Pneumotoxicity and hepatotoxicity due to Crotalaria pallida in the subchronic intoxication model in sheep

Detalhes bibliográficos
Autor(a) principal: Jaramillo-Hernández, Dumar Alexander
Data de Publicação: 2021
Outros Autores: Tamayo Rojas, Doris Juliette, Cifuentes Sánchez, Diana Consuelo [UNESP], Veloza Angulo, Luis Carlos, Molina Diaz, Víctor Manuel, Pedraza Castillo, Luz Natalia, Roque Rodriguez, Anita Isabel
Tipo de documento: Artigo
Idioma: spa
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.15381/RIVEP.V32I6.19923
http://hdl.handle.net/11449/223663
Resumo: The aim of this study was to evaluate the potential for subchronic intoxication of Crotalaria pallida in sheep. Six rams were used, fed with hay and drinking water ad libitum, and 200 g/animal/day of commercial balanced ration. The sheep were distributed into a control group (G1) with two animals and an experimental group (G2) with four animals. In the G2 diet, 8 g of dry matter (DM) of C. pallida per kilogram of body weight were included for 28 days. All animals were clinically evaluated every 24 h. Animals were weighed and blood samples were taken for hemogram and liver and kidney profile on days 0, 14 and 28 post-exposure to C. pallida. All animals were slaughtered at the end of the study and samples were collected for histopathological analysis. No significant differences were found between groups with respect to clinical examination, hemogram data and blood chemistry; however, the histopathological study showed moderate thickening of the alveolar septa in the lung, severe vacuolar change in the liver, and moderate proteinuria in the kidney in the animals exposed to C. pallida.
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spelling Pneumotoxicity and hepatotoxicity due to Crotalaria pallida in the subchronic intoxication model in sheepNeumotoxicidad y hepatotoxicidad por Crotalaria pallida en el modelo de intoxicación subcrónica en ovinosMonocrotalinePyrrolizidine alkaloidsToxic plantsToxicityThe aim of this study was to evaluate the potential for subchronic intoxication of Crotalaria pallida in sheep. Six rams were used, fed with hay and drinking water ad libitum, and 200 g/animal/day of commercial balanced ration. The sheep were distributed into a control group (G1) with two animals and an experimental group (G2) with four animals. In the G2 diet, 8 g of dry matter (DM) of C. pallida per kilogram of body weight were included for 28 days. All animals were clinically evaluated every 24 h. Animals were weighed and blood samples were taken for hemogram and liver and kidney profile on days 0, 14 and 28 post-exposure to C. pallida. All animals were slaughtered at the end of the study and samples were collected for histopathological analysis. No significant differences were found between groups with respect to clinical examination, hemogram data and blood chemistry; however, the histopathological study showed moderate thickening of the alveolar septa in the lung, severe vacuolar change in the liver, and moderate proteinuria in the kidney in the animals exposed to C. pallida.Escuela de Ciencias Animales Facultad de Ciencias Agropecuarias y Recursos Naturales Universidad de los Llanos, MetaGrupo de Investigación en Farmacología Experimental y Medicina Interna Universidad de los Llanos, MetaClínica de las Intoxicaciones y Plantas Tóxicas Universidade Estadual Paulista Júlio de Mesquita filhoFacultad de Medicina Veterinaria y Zootecnia Laboratorio de Patología Universidad CESBoehringer Ingelheim ROPU Surámerica Technical ServicesClínica de las Intoxicaciones y Plantas Tóxicas Universidade Estadual Paulista Júlio de Mesquita filhoUniversidad de los LlanosUniversidade Estadual Paulista (UNESP)Universidad CESTechnical ServicesJaramillo-Hernández, Dumar AlexanderTamayo Rojas, Doris JulietteCifuentes Sánchez, Diana Consuelo [UNESP]Veloza Angulo, Luis CarlosMolina Diaz, Víctor ManuelPedraza Castillo, Luz NataliaRoque Rodriguez, Anita Isabel2022-04-28T19:52:00Z2022-04-28T19:52:00Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.15381/RIVEP.V32I6.19923Revista de Investigaciones Veterinarias del Peru, v. 32, n. 6, 2021.1609-91171682-3419http://hdl.handle.net/11449/22366310.15381/RIVEP.V32I6.199232-s2.0-85126482548Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPspaRevista de Investigaciones Veterinarias del Peruinfo:eu-repo/semantics/openAccess2022-04-28T19:52:01Zoai:repositorio.unesp.br:11449/223663Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:44:38.319715Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Pneumotoxicity and hepatotoxicity due to Crotalaria pallida in the subchronic intoxication model in sheep
