Engineering microbial living therapeutics

Detalhes bibliográficos
Autor(a) principal: Pedrolli, Danielle B. [UNESP]
Data de Publicação: 2019
Outros Autores: Ribeiro, Nathan V. [UNESP], Squizato, Patrick N. [UNESP], Cozetto, Daniel A. [UNESP], De Jesus, Victor N. [UNESP], Freire, Paulo J.C. [UNESP], Lins, Milca R.C.R. [UNESP], Correa, Graciely G. [UNESP]
Tipo de documento: Capítulo de livro
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/B978-0-12-819178-1.00008-3
http://hdl.handle.net/11449/205350
Resumo: A vast microbial community lives on and within the human body. Recent advances in microbiome studies have shown how some living bacteria can positively influence human health. The findings have raised interest in engineering indigenous human microbes to produce and deliver vaccines, drugs, and immunomodulators directly in or on the patient’s body, targeting a range of human diseases. Engineered living microorganisms are the next generation of therapeutics, programmed to diagnose and treat infections, tumors, metabolic disorders, and neurological diseases. This disruptive treatment approach is now nearing the clinic. This chapter will cover the most recent synthetic biology tools and approaches for engineering microbes as living therapeutics. Moreover, some technical and safety issues will be addressed.
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spelling Engineering microbial living therapeuticsDesigner probioticsDrug deliveryEngineered microorganismsHuman microbiomeLiving therapeuticsSynthetic biologyA vast microbial community lives on and within the human body. Recent advances in microbiome studies have shown how some living bacteria can positively influence human health. The findings have raised interest in engineering indigenous human microbes to produce and deliver vaccines, drugs, and immunomodulators directly in or on the patient’s body, targeting a range of human diseases. Engineered living microorganisms are the next generation of therapeutics, programmed to diagnose and treat infections, tumors, metabolic disorders, and neurological diseases. This disruptive treatment approach is now nearing the clinic. This chapter will cover the most recent synthetic biology tools and approaches for engineering microbes as living therapeutics. Moreover, some technical and safety issues will be addressed.São Paulo State University (UNESP) School of Pharmaceutical Sciences Department of Bioprocess and BiotechnologySão Paulo State University (UNESP)São Paulo State University (UNESP) School of Pharmaceutical Sciences Department of Bioprocess and BiotechnologySão Paulo State University (UNESP)Universidade Estadual Paulista (Unesp)Pedrolli, Danielle B. [UNESP]Ribeiro, Nathan V. [UNESP]Squizato, Patrick N. [UNESP]Cozetto, Daniel A. [UNESP]De Jesus, Victor N. [UNESP]Freire, Paulo J.C. [UNESP]Lins, Milca R.C.R. [UNESP]Correa, Graciely G. [UNESP]2021-06-25T10:13:52Z2021-06-25T10:13:52Z2019-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bookPart71-82http://dx.doi.org/10.1016/B978-0-12-819178-1.00008-3Precision Medicine for Investigators, Practitioners and Providers, p. 71-82.http://hdl.handle.net/11449/20535010.1016/B978-0-12-819178-1.00008-32-s2.0-85093476402Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPrecision Medicine for Investigators, Practitioners and Providersinfo:eu-repo/semantics/openAccess2021-10-23T12:39:36Zoai:repositorio.unesp.br:11449/205350Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:18:28.096564Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Engineering microbial living therapeutics
title Engineering microbial living therapeutics
spellingShingle Engineering microbial living therapeutics
Pedrolli, Danielle B. [UNESP]
Designer probiotics
Drug delivery
Engineered microorganisms
Human microbiome
Living therapeutics
Synthetic biology
title_short Engineering microbial living therapeutics
title_full Engineering microbial living therapeutics
title_fullStr Engineering microbial living therapeutics
title_full_unstemmed Engineering microbial living therapeutics
title_sort Engineering microbial living therapeutics
author Pedrolli, Danielle B. [UNESP]
author_facet Pedrolli, Danielle B. [UNESP]
Ribeiro, Nathan V. [UNESP]
Squizato, Patrick N. [UNESP]
Cozetto, Daniel A. [UNESP]
De Jesus, Victor N. [UNESP]
Freire, Paulo J.C. [UNESP]
Lins, Milca R.C.R. [UNESP]
Correa, Graciely G. [UNESP]
author_role author
author2 Ribeiro, Nathan V. [UNESP]
Squizato, Patrick N. [UNESP]
Cozetto, Daniel A. [UNESP]
De Jesus, Victor N. [UNESP]
Freire, Paulo J.C. [UNESP]
Lins, Milca R.C.R. [UNESP]
Correa, Graciely G. [UNESP]
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Pedrolli, Danielle B. [UNESP]
Ribeiro, Nathan V. [UNESP]
Squizato, Patrick N. [UNESP]
Cozetto, Daniel A. [UNESP]
De Jesus, Victor N. [UNESP]
Freire, Paulo J.C. [UNESP]
Lins, Milca R.C.R. [UNESP]
Correa, Graciely G. [UNESP]
dc.subject.por.fl_str_mv Designer probiotics
Drug delivery
Engineered microorganisms
Human microbiome
Living therapeutics
Synthetic biology
topic Designer probiotics
Drug delivery
Engineered microorganisms
Human microbiome
Living therapeutics
Synthetic biology
description A vast microbial community lives on and within the human body. Recent advances in microbiome studies have shown how some living bacteria can positively influence human health. The findings have raised interest in engineering indigenous human microbes to produce and deliver vaccines, drugs, and immunomodulators directly in or on the patient’s body, targeting a range of human diseases. Engineered living microorganisms are the next generation of therapeutics, programmed to diagnose and treat infections, tumors, metabolic disorders, and neurological diseases. This disruptive treatment approach is now nearing the clinic. This chapter will cover the most recent synthetic biology tools and approaches for engineering microbes as living therapeutics. Moreover, some technical and safety issues will be addressed.
publishDate 2019
dc.date.none.fl_str_mv 2019-01-01
2021-06-25T10:13:52Z
2021-06-25T10:13:52Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/bookPart
format bookPart
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/B978-0-12-819178-1.00008-3
Precision Medicine for Investigators, Practitioners and Providers, p. 71-82.
http://hdl.handle.net/11449/205350
10.1016/B978-0-12-819178-1.00008-3
2-s2.0-85093476402
url http://dx.doi.org/10.1016/B978-0-12-819178-1.00008-3
http://hdl.handle.net/11449/205350
identifier_str_mv Precision Medicine for Investigators, Practitioners and Providers, p. 71-82.
10.1016/B978-0-12-819178-1.00008-3
2-s2.0-85093476402
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Precision Medicine for Investigators, Practitioners and Providers
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 71-82
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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