Sedative and clinical effects of the pharmacopuncture with xylazine in dogs

Detalhes bibliográficos
Autor(a) principal: Cassu, Renata Navarro
Data de Publicação: 2014
Outros Autores: Melchert, Alessandra [UNESP], Canoa, Jiancarlo Tortoza Bignelli, Martins, Paula Denise de Oliveira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S0102-86502014000100007
http://hdl.handle.net/11449/167577
Resumo: Purpose: To investigate the sedative and clinical effects of the pharmacopuncture with xylazine, compared to the conventional dose of a intramuscular injection in dogs. Methods: Twelve dogs were randomly distributed in two groups of six animals and treated as follows: control group (X-IM): 1mg kg-1 of xylazine given intramuscularly (IM); pharmacopuncture group (X-Yintang): 0.1mg kg-1 of xylazine diluted to 0.5 mL of saline injected into the Yin Tang acupoint. Heart rate, cardiac rhythm (ECG), systolic arterial blood pressure (SABP), respiratory rate (RR), rectal temperature (RT), blood glucose concentration, degree of sedation and adverse effects were evaluated. Results: Sedative effect was observed in both groups. The degree of sedation was greater in X-IM only at 15 min when compared with X-Yintang group. Cardiovascular established was observed in X-Yintang group, while marked reduction in the HR and increased incidence of ECG abnormalities were detected in X-IM. In both treatment groups, minimal changes were observed in relation to SABP, RR, RT and blood glucose. High incidence (66%) of vomiting was observed in X-IM, while this adverse effect was absent in X-Yintang. Conclusion: Pharmacopuncture with xylazine induced clinically relevant sedative effects in dogs, with the advantage of reduction of undesirable side effects associated with α2-agonists, including bradycardia, cardiac arrhythmias, and emesis.
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spelling Sedative and clinical effects of the pharmacopuncture with xylazine in dogsAcupunctureAnxiolytic agentsDogsSedationXylazinePurpose: To investigate the sedative and clinical effects of the pharmacopuncture with xylazine, compared to the conventional dose of a intramuscular injection in dogs. Methods: Twelve dogs were randomly distributed in two groups of six animals and treated as follows: control group (X-IM): 1mg kg-1 of xylazine given intramuscularly (IM); pharmacopuncture group (X-Yintang): 0.1mg kg-1 of xylazine diluted to 0.5 mL of saline injected into the Yin Tang acupoint. Heart rate, cardiac rhythm (ECG), systolic arterial blood pressure (SABP), respiratory rate (RR), rectal temperature (RT), blood glucose concentration, degree of sedation and adverse effects were evaluated. Results: Sedative effect was observed in both groups. The degree of sedation was greater in X-IM only at 15 min when compared with X-Yintang group. Cardiovascular established was observed in X-Yintang group, while marked reduction in the HR and increased incidence of ECG abnormalities were detected in X-IM. In both treatment groups, minimal changes were observed in relation to SABP, RR, RT and blood glucose. High incidence (66%) of vomiting was observed in X-IM, while this adverse effect was absent in X-Yintang. Conclusion: Pharmacopuncture with xylazine induced clinically relevant sedative effects in dogs, with the advantage of reduction of undesirable side effects associated with α2-agonists, including bradycardia, cardiac arrhythmias, and emesis.Department of Veterinary Surgery and Anestesiology Scholl of Veterinary Medicine Oeste Paulista University (UNOESTE), Presidente Prudente-SPDepartment of Clinical Veterinary Scholl of Veterinary Medicine Sao Paulo State University (UNESP), Botucatu-SPDepartment of Veterinary Anestesiology Scholl of Veterinary Medicine Andradina Educational Foundation (FEA), Andradina-SPDepartment of Veterinary Surgery and Anestesiology Scholl of Veterinary Medicine UNOESTE, Presidente Prudente-SPDepartment of Clinical Veterinary Scholl of Veterinary Medicine Sao Paulo State University (UNESP), Botucatu-SPOeste Paulista University (UNOESTE)Universidade Estadual Paulista (Unesp)Andradina Educational Foundation (FEA)UNOESTECassu, Renata NavarroMelchert, Alessandra [UNESP]Canoa, Jiancarlo Tortoza BignelliMartins, Paula Denise de Oliveira2018-12-11T16:37:27Z2018-12-11T16:37:27Z2014-01-22info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article47-52application/pdfhttp://dx.doi.org/10.1590/S0102-86502014000100007Acta Cirurgica Brasileira, v. 29, n. 1, p. 47-52, 2014.0102-86501678-2674http://hdl.handle.net/11449/16757710.1590/S0102-86502014000100007S0102-865020140001000472-s2.0-84892572719S0102-86502014000100047.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengActa Cirurgica Brasileira0,395info:eu-repo/semantics/openAccess2023-10-22T06:05:05Zoai:repositorio.unesp.br:11449/167577Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:34:51.993422Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Sedative and clinical effects of the pharmacopuncture with xylazine in dogs
