Low levels of sulfur and cobalt during the pre- and periconceptional periods affect the oocyte yield of donors and the DNA methylome of preimplantation bovine embryos
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1017/S2040174421000222 http://hdl.handle.net/11449/221740 |
Resumo: | Maternal nutrition is critical in mammalian development, influencing the epigenetic reprogramming of gametes, embryos, and fetal programming. We evaluated the effects of different levels of sulfur (S) and cobalt (Co) in the maternal diet throughout the pre- and periconceptional periods on the biochemical and reproductive parameters of the donors and the DNA methylome of the progeny in Bos indicus cattle. The low-S/Co group differed from the control with respect to homocysteine, folic acid, B12, insulin growth factor 1, and glucose. The oocyte yield was lower in heifers from the low S/Co group than that in the control heifers. Embryos from the low-S/Co group exhibited 2320 differentially methylated regions (DMRs) across the genome compared with the control embryos. We also characterized candidate DMRs linked to the DNMT1 and DNMT3B genes in the blood and sperm cells of the adult progeny. A DMR located in DNMT1 that was identified in embryos remained differentially methylated in the sperm of the progeny from the low-S/Co group. Therefore, we associated changes in specific compounds in the maternal diet with DNA methylation modifications in the progeny. Our results help to elucidate the impact of maternal nutrition on epigenetic reprogramming in livestock, opening new avenues of research to study the effect of disturbed epigenetic patterns in early life on health and fertility in adulthood. Considering that cattle are physiologically similar to humans with respect to gestational length, our study may serve as a model for studies related to the developmental origin of health and disease in humans. |
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Low levels of sulfur and cobalt during the pre- and periconceptional periods affect the oocyte yield of donors and the DNA methylome of preimplantation bovine embryosEpigeneticsintergenerational inheritancelivestockMaternal nutrition is critical in mammalian development, influencing the epigenetic reprogramming of gametes, embryos, and fetal programming. We evaluated the effects of different levels of sulfur (S) and cobalt (Co) in the maternal diet throughout the pre- and periconceptional periods on the biochemical and reproductive parameters of the donors and the DNA methylome of the progeny in Bos indicus cattle. The low-S/Co group differed from the control with respect to homocysteine, folic acid, B12, insulin growth factor 1, and glucose. The oocyte yield was lower in heifers from the low S/Co group than that in the control heifers. Embryos from the low-S/Co group exhibited 2320 differentially methylated regions (DMRs) across the genome compared with the control embryos. We also characterized candidate DMRs linked to the DNMT1 and DNMT3B genes in the blood and sperm cells of the adult progeny. A DMR located in DNMT1 that was identified in embryos remained differentially methylated in the sperm of the progeny from the low-S/Co group. Therefore, we associated changes in specific compounds in the maternal diet with DNA methylation modifications in the progeny. Our results help to elucidate the impact of maternal nutrition on epigenetic reprogramming in livestock, opening new avenues of research to study the effect of disturbed epigenetic patterns in early life on health and fertility in adulthood. Considering that cattle are physiologically similar to humans with respect to gestational length, our study may serve as a model for studies related to the developmental origin of health and disease in humans.Department of Animal Reproduction and Veterinary Radiology State University of São Paulo Júlio of Mesquita Filho Cosllege of Medicine Veterinary and Animal Science, São PauloEmbrapa Genetic Resources and Biotechnology, Distrito FederalInstitute of Genetics and Biochemistry Federal University of Uberlândia, Minas GeraisDepartment of Animal Science University of São Paulo, São PauloEmbrapa Cerrados, Distrito FederalCargill Animal Nutrition, São PauloAnimal Reproduction Laboratory College of Agronomy and Veterinary Medicine University of Brasilia, Distrito FederalSchool of Veterinary Medicine Federal University of Uberlândia, Minas GeraisDepartment of Animal Reproduction and Veterinary Radiology State University of São Paulo Júlio of Mesquita Filho Cosllege of Medicine Veterinary and Animal Science, São PauloUniversidade Estadual Paulista (UNESP)Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA)Universidade Federal de Uberlândia (UFU)Universidade de São Paulo (USP)Cargill Animal NutritionUniversity of BrasiliaNochi, Allice R. Ferreira [UNESP]Vargas, Luna N.Sartori, RobertoJúnior, Roberto G.Araújo, Davi B.Figueiredo, Ricardo A.Togawa, Roberto C.Costa, Marcos M. C.Grynberg, PriscilaMendonça, Anelise S.Kussano, Nayara R.Pivato, IvoSilva, Bianca D. M.Spricigo, José Felipe W.Leme, Ligiane O.Da Silva, Joseane P.Caetano, Alexandre R.Dode, Margot A. N.Franco, Maurício M.2022-04-28T19:40:12Z2022-04-28T19:40:12Z2022-04-04info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article231-243http://dx.doi.org/10.1017/S2040174421000222Journal of Developmental Origins of Health and Disease, v. 13, n. 2, p. 231-243, 2022.2040-17522040-1744http://hdl.handle.net/11449/22174010.1017/S20401744210002222-s2.0-85105701093Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Developmental Origins of Health and Diseaseinfo:eu-repo/semantics/openAccess2022-04-28T19:40:12Zoai:repositorio.unesp.br:11449/221740Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-28T19:40:12Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Low levels of sulfur and cobalt during the pre- and periconceptional periods affect the oocyte yield of donors and the DNA methylome of preimplantation bovine embryos |
