Overview of artemisinin effectiveness during outset years of its implementation in the western Brazilian Amazon
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/0074-02760190075 http://hdl.handle.net/11449/186732 |
Resumo: | BACKGROUND The elimination of malaria depends on the blocking of transmission and of an effective treatment. In Brazil, artemisinin therapy was introduced in 1991, and here we present a performance overview during implementation outset years. METHODS It is a retrospective cohort (1991 to 2002) of patients treated in a tertiary centre of Manaus, with positive microscopic diagnosis of Plasmodium falciparum malaria, under treatment with using injectable or rectal artemisinin derivatives, and followed over 35-days to evaluate parasite clearance, death and recurrence. FINDINGS This cohort outcome resulted 97.6% (1554/1593) of patients who completed the 35-day follow-up, 0.6% (10/1593) of death and 1.8% (29/1593) of follow-up loss. All patients that died and those that presented parasitaemia recurrence had pure P. falciparum infections and received monotherapy. Considering patients who completed 35-day treatment, 98.2% (1527/1554) presented asexual parasitaemia clearance until D4 and 1.8% (27/1554) between D5-D10. It is important to highlight that had no correlation between the five treatment schemes and the sexual parasite clearance. Finally, it is noteworthy that we were able to observe also gametocytes carriage during all follow-up (D0-D35). MAIN CONCLUSIONS Artemisinin derivatives remained effective in the treatment of falciparum malaria during first 12-years of use in north area of Brazil. |
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Overview of artemisinin effectiveness during outset years of its implementation in the western Brazilian AmazonPlasmodium falciparumartemisininparasite clearancedrug resistancetreatment effectivenesscohort studyBACKGROUND The elimination of malaria depends on the blocking of transmission and of an effective treatment. In Brazil, artemisinin therapy was introduced in 1991, and here we present a performance overview during implementation outset years. METHODS It is a retrospective cohort (1991 to 2002) of patients treated in a tertiary centre of Manaus, with positive microscopic diagnosis of Plasmodium falciparum malaria, under treatment with using injectable or rectal artemisinin derivatives, and followed over 35-days to evaluate parasite clearance, death and recurrence. FINDINGS This cohort outcome resulted 97.6% (1554/1593) of patients who completed the 35-day follow-up, 0.6% (10/1593) of death and 1.8% (29/1593) of follow-up loss. All patients that died and those that presented parasitaemia recurrence had pure P. falciparum infections and received monotherapy. Considering patients who completed 35-day treatment, 98.2% (1527/1554) presented asexual parasitaemia clearance until D4 and 1.8% (27/1554) between D5-D10. It is important to highlight that had no correlation between the five treatment schemes and the sexual parasite clearance. Finally, it is noteworthy that we were able to observe also gametocytes carriage during all follow-up (D0-D35). MAIN CONCLUSIONS Artemisinin derivatives remained effective in the treatment of falciparum malaria during first 12-years of use in north area of Brazil.