Low-dose combined oral contraceptive use is associated with lower bone mineral content variation in adolescents over a 1-year period
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://www.biomedcentral.com/1472-6823/15/15 http://hdl.handle.net/11449/128395 |
Resumo: | Background: Low-dose combined oral contraceptives (COCs) can interfere with bone mass acquisition during adolescence. This study aimed to evaluate bone mineral density (BMD) and bone mineral content (BMC) in female adolescents taking a standard low-dose COC (ethinylestradiol 20 mu g/desogestrel 150 mu g)over a 1-year period and to compare their data with those of healthy adolescents from the same age group not taking COCs.Methods: This was a non-randomized parallel-control study with a 1-year follow-up. Sixty-seven adolescents aged from 12 to 19 years, divided into COC users (n = 41) taking 20 mu g ethinylestradiol/150 mu g desogestrel and COC non-user controls (n = 26), were evaluated by bone densitometry examinations at baseline and after 12 months. Comparisons between the groups at the study onset were performed using the Mann-Whitney test with the significance level fixed at 5% or p < 0.05. Comparisons between the groups at the study onset and after 12 months were based on variations in the median percentages for bone mass variables.Results: The COC users presented with low bone mass acquisition in the lumbar spine, and had BMD and BMC median variations of 2.07% and +1.57%, respectively, between the measurements at baseline and 12 months. The control group had median variations of +12.16% and +16.84% for BMD and BMC, respectively, over the same period. The total body BMD and BMC showed similar evolutions during the study in both groups. Statistical significance (p < 0.05) was seen for the BMC percentage variation between COC users and non-users.Conclusions: Use of a low-dose COC (ethinylestradiol 20 mu g/desogestrel 150 mu g) was associated with lower bone mass acquisition in adolescents during the study period. |
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Low-dose combined oral contraceptive use is associated with lower bone mineral content variation in adolescents over a 1-year periodAdolescentBone densityBone mineral contentContraceptivesOsteoporosisBackground: Low-dose combined oral contraceptives (COCs) can interfere with bone mass acquisition during adolescence. This study aimed to evaluate bone mineral density (BMD) and bone mineral content (BMC) in female adolescents taking a standard low-dose COC (ethinylestradiol 20 mu g/desogestrel 150 mu g)over a 1-year period and to compare their data with those of healthy adolescents from the same age group not taking COCs.Methods: This was a non-randomized parallel-control study with a 1-year follow-up. Sixty-seven adolescents aged from 12 to 19 years, divided into COC users (n = 41) taking 20 mu g ethinylestradiol/150 mu g desogestrel and COC non-user controls (n = 26), were evaluated by bone densitometry examinations at baseline and after 12 months. Comparisons between the groups at the study onset were performed using the Mann-Whitney test with the significance level fixed at 5% or p < 0.05. Comparisons between the groups at the study onset and after 12 months were based on variations in the median percentages for bone mass variables.Results: The COC users presented with low bone mass acquisition in the lumbar spine, and had BMD and BMC median variations of 2.07% and +1.57%, respectively, between the measurements at baseline and 12 months. The control group had median variations of +12.16% and +16.84% for BMD and BMC, respectively, over the same period. The total body BMD and BMC showed similar evolutions during the study in both groups. Statistical significance (p < 0.05) was seen for the BMC percentage variation between COC users and non-users.Conclusions: Use of a low-dose COC (ethinylestradiol 20 mu g/desogestrel 150 mu g) was associated with lower bone mass acquisition in adolescents during the study period.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Fundação para o Desenvolvimento da UNESP (FUNDUNESP)Universidade Estadual Paulista, Departamento de Pediatria, Faculdade de Medicina de BotucatuUniversidade Estadual Paulista, Departamento de Doenças Tropicais e Diagnósticos por Imagem, Faculdade de Medicina de BotucatuFAPESP: 2011/05991-0Biomed Central LtdUniversidade Estadual Paulista (Unesp)Biason, Talita Poli [UNESP]Goldberg, Tamara Beres Lederer [UNESP]Kurokawa, Cilmery Suemi [UNESP]Moretto, Maria Regina [UNESP]Teixeira, Altamir Santos [UNESP]Nunes, Hélio Rubens de Carvalho [UNESP]2015-10-21T13:09:31Z2015-10-21T13:09:31Z2015-04-03info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1-7application/pdfhttp://www.biomedcentral.com/1472-6823/15/15Bmc Endocrine Disorders. London: Biomed Central Ltd, v. 15, p. 1-7, 2015.1472-6823http://hdl.handle.net/11449/12839510.1186/s12902-015-0012-7WOS:000354915600001WOS000354915600001.pdf721483485926039785104232695404650000-0001-7017-766X0000-0003-1380-7527Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBmc Endocrine Disorders2.0270,965info:eu-repo/semantics/openAccess2023-12-07T06:19:22Zoai:repositorio.unesp.br:11449/128395Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-12-07T06:19:22Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Low-dose combined oral contraceptive use is associated with lower bone mineral content variation in adolescents over a 1-year period |