title |
Low levels of sulfur and cobalt during the pre- and periconceptional periods affect the oocyte yield of donors and the DNA methylome of preimplantation bovine embryos |
spellingShingle |
Low levels of sulfur and cobalt during the pre- and periconceptional periods affect the oocyte yield of donors and the DNA methylome of preimplantation bovine embryos Nochi, Allice R. Ferreira [UNESP] Epigenetics intergenerational inheritance livestock |
title_short |
Low levels of sulfur and cobalt during the pre- and periconceptional periods affect the oocyte yield of donors and the DNA methylome of preimplantation bovine embryos |
title_full |
Low levels of sulfur and cobalt during the pre- and periconceptional periods affect the oocyte yield of donors and the DNA methylome of preimplantation bovine embryos |
title_fullStr |
Low levels of sulfur and cobalt during the pre- and periconceptional periods affect the oocyte yield of donors and the DNA methylome of preimplantation bovine embryos |
title_full_unstemmed |
Low levels of sulfur and cobalt during the pre- and periconceptional periods affect the oocyte yield of donors and the DNA methylome of preimplantation bovine embryos |
title_sort |
Low levels of sulfur and cobalt during the pre- and periconceptional periods affect the oocyte yield of donors and the DNA methylome of preimplantation bovine embryos |
author |
Nochi, Allice R. Ferreira [UNESP] |
author_facet |
Nochi, Allice R. Ferreira [UNESP] Vargas, Luna N. Sartori, Roberto Júnior, Roberto G. Araújo, Davi B. Figueiredo, Ricardo A. Togawa, Roberto C. Costa, Marcos M. C. Grynberg, Priscila Mendonça, Anelise S. Kussano, Nayara R. Pivato, Ivo Silva, Bianca D. M. Spricigo, José Felipe W. Leme, Ligiane O. Da Silva, Joseane P. Caetano, Alexandre R. Dode, Margot A. N. Franco, Maurício M. |
author_role |
author |
author2 |
Vargas, Luna N. Sartori, Roberto Júnior, Roberto G. Araújo, Davi B. Figueiredo, Ricardo A. Togawa, Roberto C. Costa, Marcos M. C. Grynberg, Priscila Mendonça, Anelise S. Kussano, Nayara R. Pivato, Ivo Silva, Bianca D. M. Spricigo, José Felipe W. Leme, Ligiane O. Da Silva, Joseane P. Caetano, Alexandre R. Dode, Margot A. N. Franco, Maurício M. |
author2_role |
author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA) Universidade Federal de Uberlândia (UFU) Universidade de São Paulo (USP) Cargill Animal Nutrition University of Brasilia |
dc.contributor.author.fl_str_mv |
Nochi, Allice R. Ferreira [UNESP] Vargas, Luna N. Sartori, Roberto Júnior, Roberto G. Araújo, Davi B. Figueiredo, Ricardo A. Togawa, Roberto C. Costa, Marcos M. C. Grynberg, Priscila Mendonça, Anelise S. Kussano, Nayara R. Pivato, Ivo Silva, Bianca D. M. Spricigo, José Felipe W. Leme, Ligiane O. Da Silva, Joseane P. Caetano, Alexandre R. Dode, Margot A. N. Franco, Maurício M. |
dc.subject.por.fl_str_mv |
Epigenetics intergenerational inheritance livestock |
topic |
Epigenetics intergenerational inheritance livestock |
description |
Maternal nutrition is critical in mammalian development, influencing the epigenetic reprogramming of gametes, embryos, and fetal programming. We evaluated the effects of different levels of sulfur (S) and cobalt (Co) in the maternal diet throughout the pre- and periconceptional periods on the biochemical and reproductive parameters of the donors and the DNA methylome of the progeny in Bos indicus cattle. The low-S/Co group differed from the control with respect to homocysteine, folic acid, B12, insulin growth factor 1, and glucose. The oocyte yield was lower in heifers from the low S/Co group than that in the control heifers. Embryos from the low-S/Co group exhibited 2320 differentially methylated regions (DMRs) across the genome compared with the control embryos. We also characterized candidate DMRs linked to the DNMT1 and DNMT3B genes in the blood and sperm cells of the adult progeny. A DMR located in DNMT1 that was identified in embryos remained differentially methylated in the sperm of the progeny from the low-S/Co group. Therefore, we associated changes in specific compounds in the maternal diet with DNA methylation modifications in the progeny. Our results help to elucidate the impact of maternal nutrition on epigenetic reprogramming in livestock, opening new avenues of research to study the effect of disturbed epigenetic patterns in early life on health and fertility in adulthood. Considering that cattle are physiologically similar to humans with respect to gestational length, our study may serve as a model for studies related to the developmental origin of health and disease in humans. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-04-28T19:40:12Z 2022-04-28T19:40:12Z 2022-04-04 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1017/S2040174421000222 Journal of Developmental Origins of Health and Disease, v. 13, n. 2, p. 231-243, 2022. 2040-1752 2040-1744 http://hdl.handle.net/11449/221740 10.1017/S2040174421000222 2-s2.0-85105701093 |
url |
http://dx.doi.org/10.1017/S2040174421000222 http://hdl.handle.net/11449/221740 |
identifier_str_mv |
Journal of Developmental Origins of Health and Disease, v. 13, n. 2, p. 231-243, 2022. 2040-1752 2040-1744 10.1017/S2040174421000222 2-s2.0-85105701093 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Developmental Origins of Health and Disease |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
231-243 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1803649998825455616 |