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Univ Estado Amazonas, Programa Posgrad Ciencias Hematol, Manaus, Amazonas, BrazilFundacao Vigilancia Saude, Manaus, Amazonas, BrazilFundacao Med Trop Dr Heitor Vieira Dourado, Inst Pesquisa Clin Carlos Borborema, Manaus, Amazonas, BrazilUniv Estado Amazonas, Programa Posgrad Med Trop, Manaus, Amazonas, BrazilUniv Fed Mato Grosso do Sul, Fac Med, Programa Posgrad Doencas Infecciosas & Parasitari, Campo Grande, MS, BrazilUniv Fed Mato Grosso do Sul, Fac Ciencias Farmaceut, Lab Biociencia Alimentos & Nutr, Campo Grande, MS, BrazilUniv Brasilia, Brasilia, DF, BrazilUniv Estadual Paulista, Inst Biociencia Botucatu, Botucatu, SP, BrazilUniv Estadual Paulista, Fac Med Botucatu, Botucatu, SP, BrazilFundacao Oswaldo Cruz Fiocruz, Inst Leonidas & Maria Deane, Manaus, Amazonas, BrazilUniv Fed Amazonas, Inst Ciencias Exatas & Tecnol, Itacoatiara, AM, BrazilUniv Estadual Paulista, Inst Biociencia Botucatu, Botucatu, SP, BrazilUniv Estadual Paulista, Fac Med Botucatu, Botucatu, SP, BrazilCAPES: 001Fundaco Oswaldo CruzUniv Estado AmazonasFundacao Vigilancia SaudeFundacao Med Trop Dr Heitor Vieira DouradoUniversidade Federal de Mato Grosso do Sul (UFMS)Universidade de Brasília (UnB)Universidade Estadual Paulista (Unesp)Fundacao Oswaldo Cruz FiocruzUniv Fed AmazonasPinto, Raquel de MedeirosSampaio, Vanderson de SouzaMelo, Gisely Cardoso deCosta Alecrimm, Maria das GracasMattoss, KarinePerdomo, Renata TrentinCordeiro, Sabrine da CostaAlves Parente, Ana FlaviaCarvalho, Lidia Raquel de [UNESP]Mendes, Rinaldo Poncio [UNESP]Guimaraes Lacerda, Marcus ViniciusMonteiro, Wuelton MarceloWeber, Simone Schneider2019-10-06T00:01:31Z2019-10-06T00:01:31Z2019-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article9application/pdfhttp://dx.doi.org/10.1590/0074-02760190075Memorias Do Instituto Oswaldo Cruz. Rio De Janeiro, Rj: Fundaco Oswaldo Cruz, v. 114, 9 p., 2019.0074-0276http://hdl.handle.net/11449/18673210.1590/0074-02760190075S0074-02762019000100320WOS:000466583600001S0074-02762019000100320.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMemorias Do Instituto Oswaldo Cruzinfo:eu-repo/semantics/openAccess2024-08-15T15:23:27Zoai:repositorio.unesp.br:11449/186732Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-15T15:23:27Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Overview of artemisinin effectiveness during outset years of its implementation in the western Brazilian Amazon |
title |
Overview of artemisinin effectiveness during outset years of its implementation in the western Brazilian Amazon |
spellingShingle |
Overview of artemisinin effectiveness during outset years of its implementation in the western Brazilian Amazon Pinto, Raquel de Medeiros Plasmodium falciparum artemisinin parasite clearance drug resistance treatment effectiveness cohort study |
title_short |
Overview of artemisinin effectiveness during outset years of its implementation in the western Brazilian Amazon |
title_full |
Overview of artemisinin effectiveness during outset years of its implementation in the western Brazilian Amazon |
title_fullStr |
Overview of artemisinin effectiveness during outset years of its implementation in the western Brazilian Amazon |
title_full_unstemmed |
Overview of artemisinin effectiveness during outset years of its implementation in the western Brazilian Amazon |
title_sort |
Overview of artemisinin effectiveness during outset years of its implementation in the western Brazilian Amazon |
author |
Pinto, Raquel de Medeiros |
author_facet |
Pinto, Raquel de Medeiros Sampaio, Vanderson de Souza Melo, Gisely Cardoso de Costa Alecrimm, Maria das Gracas Mattoss, Karine Perdomo, Renata Trentin Cordeiro, Sabrine da Costa Alves Parente, Ana Flavia Carvalho, Lidia Raquel de [UNESP] Mendes, Rinaldo Poncio [UNESP] Guimaraes Lacerda, Marcus Vinicius Monteiro, Wuelton Marcelo Weber, Simone Schneider |
author_role |
author |
author2 |
