Autonomic modulation at rest and in response to postural change in adolescents with Duchenne muscular dystrophy: A cross-sectional study
Autor(a) principal: | |
---|---|
Data de Publicação: | 2021 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/0004-282X-ANP-2020-0458 http://hdl.handle.net/11449/233706 |
Resumo: | Background: Analysis of autonomic modulation after postural change may inform the prognosis and guide treatment in different populations. However, this has been insufficiently explored among adolescents with Duchenne muscular dystrophy (DMD). Objective: To investigate autonomic modulation at rest and in response to an active sitting test (AST) among adolescents with DMD. Methods: Fifty-nine adolescents were included in the study and divided into two groups: 1) DMD group: adolescents diagnosed with DMD; 2) control group (CG): healthy adolescents. Participants' weight and height were assessed. Lower limb function, motor limitations and functional abilities of the participants in the DMD group were classified using the Vignos scale, Egen classification and motor function measurement, respectively. The following variables were assessed before, during and after AST: systolic blood pressure (SBP), diastolic blood pressure (DBP), respiratory rate (f), oxygen saturation and heart rate (HR). To analyze the autonomic modulation, the HR was recorded beat-by-beat. Heart rate variability (HRV) indices were calculated in the time and frequency domains. Results: Differences in relation to groups were observed for all HRV indices, except LF/HF, oxygen saturation, HR and f (p < 0.05). Differences in relation to time and the interaction effect between group and time were observed for RMSSD, SD1, SD2, SD1/SD2, LFms2 and LFnu, HFun, SBP and DBP (p < 0.05). Differences in relation to time were also observed for the indice SDNN, FC and f (p < 0.05). Conclusions: Performing the AST promoted reduced autonomic modulation and increased SBP, DBP and HR in adolescents with DMD. |
id |
UNSP_bba3d50bce9cb819fa4b41f7a44c362e |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/233706 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Autonomic modulation at rest and in response to postural change in adolescents with Duchenne muscular dystrophy: A cross-sectional studyAutonomic nervous system diseasesDuchenneHeart rateMuscular dystrophyPostureBackground: Analysis of autonomic modulation after postural change may inform the prognosis and guide treatment in different populations. However, this has been insufficiently explored among adolescents with Duchenne muscular dystrophy (DMD). Objective: To investigate autonomic modulation at rest and in response to an active sitting test (AST) among adolescents with DMD. Methods: Fifty-nine adolescents were included in the study and divided into two groups: 1) DMD group: adolescents diagnosed with DMD; 2) control group (CG): healthy adolescents. Participants' weight and height were assessed. Lower limb function, motor limitations and functional abilities of the participants in the DMD group were classified using the Vignos scale, Egen classification and motor function measurement, respectively. The following variables were assessed before, during and after AST: systolic blood pressure (SBP), diastolic blood pressure (DBP), respiratory rate (f), oxygen saturation and heart rate (HR). To analyze the autonomic modulation, the HR was recorded beat-by-beat. Heart rate variability (HRV) indices were calculated in the time and frequency domains. Results: Differences in relation to groups were observed for all HRV indices, except LF/HF, oxygen saturation, HR and f (p < 0.05). Differences in relation to time and the interaction effect between group and time were observed for RMSSD, SD1, SD2, SD1/SD2, LFms2 and LFnu, HFun, SBP and DBP (p < 0.05). Differences in relation to time were also observed for the indice SDNN, FC and f (p < 0.05). Conclusions: Performing the AST promoted reduced autonomic modulation and increased SBP, DBP and HR in adolescents with DMD.Universidade Estadual Paulista Faculdade de Ciências e Tecnologia, SPUniversidade Federal de São Paulo Escola Paulista de Medicina, SPUniversidade Estadual Paulista Faculdade de Ciências e Tecnologia, SPUniversidade Estadual Paulista (UNESP)Universidade Federal de São Paulo (UNIFESP)Rodrigues, Mariana Viana [UNESP]Stoco-Oliveira, Mileide Cristina [UNESP]da Silva, Talita DiasFerreira, CelsoValente, Heloisa Balotari [UNESP]Vanzella, Laís Manata [UNESP]Vanderlei, Luiz Carlos Marques [UNESP]2022-05-01T09:47:21Z2022-05-01T09:47:21Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article766-773http://dx.doi.org/10.1590/0004-282X-ANP-2020-0458Arquivos de Neuro-Psiquiatria, v. 79, n. 9, p. 766-773, 2021.1678-42270004-282Xhttp://hdl.handle.net/11449/23370610.1590/0004-282X-ANP-2020-04582-s2.0-85117388669Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengArquivos de Neuro-Psiquiatriainfo:eu-repo/semantics/openAccess2024-06-18T18:43:50Zoai:repositorio.unesp.br:11449/233706Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:02:11.491250Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Autonomic modulation at rest and in response to postural change in adolescents with Duchenne muscular dystrophy: A cross-sectional study |
