Potentially Probiotic Limosilactobacillus fermentum Fruit-Derived Strains Alleviate Cardiometabolic Disorders and Gut Microbiota Impairment in Male Rats Fed a High-Fat Diet
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s12602-021-09889-y http://hdl.handle.net/11449/223328 |
Resumo: | High-fat diet (HFD) consumption is a risk factor for dyslipidemias, insulin resistance, and arterial hypertension linked with gut dysbiosis. Probiotic administration has been suggested as a safe therapeutic strategy for gut microbiota modulation and treatment and/or prevention of cardiometabolic disorders. Here, we assessed the effects of a potentially probiotic formulation containing strains of the Limosilactobacillus (L.) fermentum 139, 263, and 296 on the cardiometabolic disorders and gut microbiota derangements provoked by the HFD consumption. Male Wistar rats were allocated into control diet (CTL, n = 6), HFD (n = 6), and HFD receiving L. fermentum formulation (HFD-LF, n = 6) groups for 4 weeks. L. fermentum formulation (109 colony-forming unit (CFU)/ml of each strain) was daily administered by oral gavage. After 4-week follow-up, biochemical measurements, blood pressure (BP), heart rate (HR), sympathetic tone, and gut microbiota composition were evaluated. HFD consumption for 4 weeks increased lipid profile, insulin resistance, sympathetic tone, and blood pressure and impaired gut microbiota composition in male rats. Administration of L. fermentum formulation improved the gut microbiota composition, lipid profile, insulin resistance, autonomic dysfunction, and BP in rats fed with a HFD. Administration of a potentially fruit-derived probiotic formulation of L. fermentum strains improved gut microbiota composition and alleviated hyperlipidemia, insulin resistance, and sympathetic hyperactivity and increased BP in rats fed a HFD. Our findings may encourage the development of randomized controlled trials to assess the effects of L. fermentum treatment in subjects with cardiometabolic disorders. |
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Potentially Probiotic Limosilactobacillus fermentum Fruit-Derived Strains Alleviate Cardiometabolic Disorders and Gut Microbiota Impairment in Male Rats Fed a High-Fat DietBlood pressureDyslipidemiaHigh-fat dietLimosilactobacillus fermentumProbioticHigh-fat diet (HFD) consumption is a risk factor for dyslipidemias, insulin resistance, and arterial hypertension linked with gut dysbiosis. Probiotic administration has been suggested as a safe therapeutic strategy for gut microbiota modulation and treatment and/or prevention of cardiometabolic disorders. Here, we assessed the effects of a potentially probiotic formulation containing strains of the Limosilactobacillus (L.) fermentum 139, 263, and 296 on the cardiometabolic disorders and gut microbiota derangements provoked by the HFD consumption. Male Wistar rats were allocated into control diet (CTL, n = 6), HFD (n = 6), and HFD receiving L. fermentum formulation (HFD-LF, n = 6) groups for 4 weeks. L. fermentum formulation (109 colony-forming unit (CFU)/ml of each strain) was daily administered by oral gavage. After 4-week follow-up, biochemical measurements, blood pressure (BP), heart rate (HR), sympathetic tone, and gut microbiota composition were evaluated. HFD consumption for 4 weeks increased lipid profile, insulin resistance, sympathetic tone, and blood pressure and impaired gut microbiota composition in male rats. Administration of L. fermentum formulation improved the gut microbiota composition, lipid profile, insulin resistance, autonomic dysfunction, and BP in rats fed with a HFD. Administration of a potentially fruit-derived probiotic formulation of L. fermentum strains improved gut microbiota composition and alleviated hyperlipidemia, insulin resistance, and sympathetic hyperactivity and increased BP in rats fed a HFD. Our findings may encourage the development of randomized controlled trials to assess the effects of L. fermentum treatment in subjects with cardiometabolic disorders.Department of Nutrition Health Sciences Center Federal University of Paraiba Campus I – Jd. Cidade UniversitáriaDepartment of Food Engineering Technology Center Federal University of ParaibaInstitute of Biosciences Department of General and Applied Biology São Paulo State University (UNESP)Research Resource Center Research Informatics Core University of Illinois at ChicagoDepartment of Biotechnology Biotechnology Center Federal University of ParaíbaInstitute of Biosciences Department of General and Applied Biology São Paulo State University (UNESP)Federal University of ParaibaUniversidade Estadual Paulista (UNESP)University of Illinois at ChicagoFederal University of Paraíbade Araújo Henriques Ferreira, GeorgiannaMagnani, MarcianeCabral, Lucélia [UNESP]Brandão, Larissa RamalhoNoronha, Melline Fontesde Campos Cruz, Josianede Souza, Evandro Leitede Brito Alves, José Luiz2022-04-28T19:50:02Z2022-04-28T19:50:02Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1007/s12602-021-09889-yProbiotics and Antimicrobial Proteins.1867-13141867-1306http://hdl.handle.net/11449/22332810.1007/s12602-021-09889-y2-s2.0-85123486040Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengProbiotics and Antimicrobial Proteinsinfo:eu-repo/semantics/openAccess2022-04-28T19:50:02Zoai:repositorio.unesp.br:11449/223328Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T13:45:09.975335Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Potentially Probiotic Limosilactobacillus fermentum Fruit-Derived Strains Alleviate Cardiometabolic Disorders and Gut Microbiota Impairment in Male Rats Fed a High-Fat Diet |