Sampaio, Vanderson de Souza Melo, Gisely Cardoso de Costa Alecrimm, Maria das Gracas Mattoss, Karine Perdomo, Renata Trentin Cordeiro, Sabrine da Costa Alves Parente, Ana Flavia Carvalho, Lidia Raquel de [UNESP] Mendes, Rinaldo Poncio [UNESP] Guimaraes Lacerda, Marcus Vinicius Monteiro, Wuelton Marcelo Weber, Simone Schneider |
author2_role |
author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Univ Estado Amazonas Fundacao Vigilancia Saude Fundacao Med Trop Dr Heitor Vieira Dourado Universidade Federal de Mato Grosso do Sul (UFMS) Universidade de Brasília (UnB) Universidade Estadual Paulista (Unesp) Fundacao Oswaldo Cruz Fiocruz Univ Fed Amazonas |
dc.contributor.author.fl_str_mv |
Pinto, Raquel de Medeiros Sampaio, Vanderson de Souza Melo, Gisely Cardoso de Costa Alecrimm, Maria das Gracas Mattoss, Karine Perdomo, Renata Trentin Cordeiro, Sabrine da Costa Alves Parente, Ana Flavia Carvalho, Lidia Raquel de [UNESP] Mendes, Rinaldo Poncio [UNESP] Guimaraes Lacerda, Marcus Vinicius Monteiro, Wuelton Marcelo Weber, Simone Schneider |
dc.subject.por.fl_str_mv |
Plasmodium falciparum artemisinin parasite clearance drug resistance treatment effectiveness cohort study |
topic |
Plasmodium falciparum artemisinin parasite clearance drug resistance treatment effectiveness cohort study |
description |
BACKGROUND The elimination of malaria depends on the blocking of transmission and of an effective treatment. In Brazil, artemisinin therapy was introduced in 1991, and here we present a performance overview during implementation outset years. METHODS It is a retrospective cohort (1991 to 2002) of patients treated in a tertiary centre of Manaus, with positive microscopic diagnosis of Plasmodium falciparum malaria, under treatment with using injectable or rectal artemisinin derivatives, and followed over 35-days to evaluate parasite clearance, death and recurrence. FINDINGS This cohort outcome resulted 97.6% (1554/1593) of patients who completed the 35-day follow-up, 0.6% (10/1593) of death and 1.8% (29/1593) of follow-up loss. All patients that died and those that presented parasitaemia recurrence had pure P. falciparum infections and received monotherapy. Considering patients who completed 35-day treatment, 98.2% (1527/1554) presented asexual parasitaemia clearance until D4 and 1.8% (27/1554) between D5-D10. It is important to highlight that had no correlation between the five treatment schemes and the sexual parasite clearance. Finally, it is noteworthy that we were able to observe also gametocytes carriage during all follow-up (D0-D35). MAIN CONCLUSIONS Artemisinin derivatives remained effective in the treatment of falciparum malaria during first 12-years of use in north area of Brazil. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-06T00:01:31Z 2019-10-06T00:01:31Z 2019-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/0074-02760190075 Memorias Do Instituto Oswaldo Cruz. Rio De Janeiro, Rj: Fundaco Oswaldo Cruz, v. 114, 9 p., 2019. 0074-0276 http://hdl.handle.net/11449/186732 10.1590/0074-02760190075 S0074-02762019000100320 WOS:000466583600001 S0074-02762019000100320.pdf |
url |
http://dx.doi.org/10.1590/0074-02760190075 http://hdl.handle.net/11449/186732 |
identifier_str_mv |
Memorias Do Instituto Oswaldo Cruz. Rio De Janeiro, Rj: Fundaco Oswaldo Cruz, v. 114, 9 p., 2019. 0074-0276 10.1590/0074-02760190075 S0074-02762019000100320 WOS:000466583600001 S0074-02762019000100320.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Memorias Do Instituto Oswaldo Cruz |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
9 application/pdf |
dc.publisher.none.fl_str_mv |
Fundaco Oswaldo Cruz |
publisher.none.fl_str_mv |
Fundaco Oswaldo Cruz |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128206427914240 |