Abo blood groups and helicobacter pylori cagA infection: Evidence of an association
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S1678-91992010005000004 http://hdl.handle.net/11449/225825 |
Resumo: | Diseases resulting from Helicobacter pylori infection appear to be dependent on a host of genetic traits and virulence factors possessed by this microorganism. This paper aimed to investigate the association between the ABO histo-blood groups and H. pylori cagA infections. Genomic DNA samples (n = 110) of gastric biopsies obtained from patients with endoscopic diagnosis of peptic ulcers (n = 25) and chronic active gastritis (n = 85) were analyzed by PCR using specific primers for the cagA gene. Of the samples, 66.4% (n = 73) tested positive and 33.6% (n = 37) negative for the gene. The cagA strain was predominant in peptic ulcers (n = 21; 84.0%) compared with chronic active gastritis (n = 52; 61.2%) (p = 0.05; OR 3.332; 95% CI: 1.050-10.576). Additionally, the cagA strain was prevalent in the type O blood (48/63; 76.2%) compared with other ABO phenotypes (25/47; 53.2%) (p = 0.01; OR 2.816; 95% CI: 1.246-6.364). These results suggest that H. pylori cagA infection is associated with the O blood group in Brazilian patients suffering from chronic active gastritis and peptic ulcers. |
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Abo blood groups and helicobacter pylori cagA infection: Evidence of an associationABO blood groupsCagA strainChronic active gastritisH. pylori infectionPeptic ulcersDiseases resulting from Helicobacter pylori infection appear to be dependent on a host of genetic traits and virulence factors possessed by this microorganism. This paper aimed to investigate the association between the ABO histo-blood groups and H. pylori cagA infections. Genomic DNA samples (n = 110) of gastric biopsies obtained from patients with endoscopic diagnosis of peptic ulcers (n = 25) and chronic active gastritis (n = 85) were analyzed by PCR using specific primers for the cagA gene. Of the samples, 66.4% (n = 73) tested positive and 33.6% (n = 37) negative for the gene. The cagA strain was predominant in peptic ulcers (n = 21; 84.0%) compared with chronic active gastritis (n = 52; 61.2%) (p = 0.05; OR 3.332; 95% CI: 1.050-10.576). Additionally, the cagA strain was prevalent in the type O blood (48/63; 76.2%) compared with other ABO phenotypes (25/47; 53.2%) (p = 0.01; OR 2.816; 95% CI: 1.246-6.364). These results suggest that H. pylori cagA infection is associated with the O blood group in Brazilian patients suffering from chronic active gastritis and peptic ulcers.Clinical Analysis Department School of Pharmaceutical Sciences São Paulo State University UNESP, Araraquara, São Paulo StateRegional Blood Center of São José do Rio Preto Regional Medical School Foundation FUNFARME, São José do Rio Preto, São Paulo StateImmunogenetics Laboratory Molecular Biology Department São José do Rio Preto Medical School FAMERP, São José do Rio Preto, São Paulo StateBiology Department Institute of Biosciences Letters and Exact Sciences São Paulo State University UNESP, São José do Rio Preto, São Paulo StateSpecialized Gastroenterology Laboratory Base Hospital FUNFARME, São José do Rio Preto, São Paulo StateClinical Analysis Department School of Pharmaceutical Sciences São Paulo State University UNESP, Araraquara, São Paulo StateBiology Department Institute of Biosciences Letters and Exact Sciences São Paulo State University UNESP, São José do Rio Preto, São Paulo StateUniversidade Estadual Paulista (UNESP)FUNFARMEFAMERPMattos, D. E. [UNESP]Cintra, J. R.Brandão de Mattos, C. C.Nakashima, F. [UNESP]Silva, R. C.M.A.Moreira, H. W. [UNESP]de Mattos, L. C.2022-04-28T21:00:54Z2022-04-28T21:00:54Z2010-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article87-95http://dx.doi.org/10.1590/S1678-91992010005000004Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 16, n. 1, p. 87-95, 2010.1678-9199http://hdl.handle.net/11449/22582510.1590/S1678-919920100050000042-s2.0-77950801470Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Venomous Animals and Toxins Including Tropical Diseasesinfo:eu-repo/semantics/openAccess2024-06-21T15:18:15Zoai:repositorio.unesp.br:11449/225825Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:13:35.220965Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Abo blood groups and helicobacter pylori cagA infection: Evidence of an association |
