Immunophenotypical and pathological changes in dogs experimentally infected with Ehrlichia canis
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S1984-29612022020 http://hdl.handle.net/11449/240831 |
Resumo: | Canine monocytic ehrlichiosis (CME) is one of the most important tick-borne diseases worldwide, with multisystemic presentations. Immune dysregulation has been proposed as the primary mechanism involved in its pathogenesis and in tissue injury in dogs with CME. Experimental infection of German Shepherd dogs in the present study demonstrated that CME caused marked pathological changes in their lymph nodes and spleen, and also gave rise to mononuclear infiltration in organs and tissues. Immunophenotyping of cells in lymph nodes, spleen and injured tissues highlighted differences in lymphocyte subsets, local expression of immunoglobulin subclasses and MHCII molecules between infected and control dogs. These findings suggest that the immunophenotypic and immunopathological changes in dogs with acute experimental CME are related to Th1 bias and compartmentalized immune response. |
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Immunophenotypical and pathological changes in dogs experimentally infected with Ehrlichia canisAlterações imunofenotípicas e patológicas em cães experimentalmente infectados por Ehrlichia caniscanineimmunityinfectionMonocytic ehrlichiosistick-borne diseaseCanine monocytic ehrlichiosis (CME) is one of the most important tick-borne diseases worldwide, with multisystemic presentations. Immune dysregulation has been proposed as the primary mechanism involved in its pathogenesis and in tissue injury in dogs with CME. Experimental infection of German Shepherd dogs in the present study demonstrated that CME caused marked pathological changes in their lymph nodes and spleen, and also gave rise to mononuclear infiltration in organs and tissues. Immunophenotyping of cells in lymph nodes, spleen and injured tissues highlighted differences in lymphocyte subsets, local expression of immunoglobulin subclasses and MHCII molecules between infected and control dogs. These findings suggest that the immunophenotypic and immunopathological changes in dogs with acute experimental CME are related to Th1 bias and compartmentalized immune response.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Laboratório de Patologia Veterinária Universidade de Brasília – UnBFaculdade de Medicina Veterinária Universidade Federal de Uberlândia – UFU, MGDepartamento de Medicina Veterinária Universidade do Estado de Santa Catarina – UDESC, SCClínica Veterinária Vets Pets, SPDepartamento de Patologia Reprodução e Saúde Única Faculdade Ciências Agrárias e Veterinárias – FCAV Universidade Estadual Paulista – UNESP, SPDepartamento de Clínica e Cirurgia Veterinária Faculdade Ciências Agrárias e Veterinárias – FCAV Universidade Estadual Paulista – UNESP, SPUniversidade de Sorocaba – UNISO, SPDepartamento de Patologia Reprodução e Saúde Única Faculdade Ciências Agrárias e Veterinárias – FCAV Universidade Estadual Paulista – UNESP, SPDepartamento de Clínica e Cirurgia Veterinária Faculdade Ciências Agrárias e Veterinárias – FCAV Universidade Estadual Paulista – UNESP, SPCAPES: 001Universidade de Brasília (UnB)Universidade Federal de Uberlândia (UFU)Universidade do Estado de Santa Catarina – UDESCClínica Veterinária Vets PetsUniversidade Estadual Paulista (UNESP)Universidade de Sorocaba – UNISOCastro, Márcio Botelho deSzabó, Matias Pablo JuanAquino, Lucia Padilha Cury Thomaz deDagnoni, Ana SilviaAlessi, Antonio Carlos [UNESP]Costa, Mirela Tinucci [UNESP]Nakaghi, Andréa Cristina HigaSanti, Mariele De [UNESP]Calchi, Ana Claúdia [UNESP]André, Marcos Rogério [UNESP]Machado, Rosangela Zacarias [UNESP]2023-03-01T20:34:41Z2023-03-01T20:34:41Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1590/S1984-29612022020Revista Brasileira de Parasitologia Veterinaria, v. 31, n. 2, 2022.1984-29610103-846Xhttp://hdl.handle.net/11449/24083110.1590/S1984-296120220202-s2.0-85128123573Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRevista Brasileira de Parasitologia Veterinariainfo:eu-repo/semantics/openAccess2024-06-07T13:02:16Zoai:repositorio.unesp.br:11449/240831Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:52:00.891539Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Immunophenotypical and pathological changes in dogs experimentally infected with Ehrlichia canis Alterações imunofenotípicas e patológicas em cães experimentalmente infectados por Ehrlichia canis |