title |
Autonomic modulation at rest and in response to postural change in adolescents with Duchenne muscular dystrophy: A cross-sectional study |
spellingShingle |
Autonomic modulation at rest and in response to postural change in adolescents with Duchenne muscular dystrophy: A cross-sectional study Rodrigues, Mariana Viana [UNESP] Autonomic nervous system diseases Duchenne Heart rate Muscular dystrophy Posture |
title_short |
Autonomic modulation at rest and in response to postural change in adolescents with Duchenne muscular dystrophy: A cross-sectional study |
title_full |
Autonomic modulation at rest and in response to postural change in adolescents with Duchenne muscular dystrophy: A cross-sectional study |
title_fullStr |
Autonomic modulation at rest and in response to postural change in adolescents with Duchenne muscular dystrophy: A cross-sectional study |
title_full_unstemmed |
Autonomic modulation at rest and in response to postural change in adolescents with Duchenne muscular dystrophy: A cross-sectional study |
title_sort |
Autonomic modulation at rest and in response to postural change in adolescents with Duchenne muscular dystrophy: A cross-sectional study |
author |
Rodrigues, Mariana Viana [UNESP] |
author_facet |
Rodrigues, Mariana Viana [UNESP] Stoco-Oliveira, Mileide Cristina [UNESP] da Silva, Talita Dias Ferreira, Celso Valente, Heloisa Balotari [UNESP] Vanzella, Laís Manata [UNESP] Vanderlei, Luiz Carlos Marques [UNESP] |
author_role |
author |
author2 |
Stoco-Oliveira, Mileide Cristina [UNESP] da Silva, Talita Dias Ferreira, Celso Valente, Heloisa Balotari [UNESP] Vanzella, Laís Manata [UNESP] Vanderlei, Luiz Carlos Marques [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Rodrigues, Mariana Viana [UNESP] Stoco-Oliveira, Mileide Cristina [UNESP] da Silva, Talita Dias Ferreira, Celso Valente, Heloisa Balotari [UNESP] Vanzella, Laís Manata [UNESP] Vanderlei, Luiz Carlos Marques [UNESP] |
dc.subject.por.fl_str_mv |
Autonomic nervous system diseases Duchenne Heart rate Muscular dystrophy Posture |
topic |
Autonomic nervous system diseases Duchenne Heart rate Muscular dystrophy Posture |
description |
Background: Analysis of autonomic modulation after postural change may inform the prognosis and guide treatment in different populations. However, this has been insufficiently explored among adolescents with Duchenne muscular dystrophy (DMD). Objective: To investigate autonomic modulation at rest and in response to an active sitting test (AST) among adolescents with DMD. Methods: Fifty-nine adolescents were included in the study and divided into two groups: 1) DMD group: adolescents diagnosed with DMD; 2) control group (CG): healthy adolescents. Participants' weight and height were assessed. Lower limb function, motor limitations and functional abilities of the participants in the DMD group were classified using the Vignos scale, Egen classification and motor function measurement, respectively. The following variables were assessed before, during and after AST: systolic blood pressure (SBP), diastolic blood pressure (DBP), respiratory rate (f), oxygen saturation and heart rate (HR). To analyze the autonomic modulation, the HR was recorded beat-by-beat. Heart rate variability (HRV) indices were calculated in the time and frequency domains. Results: Differences in relation to groups were observed for all HRV indices, except LF/HF, oxygen saturation, HR and f (p < 0.05). Differences in relation to time and the interaction effect between group and time were observed for RMSSD, SD1, SD2, SD1/SD2, LFms2 and LFnu, HFun, SBP and DBP (p < 0.05). Differences in relation to time were also observed for the indice SDNN, FC and f (p < 0.05). Conclusions: Performing the AST promoted reduced autonomic modulation and increased SBP, DBP and HR in adolescents with DMD. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01 2022-05-01T09:47:21Z 2022-05-01T09:47:21Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/0004-282X-ANP-2020-0458 Arquivos de Neuro-Psiquiatria, v. 79, n. 9, p. 766-773, 2021. 1678-4227 0004-282X http://hdl.handle.net/11449/233706 10.1590/0004-282X-ANP-2020-0458 2-s2.0-85117388669 |
url |
http://dx.doi.org/10.1590/0004-282X-ANP-2020-0458 http://hdl.handle.net/11449/233706 |
identifier_str_mv |
Arquivos de Neuro-Psiquiatria, v. 79, n. 9, p. 766-773, 2021. 1678-4227 0004-282X 10.1590/0004-282X-ANP-2020-0458 2-s2.0-85117388669 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
766-773 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128742802849792 |