Trypanocidal activity of mastoparan from Polybia paulista wasp venom by interaction with TcGAPDH

Detalhes bibliográficos
Autor(a) principal: Chagas Vinhote, Juliana Freire
Data de Publicação: 2017
Outros Autores: Lima, Danya Bandeira, Pessoa Bezerra de Menezes, Ramon Roseo Paula, Mello, Clarissa Perdigao, Souza, Bibiana Monson de [UNESP], Havt, Alexandre, Palma, Mario Sergio [UNESP], Santos, Ricardo Pires dos, Albuquerque, Eudenilson Lins de, Freire, Valder Nogueira, Costa Martins, Alice Maria
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.toxicon.2017.08.002
http://hdl.handle.net/11449/165808
Resumo: Chagas disease, considered a neglected disease, is a parasitic infection caused by Trypanosoma cruzi, which is endemic throughout the world. Previously, the antimicrobial effect of Mastoparan (MP) from Polybia paulista wasp venom against bacteria was described. To continue the study, we report in this short communication the antimicrobial effect of MP against Trypanosoma cruzi. MP inhibits all T. cruzi developmental forms through the inhibition of TcGAPDH suggested by the molecular docking. In conclusion, we suggest there is an antimicrobial effect also on T. cruzi. (C) 2017 Elsevier Ltd. All rights reserved.
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spelling Trypanocidal activity of mastoparan from Polybia paulista wasp venom by interaction with TcGAPDHAntiparasitic agentsMolecular dockingWasp venomMastoparanChagas disease, considered a neglected disease, is a parasitic infection caused by Trypanosoma cruzi, which is endemic throughout the world. Previously, the antimicrobial effect of Mastoparan (MP) from Polybia paulista wasp venom against bacteria was described. To continue the study, we report in this short communication the antimicrobial effect of MP against Trypanosoma cruzi. MP inhibits all T. cruzi developmental forms through the inhibition of TcGAPDH suggested by the molecular docking. In conclusion, we suggest there is an antimicrobial effect also on T. cruzi. (C) 2017 Elsevier Ltd. All rights reserved.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)FUNCAPUniv Fed Ceara, Dept Physiol & Pharmacol, Fortaleza, Ceara, BrazilUniv Fed Ceara, Dept Clin & Toxicol Anal, Fortaleza, Ceara, BrazilSao Paulo State Univ, Inst Biosci Rio Claro, Sao Paulo, BrazilUniv Fed Ceara, Comp Engn, Sobral, Ceara, BrazilUniv Fed Rio Grande do Norte, Dept Biophys & Pharmacol, Natal, RN, BrazilUniv Fed Ceara, Dept Phys, Fortaleza, Ceara, BrazilSao Paulo State Univ, Inst Biosci Rio Claro, Sao Paulo, BrazilCNPq: 151182/2013-2CNPq: 447592/2014-9Elsevier B.V.Univ Fed CearaUniversidade Estadual Paulista (Unesp)Univ Fed Rio Grande do NorteChagas Vinhote, Juliana FreireLima, Danya BandeiraPessoa Bezerra de Menezes, Ramon Roseo PaulaMello, Clarissa PerdigaoSouza, Bibiana Monson de [UNESP]Havt, AlexandrePalma, Mario Sergio [UNESP]Santos, Ricardo Pires dosAlbuquerque, Eudenilson Lins deFreire, Valder NogueiraCosta Martins, Alice Maria2018-11-28T21:36:47Z2018-11-28T21:36:47Z2017-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article168-172application/pdfhttp://dx.doi.org/10.1016/j.toxicon.2017.08.002Toxicon. Oxford: Pergamon-elsevier Science Ltd, v. 137, p. 168-172, 2017.0041-0101http://hdl.handle.net/11449/16580810.1016/j.toxicon.2017.08.002WOS:000411542300025WOS000411542300025.pdf2901888624506535Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengToxicon0,692info:eu-repo/semantics/openAccess2023-12-25T06:20:58Zoai:repositorio.unesp.br:11449/165808Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:16:10.250983Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Trypanocidal activity of mastoparan from Polybia paulista wasp venom by interaction with TcGAPDH
