Cytogenetic studies of Brazilian pediatric myelodysplastic syndrome cases: challenges and difficulties in a large and emerging country

Detalhes bibliográficos
Autor(a) principal: Velloso, E.D.R.P.
Data de Publicação: 2013
Outros Autores: Chauffaille, M.L., Peliçario, L.M., Tanizawa, R.S.S., Toledo, S.R.C., Gaiolla, Rafael Dezen [UNESP], Lopes, L.F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/1414-431X20122449
http://hdl.handle.net/11449/11516
Resumo: Myelodysplastic syndromes (MDS) and juvenile myelomonocytic leukemia (JMML) are rare hematopoietic stem cell diseases affecting children. Cytogenetics plays an important role in the diagnosis of these diseases. We report here the experience of the Cytogenetic Subcommittee of the Brazilian Cooperative Group on Pediatric Myelodysplastic Syndromes (BCG-MDS-PED). We analyzed 168 cytogenetic studies performed in 23 different cytogenetic centers; 84 of these studies were performed in patients with confirmed MDS (primary MDS, secondary MDS, JMML, and acute myeloid leukemia/MDS+Down syndrome). Clonal abnormalities were found in 36.9% of the MDS cases and cytogenetic studies were important for the detection of constitutional diseases and for differential diagnosis with other myeloid neoplasms. These data show the importance of the Cooperative Group for continuing education in order to avoid a late or wrong diagnosis.
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spelling Cytogenetic studies of Brazilian pediatric myelodysplastic syndrome cases: challenges and difficulties in a large and emerging countryChildhood myelodysplastic syndromesJuvenile myelomonocytic leukemiaCytogeneticsKaryotypeDiagnosisMyelodysplastic syndromes (MDS) and juvenile myelomonocytic leukemia (JMML) are rare hematopoietic stem cell diseases affecting children. Cytogenetics plays an important role in the diagnosis of these diseases. We report here the experience of the Cytogenetic Subcommittee of the Brazilian Cooperative Group on Pediatric Myelodysplastic Syndromes (BCG-MDS-PED). We analyzed 168 cytogenetic studies performed in 23 different cytogenetic centers; 84 of these studies were performed in patients with confirmed MDS (primary MDS, secondary MDS, JMML, and acute myeloid leukemia/MDS+Down syndrome). Clonal abnormalities were found in 36.9% of the MDS cases and cytogenetic studies were important for the detection of constitutional diseases and for differential diagnosis with other myeloid neoplasms. These data show the importance of the Cooperative Group for continuing education in order to avoid a late or wrong diagnosis.Universidade de São Paulo Faculdade de Medicina Departamento de HematologiaUniversidade Federal de São Paulo (UNIFESP) Departamento de HematologiaInstituto de Oncologia Pediátrica, Universidade Federal de São Paulo (UNIFESP)Universidade Estadual Paulista Faculdade de Medicina de Botucatu Departamento de Clínica MédicaHospital de Câncer de BarretosCentro de Tratamento Fabiana Macedo de Morais Grupo de Assistência à Criança com Câncer Grupo Cooperativo Brasileiro de Síndrome Mielodisplásica PediátricaUniversidade Estadual Paulista Faculdade de Medicina de Botucatu Departamento de Clínica MédicaAssociação Brasileira de Divulgação Científica (ABRADIC)Universidade de São Paulo (USP)Universidade Federal de São Paulo (UNIFESP)Universidade Estadual Paulista (Unesp)Hospital de Câncer de BarretosCentro de Tratamento Fabiana Macedo de Morais Grupo de Assistência à Criança com Câncer Grupo Cooperativo Brasileiro de Síndrome Mielodisplásica PediátricaVelloso, E.D.R.P.Chauffaille, M.L.Peliçario, L.M.Tanizawa, R.S.S.Toledo, S.R.C.Gaiolla, Rafael Dezen [UNESP]Lopes, L.F.2014-05-20T13:33:38Z2014-05-20T13:33:38Z2013-01-11info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article85-90application/pdfhttp://dx.doi.org/10.1590/1414-431X20122449Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 46, n. 1, p. 85-90, 2013.0100-879Xhttp://hdl.handle.net/11449/1151610.1590/1414-431X20122449S0100-879X2013000100085WOS:000316126700011S0100-879X2013000100085.pdfSciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Journal of Medical and Biological Research1.492info:eu-repo/semantics/openAccess2024-08-14T17:22:49Zoai:repositorio.unesp.br:11449/11516Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:22:49Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Cytogenetic studies of Brazilian pediatric myelodysplastic syndrome cases: challenges and difficulties in a large and emerging country
title Cytogenetic studies of Brazilian pediatric myelodysplastic syndrome cases: challenges and difficulties in a large and emerging country
spellingShingle Cytogenetic studies of Brazilian pediatric myelodysplastic syndrome cases: challenges and difficulties in a large and emerging country
Velloso, E.D.R.P.
