Sedative and clinical effects of the pharmacopuncture with xylazine in dogs
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S0102-86502014000100007 http://hdl.handle.net/11449/167577 |
Resumo: | Purpose: To investigate the sedative and clinical effects of the pharmacopuncture with xylazine, compared to the conventional dose of a intramuscular injection in dogs. Methods: Twelve dogs were randomly distributed in two groups of six animals and treated as follows: control group (X-IM): 1mg kg-1 of xylazine given intramuscularly (IM); pharmacopuncture group (X-Yintang): 0.1mg kg-1 of xylazine diluted to 0.5 mL of saline injected into the Yin Tang acupoint. Heart rate, cardiac rhythm (ECG), systolic arterial blood pressure (SABP), respiratory rate (RR), rectal temperature (RT), blood glucose concentration, degree of sedation and adverse effects were evaluated. Results: Sedative effect was observed in both groups. The degree of sedation was greater in X-IM only at 15 min when compared with X-Yintang group. Cardiovascular established was observed in X-Yintang group, while marked reduction in the HR and increased incidence of ECG abnormalities were detected in X-IM. In both treatment groups, minimal changes were observed in relation to SABP, RR, RT and blood glucose. High incidence (66%) of vomiting was observed in X-IM, while this adverse effect was absent in X-Yintang. Conclusion: Pharmacopuncture with xylazine induced clinically relevant sedative effects in dogs, with the advantage of reduction of undesirable side effects associated with α2-agonists, including bradycardia, cardiac arrhythmias, and emesis. |
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Sedative and clinical effects of the pharmacopuncture with xylazine in dogsAcupunctureAnxiolytic agentsDogsSedationXylazinePurpose: To investigate the sedative and clinical effects of the pharmacopuncture with xylazine, compared to the conventional dose of a intramuscular injection in dogs. Methods: Twelve dogs were randomly distributed in two groups of six animals and treated as follows: control group (X-IM): 1mg kg-1 of xylazine given intramuscularly (IM); pharmacopuncture group (X-Yintang): 0.1mg kg-1 of xylazine diluted to 0.5 mL of saline injected into the Yin Tang acupoint. Heart rate, cardiac rhythm (ECG), systolic arterial blood pressure (SABP), respiratory rate (RR), rectal temperature (RT), blood glucose concentration, degree of sedation and adverse effects were evaluated. Results: Sedative effect was observed in both groups. The degree of sedation was greater in X-IM only at 15 min when compared with X-Yintang group. Cardiovascular established was observed in X-Yintang group, while marked reduction in the HR and increased incidence of ECG abnormalities were detected in X-IM. In both treatment groups, minimal changes were observed in relation to SABP, RR, RT and blood glucose. High incidence (66%) of vomiting was observed in X-IM, while this adverse effect was absent in X-Yintang. Conclusion: Pharmacopuncture with xylazine induced clinically relevant sedative effects in dogs, with the advantage of reduction of undesirable side effects associated with α2-agonists, including bradycardia, cardiac arrhythmias, and emesis.Department of Veterinary Surgery and Anestesiology Scholl of Veterinary Medicine Oeste Paulista University (UNOESTE), Presidente Prudente-SPDepartment of Clinical Veterinary Scholl of Veterinary Medicine Sao Paulo State University (UNESP), Botucatu-SPDepartment of Veterinary Anestesiology Scholl of Veterinary Medicine Andradina Educational Foundation (FEA), Andradina-SPDepartment of Veterinary Surgery and Anestesiology Scholl of Veterinary Medicine UNOESTE, Presidente Prudente-SPDepartment of Clinical Veterinary Scholl of Veterinary Medicine Sao Paulo State University (UNESP), Botucatu-SPOeste Paulista University (UNOESTE)Universidade Estadual Paulista (Unesp)Andradina Educational Foundation (FEA)UNOESTECassu, Renata NavarroMelchert, Alessandra [UNESP]Canoa, Jiancarlo Tortoza BignelliMartins, Paula Denise de Oliveira2018-12-11T16:37:27Z2018-12-11T16:37:27Z2014-01-22info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article47-52application/pdfhttp://dx.doi.org/10.1590/S0102-86502014000100007Acta Cirurgica Brasileira, v. 29, n. 1, p. 47-52, 2014.0102-86501678-2674http://hdl.handle.net/11449/16757710.1590/S0102-86502014000100007S0102-865020140001000472-s2.0-84892572719S0102-86502014000100047.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengActa Cirurgica Brasileira0,395info:eu-repo/semantics/openAccess2023-10-22T06:05:05Zoai:repositorio.unesp.br:11449/167577Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:34:51.993422Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Sedative and clinical effects of the pharmacopuncture with xylazine in dogs |
