Immunophenotypical and pathological changes in dogs experimentally infected with Ehrlichia canis

Detalhes bibliográficos
Autor(a) principal: Castro, Márcio Botelho de
Data de Publicação: 2022
Outros Autores: Szabó, Matias Pablo Juan, Aquino, Lucia Padilha Cury Thomaz de, Dagnoni, Ana Silvia, Alessi, Antonio Carlos [UNESP], Costa, Mirela Tinucci [UNESP], Nakaghi, Andréa Cristina Higa, Santi, Mariele De [UNESP], Calchi, Ana Claúdia [UNESP], André, Marcos Rogério [UNESP], Machado, Rosangela Zacarias [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S1984-29612022020
http://hdl.handle.net/11449/240831
Resumo: Canine monocytic ehrlichiosis (CME) is one of the most important tick-borne diseases worldwide, with multisystemic presentations. Immune dysregulation has been proposed as the primary mechanism involved in its pathogenesis and in tissue injury in dogs with CME. Experimental infection of German Shepherd dogs in the present study demonstrated that CME caused marked pathological changes in their lymph nodes and spleen, and also gave rise to mononuclear infiltration in organs and tissues. Immunophenotyping of cells in lymph nodes, spleen and injured tissues highlighted differences in lymphocyte subsets, local expression of immunoglobulin subclasses and MHCII molecules between infected and control dogs. These findings suggest that the immunophenotypic and immunopathological changes in dogs with acute experimental CME are related to Th1 bias and compartmentalized immune response.
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spelling Immunophenotypical and pathological changes in dogs experimentally infected with Ehrlichia canisAlterações imunofenotípicas e patológicas em cães experimentalmente infectados por Ehrlichia caniscanineimmunityinfectionMonocytic ehrlichiosistick-borne diseaseCanine monocytic ehrlichiosis (CME) is one of the most important tick-borne diseases worldwide, with multisystemic presentations. Immune dysregulation has been proposed as the primary mechanism involved in its pathogenesis and in tissue injury in dogs with CME. Experimental infection of German Shepherd dogs in the present study demonstrated that CME caused marked pathological changes in their lymph nodes and spleen, and also gave rise to mononuclear infiltration in organs and tissues. Immunophenotyping of cells in lymph nodes, spleen and injured tissues highlighted differences in lymphocyte subsets, local expression of immunoglobulin subclasses and MHCII molecules between infected and control dogs. These findings suggest that the immunophenotypic and immunopathological changes in dogs with acute experimental CME are related to Th1 bias and compartmentalized immune response.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Laboratório de Patologia Veterinária Universidade de Brasília – UnBFaculdade de Medicina Veterinária Universidade Federal de Uberlândia – UFU, MGDepartamento de Medicina Veterinária Universidade do Estado de Santa Catarina – UDESC, SCClínica Veterinária Vets Pets, SPDepartamento de Patologia Reprodução e Saúde Única Faculdade Ciências Agrárias e Veterinárias – FCAV Universidade Estadual Paulista – UNESP, SPDepartamento de Clínica e Cirurgia Veterinária Faculdade Ciências Agrárias e Veterinárias – FCAV Universidade Estadual Paulista – UNESP, SPUniversidade de Sorocaba – UNISO, SPDepartamento de Patologia Reprodução e Saúde Única Faculdade Ciências Agrárias e Veterinárias – FCAV Universidade Estadual Paulista – UNESP, SPDepartamento de Clínica e Cirurgia Veterinária Faculdade Ciências Agrárias e Veterinárias – FCAV Universidade Estadual Paulista – UNESP, SPCAPES: 001Universidade de Brasília (UnB)Universidade Federal de Uberlândia (UFU)Universidade do Estado de Santa Catarina – UDESCClínica Veterinária Vets PetsUniversidade Estadual Paulista (UNESP)Universidade de Sorocaba – UNISOCastro, Márcio Botelho deSzabó, Matias Pablo JuanAquino, Lucia Padilha Cury Thomaz deDagnoni, Ana SilviaAlessi, Antonio Carlos [UNESP]Costa, Mirela Tinucci [UNESP]Nakaghi, Andréa Cristina HigaSanti, Mariele De [UNESP]Calchi, Ana Claúdia [UNESP]André, Marcos Rogério [UNESP]Machado, Rosangela Zacarias [UNESP]2023-03-01T20:34:41Z2023-03-01T20:34:41Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1590/S1984-29612022020Revista Brasileira de Parasitologia Veterinaria, v. 31, n. 2, 2022.1984-29610103-846Xhttp://hdl.handle.net/11449/24083110.1590/S1984-296120220202-s2.0-85128123573Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRevista Brasileira de Parasitologia Veterinariainfo:eu-repo/semantics/openAccess2023-03-01T20:34:42Zoai:repositorio.unesp.br:11449/240831Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-03-01T20:34:42Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Immunophenotypical and pathological changes in dogs experimentally infected with Ehrlichia canis
