Influence of different types of corticosteroids on heart rate variability of individuals with duchenne muscular dystrophy—a pilot cross sectional study
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3390/life11080752 http://hdl.handle.net/11449/229252 |
Resumo: | Individuals with Duchenne Muscular Dystrophy (DMD) have an impairment of cardiac autonomic function categorized by parasympathetic reduction and sympathetic predominance. The objective of this study was to assess the cardiac autonomic modulation of individuals with DMD undergoing therapy with Prednisone/Prednisolone and Deflazacort and compare with individuals with DMD without the use of these medications and a typically developed control group. Methods: A cross-sectional study was completed, wherein 40 boys were evaluated. The four treatment groups were: Deflazacort; Prednisone/Prednisolone; no corticoid use; and typical development. Heart Rate Variability (HRV) was investigated via linear indices (Time Domain and Frequency Domain) and non-linear indices Results: The results of this study revealed that individuals with DMD undertaking pharmacotherapies with Prednisolone demonstrated HRV comparable to the Control Typically Developed (CTD) group. In contrast, individuals with DMD undergoing pharmacotherapies with Deflazacort achieved lower HRV, akin to individuals with DMD without any medications, as demonstrated in the metrics: RMSSD; LF (n.u.), HF (n.u.), LF/HF; SD1, α1, and α1/α2, and a significant effect for SD1/SD2; %DET and Ratio; Shannon Entropy, 0 V%, 2 LV% and 2 ULV%. Conclusions: Corticosteroids have the potential to affect the cardiac autonomic modulation in adolescents with DMD. The use of Prednisone/Prednisolone appears to promote improved responses in terms of sympathovagal activity as opposed to Deflazacort. |
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Influence of different types of corticosteroids on heart rate variability of individuals with duchenne muscular dystrophy—a pilot cross sectional studyAutonomic nervous systemDeflazacortDuchenne muscular dystrophy (DMD)Heart rate variability (HRV)PrednisoneIndividuals with Duchenne Muscular Dystrophy (DMD) have an impairment of cardiac autonomic function categorized by parasympathetic reduction and sympathetic predominance. The objective of this study was to assess the cardiac autonomic modulation of individuals with DMD undergoing therapy with Prednisone/Prednisolone and Deflazacort and compare with individuals with DMD without the use of these medications and a typically developed control group. Methods: A cross-sectional study was completed, wherein 40 boys were evaluated. The four treatment groups were: Deflazacort; Prednisone/Prednisolone; no corticoid use; and typical development. Heart Rate Variability (HRV) was investigated via linear indices (Time Domain and Frequency Domain) and non-linear indices Results: The results of this study revealed that individuals with DMD undertaking pharmacotherapies with Prednisolone demonstrated HRV comparable to the Control Typically Developed (CTD) group. In contrast, individuals with DMD undergoing pharmacotherapies with Deflazacort achieved lower HRV, akin to individuals with DMD without any medications, as demonstrated in the metrics: RMSSD; LF (n.u.), HF (n.u.), LF/HF; SD1, α1, and α1/α2, and a significant effect for SD1/SD2; %DET and Ratio; Shannon Entropy, 0 V%, 2 LV% and 2 ULV%. Conclusions: Corticosteroids have the potential to affect the cardiac autonomic modulation in adolescents with DMD. The use of Prednisone/Prednisolone appears to promote improved responses in terms of sympathovagal activity as opposed to Deflazacort.