title |
Abo blood groups and helicobacter pylori cagA infection: Evidence of an association |
spellingShingle |
Abo blood groups and helicobacter pylori cagA infection: Evidence of an association Mattos, D. E. [UNESP] ABO blood groups CagA strain Chronic active gastritis H. pylori infection Peptic ulcers |
title_short |
Abo blood groups and helicobacter pylori cagA infection: Evidence of an association |
title_full |
Abo blood groups and helicobacter pylori cagA infection: Evidence of an association |
title_fullStr |
Abo blood groups and helicobacter pylori cagA infection: Evidence of an association |
title_full_unstemmed |
Abo blood groups and helicobacter pylori cagA infection: Evidence of an association |
title_sort |
Abo blood groups and helicobacter pylori cagA infection: Evidence of an association |
author |
Mattos, D. E. [UNESP] |
author_facet |
Mattos, D. E. [UNESP] Cintra, J. R. Brandão de Mattos, C. C. Nakashima, F. [UNESP] Silva, R. C.M.A. Moreira, H. W. [UNESP] de Mattos, L. C. |
author_role |
author |
author2 |
Cintra, J. R. Brandão de Mattos, C. C. Nakashima, F. [UNESP] Silva, R. C.M.A. Moreira, H. W. [UNESP] de Mattos, L. C. |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) FUNFARME FAMERP |
dc.contributor.author.fl_str_mv |
Mattos, D. E. [UNESP] Cintra, J. R. Brandão de Mattos, C. C. Nakashima, F. [UNESP] Silva, R. C.M.A. Moreira, H. W. [UNESP] de Mattos, L. C. |
dc.subject.por.fl_str_mv |
ABO blood groups CagA strain Chronic active gastritis H. pylori infection Peptic ulcers |
topic |
ABO blood groups CagA strain Chronic active gastritis H. pylori infection Peptic ulcers |
description |
Diseases resulting from Helicobacter pylori infection appear to be dependent on a host of genetic traits and virulence factors possessed by this microorganism. This paper aimed to investigate the association between the ABO histo-blood groups and H. pylori cagA infections. Genomic DNA samples (n = 110) of gastric biopsies obtained from patients with endoscopic diagnosis of peptic ulcers (n = 25) and chronic active gastritis (n = 85) were analyzed by PCR using specific primers for the cagA gene. Of the samples, 66.4% (n = 73) tested positive and 33.6% (n = 37) negative for the gene. The cagA strain was predominant in peptic ulcers (n = 21; 84.0%) compared with chronic active gastritis (n = 52; 61.2%) (p = 0.05; OR 3.332; 95% CI: 1.050-10.576). Additionally, the cagA strain was prevalent in the type O blood (48/63; 76.2%) compared with other ABO phenotypes (25/47; 53.2%) (p = 0.01; OR 2.816; 95% CI: 1.246-6.364). These results suggest that H. pylori cagA infection is associated with the O blood group in Brazilian patients suffering from chronic active gastritis and peptic ulcers. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-01-01 2022-04-28T21:00:54Z 2022-04-28T21:00:54Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1678-91992010005000004 Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 16, n. 1, p. 87-95, 2010. 1678-9199 http://hdl.handle.net/11449/225825 10.1590/S1678-91992010005000004 2-s2.0-77950801470 |
url |
http://dx.doi.org/10.1590/S1678-91992010005000004 http://hdl.handle.net/11449/225825 |
identifier_str_mv |
Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 16, n. 1, p. 87-95, 2010. 1678-9199 10.1590/S1678-91992010005000004 2-s2.0-77950801470 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Venomous Animals and Toxins Including Tropical Diseases |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
87-95 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128334040662016 |