title Trypanocidal activity of mastoparan from Polybia paulista wasp venom by interaction with TcGAPDH
spellingShingle Trypanocidal activity of mastoparan from Polybia paulista wasp venom by interaction with TcGAPDH
Chagas Vinhote, Juliana Freire
Antiparasitic agents
Molecular docking
Wasp venom
Mastoparan
title_short Trypanocidal activity of mastoparan from Polybia paulista wasp venom by interaction with TcGAPDH
title_full Trypanocidal activity of mastoparan from Polybia paulista wasp venom by interaction with TcGAPDH
title_fullStr Trypanocidal activity of mastoparan from Polybia paulista wasp venom by interaction with TcGAPDH
title_full_unstemmed Trypanocidal activity of mastoparan from Polybia paulista wasp venom by interaction with TcGAPDH
title_sort Trypanocidal activity of mastoparan from Polybia paulista wasp venom by interaction with TcGAPDH
author Chagas Vinhote, Juliana Freire
author_facet Chagas Vinhote, Juliana Freire
Lima, Danya Bandeira
Pessoa Bezerra de Menezes, Ramon Roseo Paula
Mello, Clarissa Perdigao
Souza, Bibiana Monson de [UNESP]
Havt, Alexandre
Palma, Mario Sergio [UNESP]
Santos, Ricardo Pires dos
Albuquerque, Eudenilson Lins de
Freire, Valder Nogueira
Costa Martins, Alice Maria
author_role author
author2 Lima, Danya Bandeira
Pessoa Bezerra de Menezes, Ramon Roseo Paula
Mello, Clarissa Perdigao
Souza, Bibiana Monson de [UNESP]
Havt, Alexandre
Palma, Mario Sergio [UNESP]
Santos, Ricardo Pires dos
Albuquerque, Eudenilson Lins de
Freire, Valder Nogueira
Costa Martins, Alice Maria
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Univ Fed Ceara
Universidade Estadual Paulista (Unesp)
Univ Fed Rio Grande do Norte
dc.contributor.author.fl_str_mv Chagas Vinhote, Juliana Freire
Lima, Danya Bandeira
Pessoa Bezerra de Menezes, Ramon Roseo Paula
Mello, Clarissa Perdigao
Souza, Bibiana Monson de [UNESP]
Havt, Alexandre
Palma, Mario Sergio [UNESP]
Santos, Ricardo Pires dos
Albuquerque, Eudenilson Lins de
Freire, Valder Nogueira
Costa Martins, Alice Maria
dc.subject.por.fl_str_mv Antiparasitic agents
Molecular docking
Wasp venom
Mastoparan
topic Antiparasitic agents
Molecular docking
Wasp venom
Mastoparan
description Chagas disease, considered a neglected disease, is a parasitic infection caused by Trypanosoma cruzi, which is endemic throughout the world. Previously, the antimicrobial effect of Mastoparan (MP) from Polybia paulista wasp venom against bacteria was described. To continue the study, we report in this short communication the antimicrobial effect of MP against Trypanosoma cruzi. MP inhibits all T. cruzi developmental forms through the inhibition of TcGAPDH suggested by the molecular docking. In conclusion, we suggest there is an antimicrobial effect also on T. cruzi. (C) 2017 Elsevier Ltd. All rights reserved.
publishDate 2017
dc.date.none.fl_str_mv 2017-10-01
2018-11-28T21:36:47Z
2018-11-28T21:36:47Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.toxicon.2017.08.002
Toxicon. Oxford: Pergamon-elsevier Science Ltd, v. 137, p. 168-172, 2017.
0041-0101
http://hdl.handle.net/11449/165808
10.1016/j.toxicon.2017.08.002
WOS:000411542300025
WOS000411542300025.pdf
2901888624506535
url http://dx.doi.org/10.1016/j.toxicon.2017.08.002
http://hdl.handle.net/11449/165808
identifier_str_mv Toxicon. Oxford: Pergamon-elsevier Science Ltd, v. 137, p. 168-172, 2017.
0041-0101
10.1016/j.toxicon.2017.08.002
WOS:000411542300025
WOS000411542300025.pdf
2901888624506535
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Toxicon
0,692
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 168-172
application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808129301983264768

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