Genotoxicity of textile dye C.I. Disperse Blue 291 in mouse bone marrow

Detalhes bibliográficos
Autor(a) principal: Fernandes, Fábio Henrique [UNESP]
Data de Publicação: 2019
Outros Autores: Umbuzeiro, Gisela de Aragão, Salvadori, Daisy Maria Fávero [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.mrgentox.2018.10.003
http://hdl.handle.net/11449/188225
Resumo: Color Index (C.I.) Disperse Blue 291 (DB291) is an azo dye used by the textile industry. After yarn dyeing, wastewater containing the dye, released into the aquatic environment, may pollute drinking water sources. We investigated the mutagenicity and genotoxicity of DB291 in male Swiss mice, following oral administration. Micronucleated cells, primary DNA damage (comet assay) in blood, liver, and kidney cells, and BAX, BCL2, SMAD4 and TNFA gene expression in leukocytes were evaluated. An increased frequency of micronucleated polychromatic erythrocytes (MNPCEs) was observed in animals treated with 50 mg/kg bw; no other genetic alteration was detected. Neither primary DNA damage nor changes in gene expression were observed.
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spelling Genotoxicity of textile dye C.I. Disperse Blue 291 in mouse bone marrowAzo dyeComet assayMicronucleus assayColor Index (C.I.) Disperse Blue 291 (DB291) is an azo dye used by the textile industry. After yarn dyeing, wastewater containing the dye, released into the aquatic environment, may pollute drinking water sources. We investigated the mutagenicity and genotoxicity of DB291 in male Swiss mice, following oral administration. Micronucleated cells, primary DNA damage (comet assay) in blood, liver, and kidney cells, and BAX, BCL2, SMAD4 and TNFA gene expression in leukocytes were evaluated. An increased frequency of micronucleated polychromatic erythrocytes (MNPCEs) was observed in animals treated with 50 mg/kg bw; no other genetic alteration was detected. Neither primary DNA damage nor changes in gene expression were observed.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)UNESP – São Paulo State University Medical School Department Pathology – Rubião Júnior, BotucatuUNICAMP – University of Campinas Technology School – Paschoal Marmo, LimeiraUNESP – São Paulo State University Medical School Department Pathology Rubião Júnior, BotucatuUNESP – São Paulo State University Medical School Department Pathology – Rubião Júnior, BotucatuUNESP – São Paulo State University Medical School Department Pathology Rubião Júnior, BotucatuFAPESP: 2008/10449-7FAPESP: 2014/50945-4Universidade Estadual Paulista (Unesp)Universidade Estadual de Campinas (UNICAMP)Fernandes, Fábio Henrique [UNESP]Umbuzeiro, Gisela de AragãoSalvadori, Daisy Maria Fávero [UNESP]2019-10-06T16:01:15Z2019-10-06T16:01:15Z2019-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article48-51http://dx.doi.org/10.1016/j.mrgentox.2018.10.003Mutation Research - Genetic Toxicology and Environmental Mutagenesis, v. 837, p. 48-51.1879-35921383-5718http://hdl.handle.net/11449/18822510.1016/j.mrgentox.2018.10.0032-s2.0-85055038472Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMutation Research - Genetic Toxicology and Environmental Mutagenesisinfo:eu-repo/semantics/openAccess2024-09-03T13:15:27Zoai:repositorio.unesp.br:11449/188225Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:15:27Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Genotoxicity of textile dye C.I. Disperse Blue 291 in mouse bone marrow
title Genotoxicity of textile dye C.I. Disperse Blue 291 in mouse bone marrow
spellingShingle Genotoxicity of textile dye C.I. Disperse Blue 291 in mouse bone marrow
Fernandes, Fábio Henrique [UNESP]
Azo dye
Comet assay
Micronucleus assay
title_short Genotoxicity of textile dye C.I. Disperse Blue 291 in mouse bone marrow
title_full Genotoxicity of textile dye C.I. Disperse Blue 291 in mouse bone marrow
title_fullStr Genotoxicity of textile dye C.I. Disperse Blue 291 in mouse bone marrow
title_full_unstemmed Genotoxicity of textile dye C.I. Disperse Blue 291 in mouse bone marrow
title_sort Genotoxicity of textile dye C.I. Disperse Blue 291 in mouse bone marrow
author Fernandes, Fábio Henrique [UNESP]
author_facet Fernandes, Fábio Henrique [UNESP]
Umbuzeiro, Gisela de Aragão
Salvadori, Daisy Maria Fávero [UNESP]
author_role author
author2 Umbuzeiro, Gisela de Aragão
Salvadori, Daisy Maria Fávero [UNESP]
author2_role author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade Estadual de Campinas (UNICAMP)
dc.contributor.author.fl_str_mv Fernandes, Fábio Henrique [UNESP]
Umbuzeiro, Gisela de Aragão
Salvadori, Daisy Maria Fávero [UNESP]
dc.subject.por.fl_str_mv Azo dye
Comet assay
Micronucleus assay
topic Azo dye
Comet assay
Micronucleus assay
description Color Index (C.I.) Disperse Blue 291 (DB291) is an azo dye used by the textile industry. After yarn dyeing, wastewater containing the dye, released into the aquatic environment, may pollute drinking water sources. We investigated the mutagenicity and genotoxicity of DB291 in male Swiss mice, following oral administration. Micronucleated cells, primary DNA damage (comet assay) in blood, liver, and kidney cells, and BAX, BCL2, SMAD4 and TNFA gene expression in leukocytes were evaluated. An increased frequency of micronucleated polychromatic erythrocytes (MNPCEs) was observed in animals treated with 50 mg/kg bw; no other genetic alteration was detected. Neither primary DNA damage nor changes in gene expression were observed.
publishDate 2019
dc.date.none.fl_str_mv 2019-10-06T16:01:15Z
2019-10-06T16:01:15Z
2019-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.mrgentox.2018.10.003
Mutation Research - Genetic Toxicology and Environmental Mutagenesis, v. 837, p. 48-51.
1879-3592
1383-5718
http://hdl.handle.net/11449/188225
10.1016/j.mrgentox.2018.10.003
2-s2.0-85055038472
url http://dx.doi.org/10.1016/j.mrgentox.2018.10.003
http://hdl.handle.net/11449/188225
identifier_str_mv Mutation Research - Genetic Toxicology and Environmental Mutagenesis, v. 837, p. 48-51.
1879-3592
1383-5718
10.1016/j.mrgentox.2018.10.003
2-s2.0-85055038472
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Mutation Research - Genetic Toxicology and Environmental Mutagenesis
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 48-51
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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