Immunomodulatory activities associated with beta-glucan derived from Saccharomyces cerevisiae
Autor(a) principal: | |
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Data de Publicação: | 2005 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://www.biomed.cas.cz/physiolres/2005/issue5/pelizon.htm http://hdl.handle.net/11449/33989 |
Resumo: | In this study we investigated the effect of beta-glucan derived from Saccharomyces cerevisiae on fungicidal activity, cytokine production and natural killer activity. Spleen and peritoneal cells from female C57BL/6 mice, previously injected (24 or 48 h) with 20 or 100 mu g of glucan by i.p. route, were assayed. In vivo mu-glucan administration primed spleen cells for a higher production of IL-12 and TNF-alpha when S. aureus was used as a stimulus. In addition, beta-glucan increased NK spleen cells activity against YAC target cells. Some immunomodulatory activities not yet described for beta-glucan were observed in this work. |
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Immunomodulatory activities associated with beta-glucan derived from Saccharomyces cerevisiaebeta-glucanIL-12TNF-alphaNK activityfungicidal activityIn this study we investigated the effect of beta-glucan derived from Saccharomyces cerevisiae on fungicidal activity, cytokine production and natural killer activity. Spleen and peritoneal cells from female C57BL/6 mice, previously injected (24 or 48 h) with 20 or 100 mu g of glucan by i.p. route, were assayed. In vivo mu-glucan administration primed spleen cells for a higher production of IL-12 and TNF-alpha when S. aureus was used as a stimulus. In addition, beta-glucan increased NK spleen cells activity against YAC target cells. Some immunomodulatory activities not yet described for beta-glucan were observed in this work.Univ Fed São Paulo, Inst Biosci, Dept Microbiol & Immunol, São Paulo, BrazilUniv Fed São Paulo, Fac Med, Dept Trop Dis & Diagnosis Image, São Paulo, BrazilAcad Sciences Czech Republic, Inst PhysiologyUniversidade Federal de São Paulo (UNIFESP)Universidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Pelizon, A. C.Kaneno, Ramon [UNESP]Soares, AMVCMeira, D. A.Sartori, A.2014-05-20T15:23:09Z2014-05-20T15:23:09Z2005-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article557-564http://www.biomed.cas.cz/physiolres/2005/issue5/pelizon.htmPhysiological Research. Prague 4: Acad Sciences Czech Republic, Inst Physiology, v. 54, n. 5, p. 557-564, 2005.0862-8408http://hdl.handle.net/11449/33989WOS:000233101100012884583555063780949775724161295270000-0002-4292-3298Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPhysiological Research1.3240,568info:eu-repo/semantics/openAccess2021-10-23T11:55:37Zoai:repositorio.unesp.br:11449/33989Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T11:55:37Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Immunomodulatory activities associated with beta-glucan derived from Saccharomyces cerevisiae |
title |
Immunomodulatory activities associated with beta-glucan derived from Saccharomyces cerevisiae |
spellingShingle |
Immunomodulatory activities associated with beta-glucan derived from Saccharomyces cerevisiae Pelizon, A. C. beta-glucan IL-12 TNF-alpha NK activity fungicidal activity |
title_short |
Immunomodulatory activities associated with beta-glucan derived from Saccharomyces cerevisiae |
title_full |
Immunomodulatory activities associated with beta-glucan derived from Saccharomyces cerevisiae |
title_fullStr |
Immunomodulatory activities associated with beta-glucan derived from Saccharomyces cerevisiae |
title_full_unstemmed |
Immunomodulatory activities associated with beta-glucan derived from Saccharomyces cerevisiae |
title_sort |
Immunomodulatory activities associated with beta-glucan derived from Saccharomyces cerevisiae |
author |
Pelizon, A. C. |
author_facet |
Pelizon, A. C. Kaneno, Ramon [UNESP] Soares, AMVC Meira, D. A. Sartori, A. |
author_role |
author |
author2 |
Kaneno, Ramon [UNESP] Soares, AMVC Meira, D. A. Sartori, A. |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Universidade de São Paulo (USP) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Pelizon, A. C. Kaneno, Ramon [UNESP] Soares, AMVC Meira, D. A. Sartori, A. |
dc.subject.por.fl_str_mv |
beta-glucan IL-12 TNF-alpha NK activity fungicidal activity |
topic |
beta-glucan IL-12 TNF-alpha NK activity fungicidal activity |
description |
In this study we investigated the effect of beta-glucan derived from Saccharomyces cerevisiae on fungicidal activity, cytokine production and natural killer activity. Spleen and peritoneal cells from female C57BL/6 mice, previously injected (24 or 48 h) with 20 or 100 mu g of glucan by i.p. route, were assayed. In vivo mu-glucan administration primed spleen cells for a higher production of IL-12 and TNF-alpha when S. aureus was used as a stimulus. In addition, beta-glucan increased NK spleen cells activity against YAC target cells. Some immunomodulatory activities not yet described for beta-glucan were observed in this work. |
publishDate |
2005 |
dc.date.none.fl_str_mv |
2005-01-01 2014-05-20T15:23:09Z 2014-05-20T15:23:09Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.biomed.cas.cz/physiolres/2005/issue5/pelizon.htm Physiological Research. Prague 4: Acad Sciences Czech Republic, Inst Physiology, v. 54, n. 5, p. 557-564, 2005. 0862-8408 http://hdl.handle.net/11449/33989 WOS:000233101100012 8845835550637809 4977572416129527 0000-0002-4292-3298 |
url |
http://www.biomed.cas.cz/physiolres/2005/issue5/pelizon.htm http://hdl.handle.net/11449/33989 |
identifier_str_mv |
Physiological Research. Prague 4: Acad Sciences Czech Republic, Inst Physiology, v. 54, n. 5, p. 557-564, 2005. 0862-8408 WOS:000233101100012 8845835550637809 4977572416129527 0000-0002-4292-3298 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Physiological Research 1.324 0,568 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
557-564 |
dc.publisher.none.fl_str_mv |
Acad Sciences Czech Republic, Inst Physiology |
publisher.none.fl_str_mv |
Acad Sciences Czech Republic, Inst Physiology |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1803047416218255360 |