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Paulista School of Medicine Federal University of São Paulo (EPM/UNIFESP)Cardiology Department Brigham and Women’s HospitalDepartment of Physiotherapy Faculty of Science and Technology FCT/UNESPFaculty of Medicine University of São Paulo (FMUSP)Department of Health Sciences Anhanguera College-Campus of JundiaíLaboratório de Psicologia do Esporte e do Exercício Centro de Ciências da Saúde e do Esporte Universidade do Estado de Santa CatarinaDepartment of Neurology/Neurosurgery Neuropediatrist at the Federal University of São PauloDepartment of Health Sciences University of Western Paulista (UNOESTE)Study Design and Scientific Writing Laboratory ABC Medical School (FMABC)Cardiorespiratory Research Group Department of Biological and Medical Sciences Faculty of Health and Life Sciences Oxford Brookes University, Headington Campus, Gipsy LaneDepartment of Integrated Health Education Federal University of Espírito Santo (UFES)Faculty of Medicine University of Sao Paulo City (UNICID)Department of Physiotherapy Faculty of Science and Technology FCT/UNESPFAPESP: 2011/07277-2FAPESP: 2013/00175-5FAPESP: 2016/08358-0FAPESP: 2017/24991-7CNPq: 442456/2016-6Universidade de São Paulo (USP)Brigham and Women’s HospitalUniversidade Estadual Paulista (UNESP)Anhanguera College-Campus of JundiaíUniversidade do Estado de Santa CatarinaUniversity of Western Paulista (UNOESTE)ABC Medical School (FMABC)Oxford Brookes UniversityFederal University of Espírito Santo (UFES)Dias, Rodrigo MartinsHoshi, Rosangela AkemiVanderlei, Luiz Carlos Marques [UNESP]Monteiro, Carlos Bandeira de MelloAlvarez, Mayra Priscila BoscoloCrocetta, Tânia BrusqueGrossklauss, Luis FernandoFernani, Deborah Cristina Gonçalves LuizDantas, Maria Tereza Artero PradoMartins, Fabiana Paula AlmeidaGarner, David M.Abreu, Luiz CarlosFerreira, Celsoda Silva, Talita Dias2022-04-29T08:31:25Z2022-04-29T08:31:25Z2021-08-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/life11080752Life, v. 11, n. 8, 2021.2075-1729http://hdl.handle.net/11449/22925210.3390/life110807522-s2.0-85111723229Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengLifeinfo:eu-repo/semantics/openAccess2024-06-18T18:44:28Zoai:repositorio.unesp.br:11449/229252Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T22:24:46.743786Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Influence of different types of corticosteroids on heart rate variability of individuals with duchenne muscular dystrophy—a pilot cross sectional study |
title |
Influence of different types of corticosteroids on heart rate variability of individuals with duchenne muscular dystrophy—a pilot cross sectional study |
spellingShingle |
Influence of different types of corticosteroids on heart rate variability of individuals with duchenne muscular dystrophy—a pilot cross sectional study Dias, Rodrigo Martins Autonomic nervous system Deflazacort Duchenne muscular dystrophy (DMD) Heart rate variability (HRV) Prednisone |
title_short |
Influence of different types of corticosteroids on heart rate variability of individuals with duchenne muscular dystrophy—a pilot cross sectional study |
title_full |
Influence of different types of corticosteroids on heart rate variability of individuals with duchenne muscular dystrophy—a pilot cross sectional study |
title_fullStr |
Influence of different types of corticosteroids on heart rate variability of individuals with duchenne muscular dystrophy—a pilot cross sectional study |
title_full_unstemmed |
Influence of different types of corticosteroids on heart rate variability of individuals with duchenne muscular dystrophy—a pilot cross sectional study |
title_sort |
Influence of different types of corticosteroids on heart rate variability of individuals with duchenne muscular dystrophy—a pilot cross sectional study |
author |
Dias, Rodrigo Martins |
author_facet |