Childhood myelodysplastic syndromes
Juvenile myelomonocytic leukemia
Cytogenetics
Karyotype
Diagnosis
title_short Cytogenetic studies of Brazilian pediatric myelodysplastic syndrome cases: challenges and difficulties in a large and emerging country
title_full Cytogenetic studies of Brazilian pediatric myelodysplastic syndrome cases: challenges and difficulties in a large and emerging country
title_fullStr Cytogenetic studies of Brazilian pediatric myelodysplastic syndrome cases: challenges and difficulties in a large and emerging country
title_full_unstemmed Cytogenetic studies of Brazilian pediatric myelodysplastic syndrome cases: challenges and difficulties in a large and emerging country
title_sort Cytogenetic studies of Brazilian pediatric myelodysplastic syndrome cases: challenges and difficulties in a large and emerging country
author Velloso, E.D.R.P.
author_facet Velloso, E.D.R.P.
Chauffaille, M.L.
Peliçario, L.M.
Tanizawa, R.S.S.
Toledo, S.R.C.
Gaiolla, Rafael Dezen [UNESP]
Lopes, L.F.
author_role author
author2 Chauffaille, M.L.
Peliçario, L.M.
Tanizawa, R.S.S.
Toledo, S.R.C.
Gaiolla, Rafael Dezen [UNESP]
Lopes, L.F.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Universidade Estadual Paulista (Unesp)
Hospital de Câncer de Barretos
Centro de Tratamento Fabiana Macedo de Morais Grupo de Assistência à Criança com Câncer Grupo Cooperativo Brasileiro de Síndrome Mielodisplásica Pediátrica
dc.contributor.author.fl_str_mv Velloso, E.D.R.P.
Chauffaille, M.L.
Peliçario, L.M.
Tanizawa, R.S.S.
Toledo, S.R.C.
Gaiolla, Rafael Dezen [UNESP]
Lopes, L.F.
dc.subject.por.fl_str_mv Childhood myelodysplastic syndromes
Juvenile myelomonocytic leukemia
Cytogenetics
Karyotype
Diagnosis
topic Childhood myelodysplastic syndromes
Juvenile myelomonocytic leukemia
Cytogenetics
Karyotype
Diagnosis
description Myelodysplastic syndromes (MDS) and juvenile myelomonocytic leukemia (JMML) are rare hematopoietic stem cell diseases affecting children. Cytogenetics plays an important role in the diagnosis of these diseases. We report here the experience of the Cytogenetic Subcommittee of the Brazilian Cooperative Group on Pediatric Myelodysplastic Syndromes (BCG-MDS-PED). We analyzed 168 cytogenetic studies performed in 23 different cytogenetic centers; 84 of these studies were performed in patients with confirmed MDS (primary MDS, secondary MDS, JMML, and acute myeloid leukemia/MDS+Down syndrome). Clonal abnormalities were found in 36.9% of the MDS cases and cytogenetic studies were important for the detection of constitutional diseases and for differential diagnosis with other myeloid neoplasms. These data show the importance of the Cooperative Group for continuing education in order to avoid a late or wrong diagnosis.
publishDate 2013
dc.date.none.fl_str_mv 2013-01-11
2014-05-20T13:33:38Z
2014-05-20T13:33:38Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/1414-431X20122449
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 46, n. 1, p. 85-90, 2013.
0100-879X
http://hdl.handle.net/11449/11516
10.1590/1414-431X20122449
S0100-879X2013000100085
WOS:000316126700011
S0100-879X2013000100085.pdf
url http://dx.doi.org/10.1590/1414-431X20122449
http://hdl.handle.net/11449/11516
identifier_str_mv Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 46, n. 1, p. 85-90, 2013.
0100-879X
10.1590/1414-431X20122449
S0100-879X2013000100085
WOS:000316126700011
S0100-879X2013000100085.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brazilian Journal of Medical and Biological Research
1.492
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 85-90
application/pdf
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica (ABRADIC)
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica (ABRADIC)
dc.source.none.fl_str_mv SciELO
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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