Comparison of pharmacopuncture, aquapuncture and acepromazine for sedation of horses
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1093/ecam/nel096 http://hdl.handle.net/11449/42318 |
Resumo: | Pharmacopuncture, the injection of subclinical doses of drugs into acupoints reduces drug undesirable side effects, residues in animal consumption products and treatment costs in large animals. Acepromazine (Acp) produces several undesirable effects, such as hypotension. Previous studies with the injection of 1/10 of Acp dose in dog acupoints showed its advantage for sedation, minimizing undesirable effects. Eight horses were randomly submitted to four different treatment protocols according to a Latin Square double-blind design: (i) 0.1 ml kg(1) of saline subcutaneously injected at the cervical region, (ii) 0.1 mg kg(1) of Acp injected subcutaneously at the cervical region, (iii) 0.01 ml kg(1) of saline injected into GV1 acupoint (aquapuncture) and (iv) 0.01 mg kg(1) of Acp injected into GV1 acupoint (pharmacopuncture). Heart rate, respiratory rate, head height and degree of sedation were measured before and at 30, 60 and 90 min after treatments. Signs of sedation were observed in all treated groups at 30 min and only in 1/10Acp-GV1 at 60 min after the treatments. Only the group treated with 0.1 mg kg(1) of Acp s.c. had significantly lower values of head height at 30 min. Respiratory rate tended to reduce in all groups but was significantly lower only in horses treated with 0.1 mg kg(1) of Acp s.c. Heart rate remained unchanged in all groups. Acp-pharmacopuncture on GV1 in horses produced a mild sedation when compared with the conventional dose of Acp. More investigations are necessary to determine the optimal dosage of Acp-pharmacopuncture for sedation in horses. |
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Repositório Institucional da UNESP |
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Comparison of pharmacopuncture, aquapuncture and acepromazine for sedation of horsesacupointacupunctureequineinjectionsedationPharmacopuncture, the injection of subclinical doses of drugs into acupoints reduces drug undesirable side effects, residues in animal consumption products and treatment costs in large animals. Acepromazine (Acp) produces several undesirable effects, such as hypotension. Previous studies with the injection of 1/10 of Acp dose in dog acupoints showed its advantage for sedation, minimizing undesirable effects. Eight horses were randomly submitted to four different treatment protocols according to a Latin Square double-blind design: (i) 0.1 ml kg(1) of saline subcutaneously injected at the cervical region, (ii) 0.1 mg kg(1) of Acp injected subcutaneously at the cervical region, (iii) 0.01 ml kg(1) of saline injected into GV1 acupoint (aquapuncture) and (iv) 0.01 mg kg(1) of Acp injected into GV1 acupoint (pharmacopuncture). Heart rate, respiratory rate, head height and degree of sedation were measured before and at 30, 60 and 90 min after treatments. Signs of sedation were observed in all treated groups at 30 min and only in 1/10Acp-GV1 at 60 min after the treatments. Only the group treated with 0.1 mg kg(1) of Acp s.c. had significantly lower values of head height at 30 min. Respiratory rate tended to reduce in all groups but was significantly lower only in horses treated with 0.1 mg kg(1) of Acp s.c. Heart rate remained unchanged in all groups. Acp-pharmacopuncture on GV1 in horses produced a mild sedation when compared with the conventional dose of Acp. More investigations are necessary to determine the optimal dosage of Acp-pharmacopuncture for sedation in horses.São Paulo State Univ, Fac Vet Med & Anim Sci, BR-18618000 Botucatu, SP, BrazilUniv Fed Uberlandia, Fac Vet Med, BR-38400902 Uberlandia, MG, BrazilSão Paulo State Univ, Fac Vet Med & Anim Sci, BR-18618000 Botucatu, SP, BrazilOxford University PressUniversidade Estadual Paulista (Unesp)Universidade Federal de Uberlândia (UFU)Luna, Stélio Pacca Loureiro [UNESP]Angeli, Ana L. [UNESP]Ferreira, Cristiane L. [UNESP]Lettry, Vivien [UNESP]Scognamillo-Szabo, Marcia2014-05-20T15:33:47Z2014-05-20T15:33:47Z2008-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article267-272application/pdfhttp://dx.doi.org/10.1093/ecam/nel096Evidence-based Complementary and Alternative Medicine. Oxford: Oxford Univ Press, v. 5, n. 3, p. 267-272, 2008.1741-427Xhttp://hdl.handle.net/11449/4231810.1093/ecam/nel096WOS:000258961900006WOS000258961900006.pdf44732604100996230000-0001-5312-9076Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengEvidence-based Complementary and Alternative Medicine2.064info:eu-repo/semantics/openAccess2023-10-31T06:09:31Zoai:repositorio.unesp.br:11449/42318Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:31:28.386042Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Comparison of pharmacopuncture, aquapuncture and acepromazine for sedation of horses |