title Sedative and clinical effects of the pharmacopuncture with xylazine in dogs
spellingShingle Sedative and clinical effects of the pharmacopuncture with xylazine in dogs
Cassu, Renata Navarro
Acupuncture
Anxiolytic agents
Dogs
Sedation
Xylazine
title_short Sedative and clinical effects of the pharmacopuncture with xylazine in dogs
title_full Sedative and clinical effects of the pharmacopuncture with xylazine in dogs
title_fullStr Sedative and clinical effects of the pharmacopuncture with xylazine in dogs
title_full_unstemmed Sedative and clinical effects of the pharmacopuncture with xylazine in dogs
title_sort Sedative and clinical effects of the pharmacopuncture with xylazine in dogs
author Cassu, Renata Navarro
author_facet Cassu, Renata Navarro
Melchert, Alessandra [UNESP]
Canoa, Jiancarlo Tortoza Bignelli
Martins, Paula Denise de Oliveira
author_role author
author2 Melchert, Alessandra [UNESP]
Canoa, Jiancarlo Tortoza Bignelli
Martins, Paula Denise de Oliveira
author2_role author
author
author
dc.contributor.none.fl_str_mv Oeste Paulista University (UNOESTE)
Universidade Estadual Paulista (Unesp)
Andradina Educational Foundation (FEA)
UNOESTE
dc.contributor.author.fl_str_mv Cassu, Renata Navarro
Melchert, Alessandra [UNESP]
Canoa, Jiancarlo Tortoza Bignelli
Martins, Paula Denise de Oliveira
dc.subject.por.fl_str_mv Acupuncture
Anxiolytic agents
Dogs
Sedation
Xylazine
topic Acupuncture
Anxiolytic agents
Dogs
Sedation
Xylazine
description Purpose: To investigate the sedative and clinical effects of the pharmacopuncture with xylazine, compared to the conventional dose of a intramuscular injection in dogs. Methods: Twelve dogs were randomly distributed in two groups of six animals and treated as follows: control group (X-IM): 1mg kg-1 of xylazine given intramuscularly (IM); pharmacopuncture group (X-Yintang): 0.1mg kg-1 of xylazine diluted to 0.5 mL of saline injected into the Yin Tang acupoint. Heart rate, cardiac rhythm (ECG), systolic arterial blood pressure (SABP), respiratory rate (RR), rectal temperature (RT), blood glucose concentration, degree of sedation and adverse effects were evaluated. Results: Sedative effect was observed in both groups. The degree of sedation was greater in X-IM only at 15 min when compared with X-Yintang group. Cardiovascular established was observed in X-Yintang group, while marked reduction in the HR and increased incidence of ECG abnormalities were detected in X-IM. In both treatment groups, minimal changes were observed in relation to SABP, RR, RT and blood glucose. High incidence (66%) of vomiting was observed in X-IM, while this adverse effect was absent in X-Yintang. Conclusion: Pharmacopuncture with xylazine induced clinically relevant sedative effects in dogs, with the advantage of reduction of undesirable side effects associated with α2-agonists, including bradycardia, cardiac arrhythmias, and emesis.
publishDate 2014
dc.date.none.fl_str_mv 2014-01-22
2018-12-11T16:37:27Z
2018-12-11T16:37:27Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0102-86502014000100007
Acta Cirurgica Brasileira, v. 29, n. 1, p. 47-52, 2014.
0102-8650
1678-2674
http://hdl.handle.net/11449/167577
10.1590/S0102-86502014000100007
S0102-86502014000100047
2-s2.0-84892572719
S0102-86502014000100047.pdf
url http://dx.doi.org/10.1590/S0102-86502014000100007
http://hdl.handle.net/11449/167577
identifier_str_mv Acta Cirurgica Brasileira, v. 29, n. 1, p. 47-52, 2014.
0102-8650
1678-2674
10.1590/S0102-86502014000100007
S0102-86502014000100047
2-s2.0-84892572719
S0102-86502014000100047.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Acta Cirurgica Brasileira
0,395
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 47-52
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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