Influence of different types of corticosteroids on heart rate variability of individuals with duchenne muscular dystrophy—a pilot cross sectional study

Detalhes bibliográficos
Autor(a) principal: Dias, Rodrigo Martins
Data de Publicação: 2021
Outros Autores: Hoshi, Rosangela Akemi, Vanderlei, Luiz Carlos Marques [UNESP], Monteiro, Carlos Bandeira de Mello, Alvarez, Mayra Priscila Boscolo, Crocetta, Tânia Brusque, Grossklauss, Luis Fernando, Fernani, Deborah Cristina Gonçalves Luiz, Dantas, Maria Tereza Artero Prado, Martins, Fabiana Paula Almeida, Garner, David M., Abreu, Luiz Carlos, Ferreira, Celso, da Silva, Talita Dias
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.3390/life11080752
http://hdl.handle.net/11449/229252
Resumo: Individuals with Duchenne Muscular Dystrophy (DMD) have an impairment of cardiac autonomic function categorized by parasympathetic reduction and sympathetic predominance. The objective of this study was to assess the cardiac autonomic modulation of individuals with DMD undergoing therapy with Prednisone/Prednisolone and Deflazacort and compare with individuals with DMD without the use of these medications and a typically developed control group. Methods: A cross-sectional study was completed, wherein 40 boys were evaluated. The four treatment groups were: Deflazacort; Prednisone/Prednisolone; no corticoid use; and typical development. Heart Rate Variability (HRV) was investigated via linear indices (Time Domain and Frequency Domain) and non-linear indices Results: The results of this study revealed that individuals with DMD undertaking pharmacotherapies with Prednisolone demonstrated HRV comparable to the Control Typically Developed (CTD) group. In contrast, individuals with DMD undergoing pharmacotherapies with Deflazacort achieved lower HRV, akin to individuals with DMD without any medications, as demonstrated in the metrics: RMSSD; LF (n.u.), HF (n.u.), LF/HF; SD1, α1, and α1/α2, and a significant effect for SD1/SD2; %DET and Ratio; Shannon Entropy, 0 V%, 2 LV% and 2 ULV%. Conclusions: Corticosteroids have the potential to affect the cardiac autonomic modulation in adolescents with DMD. The use of Prednisone/Prednisolone appears to promote improved responses in terms of sympathovagal activity as opposed to Deflazacort.
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spelling Influence of different types of corticosteroids on heart rate variability of individuals with duchenne muscular dystrophy—a pilot cross sectional studyAutonomic nervous systemDeflazacortDuchenne muscular dystrophy (DMD)Heart rate variability (HRV)PrednisoneIndividuals with Duchenne Muscular Dystrophy (DMD) have an impairment of cardiac autonomic function categorized by parasympathetic reduction and sympathetic predominance. The objective of this study was to assess the cardiac autonomic modulation of individuals with DMD undergoing therapy with Prednisone/Prednisolone and Deflazacort and compare with individuals with DMD without the use of these medications and a typically developed control group. Methods: A cross-sectional study was completed, wherein 40 boys were evaluated. The four treatment groups were: Deflazacort; Prednisone/Prednisolone; no corticoid use; and typical development. Heart Rate Variability (HRV) was investigated via linear indices (Time Domain and Frequency Domain) and non-linear indices Results: The results of this study revealed that individuals with DMD undertaking pharmacotherapies with Prednisolone demonstrated HRV comparable to the Control Typically Developed (CTD) group. In contrast, individuals with DMD undergoing pharmacotherapies with Deflazacort achieved lower HRV, akin to individuals with DMD without any medications, as demonstrated in the metrics: RMSSD; LF (n.u.), HF (n.u.), LF/HF; SD1, α1, and α1/α2, and a significant effect for SD1/SD2; %DET and Ratio; Shannon Entropy, 0 V%, 2 LV% and 2 ULV%. Conclusions: Corticosteroids have the potential to affect the cardiac autonomic modulation in adolescents with DMD. The use of Prednisone/Prednisolone appears to promote improved responses in terms of sympathovagal activity as opposed to Deflazacort.