Alterações imunofenotípicas e patológicas em cães experimentalmente infectados por Ehrlichia canis
title Immunophenotypical and pathological changes in dogs experimentally infected with Ehrlichia canis
spellingShingle Immunophenotypical and pathological changes in dogs experimentally infected with Ehrlichia canis
Castro, Márcio Botelho de
canine
immunity
infection
Monocytic ehrlichiosis
tick-borne disease
title_short Immunophenotypical and pathological changes in dogs experimentally infected with Ehrlichia canis
title_full Immunophenotypical and pathological changes in dogs experimentally infected with Ehrlichia canis
title_fullStr Immunophenotypical and pathological changes in dogs experimentally infected with Ehrlichia canis
title_full_unstemmed Immunophenotypical and pathological changes in dogs experimentally infected with Ehrlichia canis
title_sort Immunophenotypical and pathological changes in dogs experimentally infected with Ehrlichia canis
author Castro, Márcio Botelho de
author_facet Castro, Márcio Botelho de
Szabó, Matias Pablo Juan
Aquino, Lucia Padilha Cury Thomaz de
Dagnoni, Ana Silvia
Alessi, Antonio Carlos [UNESP]
Costa, Mirela Tinucci [UNESP]
Nakaghi, Andréa Cristina Higa
Santi, Mariele De [UNESP]
Calchi, Ana Claúdia [UNESP]
André, Marcos Rogério [UNESP]
Machado, Rosangela Zacarias [UNESP]
author_role author
author2 Szabó, Matias Pablo Juan
Aquino, Lucia Padilha Cury Thomaz de
Dagnoni, Ana Silvia
Alessi, Antonio Carlos [UNESP]
Costa, Mirela Tinucci [UNESP]
Nakaghi, Andréa Cristina Higa
Santi, Mariele De [UNESP]
Calchi, Ana Claúdia [UNESP]
André, Marcos Rogério [UNESP]
Machado, Rosangela Zacarias [UNESP]
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de Brasília (UnB)
Universidade Federal de Uberlândia (UFU)
Universidade do Estado de Santa Catarina – UDESC
Clínica Veterinária Vets Pets
Universidade Estadual Paulista (UNESP)
Universidade de Sorocaba – UNISO
dc.contributor.author.fl_str_mv Castro, Márcio Botelho de
Szabó, Matias Pablo Juan
Aquino, Lucia Padilha Cury Thomaz de
Dagnoni, Ana Silvia
Alessi, Antonio Carlos [UNESP]
Costa, Mirela Tinucci [UNESP]
Nakaghi, Andréa Cristina Higa
Santi, Mariele De [UNESP]
Calchi, Ana Claúdia [UNESP]
André, Marcos Rogério [UNESP]
Machado, Rosangela Zacarias [UNESP]
dc.subject.por.fl_str_mv canine
immunity
infection
Monocytic ehrlichiosis
tick-borne disease
topic canine
immunity
infection
Monocytic ehrlichiosis
tick-borne disease
description Canine monocytic ehrlichiosis (CME) is one of the most important tick-borne diseases worldwide, with multisystemic presentations. Immune dysregulation has been proposed as the primary mechanism involved in its pathogenesis and in tissue injury in dogs with CME. Experimental infection of German Shepherd dogs in the present study demonstrated that CME caused marked pathological changes in their lymph nodes and spleen, and also gave rise to mononuclear infiltration in organs and tissues. Immunophenotyping of cells in lymph nodes, spleen and injured tissues highlighted differences in lymphocyte subsets, local expression of immunoglobulin subclasses and MHCII molecules between infected and control dogs. These findings suggest that the immunophenotypic and immunopathological changes in dogs with acute experimental CME are related to Th1 bias and compartmentalized immune response.
publishDate 2022
dc.date.none.fl_str_mv 2022-01-01
2023-03-01T20:34:41Z
2023-03-01T20:34:41Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1984-29612022020
Revista Brasileira de Parasitologia Veterinaria, v. 31, n. 2, 2022.
1984-2961
0103-846X
http://hdl.handle.net/11449/240831
10.1590/S1984-29612022020
2-s2.0-85128123573
url http://dx.doi.org/10.1590/S1984-29612022020
http://hdl.handle.net/11449/240831
identifier_str_mv Revista Brasileira de Parasitologia Veterinaria, v. 31, n. 2, 2022.
1984-2961
0103-846X
10.1590/S1984-29612022020
2-s2.0-85128123573
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Revista Brasileira de Parasitologia Veterinaria
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1799964958708989952

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