title |
Sedative and clinical effects of the pharmacopuncture with xylazine in dogs |
spellingShingle |
Sedative and clinical effects of the pharmacopuncture with xylazine in dogs Cassu, Renata Navarro Acupuncture Anxiolytic agents Dogs Sedation Xylazine |
title_short |
Sedative and clinical effects of the pharmacopuncture with xylazine in dogs |
title_full |
Sedative and clinical effects of the pharmacopuncture with xylazine in dogs |
title_fullStr |
Sedative and clinical effects of the pharmacopuncture with xylazine in dogs |
title_full_unstemmed |
Sedative and clinical effects of the pharmacopuncture with xylazine in dogs |
title_sort |
Sedative and clinical effects of the pharmacopuncture with xylazine in dogs |
author |
Cassu, Renata Navarro |
author_facet |
Cassu, Renata Navarro Melchert, Alessandra [UNESP] Canoa, Jiancarlo Tortoza Bignelli Martins, Paula Denise de Oliveira |
author_role |
author |
author2 |
Melchert, Alessandra [UNESP] Canoa, Jiancarlo Tortoza Bignelli Martins, Paula Denise de Oliveira |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Oeste Paulista University (UNOESTE) Universidade Estadual Paulista (Unesp) Andradina Educational Foundation (FEA) UNOESTE |
dc.contributor.author.fl_str_mv |
Cassu, Renata Navarro Melchert, Alessandra [UNESP] Canoa, Jiancarlo Tortoza Bignelli Martins, Paula Denise de Oliveira |
dc.subject.por.fl_str_mv |
Acupuncture Anxiolytic agents Dogs Sedation Xylazine |
topic |
Acupuncture Anxiolytic agents Dogs Sedation Xylazine |
description |
Purpose: To investigate the sedative and clinical effects of the pharmacopuncture with xylazine, compared to the conventional dose of a intramuscular injection in dogs. Methods: Twelve dogs were randomly distributed in two groups of six animals and treated as follows: control group (X-IM): 1mg kg-1 of xylazine given intramuscularly (IM); pharmacopuncture group (X-Yintang): 0.1mg kg-1 of xylazine diluted to 0.5 mL of saline injected into the Yin Tang acupoint. Heart rate, cardiac rhythm (ECG), systolic arterial blood pressure (SABP), respiratory rate (RR), rectal temperature (RT), blood glucose concentration, degree of sedation and adverse effects were evaluated. Results: Sedative effect was observed in both groups. The degree of sedation was greater in X-IM only at 15 min when compared with X-Yintang group. Cardiovascular established was observed in X-Yintang group, while marked reduction in the HR and increased incidence of ECG abnormalities were detected in X-IM. In both treatment groups, minimal changes were observed in relation to SABP, RR, RT and blood glucose. High incidence (66%) of vomiting was observed in X-IM, while this adverse effect was absent in X-Yintang. Conclusion: Pharmacopuncture with xylazine induced clinically relevant sedative effects in dogs, with the advantage of reduction of undesirable side effects associated with α2-agonists, including bradycardia, cardiac arrhythmias, and emesis. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-01-22 2018-12-11T16:37:27Z 2018-12-11T16:37:27Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0102-86502014000100007 Acta Cirurgica Brasileira, v. 29, n. 1, p. 47-52, 2014. 0102-8650 1678-2674 http://hdl.handle.net/11449/167577 10.1590/S0102-86502014000100007 S0102-86502014000100047 2-s2.0-84892572719 S0102-86502014000100047.pdf |
url |
http://dx.doi.org/10.1590/S0102-86502014000100007 http://hdl.handle.net/11449/167577 |
identifier_str_mv |
Acta Cirurgica Brasileira, v. 29, n. 1, p. 47-52, 2014. 0102-8650 1678-2674 10.1590/S0102-86502014000100007 S0102-86502014000100047 2-s2.0-84892572719 S0102-86502014000100047.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Acta Cirurgica Brasileira 0,395 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
47-52 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128536194580480 |