Comparison of pharmacopuncture, aquapuncture and acepromazine for sedation of horses

Detalhes bibliográficos
Autor(a) principal: Luna, Stélio Pacca Loureiro [UNESP]
Data de Publicação: 2008
Outros Autores: Angeli, Ana L. [UNESP], Ferreira, Cristiane L. [UNESP], Lettry, Vivien [UNESP], Scognamillo-Szabo, Marcia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1093/ecam/nel096
http://hdl.handle.net/11449/42318
Resumo: Pharmacopuncture, the injection of subclinical doses of drugs into acupoints reduces drug undesirable side effects, residues in animal consumption products and treatment costs in large animals. Acepromazine (Acp) produces several undesirable effects, such as hypotension. Previous studies with the injection of 1/10 of Acp dose in dog acupoints showed its advantage for sedation, minimizing undesirable effects. Eight horses were randomly submitted to four different treatment protocols according to a Latin Square double-blind design: (i) 0.1 ml kg(1) of saline subcutaneously injected at the cervical region, (ii) 0.1 mg kg(1) of Acp injected subcutaneously at the cervical region, (iii) 0.01 ml kg(1) of saline injected into GV1 acupoint (aquapuncture) and (iv) 0.01 mg kg(1) of Acp injected into GV1 acupoint (pharmacopuncture). Heart rate, respiratory rate, head height and degree of sedation were measured before and at 30, 60 and 90 min after treatments. Signs of sedation were observed in all treated groups at 30 min and only in 1/10Acp-GV1 at 60 min after the treatments. Only the group treated with 0.1 mg kg(1) of Acp s.c. had significantly lower values of head height at 30 min. Respiratory rate tended to reduce in all groups but was significantly lower only in horses treated with 0.1 mg kg(1) of Acp s.c. Heart rate remained unchanged in all groups. Acp-pharmacopuncture on GV1 in horses produced a mild sedation when compared with the conventional dose of Acp. More investigations are necessary to determine the optimal dosage of Acp-pharmacopuncture for sedation in horses.
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spelling Comparison of pharmacopuncture, aquapuncture and acepromazine for sedation of horsesacupointacupunctureequineinjectionsedationPharmacopuncture, the injection of subclinical doses of drugs into acupoints reduces drug undesirable side effects, residues in animal consumption products and treatment costs in large animals. Acepromazine (Acp) produces several undesirable effects, such as hypotension. Previous studies with the injection of 1/10 of Acp dose in dog acupoints showed its advantage for sedation, minimizing undesirable effects. Eight horses were randomly submitted to four different treatment protocols according to a Latin Square double-blind design: (i) 0.1 ml kg(1) of saline subcutaneously injected at the cervical region, (ii) 0.1 mg kg(1) of Acp injected subcutaneously at the cervical region, (iii) 0.01 ml kg(1) of saline injected into GV1 acupoint (aquapuncture) and (iv) 0.01 mg kg(1) of Acp injected into GV1 acupoint (pharmacopuncture). Heart rate, respiratory rate, head height and degree of sedation were measured before and at 30, 60 and 90 min after treatments. Signs of sedation were observed in all treated groups at 30 min and only in 1/10Acp-GV1 at 60 min after the treatments. Only the group treated with 0.1 mg kg(1) of Acp s.c. had significantly lower values of head height at 30 min. Respiratory rate tended to reduce in all groups but was significantly lower only in horses treated with 0.1 mg kg(1) of Acp s.c. Heart rate remained unchanged in all groups. Acp-pharmacopuncture on GV1 in horses produced a mild sedation when compared with the conventional dose of Acp. More investigations are necessary to determine the optimal dosage of Acp-pharmacopuncture for sedation in horses.São Paulo State Univ, Fac Vet Med & Anim Sci, BR-18618000 Botucatu, SP, BrazilUniv Fed Uberlandia, Fac Vet Med, BR-38400902 Uberlandia, MG, BrazilSão Paulo State Univ, Fac Vet Med & Anim Sci, BR-18618000 Botucatu, SP, BrazilOxford University PressUniversidade Estadual Paulista (Unesp)Universidade Federal de Uberlândia (UFU)Luna, Stélio Pacca Loureiro [UNESP]Angeli, Ana L. [UNESP]Ferreira, Cristiane L. [UNESP]Lettry, Vivien [UNESP]Scognamillo-Szabo, Marcia2014-05-20T15:33:47Z2014-05-20T15:33:47Z2008-09-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article267-272application/pdfhttp://dx.doi.org/10.1093/ecam/nel096Evidence-based Complementary and Alternative Medicine. Oxford: Oxford Univ Press, v. 5, n. 3, p. 267-272, 2008.1741-427Xhttp://hdl.handle.net/11449/4231810.1093/ecam/nel096WOS:000258961900006WOS000258961900006.pdf44732604100996230000-0001-5312-9076Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengEvidence-based Complementary and Alternative Medicine2.064info:eu-repo/semantics/openAccess2023-10-31T06:09:31Zoai:repositorio.unesp.br:11449/42318Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:31:28.386042Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Comparison of pharmacopuncture, aquapuncture and acepromazine for sedation of horses