Dias, Rodrigo Martins Hoshi, Rosangela Akemi Vanderlei, Luiz Carlos Marques [UNESP] Monteiro, Carlos Bandeira de Mello Alvarez, Mayra Priscila Boscolo Crocetta, Tânia Brusque Grossklauss, Luis Fernando Fernani, Deborah Cristina Gonçalves Luiz Dantas, Maria Tereza Artero Prado Martins, Fabiana Paula Almeida Garner, David M. Abreu, Luiz Carlos Ferreira, Celso da Silva, Talita Dias |
author_role |
author |
author2 |
Hoshi, Rosangela Akemi Vanderlei, Luiz Carlos Marques [UNESP] Monteiro, Carlos Bandeira de Mello Alvarez, Mayra Priscila Boscolo Crocetta, Tânia Brusque Grossklauss, Luis Fernando Fernani, Deborah Cristina Gonçalves Luiz Dantas, Maria Tereza Artero Prado Martins, Fabiana Paula Almeida Garner, David M. Abreu, Luiz Carlos Ferreira, Celso da Silva, Talita Dias |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Brigham and Women’s Hospital Universidade Estadual Paulista (UNESP) Anhanguera College-Campus of Jundiaí Universidade do Estado de Santa Catarina University of Western Paulista (UNOESTE) ABC Medical School (FMABC) Oxford Brookes University Federal University of Espírito Santo (UFES) |
dc.contributor.author.fl_str_mv |
Dias, Rodrigo Martins Hoshi, Rosangela Akemi Vanderlei, Luiz Carlos Marques [UNESP] Monteiro, Carlos Bandeira de Mello Alvarez, Mayra Priscila Boscolo Crocetta, Tânia Brusque Grossklauss, Luis Fernando Fernani, Deborah Cristina Gonçalves Luiz Dantas, Maria Tereza Artero Prado Martins, Fabiana Paula Almeida Garner, David M. Abreu, Luiz Carlos Ferreira, Celso da Silva, Talita Dias |
dc.subject.por.fl_str_mv |
Autonomic nervous system Deflazacort Duchenne muscular dystrophy (DMD) Heart rate variability (HRV) Prednisone |
topic |
Autonomic nervous system Deflazacort Duchenne muscular dystrophy (DMD) Heart rate variability (HRV) Prednisone |
description |
Individuals with Duchenne Muscular Dystrophy (DMD) have an impairment of cardiac autonomic function categorized by parasympathetic reduction and sympathetic predominance. The objective of this study was to assess the cardiac autonomic modulation of individuals with DMD undergoing therapy with Prednisone/Prednisolone and Deflazacort and compare with individuals with DMD without the use of these medications and a typically developed control group. Methods: A cross-sectional study was completed, wherein 40 boys were evaluated. The four treatment groups were: Deflazacort; Prednisone/Prednisolone; no corticoid use; and typical development. Heart Rate Variability (HRV) was investigated via linear indices (Time Domain and Frequency Domain) and non-linear indices Results: The results of this study revealed that individuals with DMD undertaking pharmacotherapies with Prednisolone demonstrated HRV comparable to the Control Typically Developed (CTD) group. In contrast, individuals with DMD undergoing pharmacotherapies with Deflazacort achieved lower HRV, akin to individuals with DMD without any medications, as demonstrated in the metrics: RMSSD; LF (n.u.), HF (n.u.), LF/HF; SD1, α1, and α1/α2, and a significant effect for SD1/SD2; %DET and Ratio; Shannon Entropy, 0 V%, 2 LV% and 2 ULV%. Conclusions: Corticosteroids have the potential to affect the cardiac autonomic modulation in adolescents with DMD. The use of Prednisone/Prednisolone appears to promote improved responses in terms of sympathovagal activity as opposed to Deflazacort. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-08-01 2022-04-29T08:31:25Z 2022-04-29T08:31:25Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3390/life11080752 Life, v. 11, n. 8, 2021. 2075-1729 http://hdl.handle.net/11449/229252 10.3390/life11080752 2-s2.0-85111723229 |
url |
http://dx.doi.org/10.3390/life11080752 http://hdl.handle.net/11449/229252 |
identifier_str_mv |
Life, v. 11, n. 8, 2021. 2075-1729 10.3390/life11080752 2-s2.0-85111723229 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Life |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129425484546048 |