Pneumotoxicity and hepatotoxicity due to Crotalaria pallida in the subchronic intoxication model in sheep
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | spa |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.15381/RIVEP.V32I6.19923 http://hdl.handle.net/11449/223663 |
Resumo: | The aim of this study was to evaluate the potential for subchronic intoxication of Crotalaria pallida in sheep. Six rams were used, fed with hay and drinking water ad libitum, and 200 g/animal/day of commercial balanced ration. The sheep were distributed into a control group (G1) with two animals and an experimental group (G2) with four animals. In the G2 diet, 8 g of dry matter (DM) of C. pallida per kilogram of body weight were included for 28 days. All animals were clinically evaluated every 24 h. Animals were weighed and blood samples were taken for hemogram and liver and kidney profile on days 0, 14 and 28 post-exposure to C. pallida. All animals were slaughtered at the end of the study and samples were collected for histopathological analysis. No significant differences were found between groups with respect to clinical examination, hemogram data and blood chemistry; however, the histopathological study showed moderate thickening of the alveolar septa in the lung, severe vacuolar change in the liver, and moderate proteinuria in the kidney in the animals exposed to C. pallida. |
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Pneumotoxicity and hepatotoxicity due to Crotalaria pallida in the subchronic intoxication model in sheepNeumotoxicidad y hepatotoxicidad por Crotalaria pallida en el modelo de intoxicación subcrónica en ovinosMonocrotalinePyrrolizidine alkaloidsToxic plantsToxicityThe aim of this study was to evaluate the potential for subchronic intoxication of Crotalaria pallida in sheep. Six rams were used, fed with hay and drinking water ad libitum, and 200 g/animal/day of commercial balanced ration. The sheep were distributed into a control group (G1) with two animals and an experimental group (G2) with four animals. In the G2 diet, 8 g of dry matter (DM) of C. pallida per kilogram of body weight were included for 28 days. All animals were clinically evaluated every 24 h. Animals were weighed and blood samples were taken for hemogram and liver and kidney profile on days 0, 14 and 28 post-exposure to C. pallida. All animals were slaughtered at the end of the study and samples were collected for histopathological analysis. No significant differences were found between groups with respect to clinical examination, hemogram data and blood chemistry; however, the histopathological study showed moderate thickening of the alveolar septa in the lung, severe vacuolar change in the liver, and moderate proteinuria in the kidney in the animals exposed to C. pallida.Escuela de Ciencias Animales Facultad de Ciencias Agropecuarias y Recursos Naturales Universidad de los Llanos, MetaGrupo de Investigación en Farmacología Experimental y Medicina Interna Universidad de los Llanos, MetaClínica de las Intoxicaciones y Plantas Tóxicas Universidade Estadual Paulista Júlio de Mesquita filhoFacultad de Medicina Veterinaria y Zootecnia Laboratorio de Patología Universidad CESBoehringer Ingelheim ROPU Surámerica Technical ServicesClínica de las Intoxicaciones y Plantas Tóxicas Universidade Estadual Paulista Júlio de Mesquita filhoUniversidad de los LlanosUniversidade Estadual Paulista (UNESP)Universidad CESTechnical ServicesJaramillo-Hernández, Dumar AlexanderTamayo Rojas, Doris JulietteCifuentes Sánchez, Diana Consuelo [UNESP]Veloza Angulo, Luis CarlosMolina Diaz, Víctor ManuelPedraza Castillo, Luz NataliaRoque Rodriguez, Anita Isabel2022-04-28T19:52:00Z2022-04-28T19:52:00Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.15381/RIVEP.V32I6.19923Revista de Investigaciones Veterinarias del Peru, v. 32, n. 6, 2021.1609-91171682-3419http://hdl.handle.net/11449/22366310.15381/RIVEP.V32I6.199232-s2.0-85126482548Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPspaRevista de Investigaciones Veterinarias del Peruinfo:eu-repo/semantics/openAccess2022-04-28T19:52:01Zoai:repositorio.unesp.br:11449/223663Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:44:38.319715Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Pneumotoxicity and hepatotoxicity due to Crotalaria pallida in the subchronic intoxication model in sheep Neumotoxicidad y hepatotoxicidad por Crotalaria pallida en el modelo de intoxicación subcrónica en ovinos |
