Studies of natural killer cells in patients with paracoccidioidomycosis
Autor(a) principal: | |
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Data de Publicação: | 1991 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1080/02681219180000601 http://hdl.handle.net/11449/227862 |
Resumo: | The number and activity of natural killer (NK) cells were studied in 34 untreated patients with paracoccidioidomycosis, 20 with the chronic form of the disease and 14 with the acute form. NK cells were detected with monoclonal antibody Leu-11c and the cytotoxic activity was measured using a single cell assay against K562 target cells. Both groups of patients had an increased number of circulating NK cells, their cytotoxic activity being significantly lower than in the healthy controls. These findings may be of importance in the immunological disturbances associated with paracoccidioidomycosis since NK cells exert important immune effector functions and may play a role in resistance against Paracoccidioides brasiliensis. © 1991 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted. |
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Studies of natural killer cells in patients with paracoccidioidomycosisThe number and activity of natural killer (NK) cells were studied in 34 untreated patients with paracoccidioidomycosis, 20 with the chronic form of the disease and 14 with the acute form. NK cells were detected with monoclonal antibody Leu-11c and the cytotoxic activity was measured using a single cell assay against K562 target cells. Both groups of patients had an increased number of circulating NK cells, their cytotoxic activity being significantly lower than in the healthy controls. These findings may be of importance in the immunological disturbances associated with paracoccidioidomycosis since NK cells exert important immune effector functions and may play a role in resistance against Paracoccidioides brasiliensis. © 1991 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.Department of Microbiology and Immunology, Institute of Biological Sciences, São Paulo State University (UNESP)Department of Infectious and Parasitologic Diseases, Dermatology and Radiology, School of Medicine, UNESP, Botucatu, São PauloDepartment of Microbiology and Immunology, Institute of Biological Sciences, São Paulo State University (UNESP)Department of Infectious and Parasitologic Diseases, Dermatology and Radiology, School of Medicine, UNESP, Botucatu, São PauloUniversidade Estadual Paulista (UNESP)Peraçoli, M. T.S. [UNESP]Soares, A. M.V.C. [UNESP]Mendes, R. P. [UNESP]Marques, S. A. [UNESP]Pereira, P. C.M. [UNESP]Rezkallah-Iwasso, M. T. [UNESP]2022-04-29T07:20:29Z2022-04-29T07:20:29Z1991-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article373-380http://dx.doi.org/10.1080/02681219180000601Medical Mycology, v. 29, n. 6, p. 373-380, 1991.1369-3786http://hdl.handle.net/11449/22786210.1080/026812191800006012-s2.0-84907133851Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMedical Mycologyinfo:eu-repo/semantics/openAccess2022-04-29T07:20:29Zoai:repositorio.unesp.br:11449/227862Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-29T07:20:29Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Studies of natural killer cells in patients with paracoccidioidomycosis |
title |
Studies of natural killer cells in patients with paracoccidioidomycosis |
spellingShingle |
Studies of natural killer cells in patients with paracoccidioidomycosis Peraçoli, M. T.S. [UNESP] |
title_short |
Studies of natural killer cells in patients with paracoccidioidomycosis |
title_full |
Studies of natural killer cells in patients with paracoccidioidomycosis |
title_fullStr |
Studies of natural killer cells in patients with paracoccidioidomycosis |
title_full_unstemmed |
Studies of natural killer cells in patients with paracoccidioidomycosis |
title_sort |
Studies of natural killer cells in patients with paracoccidioidomycosis |
author |
Peraçoli, M. T.S. [UNESP] |
author_facet |
Peraçoli, M. T.S. [UNESP] Soares, A. M.V.C. [UNESP] Mendes, R. P. [UNESP] Marques, S. A. [UNESP] Pereira, P. C.M. [UNESP] Rezkallah-Iwasso, M. T. [UNESP] |
author_role |
author |
author2 |
Soares, A. M.V.C. [UNESP] Mendes, R. P. [UNESP] Marques, S. A. [UNESP] Pereira, P. C.M. [UNESP] Rezkallah-Iwasso, M. T. [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Peraçoli, M. T.S. [UNESP] Soares, A. M.V.C. [UNESP] Mendes, R. P. [UNESP] Marques, S. A. [UNESP] Pereira, P. C.M. [UNESP] Rezkallah-Iwasso, M. T. [UNESP] |
description |
The number and activity of natural killer (NK) cells were studied in 34 untreated patients with paracoccidioidomycosis, 20 with the chronic form of the disease and 14 with the acute form. NK cells were detected with monoclonal antibody Leu-11c and the cytotoxic activity was measured using a single cell assay against K562 target cells. Both groups of patients had an increased number of circulating NK cells, their cytotoxic activity being significantly lower than in the healthy controls. These findings may be of importance in the immunological disturbances associated with paracoccidioidomycosis since NK cells exert important immune effector functions and may play a role in resistance against Paracoccidioides brasiliensis. © 1991 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted. |
publishDate |
1991 |
dc.date.none.fl_str_mv |
1991-01-01 2022-04-29T07:20:29Z 2022-04-29T07:20:29Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1080/02681219180000601 Medical Mycology, v. 29, n. 6, p. 373-380, 1991. 1369-3786 http://hdl.handle.net/11449/227862 10.1080/02681219180000601 2-s2.0-84907133851 |
url |
http://dx.doi.org/10.1080/02681219180000601 http://hdl.handle.net/11449/227862 |
identifier_str_mv |
Medical Mycology, v. 29, n. 6, p. 373-380, 1991. 1369-3786 10.1080/02681219180000601 2-s2.0-84907133851 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Medical Mycology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
373-380 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965515850973184 |