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Paulista School of Medicine Federal University of São Paulo (EPM/UNIFESP)Cardiology Department Brigham and Women’s HospitalDepartment of Physiotherapy Faculty of Science and Technology FCT/UNESPFaculty of Medicine University of São Paulo (FMUSP)Department of Health Sciences Anhanguera College-Campus of JundiaíLaboratório de Psicologia do Esporte e do Exercício Centro de Ciências da Saúde e do Esporte Universidade do Estado de Santa CatarinaDepartment of Neurology/Neurosurgery Neuropediatrist at the Federal University of São PauloDepartment of Health Sciences University of Western Paulista (UNOESTE)Study Design and Scientific Writing Laboratory ABC Medical School (FMABC)Cardiorespiratory Research Group Department of Biological and Medical Sciences Faculty of Health and Life Sciences Oxford Brookes University, Headington Campus, Gipsy LaneDepartment of Integrated Health Education Federal University of Espírito Santo (UFES)Faculty of Medicine University of Sao Paulo City (UNICID)Department of Physiotherapy Faculty of Science and Technology FCT/UNESPFAPESP: 2011/07277-2FAPESP: 2013/00175-5FAPESP: 2016/08358-0FAPESP: 2017/24991-7CNPq: 442456/2016-6Universidade de São Paulo (USP)Brigham and Women’s HospitalUniversidade Estadual Paulista (UNESP)Anhanguera College-Campus of JundiaíUniversidade do Estado de Santa CatarinaUniversity of Western Paulista (UNOESTE)ABC Medical School (FMABC)Oxford Brookes UniversityFederal University of Espírito Santo (UFES)Dias, Rodrigo MartinsHoshi, Rosangela AkemiVanderlei, Luiz Carlos Marques [UNESP]Monteiro, Carlos Bandeira de MelloAlvarez, Mayra Priscila BoscoloCrocetta, Tânia BrusqueGrossklauss, Luis FernandoFernani, Deborah Cristina Gonçalves LuizDantas, Maria Tereza Artero PradoMartins, Fabiana Paula AlmeidaGarner, David M.Abreu, Luiz CarlosFerreira, Celsoda Silva, Talita Dias2022-04-29T08:31:25Z2022-04-29T08:31:25Z2021-08-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/life11080752Life, v. 11, n. 8, 2021.2075-1729http://hdl.handle.net/11449/22925210.3390/life110807522-s2.0-85111723229Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengLifeinfo:eu-repo/semantics/openAccess2024-06-18T18:44:28Zoai:repositorio.unesp.br:11449/229252Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:24:46.743786Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Influence of different types of corticosteroids on heart rate variability of individuals with duchenne muscular dystrophy—a pilot cross sectional study
title Influence of different types of corticosteroids on heart rate variability of individuals with duchenne muscular dystrophy—a pilot cross sectional study
spellingShingle Influence of different types of corticosteroids on heart rate variability of individuals with duchenne muscular dystrophy—a pilot cross sectional study
Dias, Rodrigo Martins
Autonomic nervous system
Deflazacort
Duchenne muscular dystrophy (DMD)
Heart rate variability (HRV)
Prednisone
title_short Influence of different types of corticosteroids on heart rate variability of individuals with duchenne muscular dystrophy—a pilot cross sectional study
title_full Influence of different types of corticosteroids on heart rate variability of individuals with duchenne muscular dystrophy—a pilot cross sectional study
title_fullStr Influence of different types of corticosteroids on heart rate variability of individuals with duchenne muscular dystrophy—a pilot cross sectional study
title_full_unstemmed Influence of different types of corticosteroids on heart rate variability of individuals with duchenne muscular dystrophy—a pilot cross sectional study
title_sort Influence of different types of corticosteroids on heart rate variability of individuals with duchenne muscular dystrophy—a pilot cross sectional study
author Dias, Rodrigo Martins
author_facet Dias, Rodrigo Martins
Hoshi, Rosangela Akemi
Vanderlei, Luiz Carlos Marques [UNESP]
Monteiro, Carlos Bandeira de Mello
Alvarez, Mayra Priscila Boscolo
Crocetta, Tânia Brusque
Grossklauss, Luis Fernando
Fernani, Deborah Cristina Gonçalves Luiz
Dantas, Maria Tereza Artero Prado
Martins, Fabiana Paula Almeida
Garner, David M.