title |
Low-dose combined oral contraceptive use is associated with lower bone mineral content variation in adolescents over a 1-year period |
spellingShingle |
Low-dose combined oral contraceptive use is associated with lower bone mineral content variation in adolescents over a 1-year period Biason, Talita Poli [UNESP] Adolescent Bone density Bone mineral content Contraceptives Osteoporosis |
title_short |
Low-dose combined oral contraceptive use is associated with lower bone mineral content variation in adolescents over a 1-year period |
title_full |
Low-dose combined oral contraceptive use is associated with lower bone mineral content variation in adolescents over a 1-year period |
title_fullStr |
Low-dose combined oral contraceptive use is associated with lower bone mineral content variation in adolescents over a 1-year period |
title_full_unstemmed |
Low-dose combined oral contraceptive use is associated with lower bone mineral content variation in adolescents over a 1-year period |
title_sort |
Low-dose combined oral contraceptive use is associated with lower bone mineral content variation in adolescents over a 1-year period |
author |
Biason, Talita Poli [UNESP] |
author_facet |
Biason, Talita Poli [UNESP] Goldberg, Tamara Beres Lederer [UNESP] Kurokawa, Cilmery Suemi [UNESP] Moretto, Maria Regina [UNESP] Teixeira, Altamir Santos [UNESP] Nunes, Hélio Rubens de Carvalho [UNESP] |
author_role |
author |
author2 |
Goldberg, Tamara Beres Lederer [UNESP] Kurokawa, Cilmery Suemi [UNESP] Moretto, Maria Regina [UNESP] Teixeira, Altamir Santos [UNESP] Nunes, Hélio Rubens de Carvalho [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Biason, Talita Poli [UNESP] Goldberg, Tamara Beres Lederer [UNESP] Kurokawa, Cilmery Suemi [UNESP] Moretto, Maria Regina [UNESP] Teixeira, Altamir Santos [UNESP] Nunes, Hélio Rubens de Carvalho [UNESP] |
dc.subject.por.fl_str_mv |
Adolescent Bone density Bone mineral content Contraceptives Osteoporosis |
topic |
Adolescent Bone density Bone mineral content Contraceptives Osteoporosis |
description |
Background: Low-dose combined oral contraceptives (COCs) can interfere with bone mass acquisition during adolescence. This study aimed to evaluate bone mineral density (BMD) and bone mineral content (BMC) in female adolescents taking a standard low-dose COC (ethinylestradiol 20 mu g/desogestrel 150 mu g)over a 1-year period and to compare their data with those of healthy adolescents from the same age group not taking COCs.Methods: This was a non-randomized parallel-control study with a 1-year follow-up. Sixty-seven adolescents aged from 12 to 19 years, divided into COC users (n = 41) taking 20 mu g ethinylestradiol/150 mu g desogestrel and COC non-user controls (n = 26), were evaluated by bone densitometry examinations at baseline and after 12 months. Comparisons between the groups at the study onset were performed using the Mann-Whitney test with the significance level fixed at 5% or p < 0.05. Comparisons between the groups at the study onset and after 12 months were based on variations in the median percentages for bone mass variables.Results: The COC users presented with low bone mass acquisition in the lumbar spine, and had BMD and BMC median variations of 2.07% and +1.57%, respectively, between the measurements at baseline and 12 months. The control group had median variations of +12.16% and +16.84% for BMD and BMC, respectively, over the same period. The total body BMD and BMC showed similar evolutions during the study in both groups. Statistical significance (p < 0.05) was seen for the BMC percentage variation between COC users and non-users.Conclusions: Use of a low-dose COC (ethinylestradiol 20 mu g/desogestrel 150 mu g) was associated with lower bone mass acquisition in adolescents during the study period. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-10-21T13:09:31Z 2015-10-21T13:09:31Z 2015-04-03 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.biomedcentral.com/1472-6823/15/15 Bmc Endocrine Disorders. London: Biomed Central Ltd, v. 15, p. 1-7, 2015. 1472-6823 http://hdl.handle.net/11449/128395 10.1186/s12902-015-0012-7 WOS:000354915600001 WOS000354915600001.pdf 7214834859260397 8510423269540465 0000-0001-7017-766X 0000-0003-1380-7527 |
url |
http://www.biomedcentral.com/1472-6823/15/15 http://hdl.handle.net/11449/128395 |
identifier_str_mv |
Bmc Endocrine Disorders. London: Biomed Central Ltd, v. 15, p. 1-7, 2015. 1472-6823 10.1186/s12902-015-0012-7 WOS:000354915600001 WOS000354915600001.pdf 7214834859260397 8510423269540465 0000-0001-7017-766X 0000-0003-1380-7527 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Bmc Endocrine Disorders 2.027 0,965 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1-7 application/pdf |
dc.publisher.none.fl_str_mv |
Biomed Central Ltd |
publisher.none.fl_str_mv |
Biomed Central Ltd |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1803046840447270912 |