title |
Pneumotoxicity and hepatotoxicity due to Crotalaria pallida in the subchronic intoxication model in sheep |
spellingShingle |
Pneumotoxicity and hepatotoxicity due to Crotalaria pallida in the subchronic intoxication model in sheep Jaramillo-Hernández, Dumar Alexander Monocrotaline Pyrrolizidine alkaloids Toxic plants Toxicity |
title_short |
Pneumotoxicity and hepatotoxicity due to Crotalaria pallida in the subchronic intoxication model in sheep |
title_full |
Pneumotoxicity and hepatotoxicity due to Crotalaria pallida in the subchronic intoxication model in sheep |
title_fullStr |
Pneumotoxicity and hepatotoxicity due to Crotalaria pallida in the subchronic intoxication model in sheep |
title_full_unstemmed |
Pneumotoxicity and hepatotoxicity due to Crotalaria pallida in the subchronic intoxication model in sheep |
title_sort |
Pneumotoxicity and hepatotoxicity due to Crotalaria pallida in the subchronic intoxication model in sheep |
author |
Jaramillo-Hernández, Dumar Alexander |
author_facet |
Jaramillo-Hernández, Dumar Alexander Tamayo Rojas, Doris Juliette Cifuentes Sánchez, Diana Consuelo [UNESP] Veloza Angulo, Luis Carlos Molina Diaz, Víctor Manuel Pedraza Castillo, Luz Natalia Roque Rodriguez, Anita Isabel |
author_role |
author |
author2 |
Tamayo Rojas, Doris Juliette Cifuentes Sánchez, Diana Consuelo [UNESP] Veloza Angulo, Luis Carlos Molina Diaz, Víctor Manuel Pedraza Castillo, Luz Natalia Roque Rodriguez, Anita Isabel |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidad de los Llanos Universidade Estadual Paulista (UNESP) Universidad CES Technical Services |
dc.contributor.author.fl_str_mv |
Jaramillo-Hernández, Dumar Alexander Tamayo Rojas, Doris Juliette Cifuentes Sánchez, Diana Consuelo [UNESP] Veloza Angulo, Luis Carlos Molina Diaz, Víctor Manuel Pedraza Castillo, Luz Natalia Roque Rodriguez, Anita Isabel |
dc.subject.por.fl_str_mv |
Monocrotaline Pyrrolizidine alkaloids Toxic plants Toxicity |
topic |
Monocrotaline Pyrrolizidine alkaloids Toxic plants Toxicity |
description |
The aim of this study was to evaluate the potential for subchronic intoxication of Crotalaria pallida in sheep. Six rams were used, fed with hay and drinking water ad libitum, and 200 g/animal/day of commercial balanced ration. The sheep were distributed into a control group (G1) with two animals and an experimental group (G2) with four animals. In the G2 diet, 8 g of dry matter (DM) of C. pallida per kilogram of body weight were included for 28 days. All animals were clinically evaluated every 24 h. Animals were weighed and blood samples were taken for hemogram and liver and kidney profile on days 0, 14 and 28 post-exposure to C. pallida. All animals were slaughtered at the end of the study and samples were collected for histopathological analysis. No significant differences were found between groups with respect to clinical examination, hemogram data and blood chemistry; however, the histopathological study showed moderate thickening of the alveolar septa in the lung, severe vacuolar change in the liver, and moderate proteinuria in the kidney in the animals exposed to C. pallida. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01 2022-04-28T19:52:00Z 2022-04-28T19:52:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.15381/RIVEP.V32I6.19923 Revista de Investigaciones Veterinarias del Peru, v. 32, n. 6, 2021. 1609-9117 1682-3419 http://hdl.handle.net/11449/223663 10.15381/RIVEP.V32I6.19923 2-s2.0-85126482548 |
url |
http://dx.doi.org/10.15381/RIVEP.V32I6.19923 http://hdl.handle.net/11449/223663 |
identifier_str_mv |
Revista de Investigaciones Veterinarias del Peru, v. 32, n. 6, 2021. 1609-9117 1682-3419 10.15381/RIVEP.V32I6.19923 2-s2.0-85126482548 |
dc.language.iso.fl_str_mv |
spa |
language |
spa |
dc.relation.none.fl_str_mv |
Revista de Investigaciones Veterinarias del Peru |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808129352995438592 |