title |
Immunophenotypical and pathological changes in dogs experimentally infected with Ehrlichia canis |
spellingShingle |
Immunophenotypical and pathological changes in dogs experimentally infected with Ehrlichia canis Castro, Márcio Botelho de canine immunity infection Monocytic ehrlichiosis tick-borne disease |
title_short |
Immunophenotypical and pathological changes in dogs experimentally infected with Ehrlichia canis |
title_full |
Immunophenotypical and pathological changes in dogs experimentally infected with Ehrlichia canis |
title_fullStr |
Immunophenotypical and pathological changes in dogs experimentally infected with Ehrlichia canis |
title_full_unstemmed |
Immunophenotypical and pathological changes in dogs experimentally infected with Ehrlichia canis |
title_sort |
Immunophenotypical and pathological changes in dogs experimentally infected with Ehrlichia canis |
author |
Castro, Márcio Botelho de |
author_facet |
Castro, Márcio Botelho de Szabó, Matias Pablo Juan Aquino, Lucia Padilha Cury Thomaz de Dagnoni, Ana Silvia Alessi, Antonio Carlos [UNESP] Costa, Mirela Tinucci [UNESP] Nakaghi, Andréa Cristina Higa Santi, Mariele De [UNESP] Calchi, Ana Claúdia [UNESP] André, Marcos Rogério [UNESP] Machado, Rosangela Zacarias [UNESP] |
author_role |
author |
author2 |
Szabó, Matias Pablo Juan Aquino, Lucia Padilha Cury Thomaz de Dagnoni, Ana Silvia Alessi, Antonio Carlos [UNESP] Costa, Mirela Tinucci [UNESP] Nakaghi, Andréa Cristina Higa Santi, Mariele De [UNESP] Calchi, Ana Claúdia [UNESP] André, Marcos Rogério [UNESP] Machado, Rosangela Zacarias [UNESP] |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de Brasília (UnB) Universidade Federal de Uberlândia (UFU) Universidade do Estado de Santa Catarina – UDESC Clínica Veterinária Vets Pets Universidade Estadual Paulista (UNESP) Universidade de Sorocaba – UNISO |
dc.contributor.author.fl_str_mv |
Castro, Márcio Botelho de Szabó, Matias Pablo Juan Aquino, Lucia Padilha Cury Thomaz de Dagnoni, Ana Silvia Alessi, Antonio Carlos [UNESP] Costa, Mirela Tinucci [UNESP] Nakaghi, Andréa Cristina Higa Santi, Mariele De [UNESP] Calchi, Ana Claúdia [UNESP] André, Marcos Rogério [UNESP] Machado, Rosangela Zacarias [UNESP] |
dc.subject.por.fl_str_mv |
canine immunity infection Monocytic ehrlichiosis tick-borne disease |
topic |
canine immunity infection Monocytic ehrlichiosis tick-borne disease |
description |
Canine monocytic ehrlichiosis (CME) is one of the most important tick-borne diseases worldwide, with multisystemic presentations. Immune dysregulation has been proposed as the primary mechanism involved in its pathogenesis and in tissue injury in dogs with CME. Experimental infection of German Shepherd dogs in the present study demonstrated that CME caused marked pathological changes in their lymph nodes and spleen, and also gave rise to mononuclear infiltration in organs and tissues. Immunophenotyping of cells in lymph nodes, spleen and injured tissues highlighted differences in lymphocyte subsets, local expression of immunoglobulin subclasses and MHCII molecules between infected and control dogs. These findings suggest that the immunophenotypic and immunopathological changes in dogs with acute experimental CME are related to Th1 bias and compartmentalized immune response. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-01 2023-03-01T20:34:41Z 2023-03-01T20:34:41Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1984-29612022020 Revista Brasileira de Parasitologia Veterinaria, v. 31, n. 2, 2022. 1984-2961 0103-846X http://hdl.handle.net/11449/240831 10.1590/S1984-29612022020 2-s2.0-85128123573 |
url |
http://dx.doi.org/10.1590/S1984-29612022020 http://hdl.handle.net/11449/240831 |
identifier_str_mv |
Revista Brasileira de Parasitologia Veterinaria, v. 31, n. 2, 2022. 1984-2961 0103-846X 10.1590/S1984-29612022020 2-s2.0-85128123573 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Revista Brasileira de Parasitologia Veterinaria |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128868616241152 |