Abreu, Luiz Carlos
Ferreira, Celso
da Silva, Talita Dias
author_role author
author2 Hoshi, Rosangela Akemi
Vanderlei, Luiz Carlos Marques [UNESP]
Monteiro, Carlos Bandeira de Mello
Alvarez, Mayra Priscila Boscolo
Crocetta, Tânia Brusque
Grossklauss, Luis Fernando
Fernani, Deborah Cristina Gonçalves Luiz
Dantas, Maria Tereza Artero Prado
Martins, Fabiana Paula Almeida
Garner, David M.
Abreu, Luiz Carlos
Ferreira, Celso
da Silva, Talita Dias
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
Brigham and Women’s Hospital
Universidade Estadual Paulista (UNESP)
Anhanguera College-Campus of Jundiaí
Universidade do Estado de Santa Catarina
University of Western Paulista (UNOESTE)
ABC Medical School (FMABC)
Oxford Brookes University
Federal University of Espírito Santo (UFES)
dc.contributor.author.fl_str_mv Dias, Rodrigo Martins
Hoshi, Rosangela Akemi
Vanderlei, Luiz Carlos Marques [UNESP]
Monteiro, Carlos Bandeira de Mello
Alvarez, Mayra Priscila Boscolo
Crocetta, Tânia Brusque
Grossklauss, Luis Fernando
Fernani, Deborah Cristina Gonçalves Luiz
Dantas, Maria Tereza Artero Prado
Martins, Fabiana Paula Almeida
Garner, David M.
Abreu, Luiz Carlos
Ferreira, Celso
da Silva, Talita Dias
dc.subject.por.fl_str_mv Autonomic nervous system
Deflazacort
Duchenne muscular dystrophy (DMD)
Heart rate variability (HRV)
Prednisone
topic Autonomic nervous system
Deflazacort
Duchenne muscular dystrophy (DMD)
Heart rate variability (HRV)
Prednisone
description Individuals with Duchenne Muscular Dystrophy (DMD) have an impairment of cardiac autonomic function categorized by parasympathetic reduction and sympathetic predominance. The objective of this study was to assess the cardiac autonomic modulation of individuals with DMD undergoing therapy with Prednisone/Prednisolone and Deflazacort and compare with individuals with DMD without the use of these medications and a typically developed control group. Methods: A cross-sectional study was completed, wherein 40 boys were evaluated. The four treatment groups were: Deflazacort; Prednisone/Prednisolone; no corticoid use; and typical development. Heart Rate Variability (HRV) was investigated via linear indices (Time Domain and Frequency Domain) and non-linear indices Results: The results of this study revealed that individuals with DMD undertaking pharmacotherapies with Prednisolone demonstrated HRV comparable to the Control Typically Developed (CTD) group. In contrast, individuals with DMD undergoing pharmacotherapies with Deflazacort achieved lower HRV, akin to individuals with DMD without any medications, as demonstrated in the metrics: RMSSD; LF (n.u.), HF (n.u.), LF/HF; SD1, α1, and α1/α2, and a significant effect for SD1/SD2; %DET and Ratio; Shannon Entropy, 0 V%, 2 LV% and 2 ULV%. Conclusions: Corticosteroids have the potential to affect the cardiac autonomic modulation in adolescents with DMD. The use of Prednisone/Prednisolone appears to promote improved responses in terms of sympathovagal activity as opposed to Deflazacort.
publishDate 2021
dc.date.none.fl_str_mv 2021-08-01
2022-04-29T08:31:25Z
2022-04-29T08:31:25Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.3390/life11080752
Life, v. 11, n. 8, 2021.
2075-1729
http://hdl.handle.net/11449/229252
10.3390/life11080752
2-s2.0-85111723229
url http://dx.doi.org/10.3390/life11080752
http://hdl.handle.net/11449/229252
identifier_str_mv Life, v. 11, n. 8, 2021.
2075-1729
10.3390/life11080752
2-s2.0-85111723229
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Life
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
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