Neumotoxicidad y hepatotoxicidad por Crotalaria pallida en el modelo de intoxicación subcrónica en ovinos
title Pneumotoxicity and hepatotoxicity due to Crotalaria pallida in the subchronic intoxication model in sheep
spellingShingle Pneumotoxicity and hepatotoxicity due to Crotalaria pallida in the subchronic intoxication model in sheep
Jaramillo-Hernández, Dumar Alexander
Monocrotaline
Pyrrolizidine alkaloids
Toxic plants
Toxicity
title_short Pneumotoxicity and hepatotoxicity due to Crotalaria pallida in the subchronic intoxication model in sheep
title_full Pneumotoxicity and hepatotoxicity due to Crotalaria pallida in the subchronic intoxication model in sheep
title_fullStr Pneumotoxicity and hepatotoxicity due to Crotalaria pallida in the subchronic intoxication model in sheep
title_full_unstemmed Pneumotoxicity and hepatotoxicity due to Crotalaria pallida in the subchronic intoxication model in sheep
title_sort Pneumotoxicity and hepatotoxicity due to Crotalaria pallida in the subchronic intoxication model in sheep
author Jaramillo-Hernández, Dumar Alexander
author_facet Jaramillo-Hernández, Dumar Alexander
Tamayo Rojas, Doris Juliette
Cifuentes Sánchez, Diana Consuelo [UNESP]
Veloza Angulo, Luis Carlos
Molina Diaz, Víctor Manuel
Pedraza Castillo, Luz Natalia
Roque Rodriguez, Anita Isabel
author_role author
author2 Tamayo Rojas, Doris Juliette
Cifuentes Sánchez, Diana Consuelo [UNESP]
Veloza Angulo, Luis Carlos
Molina Diaz, Víctor Manuel
Pedraza Castillo, Luz Natalia
Roque Rodriguez, Anita Isabel
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad de los Llanos
Universidade Estadual Paulista (UNESP)
Universidad CES
Technical Services
dc.contributor.author.fl_str_mv Jaramillo-Hernández, Dumar Alexander
Tamayo Rojas, Doris Juliette
Cifuentes Sánchez, Diana Consuelo [UNESP]
Veloza Angulo, Luis Carlos
Molina Diaz, Víctor Manuel
Pedraza Castillo, Luz Natalia
Roque Rodriguez, Anita Isabel
dc.subject.por.fl_str_mv Monocrotaline
Pyrrolizidine alkaloids
Toxic plants
Toxicity
topic Monocrotaline
Pyrrolizidine alkaloids
Toxic plants
Toxicity
description The aim of this study was to evaluate the potential for subchronic intoxication of Crotalaria pallida in sheep. Six rams were used, fed with hay and drinking water ad libitum, and 200 g/animal/day of commercial balanced ration. The sheep were distributed into a control group (G1) with two animals and an experimental group (G2) with four animals. In the G2 diet, 8 g of dry matter (DM) of C. pallida per kilogram of body weight were included for 28 days. All animals were clinically evaluated every 24 h. Animals were weighed and blood samples were taken for hemogram and liver and kidney profile on days 0, 14 and 28 post-exposure to C. pallida. All animals were slaughtered at the end of the study and samples were collected for histopathological analysis. No significant differences were found between groups with respect to clinical examination, hemogram data and blood chemistry; however, the histopathological study showed moderate thickening of the alveolar septa in the lung, severe vacuolar change in the liver, and moderate proteinuria in the kidney in the animals exposed to C. pallida.
publishDate 2021
dc.date.none.fl_str_mv 2021-01-01
2022-04-28T19:52:00Z
2022-04-28T19:52:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.15381/RIVEP.V32I6.19923
Revista de Investigaciones Veterinarias del Peru, v. 32, n. 6, 2021.
1609-9117
1682-3419
http://hdl.handle.net/11449/223663
10.15381/RIVEP.V32I6.19923
2-s2.0-85126482548
url http://dx.doi.org/10.15381/RIVEP.V32I6.19923
http://hdl.handle.net/11449/223663
identifier_str_mv Revista de Investigaciones Veterinarias del Peru, v. 32, n. 6, 2021.
1609-9117
1682-3419
10.15381/RIVEP.V32I6.19923
2-s2.0-85126482548
dc.language.iso.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv Revista de Investigaciones Veterinarias del Peru
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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