title Comparison of pharmacopuncture, aquapuncture and acepromazine for sedation of horses
spellingShingle Comparison of pharmacopuncture, aquapuncture and acepromazine for sedation of horses
Luna, Stélio Pacca Loureiro [UNESP]
acupoint
acupuncture
equine
injection
sedation
title_short Comparison of pharmacopuncture, aquapuncture and acepromazine for sedation of horses
title_full Comparison of pharmacopuncture, aquapuncture and acepromazine for sedation of horses
title_fullStr Comparison of pharmacopuncture, aquapuncture and acepromazine for sedation of horses
title_full_unstemmed Comparison of pharmacopuncture, aquapuncture and acepromazine for sedation of horses
title_sort Comparison of pharmacopuncture, aquapuncture and acepromazine for sedation of horses
author Luna, Stélio Pacca Loureiro [UNESP]
author_facet Luna, Stélio Pacca Loureiro [UNESP]
Angeli, Ana L. [UNESP]
Ferreira, Cristiane L. [UNESP]
Lettry, Vivien [UNESP]
Scognamillo-Szabo, Marcia
author_role author
author2 Angeli, Ana L. [UNESP]
Ferreira, Cristiane L. [UNESP]
Lettry, Vivien [UNESP]
Scognamillo-Szabo, Marcia
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade Federal de Uberlândia (UFU)
dc.contributor.author.fl_str_mv Luna, Stélio Pacca Loureiro [UNESP]
Angeli, Ana L. [UNESP]
Ferreira, Cristiane L. [UNESP]
Lettry, Vivien [UNESP]
Scognamillo-Szabo, Marcia
dc.subject.por.fl_str_mv acupoint
acupuncture
equine
injection
sedation
topic acupoint
acupuncture
equine
injection
sedation
description Pharmacopuncture, the injection of subclinical doses of drugs into acupoints reduces drug undesirable side effects, residues in animal consumption products and treatment costs in large animals. Acepromazine (Acp) produces several undesirable effects, such as hypotension. Previous studies with the injection of 1/10 of Acp dose in dog acupoints showed its advantage for sedation, minimizing undesirable effects. Eight horses were randomly submitted to four different treatment protocols according to a Latin Square double-blind design: (i) 0.1 ml kg(1) of saline subcutaneously injected at the cervical region, (ii) 0.1 mg kg(1) of Acp injected subcutaneously at the cervical region, (iii) 0.01 ml kg(1) of saline injected into GV1 acupoint (aquapuncture) and (iv) 0.01 mg kg(1) of Acp injected into GV1 acupoint (pharmacopuncture). Heart rate, respiratory rate, head height and degree of sedation were measured before and at 30, 60 and 90 min after treatments. Signs of sedation were observed in all treated groups at 30 min and only in 1/10Acp-GV1 at 60 min after the treatments. Only the group treated with 0.1 mg kg(1) of Acp s.c. had significantly lower values of head height at 30 min. Respiratory rate tended to reduce in all groups but was significantly lower only in horses treated with 0.1 mg kg(1) of Acp s.c. Heart rate remained unchanged in all groups. Acp-pharmacopuncture on GV1 in horses produced a mild sedation when compared with the conventional dose of Acp. More investigations are necessary to determine the optimal dosage of Acp-pharmacopuncture for sedation in horses.
publishDate 2008
dc.date.none.fl_str_mv 2008-09-01
2014-05-20T15:33:47Z
2014-05-20T15:33:47Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1093/ecam/nel096
Evidence-based Complementary and Alternative Medicine. Oxford: Oxford Univ Press, v. 5, n. 3, p. 267-272, 2008.
1741-427X
http://hdl.handle.net/11449/42318
10.1093/ecam/nel096
WOS:000258961900006
WOS000258961900006.pdf
4473260410099623
0000-0001-5312-9076
url http://dx.doi.org/10.1093/ecam/nel096
http://hdl.handle.net/11449/42318
identifier_str_mv Evidence-based Complementary and Alternative Medicine. Oxford: Oxford Univ Press, v. 5, n. 3, p. 267-272, 2008.
1741-427X
10.1093/ecam/nel096
WOS:000258961900006
WOS000258961900006.pdf
4473260410099623
0000-0001-5312-9076
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Evidence-based Complementary and Alternative Medicine
2.064
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 267-272
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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