title |
Potentially Probiotic Limosilactobacillus fermentum Fruit-Derived Strains Alleviate Cardiometabolic Disorders and Gut Microbiota Impairment in Male Rats Fed a High-Fat Diet |
spellingShingle |
Potentially Probiotic Limosilactobacillus fermentum Fruit-Derived Strains Alleviate Cardiometabolic Disorders and Gut Microbiota Impairment in Male Rats Fed a High-Fat Diet de Araújo Henriques Ferreira, Georgianna Blood pressure Dyslipidemia High-fat diet Limosilactobacillus fermentum Probiotic |
title_short |
Potentially Probiotic Limosilactobacillus fermentum Fruit-Derived Strains Alleviate Cardiometabolic Disorders and Gut Microbiota Impairment in Male Rats Fed a High-Fat Diet |
title_full |
Potentially Probiotic Limosilactobacillus fermentum Fruit-Derived Strains Alleviate Cardiometabolic Disorders and Gut Microbiota Impairment in Male Rats Fed a High-Fat Diet |
title_fullStr |
Potentially Probiotic Limosilactobacillus fermentum Fruit-Derived Strains Alleviate Cardiometabolic Disorders and Gut Microbiota Impairment in Male Rats Fed a High-Fat Diet |
title_full_unstemmed |
Potentially Probiotic Limosilactobacillus fermentum Fruit-Derived Strains Alleviate Cardiometabolic Disorders and Gut Microbiota Impairment in Male Rats Fed a High-Fat Diet |
title_sort |
Potentially Probiotic Limosilactobacillus fermentum Fruit-Derived Strains Alleviate Cardiometabolic Disorders and Gut Microbiota Impairment in Male Rats Fed a High-Fat Diet |
author |
de Araújo Henriques Ferreira, Georgianna |
author_facet |
de Araújo Henriques Ferreira, Georgianna Magnani, Marciane Cabral, Lucélia [UNESP] Brandão, Larissa Ramalho Noronha, Melline Fontes de Campos Cruz, Josiane de Souza, Evandro Leite de Brito Alves, José Luiz |
author_role |
author |
author2 |
Magnani, Marciane Cabral, Lucélia [UNESP] Brandão, Larissa Ramalho Noronha, Melline Fontes de Campos Cruz, Josiane de Souza, Evandro Leite de Brito Alves, José Luiz |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Federal University of Paraiba Universidade Estadual Paulista (UNESP) University of Illinois at Chicago Federal University of Paraíba |
dc.contributor.author.fl_str_mv |
de Araújo Henriques Ferreira, Georgianna Magnani, Marciane Cabral, Lucélia [UNESP] Brandão, Larissa Ramalho Noronha, Melline Fontes de Campos Cruz, Josiane de Souza, Evandro Leite de Brito Alves, José Luiz |
dc.subject.por.fl_str_mv |
Blood pressure Dyslipidemia High-fat diet Limosilactobacillus fermentum Probiotic |
topic |
Blood pressure Dyslipidemia High-fat diet Limosilactobacillus fermentum Probiotic |
description |
High-fat diet (HFD) consumption is a risk factor for dyslipidemias, insulin resistance, and arterial hypertension linked with gut dysbiosis. Probiotic administration has been suggested as a safe therapeutic strategy for gut microbiota modulation and treatment and/or prevention of cardiometabolic disorders. Here, we assessed the effects of a potentially probiotic formulation containing strains of the Limosilactobacillus (L.) fermentum 139, 263, and 296 on the cardiometabolic disorders and gut microbiota derangements provoked by the HFD consumption. Male Wistar rats were allocated into control diet (CTL, n = 6), HFD (n = 6), and HFD receiving L. fermentum formulation (HFD-LF, n = 6) groups for 4 weeks. L. fermentum formulation (109 colony-forming unit (CFU)/ml of each strain) was daily administered by oral gavage. After 4-week follow-up, biochemical measurements, blood pressure (BP), heart rate (HR), sympathetic tone, and gut microbiota composition were evaluated. HFD consumption for 4 weeks increased lipid profile, insulin resistance, sympathetic tone, and blood pressure and impaired gut microbiota composition in male rats. Administration of L. fermentum formulation improved the gut microbiota composition, lipid profile, insulin resistance, autonomic dysfunction, and BP in rats fed with a HFD. Administration of a potentially fruit-derived probiotic formulation of L. fermentum strains improved gut microbiota composition and alleviated hyperlipidemia, insulin resistance, and sympathetic hyperactivity and increased BP in rats fed a HFD. Our findings may encourage the development of randomized controlled trials to assess the effects of L. fermentum treatment in subjects with cardiometabolic disorders. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-04-28T19:50:02Z 2022-04-28T19:50:02Z 2022-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s12602-021-09889-y Probiotics and Antimicrobial Proteins. 1867-1314 1867-1306 http://hdl.handle.net/11449/223328 10.1007/s12602-021-09889-y 2-s2.0-85123486040 |
url |
http://dx.doi.org/10.1007/s12602-021-09889-y http://hdl.handle.net/11449/223328 |
identifier_str_mv |
Probiotics and Antimicrobial Proteins. 1867-1314 1867-1306 10.1007/s12602-021-09889-y 2-s2.0-85123486040 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Probiotics and Antimicrobial Proteins |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128271073673216 |