulcers (n = 25) and chronic active gastritis (n = 85) were analyzed by PCR using specific primers for the cagA gene. Of the samples, 66.4% (n = 73) tested positive and 33.6% (n = 37) negative for the gene. The cagA strain was predominant in peptic ulcers (n = 21; 84.0%) compared with chronic active gastritis (n = 52; 61.2%) (p = 0.05; OR 3.332; 95% CI: 1.050-10.576). Additionally, the cagA strain was prevalent in the type O blood (48/63; 76.2%) compared with other ABO phenotypes (25/47; 53.2%) (p = 0.01; OR 2.816; 95% CI: 1.246-6.364). These results suggest that H. pylori cagA infection is associated with the O blood group in Brazilian patients suffering from chronic active gastritis and peptic ulcers.
publishDate 2010
dc.date.none.fl_str_mv 2010-01-01
2022-04-28T21:00:54Z
2022-04-28T21:00:54Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1678-91992010005000004
Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 16, n. 1, p. 87-95, 2010.
1678-9199
http://hdl.handle.net/11449/225825
10.1590/S1678-91992010005000004
2-s2.0-77950801470
url http://dx.doi.org/10.1590/S1678-91992010005000004
http://hdl.handle.net/11449/225825
identifier_str_mv Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 16, n. 1, p. 87-95, 2010.
1678-9199
10.1590/S1678-91992010005000004
2-s2.0-77950801470
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Venomous Animals and Toxins Including Tropical Diseases
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 87-95
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1799964465694769152

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