title |
Comparison of pharmacopuncture, aquapuncture and acepromazine for sedation of horses |
spellingShingle |
Comparison of pharmacopuncture, aquapuncture and acepromazine for sedation of horses Luna, Stélio Pacca Loureiro [UNESP] acupoint acupuncture equine injection sedation |
title_short |
Comparison of pharmacopuncture, aquapuncture and acepromazine for sedation of horses |
title_full |
Comparison of pharmacopuncture, aquapuncture and acepromazine for sedation of horses |
title_fullStr |
Comparison of pharmacopuncture, aquapuncture and acepromazine for sedation of horses |
title_full_unstemmed |
Comparison of pharmacopuncture, aquapuncture and acepromazine for sedation of horses |
title_sort |
Comparison of pharmacopuncture, aquapuncture and acepromazine for sedation of horses |
author |
Luna, Stélio Pacca Loureiro [UNESP] |
author_facet |
Luna, Stélio Pacca Loureiro [UNESP] Angeli, Ana L. [UNESP] Ferreira, Cristiane L. [UNESP] Lettry, Vivien [UNESP] Scognamillo-Szabo, Marcia |
author_role |
author |
author2 |
Angeli, Ana L. [UNESP] Ferreira, Cristiane L. [UNESP] Lettry, Vivien [UNESP] Scognamillo-Szabo, Marcia |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Federal de Uberlândia (UFU) |
dc.contributor.author.fl_str_mv |
Luna, Stélio Pacca Loureiro [UNESP] Angeli, Ana L. [UNESP] Ferreira, Cristiane L. [UNESP] Lettry, Vivien [UNESP] Scognamillo-Szabo, Marcia |
dc.subject.por.fl_str_mv |
acupoint acupuncture equine injection sedation |
topic |
acupoint acupuncture equine injection sedation |
description |
Pharmacopuncture, the injection of subclinical doses of drugs into acupoints reduces drug undesirable side effects, residues in animal consumption products and treatment costs in large animals. Acepromazine (Acp) produces several undesirable effects, such as hypotension. Previous studies with the injection of 1/10 of Acp dose in dog acupoints showed its advantage for sedation, minimizing undesirable effects. Eight horses were randomly submitted to four different treatment protocols according to a Latin Square double-blind design: (i) 0.1 ml kg(1) of saline subcutaneously injected at the cervical region, (ii) 0.1 mg kg(1) of Acp injected subcutaneously at the cervical region, (iii) 0.01 ml kg(1) of saline injected into GV1 acupoint (aquapuncture) and (iv) 0.01 mg kg(1) of Acp injected into GV1 acupoint (pharmacopuncture). Heart rate, respiratory rate, head height and degree of sedation were measured before and at 30, 60 and 90 min after treatments. Signs of sedation were observed in all treated groups at 30 min and only in 1/10Acp-GV1 at 60 min after the treatments. Only the group treated with 0.1 mg kg(1) of Acp s.c. had significantly lower values of head height at 30 min. Respiratory rate tended to reduce in all groups but was significantly lower only in horses treated with 0.1 mg kg(1) of Acp s.c. Heart rate remained unchanged in all groups. Acp-pharmacopuncture on GV1 in horses produced a mild sedation when compared with the conventional dose of Acp. More investigations are necessary to determine the optimal dosage of Acp-pharmacopuncture for sedation in horses. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-09-01 2014-05-20T15:33:47Z 2014-05-20T15:33:47Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1093/ecam/nel096 Evidence-based Complementary and Alternative Medicine. Oxford: Oxford Univ Press, v. 5, n. 3, p. 267-272, 2008. 1741-427X http://hdl.handle.net/11449/42318 10.1093/ecam/nel096 WOS:000258961900006 WOS000258961900006.pdf 4473260410099623 0000-0001-5312-9076 |
url |
http://dx.doi.org/10.1093/ecam/nel096 http://hdl.handle.net/11449/42318 |
identifier_str_mv |
Evidence-based Complementary and Alternative Medicine. Oxford: Oxford Univ Press, v. 5, n. 3, p. 267-272, 2008. 1741-427X 10.1093/ecam/nel096 WOS:000258961900006 WOS000258961900006.pdf 4473260410099623 0000-0001-5312-9076 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Evidence-based Complementary and Alternative Medicine 2.064 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
267-272 application/pdf |
dc.publisher.none.fl_str_mv |
Oxford University Press |
publisher.none.fl_str_mv |
Oxford University Press |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128666605977600 |